DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Irk2 and Kcnj16

DIOPT Version :9

Sequence 1:	NP_001287485.1	Gene:	Irk2 / 42770	FlyBaseID:	FBgn0039081	Length:	454	Species:	Drosophila melanogaster
Sequence 2:	NP_001239136.1	Gene:	Kcnj16 / 16517	MGIID:	1314842	Length:	419	Species:	Mus musculus

Alignment Length:	371	Identity:	151/371 - (40%)
Similarity:	214/371 - (57%)	Gaps:	27/371 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 SYYGLSQN----GKPFPRQPSCRSRNFRPGSMRRVRRRAVFKNGDCNVVQKHLQRRRVRFLQDMY 125
            ||||.|..    ...:|..|.    .......||.|||.:.|:|.|||..||:......::.|::
Mouse     2 SYYGSSYRIVNVDSKYPGYPP----EHAIAEKRRARRRLLHKDGSCNVYFKHIFGEWGSYMVDIF 62

  Fly   126 TTMVDWQWRWTLLAFALSFILSWLFFALIWWLIIYTHGD-LEEPHLPENQEESGWAPCVSAIDGF 189
            ||:||.:||...:.|:||:|||||.|..|:|||.:.||| |.:|.:         .|||..:..|
Mouse    63 TTLVDTKWRHMFVIFSLSYILSWLIFGSIFWLIAFHHGDLLSDPDI---------TPCVDNVHSF 118

  Fly   190 TSCFLFSIETQHTIGYGVRTTSPECPEAIFMMCFQSIYGVMSSAFMAGIVFAKMTRAKQRAQTLL 254
            |:.||||:|||.|||||.|..:.||..|:..:..|||...:.:.|:.|...|||..|::||||:.
Mouse   119 TAAFLFSLETQTTIGYGYRCVTEECSVAVLTVILQSILSCIINTFIIGAALAKMATARKRAQTIR 183

  Fly   255 FSKHAVICQRDGTLSLMFRVGDMRKSHIIGAGVRAQLIRTKSTKEGEVMTQYFTELEIGTDDSGS 319
            ||..|:|..|||.|.||:|:||.|.:|::...|||||:|.....||. ||..|.:|::..|
Mouse   184 FSYFALIGMRDGKLCLMWRIGDFRPNHVVEGTVRAQLLRYSEDSEGR-MTMAFKDLKLVND---- 243

  Fly   320 DLFFIWPMVIEHKIDENSPLYNLNATDMLQDKFEIVVILEGTVESTGQSTQARSSYINTEILWGH 384
            .:..:.|:.|.|:||..||||.|:...:.:|.|||:|....|.:|||.|.|:|||||..||||||
Mouse   244 QIILVTPVTIVHEIDHESPLYALDRKAVAKDNFEILVTFIYTGDSTGTSHQSRSSYIPREILWGH 308

  Fly   385 RFDPVVLYNKDLQAYEIDYARFNETTQVDTPLCSARELNEIYKIQE 430
            ||..|:...:  :.|:::..:|..:.:|..|.|||::|:  :|.|:
Mouse   309 RFHDVLEVKR--KYYKVNCLQFEGSVEVYAPFCSAKQLD--WKDQQ 350

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Irk2	NP_001287485.1	IRK	100..434	CDD:279361	139/332 (42%)
Kcnj16	NP_001239136.1	IRK	37..173	CDD:395797	60/144 (42%)
		Selectivity filter. /evidence=ECO:0000250	131..136		4/4 (100%)
		IRK_C	182..349	CDD:407551	72/175 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837122
Domainoid	1	1.000	155	1.000	Domainoid score	I4214
eggNOG	1	0.900	-	-		E1_KOG3827
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4709
OMA	1	1.010	-	-		QHG59160
OrthoDB	1	1.010	-	-		D289862at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11767
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	10	9.770