DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG4393 and Anks1b

DIOPT Version :10

Sequence 1:NP_651143.2 Gene:CG4393 / 42764 FlyBaseID:FBgn0039075 Length:1325 Species:Drosophila melanogaster
Sequence 2:XP_017450317.2 Gene:Anks1b / 314721 RGDID:1565556 Length:1281 Species:Rattus norvegicus


Alignment Length:1501 Identity:430/1501 - (28%)
Similarity:612/1501 - (40%) Gaps:469/1501 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MGKDQEFLEAARNGNISHIEKVLTQK-----AKRAGP-----LASLRRGTGVNVQDSGGYSALHH 55
            ||||||.|||||.||::.:||:|:.:     ...:||     |.|:.||..||..||.||:||||
  Rat     1 MGKDQELLEAARTGNVALVEKLLSGRKGGILGGGSGPLPLSNLLSIWRGPNVNCTDSSGYTALHH 65

  Fly    56 ACLNGHEDIVRLLLAHEASPNLPDSRGSSPLHLAAWAGETEIVRLLLTHPYRPASANLQTIEQET 120
            |.||||:|||..||..|||.|:.|::|..|:|||||.|:.|||::|:.|....:..|.|..|.||
  Rat    66 AALNGHKDIVLKLLQFEASTNVADNKGYFPIHLAAWKGDVEIVKILIHHGPSHSRVNEQNNENET 130

  Fly   121 PLHCAAQHGHTGALALLLHHDADPNMRNSRGETPLDLAAQYGRLQAVQMLIRAHPELIAHLGTEA 185
            .||||||:||:..:|:||....||.:|||:.||||||||.||||:.|:|:|.|||.|:: ..|. 
  Rat   131 ALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLAALYGRLRVVKMIISAHPNLMS-CNTR- 193

  Fly   186 LERGTPSPSSPASPSRAIFPHTCLHLASRNGHKSVVEVLLSAGVSVNLLTPSGTALHEAALCGKE 250
                               .||.||||:|||||:||:|||.||:.|:..|..|:|||||||.||.
  Rat   194 -------------------KHTPLHLAARNGHKAVVQVLLEAGMDVSCQTEKGSALHEAALFGKV 239

  Fly   251 NVVRTLLKAGINLNATDNEGRTALDILREFPPHVTKHIVAVINNFRNQMDTDEG---DEVIYRQH 312
            :|||.||:.||:.|..|:.|||.||||:|.|...:..|..::.::.      ||   ..|:..:|
  Rat   240 DVVRVLLETGIDANIKDSLGRTVLDILKEHPSQKSLQIATLLQDYL------EGVGRSVVLEEEH 298

  Fly   313 SGPPNSGRGQNKHHSQQQPPLSNHYHFNSNNHLLNHSHSMQQSGYSKQRLSAGNGGPYNGGKSLD 377
            :          :..:.|:..||                |..||...|.:.....|   ...|.||
  Rat   299 A----------QEDTAQETRLS----------------SPAQSPSQKTKSETVTG---ELSKLLD 334

  Fly   378 --SALQPEDRFYQDLNAHSPLH--------SQNEMG--GGYSVSPSSSLSSFEPASV-----SPR 425
              ...|.:|..::||......|        |:.|:|  |..||..||:: :..|..|     .|.
  Rat   335 EIKLCQEKDYSFEDLCHTISDHYLDNLSKISEEELGKNGSQSVRTSSTI-NLSPGEVEDEEEDPN 398

  Fly   426 SRCSTG------------GLGQPMHMSTFAPAGPPKKPPRRNLSVSPTHAGPGQQFSYSSPSSQS 478
            |...||            .||.||    .|....|||                            
  Rat   399 SCGPTGLWEALTPCNGCRNLGFPM----LAQESYPKK---------------------------- 431

  Fly   479 QSQSHGHGQNQVRRQPASESPYSHQSHGSVGGMSFDETQLRERQRNDRLYASARQSTRSAIAGGM 543
                        |..|....|                              ||...|..      
  Rat   432 ------------RNYPMEIVP------------------------------SASLDTFP------ 448

  Fly   544 SLSSSNDMLDRQCSSSELNSETSVPNSSGDSPAT-NSMKRPIPAPRSSTTKLSKELLKSAESATL 607
              |.:.:.|.....::......|:..:...||.| |:.:..|.||.:.                 
  Rat   449 --SENENFLCELVDTAVTKKPCSLEIARAPSPRTDNASEVAITAPGTG----------------- 494

  Fly   608 KSYNPNRKLKRNRNSSGANGAAKSNGGDENCEAKQQIPSSPTHYKQPPTPDHPPPSSSQAERTIH 672
                      .:||||..                             ||||..|||...|.:.|.
  Rat   495 ----------HHRNSSTG-----------------------------PTPDCSPPSPDTALKNIV 520

  Fly   673 ERIRPLSQEYKRRSALLQL--------QAAQQLMIETGSSPSKLLPTLSTPGYDYDDTVTVVPRC 729
            :.|||  |..:|.|.:..|        |...::...||.:.....|.:|.|              
  Rat   521 KVIRP--QPKQRTSIVSSLDFQRMNHNQEYFEISTSTGCTSFTSSPPVSPP-------------- 569

  Fly   730 PAPSSGSLSSSISCSD---HSLSHSTDYVEEFVSDVP-------FAGLLKGASQQLKEQPEVKLK 784
                    :||:..::   ....|:.|..::...:.|       |||||.|:|... |.||....
  Rat   570 --------TSSVETTEIKNEGAEHTDDLSQQEDDEHPKEYDAGQFAGLLHGSSPAC-EAPENPFH 625

  Fly   785 I-----------QEESKPQQTLPRVRPPIPTKPAIPEKKFAKPPT----------------TPTN 822
            :           :|.|.....||..:.||...|. |..|..||..                |...
  Rat   626 LYGKRNQGEDGQEEASLANSPLPFKQTPIENNPE-PSVKKIKPKVVSRTIFHKRSHQLENHTIVG 689

  Fly   823 QSLEANGNSSSDV-VIKP----------------PRS-----PSKSPSKTSNKSPVKSPGKSPAK 865
            ..:...|:.:.|. .:.|                |::     .||:.|| |:...:..|.|..|:
  Rat   690 TRMSRGGSRNGDQWGVNPGGFVERACTLGRIRSLPKALIDMHLSKNVSK-SDSDLIAYPSKDKAR 753

  Fly   866 SPGSGHSAARNSINLLSPFNAEEAR------KKISEIIENFGSGILNTSITPTHDIELDFEDMEV 924
            ...|..|.|..|    |..|:|...      ::|.:|:.:...|           |..:.|.|..
  Rat   754 VNWSKSSTAERS----SKDNSERTPSFTSEWEEIDKIMNSIDVG-----------INSELEGMNG 803

  Fly   925 PN-ERRELATRLRAAGLLHLERILFENGYDNYKFV-NNVFEEPD---IPLLHIPERDAPKLLRFV 984
            |. ..:.:...|.:.||...|..|..||:||.:|: :||.|:.|   |.:|:...|.  ::|:.:
  Rat   804 PRCPVQTVGQWLESIGLPQYENHLTANGFDNVQFMGSNVMEDQDLLEIGILNSGHRQ--RILQAI 866

  Fly   985 QSLPPAE------FQPQVPVKTQQENKQMGVATLQQWLNTIALPEYLEFFNKHLYNTIESVCGVW 1043
            |.||...      :.|               .::.:||::|.|.:|.:.|..:.|.:::.:..:|
  Rat   867 QLLPKMRPIGHDGYHP---------------TSVAEWLDSIELGDYTKAFLINGYTSMDLLKKIW 916

  Fly  1044 DVELQTVLEINKLGHRRRILQSLAYIRQMRDSDSKSQKT-----PLGENNETNQL---------T 1094
            ::||..||:|:.:|||:|||.||. .|...|...|..::     |.| |:...||         |
  Rat   917 ELELINVLKISLIGHRKRILASLG-DRLHEDPPQKPPRSITLREPSG-NHTPPQLSPSLSQSTYT 979

  Fly  1095 TNGN---------GTAR--------EAPPR-----------------------LPANPVH--HRN 1117
            |.|:         |.||        :..||                       .|.:.:|  |..
  Rat   980 TGGSLDVPHIIMQGDARRRRNENYFDDIPRSKLERQMAQQSSVCEIWTNQNAGFPFSAIHQVHNT 1044

  Fly  1118 SITGYRKSRPAPPPPAPPARKTAALQIRAPSELLLGLPANLRTTEWRHSAQTLLNEHINYEVQYL 1182
            ...|                 ..::.:|.|:|.....|...    |:|..:.|:.:..:|:..||
  Rat  1045 GDWG-----------------EPSITLRPPNEATASTPVQY----WQHHPEKLIFQSCDYKAFYL 1088

  Fly  1183 GSTVVKELRGTESTKKSIQKLKTS---ADGEVKSGSPLSLAICHRGVEFKDVNSKRTICEHEIQN 1244
            ||.::|||||||||:.:..|::.:   :..::|....:.|::.::||:|.|..:|..|.||||:|
  Rat  1089 GSMLIKELRGTESTQDACAKMRANCQKSTEQMKKVPTIILSVSYKGVKFIDAANKNIIAEHEIRN 1153

  Fly  1245 INCACQDSEDLRHFAYITKE--QDLHYCHVFLVESTDLASEIILTLGQAFEVAYQLAL--RDG-- 1303
            |:||.||.|||..||||||:  .:.||||||.....:||.||||||||||||||||||  |.|  
  Rat  1154 ISCAAQDPEDLSTFAYITKDLKSNHHYCHVFTAFDVNLAYEIILTLGQAFEVAYQLALQARKGGH 1218

  Fly  1304 ITTTPE 1309
            .:|.||
  Rat  1219 SSTLPE 1224

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG4393NP_651143.2 ANKYR <36..274 CDD:440430 123/237 (52%)
ANK repeat 49..79 CDD:293786 20/29 (69%)
ANK repeat 81..115 CDD:293786 14/33 (42%)
ANK repeat 117..148 CDD:293786 16/30 (53%)
ANK repeat 181..233 CDD:293786 20/51 (39%)
ANK repeat 237..267 CDD:293786 18/29 (62%)
SAM_AIDA1AB-like_repeat2 1005..1069 CDD:188899 21/63 (33%)
PTB_Anks 1161..1305 CDD:269972 73/152 (48%)
Anks1bXP_017450317.2 ANK repeat 7..56 CDD:293786 18/48 (38%)
ANKYR 42..269 CDD:440430 129/247 (52%)
ANK repeat 58..89 CDD:293786 20/30 (67%)
ANK repeat 91..125 CDD:293786 14/33 (42%)
ANK repeat 127..158 CDD:293786 16/30 (53%)
ANK repeat 160..191 CDD:293786 19/31 (61%)
ANK repeat 193..223 CDD:293786 19/49 (39%)
ANK repeat 226..256 CDD:293786 18/29 (62%)
SAM_AIDA1AB-like_repeat1 807..873 CDD:188898 21/67 (31%)
SAM_AIDA1AB-like_repeat2 878..942 CDD:188899 22/79 (28%)
PTB_Anks 1067..1216 CDD:269972 72/152 (47%)

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