DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Irk2 and kcnj9

DIOPT Version :9

Sequence 1:	NP_001287485.1	Gene:	Irk2 / 42770	FlyBaseID:	FBgn0039081	Length:	454	Species:	Drosophila melanogaster
Sequence 2:	XP_009297143.1	Gene:	kcnj9 / 100334285	ZFINID:	ZDB-GENE-081104-42	Length:	503	Species:	Danio rerio

Alignment Length:	436	Identity:	174/436 - (39%)
Similarity:	257/436 - (58%)	Gaps:	34/436 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 NFSTHSAAPTSTTIPTTTQANGGEQATQPLKKAIEADPDSLDSVISNPQSYPITIVPNRPTSYYG 68
            |....|....|.::|..      |:..:|:::|.:..|.:.:...|....:.:|.....||.  .
Zfish     5 NTGFSSCPEESLSLPVP------EKGEEPVEEAPKEAPPTDEQNTSEELGHVVTTETAPPTQ--A 61

  Fly    69 LSQNGKPFPRQPSCRSR-----------------NFRPGSMRRVRRRAVFKNGDCNVVQKHLQRR 116
            .|.|...|..:.:.|..                 .|.....:|.|:|.|.|||.|| ||....|.
Zfish    62 PSNNSMTFQDKMAAREAQANQHRKKIQVVGQERGRFGWARSKRKRQRYVEKNGRCN-VQHGNMRE 125

  Fly   117 RVRFLQDMYTTMVDWQWRWTLLAFALSFILSWLFFALIWWLIIYTHGDLEEPHLPENQEESGWAP 181
            ..|:|.|::||:||..||.:||.|.:::.::||||..||:||.|..|||:  ||    |:..|.|
Zfish   126 TYRYLTDIFTTLVDLNWRCSLLVFVMAYAVTWLFFGAIWYLIAYCRGDLD--HL----EDESWTP 184

  Fly   182 CVSAIDGFTSCFLFSIETQHTIGYGVRTTSPECPEAIFMMCFQSIYGVMSSAFMAGIVFAKMTRA 246
            ||:.::||.|.|||||||:.|||||.|..:.:||....::..|:|.|.|.:|||.|.:|.|:::.
Zfish   185 CVNNVNGFISAFLFSIETETTIGYGYRVITDQCPVGTMLLLLQAILGSMVNAFMVGCMFVKISQP 249

  Fly   247 KQRAQTLLFSKHAVICQRDGTLSLMFRVGDMRKSHIIGAGVRAQLIRTKSTKEGEVMTQYFTELE 311
            .:||:||:||::|||..||..|.|||||||:|.|||:||.:||:||::|.|:|||.:....|::.
Zfish   250 NKRAETLVFSRNAVISLRDDKLCLMFRVGDLRSSHIVGANMRAKLIKSKQTQEGEFIPLDQTDIS 314

  Fly   312 IGTDDSGSDLFFIWPMVIEHKIDENSPLYNLNATDMLQDKFEIVVILEGTVESTGQSTQARSSYI 376
            :|.:.....||.:.|:||.|:||..||.::::...:.::.|||||||||.||:||.:.||||||:
Zfish   315 VGFETGDDRLFLVSPLVISHEIDVRSPFWDMSQNQLEKEDFEIVVILEGMVEATGMTCQARSSYL 379

  Fly   377 NTEILWGHRFDPVVLYNKDLQAYEIDYARFNETTQVDTPLCSAREL 422
            ..|::|||||.|::...:..  :::||..|:.|.:||||.||||||
Zfish   380 AEEVMWGHRFSPMMCLAEGF--FDVDYGAFHHTFEVDTPSCSAREL 423

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Irk2	NP_001287485.1	IRK	100..434	CDD:279361	154/323 (48%)
kcnj9	XP_009297143.1	IRK	110..419	CDD:279361	148/317 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	195	1.000	Domainoid score	I3095
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	366	1.000	Inparanoid score	I2116
OMA	1	1.010	-	-		QHG59160
OrthoDB	1	1.010	-	-		D289862at33208
OrthoFinder	1	1.000	-	-		FOG0000937
OrthoInspector	1	1.000	-	-		mtm6353
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11767
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X128
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	10.080