DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4393 and CG11168

DIOPT Version :9

Sequence 1:	NP_001287483.1	Gene:	CG4393 / 42764	FlyBaseID:	FBgn0039075	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_001262939.1	Gene:	CG11168 / 42981	FlyBaseID:	FBgn0039249	Length:	863	Species:	Drosophila melanogaster

Alignment Length:	1351	Identity:	412/1351 - (30%)
Similarity:	546/1351 - (40%)	Gaps:	531/1351 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGKDQEFLEAARNGNISHIEKVLTQKAKRAGPLASLRRGTGVNVQDSGGYSALHHACLNGHEDIV 65
            |||||..|||:|.|:|..::|:|...:||.|||:|.||...:|.||..||::|||||||||.:||
  Fly     1 MGKDQHLLEASRAGDIKTVDKLLEHSSKRHGPLSSFRRSPSINCQDMNGYTSLHHACLNGHSNIV 65

  Fly    66 RLLLAHEASPNLPDSRGSSPLHLAAWAGETEIVRLLLTHPYRPASANLQTIEQETPLHCAAQHGH 130
            ||||:|.|..::||.|||:||.||||||..:||::||.|....|:.|.||||.|||||..|||||
  Fly    66 RLLLSHNALLDVPDIRGSTPLFLAAWAGHQDIVKMLLMHSPTGANPNAQTIENETPLHSGAQHGH 130

  Fly   131 TGALALLLHHDADPNMRNSRGETPLDLAAQYGRLQAVQMLIRAHPELIAHLGTEALERGTPSPSS 195
            ...:|:||.:.|||.:||:..:|.||||||:||||.||.|:|.:|:||  |..:.||........
  Fly   131 NAVVAILLSYGADPAIRNNSFQTALDLAAQFGRLQVVQTLLRVYPDLI--LPYKRLEDDNEELLG 193

  Fly   196 PASPSRAIFPHTCLHLASRNGHKSVVEVLLSAGVSVNLLTPSGTALHEAALCGKENVVRTLLKAG 260
             ..|.:.||.|||||||||||||.|||.||:|||.||:||.:|:||||||||||::||.||||||
  Fly   194 -CMPIKHIFTHTCLHLASRNGHKKVVETLLAAGVDVNILTNAGSALHEAALCGKKSVVVTLLKAG 257

  Fly   261 INLNATDNEGRTALDILREFPPHVTKHIVAVINNFRNQMDTDEGDEVIYRQHSGPPNSGRGQNKH 325
            |.::|||..||||||||.::|||||..||..||.|....          |:|
  Fly   258 IYVHATDGNGRTALDILSDYPPHVTYDIVGAINEFTQAA----------REH------------- 299

  Fly   326 HSQQQPPLSNHYHFNSNNHLLNHSHSMQQSGYSKQRLSAGNGGPYNGGKSLDSALQPEDRFYQDL 390
                |.||.          :.|.:.|:.:..|.|              .|....:.|..|..||
  Fly   300 ----QKPLV----------VENGTQSLPKRLYEK--------------NSQRQKVPPRQRKKQD- 335

  Fly   391 NAHSPLHSQNEMGGGYSVSPSSSLSSFEPASVSPRSRCSTGGLGQPMHMSTFAPAGPPKKPPRRN 455
                  |..|.:        |.||||                      :..||      |||...
  Fly   336 ------HQANGL--------SHSLSS----------------------LDIFA------KPPENY 358

  Fly   456 LSVSPTHAGPGQQFSYSSPSSQSQSQSHGHGQN------QVRRQPASES--PYSHQSHGSVGGMS 512
            |.:.|.         ....|..:.|....:|.|      .|.:||...|  ..|..|:|||...|
  Fly   359 LQMKPI---------IHQKSCDNMSDFRTNGSNLLTSYKPVYKQPMLPSFRMDSDISNGSVPSRS 414

  Fly   513 FDETQ-LRERQRNDRLYASARQSTRSAIAGGMSLSSSNDMLDRQCSSSELNSETSVPNSSGDSPA 576
            ::... ||....:|...||               :|||..:.:|..::.:..:...|
  Fly   415 YEYINLLRNGSHSDDNSAS---------------TSSNSAVRQQAVATYVEMKLPTP-------- 456

  Fly   577 TNSMKRPIPAPRSSTTKLSKELLKSAESATLKSYNPNRKLKRNRNSSGANGAAKSNGGDENCEAK 641
                  |:|.||   |:::.|....|....::..:....:..|.||:|       ||      .|
  Fly   457 ------PVPKPR---TRINGEYNDYANVVPIEEGSCVAAVDNNNNSNG-------NG------TK 499

  Fly   642 QQIPSSPTHYKQPPTPDHPPPSSSQAERTIHERIRPLSQEYKRRSALLQLQAAQQLMIETGSSPS 706
            .::      .:..||||:|||:.::|||||...::|.:   .|:::||:
  Fly   500 LRL------VRHSPTPDYPPPTVTEAERTIFNFMQPAT---LRKNSLLE---------------- 539

  Fly   707 KLLPTLSTPGYDYDDTVTVVPRCPAPSSGSLSSSISCSDHSLSHSTDYVEEFVSDVPFAGLLKGA 771
                                   ||.|..:.:|.          |:|.|||:|:|:|||||.||:
  Fly   540 -----------------------PAESPRTTNSV----------SSDQVEEYVADIPFAGLFKGS 571

  Fly   772 SQQLKEQPEVKLKIQEESKPQQTLPRVRPPIPTKPAIPEKKFAKPPTTPTNQSLEANGNSSSDVV 836
                                  ||                                  |.|||||
  Fly   572 ----------------------TL----------------------------------NLSSDVV 580

  Fly   837 -----IKPPRSPSKSPSKTSNKSPVKSPGKSPAKSPGSGHSAARNSINLLSPFNAEEARKKISEI 896
                 :...|...:|||.. ..:.|::..:|.:|...|.         |...|:|.....:|..|
  Fly   581 DGIGAVPGDREFLQSPSMV-RSAHVQNHRRSLSKQRYSA---------LGEDFSASRVWAEIDTI 635

  Fly   897 IENFGSGILNTSITPTHDIELDFEDMEVPNERRELATRLRAAGLLHLERILFENGYDNYKFVNNV 961
            .||.|                        ||
  Fly   636 FENIG------------------------NE---------------------------------- 642

  Fly   962 FEEPDIPLLHIPERDAPKLLRFVQSLPPAEFQPQVPVKTQQENKQMGVATLQQWLNTIALPEYLE 1026
                                                           |:|::|        |..|
  Fly   643 -----------------------------------------------VSTVEQ--------EVEE 652

  Fly  1027 FFNKHLYNTIESVCGVWDVELQTVLEINKLGHRRRILQSLAYIRQMRDSDSKSQKTPLGENNETN 1091
            |.
  Fly   653 FV--------------------------------------------------------------- 654

  Fly  1092 QLTTNGNGTAREAPPRLPANPVHHRNSITGYRKSRPAPPPPAPPARKTAALQIRAPSELLLGLPA 1156
                       |.|..|         |:...|:|                |.||.|:|||||...
  Fly   655 -----------EDPSSL---------SLEDSRQS----------------LHIRDPAELLLGRKP 683

  Fly  1157 NLRTTEWRHSAQTLLNEHINYEVQYLGSTVVKELRGTESTKKSIQKLKTSADGEVKSGSPLS--- 1218
            :..::.|.||..|.:...|.|.:.||||||:::|:||.||:|||||||  .|..:||.:.:|
  Fly   684 SAASSNWCHSPYTFIYGEIRYSLFYLGSTVIRKLQGTLSTRKSIQKLK--IDENLKSAASVSDFS 746

  Fly  1219 ------------------------LAICHRGVEFKDVNSKRTICEHEIQNINCACQDSEDLRHFA 1259
                                    :|:...||:|.|.:.|..||.|:|:||||.||||||||:||
  Fly   747 LLENCTTSTKYLKAANHQTRLNVDIAVSCVGVKFIDHDKKTAICCHDIENINCVCQDSEDLRYFA 811

  Fly  1260 YITKEQDLHYCHVFLVESTDLASEIILTLGQAFEVAYQLAL-RDGITTTPE 1309
            ||||||||||||||:|:|.:||.|||:|||||||||||||| |.|.:...|
  Fly   812 YITKEQDLHYCHVFMVDSLELAKEIIMTLGQAFEVAYQLALSRQGTSLNEE 862

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4393	NP_001287483.1	Ank_2	<10..79	CDD:289560	36/68 (53%)
		ANK	43..171	CDD:238125	77/127 (61%)
		ANK repeat	49..79	CDD:293786	19/29 (66%)
		Ank_2	53..148	CDD:289560	57/94 (61%)
		ANK repeat	81..115	CDD:293786	18/33 (55%)
		ANK	112..257	CDD:238125	86/144 (60%)
		ANK repeat	117..148	CDD:293786	17/30 (57%)
		Ank_2	122..233	CDD:289560	61/110 (55%)
		ANK repeat	181..233	CDD:293786	28/51 (55%)
		Ank_5	224..276	CDD:290568	37/51 (73%)
		ANK repeat	237..267	CDD:293786	21/29 (72%)
		SAM_AIDA1AB-like_repeat2	1005..1069	CDD:188899	6/63 (10%)
		SAM	1009..1075	CDD:197735	6/65 (9%)
		PTB_Anks	1161..1305	CDD:269972	89/171 (52%)
CG11168	NP_001262939.1	Ank_4	6..69	CDD:290365	34/62 (55%)
		ANK repeat	7..46	CDD:293786	17/38 (45%)
		ANK	43..171	CDD:238125	77/127 (61%)
		ANK repeat	48..79	CDD:293786	19/30 (63%)
		Ank_2	53..148	CDD:289560	57/94 (61%)
		ANK repeat	81..115	CDD:293786	18/33 (55%)
		ANK	112..254	CDD:238125	86/144 (60%)
		ANK repeat	117..148	CDD:293786	17/30 (57%)
		Ank_2	122..230	CDD:289560	61/110 (55%)
		ANK repeat	204..232	CDD:293786	22/27 (81%)
		Ank_5	221..273	CDD:290568	37/51 (73%)
		ANK repeat	234..264	CDD:293786	21/29 (72%)
		PTB_Anks	688..857	CDD:269972	88/170 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462398
Domainoid	1	1.000	57	1.000	Domainoid score	I7237
eggNOG	1	0.900	-	-		E2759_KOG0507
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	203	1.000	Inparanoid score	I2451
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D252573at33208
OrthoFinder	1	1.000	-	-		FOG0003340
OrthoInspector	1	1.000	-	-		mtm6490
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24174
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	9	8.900