DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Irk2 and kcnj2

DIOPT Version :9

Sequence 1:	NP_001287485.1	Gene:	Irk2 / 42770	FlyBaseID:	FBgn0039081	Length:	454	Species:	Drosophila melanogaster
Sequence 2:	XP_004916397.1	Gene:	kcnj2 / 100497641	XenbaseID:	XB-GENE-1012188	Length:	425	Species:	Xenopus tropicalis

Alignment Length:	361	Identity:	171/361 - (47%)
Similarity:	236/361 - (65%)	Gaps:	30/361 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 YGLSQNGKP--FPRQPSCRSRNFRPGSMRRVRRRAVFKNGDCNVVQKHLQRRRVRFLQDMYTTMV 129
            ||   |||.  ..|| .|||             |.|.|:|.|||...::..:..|:|.|::||.|
Frog    30 YG---NGKSKIHTRQ-QCRS-------------RFVKKDGHCNVQFINVSEKGQRYLSDIFTTCV 77

  Fly   130 DWQWRWTLLAFALSFILSWLFFALIWWLIIYTHGDLEEPHLPENQEESGWAPCVSAIDGFTSCFL 194
            |.:|||.|:.|.|:||||||||..::|||...|.||   ..||:.:     |||:.:..||:.||
Frog    78 DIRWRWMLVIFCLAFILSWLFFGCVFWLIALLHEDL---GAPESHK-----PCVTQVSSFTAAFL 134

  Fly   195 FSIETQHTIGYGVRTTSPECPEAIFMMCFQSIYGVMSSAFMAGIVFAKMTRAKQRAQTLLFSKHA 259
            ||||||.|||||.|..:.|||.|:||:.||||.|.:..||:.|.|.|||.:.|:|.:||:||.:|
Frog   135 FSIETQTTIGYGFRCVTDECPIAVFMVVFQSIVGCIIDAFIIGAVMAKMAKPKKRNETLVFSDNA 199

  Fly   260 VICQRDGTLSLMFRVGDMRKSHIIGAGVRAQLIRTKSTKEGEVMTQYFTELEIGTDDSGSDLFFI 324
            ||..|||.|.||:|||::||||::.|.|||||::::.|.|||.:.....::.:|.|.....:|.:
Frog   200 VIAMRDGKLCLMWRVGNLRKSHLVEAHVRAQLLKSRITSEGEYIPLDQIDINVGFDSGIDRIFLV 264

  Fly   325 WPMVIEHKIDENSPLYNLNATDMLQDKFEIVVILEGTVESTGQSTQARSSYINTEILWGHRFDPV 389
            .|:.|.|:|:|.||||:|:..|:....|||||||||.||:|..:||.||||:.:|||||||::||
Frog   265 SPITIVHEINEESPLYDLSKQDLDNSDFEIVVILEGMVEATAMTTQCRSSYLASEILWGHRYEPV 329

  Fly   390 VLYNKDLQAYEIDYARFNETTQV-DTPLCSARELNE 424
            :...::.  |::||:||::|.:| :||||.||:|.|
Frog   330 LFEERNY--YKVDYSRFHKTYEVPNTPLCCARDLAE 363

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Irk2	NP_001287485.1	IRK	100..434	CDD:279361	160/326 (49%)
kcnj2	XP_004916397.1	IRK_N	1..47	CDD:369890	10/33 (30%)
		IRK	48..186	CDD:366415	72/145 (50%)
		IRK_C	193..366	CDD:375232	85/173 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	201	1.000	Domainoid score	I2943
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	363	1.000	Inparanoid score	I2130
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D289862at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm9384
Panther	1	1.100	-	-	O	PTHR11767
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X128
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	7.160