DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Irk2 and Kcnj12

DIOPT Version :9

Sequence 1:	NP_001287485.1	Gene:	Irk2 / 42770	FlyBaseID:	FBgn0039081	Length:	454	Species:	Drosophila melanogaster
Sequence 2:	XP_017452453.1	Gene:	Kcnj12 / 117052	RGDID:	621660	Length:	529	Species:	Rattus norvegicus

Alignment Length:	491	Identity:	194/491 - (39%)
Similarity:	278/491 - (56%)	Gaps:	69/491 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 AAPTSTTIPTTTQANGGEQATQ----------------------PLK------KAIEADPDSLD- 45
            :.||..|.|..:|..|.|.::|                      ||:      ||.|..|..:.
  Rat    28 STPTLATFPWKSQEPGAEMSSQNSPRVPQPRQPSASWPRQKQHPPLQPRASATKAHEVPPPGVSL 92

  Fly    46 ---------SVISNPQSYPITIVPNRPTSYYGLSQNGKPFPRQPSCRSRNFRPGSM---RRVRRR 98
                     .:.:..::.|.:||.:.....:.::.:|          :..|..|.:   ||.|.|
  Rat    93 GAGQGPPDPGMTAASRANPYSIVSSEEDGLHLVTMSG----------ANGFGNGKVHTRRRCRNR 147

  Fly    99 AVFKNGDCNVVQKHLQRRRVRFLQDMYTTMVDWQWRWTLLAFALSFILSWLFFALIWWLIIYTHG 163
            .|.|||.||:...::..:..|:|.||:||.||.:||:.||.|:|:|:.|||.|.:|:|:|...||
  Rat   148 FVKKNGQCNIEFANMDEKSQRYLADMFTTCVDIRWRYMLLIFSLAFLASWLLFGIIFWVIAVAHG 212

  Fly   164 DLEEPHLPENQEESGWAPCVSAIDGFTSCFLFSIETQHTIGYGVRTTSPECPEAIFMMCFQSIYG 228
            |||.      .|..|..|||..:.||.:.||||||||.|||||:|..:.|||.|:||:..|||.|
  Rat   213 DLEP------AEGRGRTPCVLQVHGFMAAFLFSIETQTTIGYGLRCVTEECPVAVFMVVAQSIVG 271

  Fly   229 VMSSAFMAGIVFAKMTRAKQRAQTLLFSKHAVICQRDGTLSLMFRVGDMRKSHIIGAGVRAQLIR 293
            .:..:||.|.:.|||.|.|:||||||||.:||:..|||.|.||:|||::|||||:.|.||||||:
  Rat   272 CIIDSFMIGAIMAKMARPKKRAQTLLFSHNAVVALRDGKLCLMWRVGNLRKSHIVEAHVRAQLIK 336

  Fly   294 TKSTKEGEVMTQYFTELEIGTDDSGSDLFFIWPMVIEHKIDENSPLYNLNATDMLQDKFEIVVIL 358
            .:.|:|||.:.....::::|.|.....:|.:.|:.|.|:|||.|||:.::..|:..|.|||||||
  Rat   337 PRVTEEGEYIPLDQIDIDVGFDKGLDRIFLVSPITILHEIDEASPLFGISRQDLETDDFEIVVIL 401

  Fly   359 EGTVESTGQSTQARSSYINTEILWGHRFDPVVLYNKDLQAYEIDYARFNETTQV-DTPLCSAREL 422
            ||.||:|..:|||||||:..||||||||:||:...|:  .|:|||:.|::|.:| .||.|||::|
  Rat   402 EGMVEATAMTTQARSSYLANEILWGHRFEPVLFEEKN--QYKIDYSHFHKTYEVPSTPRCSAKDL 464

  Fly   423 NEIYKIQEGFRTPAETTFTMRQ----LSHNHSDQAS 454
                 ::..|..|:..:|....    ||.:..|:.:
  Rat   465 -----VENKFLLPSANSFCYENELAFLSRDEEDEVA 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Irk2	NP_001287485.1	IRK	100..434	CDD:279361	165/334 (49%)
Kcnj12	XP_017452453.1	IRK_N	105..148	CDD:285640	9/52 (17%)
Kcnj12	XP_017452453.1	IRK	149..476	CDD:279361	166/339 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	196	1.000	Domainoid score	I3027
eggNOG	1	0.900	-	-		E1_KOG3827
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H7793
Inparanoid	1	1.050	362	1.000	Inparanoid score	I2118
OMA	1	1.010	-	-		QHG59160
OrthoDB	1	1.010	-	-		D289862at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm12329
orthoMCL	1	0.900	-	-		OOG6_101017
Panther	1	1.100	-	-	O	PTHR11767
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X128
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.880