DRSC/TRiP Functional Genomics Resources

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Protein Alignment Irk2 and Kcnj4

DIOPT Version :10

Sequence 1:NP_001287485.1 Gene:Irk2 / 42770 FlyBaseID:FBgn0039081 Length:454 Species:Drosophila melanogaster
Sequence 2:NP_446322.2 Gene:Kcnj4 / 116649 RGDID:621436 Length:446 Species:Rattus norvegicus


Alignment Length:370 Identity:175/370 - (47%)
Similarity:236/370 - (63%) Gaps:28/370 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly    67 YGLSQNGKP-FPRQPSCRSRNFRPGSMRRVRRRAVFKNGDCNVVQKHLQRRRVRFLQDMYTTMVD 130
            :|.|:||:. .||              |:.|.|.|.|||.|||...:|..:..|::.|::||.||
  Rat     2 HGHSRNGQAHVPR--------------RKRRNRFVKKNGQCNVYFANLSNKSQRYMADIFTTCVD 52

  Fly   131 WQWRWTLLAFALSFILSWLFFALIWWLIIYTHGDLE-EPHLPENQEESG---------WAPCVSA 185
            .:||:.|:.|:.:|::|||||.|::|.|.:.||||| .|..|......|         ..||:..
  Rat    53 TRWRYMLMIFSAAFLVSWLFFGLLFWCIAFFHGDLEPSPSGPTAGGPGGNGGGAAPTAAKPCIMH 117

  Fly   186 IDGFTSCFLFSIETQHTIGYGVRTTSPECPEAIFMMCFQSIYGVMSSAFMAGIVFAKMTRAKQRA 250
            ::||...||||:|||.|||||.|..:.|||.|:..:..|||.|.:..:||.|.:.|||.|.|:||
  Rat   118 VNGFLGAFLFSVETQTTIGYGFRCVTEECPLAVIAVVVQSIVGCVIDSFMIGTIMAKMARPKKRA 182

  Fly   251 QTLLFSKHAVICQRDGTLSLMFRVGDMRKSHIIGAGVRAQLIRTKSTKEGEVMTQYFTELEIGTD 315
            ||||||.||||..|||.|.||:|||::|||||:.|.||||||:...|:|||.:.....:|.:|.|
  Rat   183 QTLLFSHHAVISVRDGKLCLMWRVGNLRKSHIVEAHVRAQLIKPYMTQEGEYLPLDQRDLNVGYD 247

  Fly   316 DSGSDLFFIWPMVIEHKIDENSPLYNLNATDMLQDKFEIVVILEGTVESTGQSTQARSSYINTEI 380
            .....:|.:.|::|.|:|||:||||.:...::..:.|||||||||.||:|..:|||||||:.:||
  Rat   248 IGLDRIFLVSPIIIVHEIDEDSPLYGMGKEELESEDFEIVVILEGMVEATAMTTQARSSYLASEI 312

  Fly   381 LWGHRFDPVVLYNKDLQAYEIDYARFNETTQV-DTPLCSARELNE 424
            ||||||:|||...|  ..|::||:||::|.:| .||.||||||.|
  Rat   313 LWGHRFEPVVFEEK--SHYKVDYSRFHKTYEVAGTPCCSARELQE 355

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Irk2NP_001287485.1 IRK 100..246 CDD:460023 66/155 (43%)
IRK_C 253..424 CDD:465439 93/171 (54%)
Kcnj4NP_446322.2 IRK 22..178 CDD:460023 66/155 (43%)
Val/Gly/Ala/Pro stretch 91..111 3/19 (16%)
Selectivity filter. /evidence=ECO:0000250 134..139 4/4 (100%)
IRK_C 185..357 CDD:465439 94/173 (54%)
PDZ-binding. /evidence=ECO:0000255 444..446
Blue background indicates that the domain is not in the aligned region.

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