DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4374 and MESR4

DIOPT Version :9

Sequence 1:	NP_001262874.1	Gene:	CG4374 / 42767	FlyBaseID:	FBgn0039078	Length:	772	Species:	Drosophila melanogaster
Sequence 2:	NP_001097359.1	Gene:	MESR4 / 36986	FlyBaseID:	FBgn0034240	Length:	2171	Species:	Drosophila melanogaster

Alignment Length:	715	Identity:	137/715 - (19%)
Similarity:	217/715 - (30%)	Gaps:	243/715 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   157 QDKDNSRLDSSSIFEDLDR---------------YCW----QQQPVTTSASNGGSASTNQPSPTS 202
            :||:...||.|:..:.||.               ..|    |.|.|.............:.|..:
  Fly  1505 EDKEEKPLDGSTEEKALDADDELEPKKEEDQVDVSIWKNLLQNQAVAIPEEQAVKDEEREDSLVN 1569

  Fly   203 -PQGHLQQQQQHQQHQQLQQQQQQQQQQQPNANSSSAASSGAGSSSDTISSLDTTDGQIYTLTVL 266
             |...|........:.:|.:.......:|.:||.||..:.|..:|||
  Fly  1570 LPPAKLHVAWSDHDYCKLYRTPAPSPVKQKSANKSSIKTPGENASSD------------------ 1616

  Fly   267 NGGEPWLKRSESEQLPTSLDLDS---LLGSFPGYIKSEYPYDDSGFSTDGKDVIGNGTDGLSSIS 328
                     |:|....:|.|.||   ..||           :.|..|::.....||..|..||.:
  Fly  1617 ---------SDSSSSSSSSDSDSSSCSCGS-----------NCSCSSSNSSSSSGNSDDSDSSTA 1661

  Fly   329 QPQNQGQQAQQTLPSLVTAISLA----GGNDLGQ---QLAQFQNNN--------------NDWHM 372
            :...|.:..:::|....::.||.    |.|:..|   ..|..:|||              :|:..
  Fly  1662 RGSPQKRSRKKSLKVKKSSESLKIDQNGQNEQNQVEDTTAVNENNNPVAPPSPKPPMYNESDFDT 1726

  Fly   373 ADHNTETE--QSTAESLLRSALQGKGYAKGLHMQNGLTMPVVKDEDMRRLLFADEAAALGFADST 435
            |..:|:.|  .|..:.|....|..|                      |..|.|:.|        .
  Fly  1727 AFSDTDEEFYDSHPQKLANELLTQK----------------------REALMAEHA--------P 1761

  Fly   436 LSAAQMFDEAQGIHLSSQQQQQQQQQQQQAHNGNANILVDDMFLSLENAFSDDFEKI--KRIANE 498
            :..:..:|..:....|:....::                       .:||:|..||:  |:...|
  Fly  1762 MRPSNNYDIVENSRPSTPSLPEE-----------------------ASAFADKREKVRNKKKKRE 1803

  Fly   499 VQQFCSAG-----SSGTPTPGDYVPSSDVLMQISPSPAVTSAGQLQPPQPLKPEVSTSTSPTSAV 558
            .:..|.:|     :|.||.|.|.:|....:  |:|         |:||.|:.....:|..|.:.:
  Fly  1804 RKSTCKSGKLQPVASTTPPPMDRIPGMPGM--IAP---------LEPPTPILSHPESSLFPVTPL 1857

  Fly   559 V----------------ASAASNHVRSGGGVVKPKKAYKRSSSNNNNPNVANNNQSSGGNPLIAG 607
            .                .|.|...::......:|.|.|..:|.:.|...|.       ..||..|
  Fly  1858 THRQLQSSMTRMSEGSSCSDADGQLKRSKRQRRPNKFYGYTSDDENMSAVL-------APPLQVG 1915

  Fly   608 --------------------SGSGSSSSSGSASSSSNSPPANSGGSSSSSSGSTQRKERSLHYCS 652
                                :.....:.:.:.||..:...:|.|.:.||...|.||        |
  Fly  1916 MQLIKPQPPPQLTWAKEDLPTPPKQRNRNNNNSSHHHHSHSNGGMAGSSRKRSKQR--------S 1972

  Fly   653 ICAKGFKDKYSVNVHIRTHTGEKPFACSLCGKSFRQKAHLAKHYQTHMTQKNNGNIIKGGSGKHQ 717
            :...|               |.:|        :.|.|.....|.....|.|...:::. .:....
  Fly  1973 LFGAG---------------GSRP--------AKRHKPDPNDHLPPIPTLKIRPSLLP-TTAPPS 2013

  Fly   718 RSSGSSAGSARASLN-----QRQQQLGGGVVPPSLPVMISNPNTPPGGV------LPPANGLLAN 771
            .||.||:....|.:|     ...|.....|:|..|||.:..|..||...      :|||  ||.|
  Fly  2014 DSSESSSDDEEAEVNVTSVVPTPQPAPPPVLPTPLPVALPVPPPPPPAATAFNQPIPPA--LLPN 2076

Fly 772 771
Fly 2077 2076

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4374	NP_001262874.1	zf-C2H2	649..671	CDD:278523	2/21 (10%)
		C2H2 Zn finger	651..671	CDD:275370	2/19 (11%)
		zf-H2C2_2	663..688	CDD:290200	2/24 (8%)
		C2H2 Zn finger	679..699	CDD:275370	3/19 (16%)
MESR4	NP_001097359.1	C2H2 Zn finger	1272..1288	CDD:275368
		C2H2 Zn finger	1295..1315	CDD:275370
		C2H2 Zn finger	1323..1341	CDD:275370
		PHD_ING	2110..2156	CDD:276980
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24393
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100