DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4393 and caskin1

DIOPT Version :9

Sequence 1:	NP_001287483.1	Gene:	CG4393 / 42764	FlyBaseID:	FBgn0039075	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	XP_009297876.1	Gene:	caskin1 / 563678	ZFINID:	ZDB-GENE-071115-3	Length:	1555	Species:	Danio rerio

Alignment Length:	1389	Identity:	320/1389 - (23%)
Similarity:	510/1389 - (36%)	Gaps:	419/1389 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGKDQEFLEAARNGNISHIEKVLTQ-KAKRAGPLASLRRGTGVNVQDSGGYSALHHACLNGHEDI 64
            ||||||.|:|.:..::..::|:|.: |..:|..|.|.:| ..||.||:.|:|.||||.|||:.::
Zfish     1 MGKDQELLQAVKTEDLMTVQKLLQRPKPGKAKLLGSAKR-VNVNFQDTDGFSPLHHAALNGNVEV 64

  Fly    65 VRLLLAHEASPNLPDSRGSSPLHLAAWAGETEIVRLLLTHPYRPASANLQTIEQETPLHCAAQHG 129
            :.|||..:|..::.|.:|..|||.|||.|::|.::|||.   ..:|.|.|:.|.:.|||.|||||
Zfish    65 ISLLLDSQALVDIRDQKGMRPLHYAAWQGKSEPMKLLLK---SGSSVNGQSDEGQIPLHLAAQHG 126

  Fly   130 HTGALALLLHHDADPNMRNSRGETPLDLAAQYGRLQAVQMLIRAHPELIAHLGTEALERGTPSPS 194
            |.....:||.|.::|.:.::.|:||||||.::||:..||:|:.::  :.|.|    ||   |.|.
Zfish   127 HYDVSEMLLQHQSNPCIVDNAGKTPLDLACEFGRVGVVQLLLNSN--MCAAL----LE---PKPG 182

  Fly   195 SPASPSRAIFPHTCLHLASRNGHKSVVEVLLSAGVSVNLLTPSGTALHEAALCGKENVVRTLLKA 259
            ....|:..    :.||||::|||..::.:|:.||:.:|..|.:||||||||||||.:|||.||.:
Zfish   183 DSTDPNGT----SPLHLAAKNGHIDIIRLLIQAGIDINRQTKAGTALHEAALCGKTDVVRLLLDS 243

  Fly   260 GINLNATDNEGRTALDILREF-PPHVTKHI----------------VAVINNFRNQMDTDE---- 303
            |||....:...:|||||:.:| ....::.|                |..:.::.|..|...
Zfish   244 GINAAVRNTYSQTALDIVYQFTATQASREIKQMLRGKMRDASAALQVRALKDYCNNYDLTSLNIK 308

  Fly   304 -GDEV-IYRQHSGPPNSGRGQNKHHSQQQPPLSNHYHFNSNNHLLNHSHSMQQSGYSKQRLSAGN 366
             ||.: :..|||    .||.:...|..:           :.|..:.:..|......||:..:||:
Zfish   309 AGDVITVLEQHS----DGRWKGCIHDNR-----------TGNDRVGYFPSSMVEVISKRPGAAGS 358

  Fly   367 GGPYNGGKSLDSALQPEDRFYQDLNAHSPLHSQNEMGGGYSVSPSSSLSSFEPASVSPRSRCSTG 431
            .       |..:..|.    ||.:...:|:..        .|||:.::.:
Zfish   359 W-------STVTCTQQ----YQKIQLCAPVCG--------PVSPAVAMVN--------------- 389

  Fly   432 GLGQPMHMSTFAPAGPPKKPPRRNLSVSPTHAGPGQQFSYSSPSSQSQSQSHGHGQNQVRRQPAS 496
              |...|.....|. ||..||..:|   |.....|...|.::|......|...:.|:....:.:.
Zfish   390 --GDSYHEIHILPP-PPPPPPHSHL---PLFTSFGYNRSPNTPEEPHSGQEAKNDQDLASSRGSE 448

  Fly   497 ESPYSH--QSHGSVGGMSFDETQLRERQRNDRLYASARQSTRSAIAGG--MSLSSSNDMLD-RQC 556
            .||:..  .:.|..||.|.:...||:                 .:|||  .|:.||..:.. |..
Zfish   449 SSPHGSPTPAGGPQGGSSEEIWVLRK-----------------PVAGGDRSSVGSSGSVASARSS 496

  Fly   557 SSSELNSETSVPNSSGDSPATNSMKRPIPAPRSSTTKLSKELLKSAESATLKSYNPNRKLKRNRN 621
            .|.:....||:.::..:.      .:.:....|.:.|..:.||:..:|....|:
Zfish   497 GSGQSAGSTSILHAQAEG------VKLLATVLSQSAKAKEHLLEQTKSLDHPSH----------- 544

  Fly   622 SSGANGAAKSNGGDENCEAKQQIPSSPTHYKQP------PTPDHPPPSSSQAERTIHERIRPLSQ 680
                   |.||.|..:  ..|.:.|.|.| :||      ......||....:|..|..    ||:
Zfish   545 -------ASSNKGPSS--RSQSLSSCPLH-EQPYGEAVSQRKGEAPPEGKSSEAVIEW----LSE 595

  Fly   681 EYKRRSALLQLQAAQQLMIETGSSPSKLLPTLS-------------TPGYDYDDTVTV------- 725
                    .|||......|..|..    :||:|             .||:....|..:
Zfish   596 --------FQLQVYAPNFINAGYD----IPTISRMTPEDLTAIGVTKPGHRKKITSEINKISVNE 648

  Fly   726 -VPRCPAPSSGSLSSSISCSD-HSLSHSTDYVE-EFVSDVPFAGLLKGASQQLKEQPEVKL---- 783
             :|.....|.|...:.|..|. |.:.....|.. :|::|:.:..|.:....:|..|.::.|
Zfish   649 WLPDQKPASLGEWLAMIGLSQYHQVLVQNGYENIDFITDITWEDLQEIGITKLGHQKKLMLAVKK 713

  Fly   784 --KIQEESKPQQTLPRVRPPIPTKPAIPEKKFAKPPTTPTNQSLEANGNSSSDVVIKPPRSPSKS 846
              :|::.|..:.||.:                 |||......::|:           ||
Zfish   714 LAEIKKASDGRNTLRK-----------------KPPAAQEVMAIES-----------PP------ 744

  Fly   847 PSKTSNKSPVKSPGKSPAKSPGSGHSAARNSINLLSPFNAEEARKKISEIIENFGSGILNTSITP 911
                                        .:|...:||        |:|...::..||.|..::|.
Zfish   745 ----------------------------HDSGECMSP--------KMSTFQDSELSGELQAALTR 773

  Fly   912 THDIELDFEDMEVPNERRELATRLRAAGLLHLERILFENGYDNYKFVNNVFEEPDIPLLHIPERD 976
            ..|::          :..|:.|.   :|..|..|.|.||..:..:..    ||...|    |:::
Zfish   774 PADVQ----------DGTEVRTN---SGPQHRARSLHENSINKSRDT----EEHSGP----PKKE 817

  Fly   977 A------------------PKLLR-FVQSLPPAEFQPQVPVKTQQENKQMGVATLQQWLNTIALP 1022
            |                  ||..: :.|...|....||.|.||:....|   .|..........|
Zfish   818 ARTMRQSSQGGQRNVSSSQPKPRQSYPQGTGPPYTPPQTPTKTKPPASQ---TTSNPPGKPKPSP 879

  Fly  1023 EYLEFFNKHLYNTIESVCGVWDVELQTVLEINKLGHRRRILQ----------------------- 1064
            :.::                     ||...|...||.:...|
Zfish   880 QIVQ---------------------QTEKPITPRGHPQSPTQRSHPHPAAQPVESIEAPPQGPAV 923

  Fly  1065 SLAYIRQMRDSDSKSQKTPL---------------GENNETNQLTTNGNGTAREAPPRLPANPVH 1114
            |:..:....|.|....:..|               ||.........:..|......||     |.
Zfish   924 SVPLLCLPPDGDEACDEYGLPKKRAHSLNRYAVSDGEQERDELNVPDSGGKYATVQPR-----VG 983

  Fly  1115 HRNSITG-------------YRKSRPAPPPPAPPARKTAALQIRAPSELLLGLPANLRTTEWRHS 1166
            ..||:.|             .|:.:..|||| ||.|.::|:...:         :||.......:
Zfish   984 RSNSMKGQADKNVNRSQSFALRQKKKGPPPP-PPKRSSSAISSSS---------SNLTEVPKETN 1038

  Fly  1167 AQTLLNEHINYEVQY----LGSTVVKELRGTESTKKSIQKLKTSADG--------------EVKS 1213
            :..||:  |.|:.|.    ||.||.....|:..:..::.::.:...|              :|.|
Zfish  1039 SGPLLD--IPYQPQRRASDLGGTVDTGSAGSVRSIAAMLEMSSIGGGAKGLALQKSAGHYLQVGS 1101

  Fly  1214 GSPLSLAICHRGVEFKDVNSKRTI 1237
            |:....||   |::.:.||.:|||
Zfish  1102 GAKQRDAI---GLDGEVVNRRRTI 1122

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4393	NP_001287483.1	Ank_2	<10..79	CDD:289560	25/69 (36%)
		ANK	43..171	CDD:238125	57/127 (45%)
		ANK repeat	49..79	CDD:293786	13/29 (45%)
		Ank_2	53..148	CDD:289560	41/94 (44%)
		ANK repeat	81..115	CDD:293786	14/33 (42%)
		ANK	112..257	CDD:238125	62/144 (43%)
		ANK repeat	117..148	CDD:293786	14/30 (47%)
		Ank_2	122..233	CDD:289560	41/110 (37%)
		ANK repeat	181..233	CDD:293786	16/51 (31%)
		Ank_5	224..276	CDD:290568	28/51 (55%)
		ANK repeat	237..267	CDD:293786	20/29 (69%)
		SAM_AIDA1AB-like_repeat2	1005..1069	CDD:188899	10/86 (12%)
		SAM	1009..1075	CDD:197735	9/88 (10%)
		PTB_Anks	1161..1305	CDD:269972	22/95 (23%)
caskin1	XP_009297876.1	Ank_4	7..69	CDD:290365	23/62 (37%)
		ANK repeat	7..46	CDD:293786	11/39 (28%)
		ANK	43..168	CDD:238125	57/127 (45%)
		ANK repeat	48..79	CDD:293786	13/30 (43%)
		Ank_2	53..145	CDD:289560	41/94 (44%)
		ANK repeat	81..112	CDD:293786	14/33 (42%)
		ANK	109..241	CDD:238125	62/144 (43%)
		ANK repeat	114..145	CDD:293786	14/30 (47%)
		Ank_2	119..218	CDD:289560	42/111 (38%)
		ANK repeat	147..186	CDD:293786	18/47 (38%)
		ANK repeat	188..218	CDD:293786	11/33 (33%)
		Ank_5	208..261	CDD:290568	29/52 (56%)
		ANK repeat	221..251	CDD:293786	20/29 (69%)
		SH3	288..349	CDD:302595	13/75 (17%)
		Caskin1-CID	467..524	CDD:293208	12/79 (15%)
		SAM	581..644	CDD:197735	16/78 (21%)
		SAM_caskin1,2_repeat1	583..648	CDD:188896	15/80 (19%)
		SAM_caskin1,2_repeat2	649..719	CDD:188897	14/69 (20%)
		SAM	655..716	CDD:197735	12/60 (20%)
		Caskin-Pro-rich	944..1013	CDD:293512	11/73 (15%)
		Caskin-tail	1496..1555	CDD:293238
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0507
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810