DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4393 and Anks1b

DIOPT Version :9

Sequence 1:	NP_001287483.1	Gene:	CG4393 / 42764	FlyBaseID:	FBgn0039075	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	XP_030101220.1	Gene:	Anks1b / 77531	MGIID:	1924781	Length:	1339	Species:	Mus musculus

Alignment Length:	1534	Identity:	441/1534 - (28%)
Similarity:	621/1534 - (40%)	Gaps:	502/1534 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGKDQEFLEAARNGNISHIEKVLTQK-----AKRAGP-----LASLRRGTGVNVQDSGGYSALHH 55
            ||||||.|||||.||::.:||:|:.:     ...:||     |.|:.||..||..||.||:||||
Mouse     1 MGKDQELLEAARTGNVALVEKLLSGRKGGILGGGSGPLPLSNLLSIWRGPNVNCTDSSGYTALHH 65

  Fly    56 ACLNGHEDIVRLLLAHEASPNLPDSRGSSPLHLAAWAGETEIVRLLLTHPYRPASANLQTIEQET 120
            |.||||:|||..||.:|||.|:.|::|..|:|||||.|:.|||::|:.|....:..|.|..|.||
Mouse    66 AALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIVKILIHHGPSHSRVNEQNNENET 130

  Fly   121 PLHCAAQHGHTGALALLLHHDADPNMRNSRGETPLDLAAQYGRLQAVQMLIRAHPELIAHLGTEA 185
            .||||||:||:..:|:||....||.:|||:.||||||||.||||:.|:|:|.|||.|:: ..|.
Mouse   131 ALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLAALYGRLRVVKMIISAHPNLMS-CNTR- 193

  Fly   186 LERGTPSPSSPASPSRAIFPHTCLHLASRNGHKSVVEVLLSAGVSVNLLTPSGTALHEAALCGKE 250
                               .||.||||:|||||:||:|||.||:.|:..|..|:|||||||.||.
Mouse   194 -------------------KHTPLHLAARNGHKAVVQVLLEAGMDVSCQTEKGSALHEAALFGKV 239

  Fly   251 NVVRTLLKAGINLNATDNEGRTALDILREFPPHVTKHIVAVINNFRNQMDTDEGDEVIYRQHSGP 315
            :|||.||:.||:.|..|:.|||.||||:|.|...:..|..::.::.
Mouse   240 DVVRVLLETGIDANIKDSLGRTVLDILKEHPSQKSLQIATLLQDYL------------------- 285

  Fly   316 PNSGRGQN----KHHSQQQPPLSNHYHFNSNNHLLNHSHSMQQSGYSKQRLSAGNGGPYNGGKSL 376
              .|.|::    :.|:|:...        ...||.:.:.|.|:   :|.....|     ...|.|
Mouse   286 --EGAGRSAAVLEEHAQEDTA--------QETHLSSPAESPQK---TKSETVTG-----ELSKLL 332

  Fly   377 D--SALQPEDRFYQDLNAHSPLH--------SQNEMG--GGYSVSPSSSLSSFEPASV-----SP 424
            |  ...|.:|..::||......|        |:.|:|  |..||..||:: :..|..|     .|
Mouse   333 DEIKLCQEKDYSFEDLCHTISDHYLDNLSKISEEELGKNGSQSVRTSSTI-NLSPGEVEDEEEDP 396

  Fly   425 RSRCSTG------------GLGQPMHMSTFAPAGPPKKPPRRNLSVSPTHAGPGQQFSYSSPSSQ 477
            .|...||            .||.||    .|....|||
Mouse   397 NSCGPTGLWEALTPCNGCRNLGFPM----LAQESYPKK--------------------------- 430

  Fly   478 SQSQSHGHGQNQVRRQPASESPYSHQSHGSVGGMSFDETQLRERQRNDRLYASARQSTRSAIAGG 542
                         |..|....|                              ||...|..
Mouse   431 -------------RNFPMEMEP------------------------------SASLDTFP----- 447

  Fly   543 MSLSSSNDMLDRQCSSSELNSETSVPNSSGDSPAT-NSMKRPIPAPRSSTTKLSKELLKSAESAT 606
               |.:.:.|.....::......|:..:...||.| |:.:..|.||.:|
Mouse   448 ---SENENFLCELVDTAVTKKPCSLEIARAPSPRTDNASEVAITAPGTS---------------- 493

  Fly   607 LKSYNPNRKLKRNRNSSGANGAAKSNGGDENCEAKQQIPSSPTHYKQPPTPDHPPPSSSQAERTI 671
                       .:||||..                             ||||..|||...|.:.|
Mouse   494 -----------HHRNSSTG-----------------------------PTPDCSPPSPDTALKNI 518

  Fly   672 HERIRPLSQEYKRRSALLQL--------QAAQQLMIETG-----SSPSKLLPTLSTPGYDYDDTV 723
            .:.|||  |..:|.|.:..|        |...::...||     |||:...||.|.      :|.
Mouse   519 VKVIRP--QPKQRTSIVSSLDFQRMNHNQEYFEISTSTGCTSFTSSPAASPPTSSV------ETT 575

  Fly   724 TVVPRCPAPSSGSLSSSISCSDHSLSHSTDYVEEFVSDVP-------FAGLLKGASQQLKEQPEV 781
            .|                  .:....|:.|..::...:.|       |||||.|:|... |.||.
Mouse   576 EV------------------KNEGAEHADDLSQQEDDEPPKEYDAGQFAGLLHGSSPAC-ESPEN 621

  Fly   782 KLKI-----------QEESKPQQTLPRVRPPIPTKPAIPEKKFAKPPTT------PTNQSLE--- 826
            ...:           .|.|.....||..:.||...|. |..|..||...      ..|..||
Mouse   622 PFHLYGKRNTCEDGPDEASLANSPLPFKQTPIENNPE-PSVKKVKPKVVSRTIFHKRNHQLENHT 685

  Fly   827 -------ANGNSSSDV-VIKP----------------PRS-----PSKSPSKTSNKSPVKSPGKS 862
                   .:|:.:.|. .:.|                |::     .||:.|| |:...:..|.|.
Mouse   686 IVGTRMSRSGSRNGDQWGVNPGGFVERACTLGRIRSLPKALIDMHLSKNVSK-SDSDLIAYPSKD 749

  Fly   863 PAKSPGSGHSAARNSINLLSPFNAEEAR------KKISEIIENFGSGI------LNTSITPTHDI 915
            .|:...|..|.|..|    |..|:|...      ::|.:|:.:...||      :|...:
Mouse   750 KARVNWSKSSTAERS----SKDNSERTPSFTSEWEEIDKIMNSIDVGINSELEGMNAQCS----- 805

  Fly   916 ELDF-EDMEVPNERRELATR----------------------LRAAGLLHLERILFENGYDNYKF 957
            ||.| .|......:||||..                      |.:.||...|..|..||:|:.:|
Mouse   806 ELYFMADWVAWESQRELALHLGPSWEDVHWGPRCPVQTVGQWLESIGLPQYENHLMANGFDSVQF 870

  Fly   958 V-NNVFEEPD---IPLLHIPERDAPKLLRFVQSLPPAE------FQPQVPVKTQQENKQMGVATL 1012
            : :||.|:.|   |.:|:...|.  ::|:.:|.||...      :.|               .::
Mouse   871 MGSNVMEDQDLLEIGILNSGHRQ--RILQAIQLLPKMRPIGHDGYHP---------------TSV 918

  Fly  1013 QQWLNTIALPEYLEFFNKHLYNTIESVCGVWDVELQTVLEINKLGHRRRILQSLAYIRQMRDSDS 1077
            .:||::|.|.:|.:.|..:.|.:::.:..:|::||..||:|:.:|||:|||.||.    .|..|.
Mouse   919 AEWLDSIELGDYTKAFLINGYTSMDLLKKIWELELINVLKISLIGHRKRILASLG----DRLHDD 979

  Fly  1078 KSQKTP----LGE---NNETNQL---------TTNGN---------GTAR--------EAPPR-- 1107
            ..||.|    |.|   |:...||         ||.|:         |.||        :..||
Mouse   980 PPQKPPRSITLREPSGNHTPPQLSPSLSQSTYTTGGSLDVPHIIMQGDARRRRNENYFDDIPRSK 1044

  Fly  1108 ---------------------LPANPVH--HRNSITGYRKSRPAPPPPAPPARKTAALQIRAPSE 1149
                                 .|.:.:|  |.....|                 ..::.:|.|:|
Mouse  1045 LERQMAQQSSVCEIWTNQNAGFPFSAIHQVHNTGDWG-----------------EPSITLRPPNE 1092

  Fly  1150 LLLGLPANLRTTEWRHSAQTLLNEHINYEVQYLGSTVVKELRGTESTKKSIQKLKTS---ADGEV 1211
            .....|...    |:|..:.|:.:..:|:..||||.::|||||||||:.:..|::.:   :..::
Mouse  1093 ATASTPVQY----WQHHPEKLIFQSCDYKAFYLGSMLIKELRGTESTQDACAKMRANCQKSTEQM 1153

  Fly  1212 KSGSPLSLAICHRGVEFKDVNSKRTICEHEIQNINCACQDSEDLRHFAYITKE--QDLHYCHVFL 1274
            |....:.|::.::||:|.|..:|..|.||||:||:||.||.|||..||||||:  .:.||||||.
Mouse  1154 KKVPTIILSVSYKGVKFIDAANKNIIAEHEIRNISCAAQDPEDLSTFAYITKDLKSNHHYCHVFT 1218

  Fly  1275 VESTDLASEIILTLGQAFEVAYQLAL--RDG--ITTTPE 1309
            ....:||.||||||||||||||||||  |.|  .:|.||
Mouse  1219 AFDVNLAYEIILTLGQAFEVAYQLALQARKGGHSSTLPE 1257

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4393	NP_001287483.1	Ank_2	<10..79	CDD:289560	38/78 (49%)
		ANK	43..171	CDD:238125	72/127 (57%)
		ANK repeat	49..79	CDD:293786	20/29 (69%)
		Ank_2	53..148	CDD:289560	49/94 (52%)
		ANK repeat	81..115	CDD:293786	14/33 (42%)
		ANK	112..257	CDD:238125	74/144 (51%)
		ANK repeat	117..148	CDD:293786	16/30 (53%)
		Ank_2	122..233	CDD:289560	55/110 (50%)
		ANK repeat	181..233	CDD:293786	20/51 (39%)
		Ank_5	224..276	CDD:290568	29/51 (57%)
		ANK repeat	237..267	CDD:293786	18/29 (62%)
		SAM_AIDA1AB-like_repeat2	1005..1069	CDD:188899	21/63 (33%)
		SAM	1009..1075	CDD:197735	22/65 (34%)
		PTB_Anks	1161..1305	CDD:269972	73/152 (48%)
Anks1b	XP_030101220.1	PHA02874	7..385	CDD:165205	170/436 (39%)
		ANK repeat	7..56	CDD:293786	18/48 (38%)
		ANK repeat	58..89	CDD:293786	20/30 (67%)
		Ank_2	63..158	CDD:372319	49/94 (52%)
		ANK repeat	91..125	CDD:293786	14/33 (42%)
		ANK repeat	127..158	CDD:293786	16/30 (53%)
		ANK repeat	160..191	CDD:293786	19/31 (61%)
		Ank_2	165..256	CDD:372319	55/111 (50%)
		ANK repeat	193..223	CDD:293786	19/49 (39%)
		ANK repeat	226..256	CDD:293786	18/29 (62%)
		Retinal	<480..>629	CDD:373855	49/231 (21%)
		SAM_AIDA1AB-like_repeat1	840..906	CDD:188898	20/67 (30%)
		SAM_AIDA1AB-like_repeat2	911..975	CDD:188899	22/82 (27%)
		PTB_Anks	1100..1249	CDD:269972	72/152 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	128	1.000	Domainoid score	I5300
eggNOG	1	0.900	-	-		E2759_KOG0507
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	468	1.000	Inparanoid score	I1512
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D252573at33208
OrthoFinder	1	1.000	-	-		FOG0003340
OrthoInspector	1	1.000	-	-		mtm8806
orthoMCL	1	0.900	-	-		OOG6_105646
Panther	1	1.100	-	-	O	PTHR24174
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1976
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.870