DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG4393 and CASKIN2

DIOPT Version :9

Sequence 1:NP_001287483.1 Gene:CG4393 / 42764 FlyBaseID:FBgn0039075 Length:1325 Species:Drosophila melanogaster
Sequence 2:NP_065804.2 Gene:CASKIN2 / 57513 HGNCID:18200 Length:1202 Species:Homo sapiens


Alignment Length:1433 Identity:339/1433 - (23%)
Similarity:493/1433 - (34%) Gaps:467/1433 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MGKDQEFLEAARNGNISHIEKVLTQ-KAKRAGPLASLRRGTGVNVQDSGGYSALHHACLNGHEDI 64
            ||::|:.:.|.:||:::.::|::.: ||.:...|.|.:| ..||.||:.|:||||||.|.|..::
Human     1 MGREQDLILAVKNGDVTGVQKLVAKVKATKTKLLGSTKR-LNVNYQDADGFSALHHAALGGSLEL 64

  Fly    65 VRLLLAHEASPNLPDSRGSSPLHLAAWAGETEIVRLLLTHPYRPASANLQTIEQETPLHCAAQHG 129
            :.|||..:|:.::.||.|..|||.|||.|..|.|||||.   ..|:.|..:::.:.|||.|||:|
Human    65 IALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLLLR---ASAAVNAASLDGQIPLHLAAQYG 126

  Fly   130 HTGALALLLHHDADPNMRNSRGETPLDLAAQYGRLQAVQMLIRAHPELIAHLGTEALERGTPSPS 194
            |.....:||.|.::|.:.|...:||||||.::|||:..|:|:.:| ..:|.|..||.:...|:.:
Human   127 HYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGRLKVAQLLLNSH-LCVALLEGEAKDPCDPNYT 190

  Fly   195 SPASPSRAIFPHTCLHLASRNGHKSVVEVLLSAGVSVNLLTPSGTALHEAALCGKENVVRTLLKA 259
            :|            ||||::|||:.|:..||.||:.:|..|.:|||||||||.||..|||.||:.
Human   191 TP------------LHLAAKNGHREVIRQLLRAGIEINRQTKTGTALHEAALYGKTEVVRLLLEG 243

  Fly   260 GINLNATDNEGRTALDILREF-PPHVTKHI------------VAVINNFRN-----QMDTDEGDE 306
            |:::|..:...:|||||:.:| ....::.|            |..:.:|.|     .::...||.
Human   244 GVDVNIRNTYNQTALDIVNQFTTSQASREIKQLLREASGILKVRALKDFWNLHDPTALNVRAGDV 308

  Fly   307 V-IYRQHSGPPNSGRGQNKHHSQQ----------------------------------------- 329
            : :..||  |....:| :.|.||:                                         
Human   309 ITVLEQH--PDGRWKG-HIHESQRGTDRIGYFPPGIVEVVSKRVGIPAARLPSAPTPLRPGFSRT 370

  Fly   330 -QPPLSNHYHFNSNNHLLNHSHSMQQSGYSK-----QRLSAGNGGPYNGGKSLDSALQPEDRFYQ 388
             |||.      ....|.|.:| .:.:.|.|.     .|.|.|:.|.....:|..|....|     
Human   371 PQPPA------EEPPHPLTYS-QLPRVGLSPDSPAGDRNSVGSEGSVGSIRSAGSGQSSE----- 423

  Fly   389 DLNAHSP-LHSQNEMGGGYSVSPSSS----LSSFEPASVS------PRSRCSTGGL--------- 433
            ..|.|.| |..:|.     ...||:.    |....|.|::      |.:.|.:|..         
Human   424 GTNGHGPGLLIENA-----QPLPSAGEDQVLPGLHPPSLADNLSHRPLANCRSGEQIFTQDVRPE 483

  Fly   434 -------GQPMH-----------MSTFAPAG---P--PKKPPRRNLSVSPTHAGPGQQFSYSSPS 475
                   .|.:|           .:.|..||   |  .:..|....::..|.  ||.:...:|..
Human   484 QLLEGKDAQAIHNWLSEFQLEGYTAHFLQAGYDVPTISRMTPEDLTAIGVTK--PGHRKKIASEI 546

  Fly   476 SQSQSQSH--------------GHGQNQVRRQPASESPYSHQSHGSVGGMSFDETQ---LRERQR 523
            :|......              ..|..|..:|..|.   .:.|.|.|..::::|.|   :.:...
Human   547 AQLSIAEWLPSYIPTDLLEWLCALGLPQYHKQLVSS---GYDSMGLVADLTWEELQEIGVNKLGH 608

  Fly   524 NDRLYASARQ--STRSAIAGGMSLSSSNDMLDRQCSSSELNSETSVPNSSGDSPATNSMKRPIPA 586
            ..:|....::  ..|..:..|.:||...   .|.....||.:...:.|  |:.|||       ..
Human   609 QKKLMLGVKRLAELRRGLLQGEALSEGG---RRLAKGPELMAIEGLEN--GEGPAT-------AG 661

  Fly   587 PRSST---TKLSKEL-------------LKSAESATLKSYNPNRKLKRNRNS--SGANGAAKSNG 633
            ||..|   ::||.||             |..|.|.:.:|..     .|:|.|  |....|.:.:|
Human   662 PRLLTFQGSELSPELQAAMAGGGPEPLPLPPARSPSQESIG-----ARSRGSGHSQEQPAPQPSG 721

  Fly   634 GDENCEAKQQIPSSPTHYKQPPTPDHPPPSSSQAERTIHERIRPLSQEYKRRSALLQLQAAQQLM 698
            ||         ||.|.....|...:.||                     |..|:|........:.
Human   722 GD---------PSPPQERNLPEGTERPP---------------------KLCSSLPGQGPPPYVF 756

  Fly   699 IETGSSPSKLLPTLSTPGYDYDDTVTVVPRC-----PAPSSGSLSSSISCSDHSLSH--STDYVE 756
            :....|||...|. ..||..:..:....|..     |.|...|         ||||.  .|:...
Human   757 MYPQGSPSSPAPG-PPPGAPWAFSYLAGPPATPPDPPRPKRRS---------HSLSRPGPTEGDA 811

  Fly   757 EFVSDVPFAGLLKGASQQLKEQPEVKLKIQEESKPQQTLPRVRPPIPTKPAIPEKKFAKPPTTPT 821
            |..::.|....| |:...|..:|           .:..|.|..|.:...||         ..||.
Human   812 EGEAEGPVGSTL-GSYATLTRRP-----------GRSALVRTSPSVTPTPA---------RGTPR 855

  Fly   822 NQSLEANGNSSSDVVIKPPRSPSKSPSKTSNKSPV-----KSPG----------------KSPAK 865
            :||.........     ||..|.|..|..|..||.     :|||                ..|::
Human   856 SQSFALRARRKG-----PPPPPPKRLSSVSGPSPEPPPLDESPGPKEGATGPRRRTLSEPAGPSE 915

  Fly   866 SPG------------------SGHSAARNSINLLSPFNAEEARKKISEIIENFGSGILNTSITPT 912
            .||                  .|...:|.|.....|| |||....|.:..:..|.....|.:.|.
Human   916 PPGPPAPAGPASDTEEEEPGPEGTPPSRGSSGEGLPF-AEEGNLTIKQRPKPAGPPPRETPVPPG 979

  Fly   913 HDIELDFED--MEVP--NERRELATRLRAAGLLHLERILFENGYDNYKFVNNVFEEPDIPLLHIP 973
            .|..|...|  ...|  .||..|.|.|.|.|                  |.:....|..||....
Human   980 LDFNLTESDTVKRRPKCREREPLQTALLAFG------------------VASATPGPAAPLPSPT 1026

  Fly   974 ERDAPKLLRFVQSLP---PAE-----------FQPQVPVKTQQENKQMGVATLQQWLNTIALP-E 1023
            ..::|......|..|   ||:           .||.||                      ..| .
Human  1027 PGESPPASSLPQPEPSSLPAQGVPTPLAPSPAMQPPVP----------------------PCPGP 1069

  Fly  1024 YLEFFNKHLYNTIESVCGVWDVELQ------TVLEINKLGHRRRILQSLAYIRQMRDSDSKSQKT 1082
            .||          .|....|:.|.:      .:|::...|                       ..
Human  1070 GLE----------SSAASRWNGETEPPAAPAALLKVPGAG-----------------------TA 1101

  Fly  1083 PLGENNETNQLTTNGNGTAREAPPRLPANPVHHRNSITGYRKSRPAPPPPAPPARKT-----AAL 1142
            |...:....||..:|...|    |||...||                |||.|.:..|     |..
Human  1102 PKPVSVACTQLAFSGPKLA----PRLGPRPV----------------PPPRPESTGTVGPGQAQQ 1146

  Fly  1143 QIRAPSELLLGLPANLRTTEWRHSAQTLLNEHINYEVQYLGSTVVKELRGT--ESTKKSIQKLKT 1205
            ::...|.   .|.|.||..|                 :.:|:   ||..||  .|||..:..:.|
Human  1147 RLEQTSS---SLAAALRAAE-----------------KSIGT---KEQEGTPSASTKHILDDIST 1188

  Fly  1206 SAD 1208
            ..|
Human  1189 MFD 1191

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG4393NP_001287483.1 Ank_2 <10..79 CDD:289560 26/69 (38%)
ANK 43..171 CDD:238125 57/127 (45%)
ANK repeat 49..79 CDD:293786 13/29 (45%)
Ank_2 53..148 CDD:289560 40/94 (43%)
ANK repeat 81..115 CDD:293786 16/33 (48%)
ANK 112..257 CDD:238125 60/144 (42%)
ANK repeat 117..148 CDD:293786 12/30 (40%)
Ank_2 122..233 CDD:289560 42/110 (38%)
ANK repeat 181..233 CDD:293786 17/51 (33%)
Ank_5 224..276 CDD:290568 27/51 (53%)
ANK repeat 237..267 CDD:293786 18/29 (62%)
SAM_AIDA1AB-like_repeat2 1005..1069 CDD:188899 8/70 (11%)
SAM 1009..1075 CDD:197735 8/72 (11%)
PTB_Anks 1161..1305 CDD:269972 11/50 (22%)
CASKIN2NP_065804.2 ANK 7..135 CDD:238125 52/131 (40%)
ANK repeat 7..46 CDD:293786 11/39 (28%)
ANK repeat 48..79 CDD:293786 13/30 (43%)
ANK 1 48..77 13/28 (46%)
Ank_2 53..145 CDD:289560 40/94 (43%)
ANK 76..209 CDD:238125 57/148 (39%)
ANK 2 81..110 15/31 (48%)
ANK repeat 85..112 CDD:293786 15/29 (52%)
ANK repeat 114..145 CDD:293786 12/30 (40%)
ANK 3 114..143 12/28 (43%)
ANK 4 147..176 12/29 (41%)
Ank_2 152..251 CDD:289560 48/111 (43%)
ANK repeat 158..219 CDD:293786 25/73 (34%)
ANK 183..311 CDD:238125 46/139 (33%)
ANK 5 188..217 13/40 (33%)
ANK 6 220..249 17/28 (61%)
ANK repeat 221..251 CDD:293786 18/29 (62%)
SH3_Caskin2 284..345 CDD:212996 12/63 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 355..460 25/121 (21%)
SAM_caskin1,2_repeat1 488..553 CDD:188896 12/66 (18%)
SAM 494..549 CDD:197735 10/56 (18%)
SAM_caskin1,2_repeat2 554..624 CDD:188897 10/72 (14%)
SAM 560..621 CDD:197735 10/63 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 676..1104 111/572 (19%)
Caskin-Pro-rich 798..883 CDD:293512 27/119 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1116..1181 26/107 (24%)
Caskin-tail 1145..1202 CDD:293238 16/70 (23%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0507
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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