DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4393 and Caskin2

DIOPT Version :9

Sequence 1:	NP_001287483.1	Gene:	CG4393 / 42764	FlyBaseID:	FBgn0039075	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_001100535.1	Gene:	Caskin2 / 303678	RGDID:	1309738	Length:	1200	Species:	Rattus norvegicus

Alignment Length:	1406	Identity:	348/1406 - (24%)
Similarity:	514/1406 - (36%)	Gaps:	415/1406 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGKDQEFLEAARNGNISHIEKVLTQ-KAKRAGPLASLRRGTGVNVQDSGGYSALHHACLNGHEDI 64
            ||::|:.:.|.:||:::.::|::.: ||.:...|.|.:| ..:|.||:.|:||||||.|.|..::
  Rat     1 MGREQDLILAVKNGDVTCVQKLVAKVKAAKTKLLGSTKR-LNINYQDADGFSALHHAALGGSLEL 64

  Fly    65 VRLLLAHEASPNLPDSRGSSPLHLAAWAGETEIVRLLLTHPYRPASANLQTIEQETPLHCAAQHG 129
            :.|||..:|:.::.||.|..|||.|||.|..|.|:|||.   ..|:.|..:::.:.|||.|||:|
  Rat    65 IALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVKLLLR---ASAAVNAASLDGQIPLHLAAQYG 126

  Fly   130 HTGALALLLHHDADPNMRNSRGETPLDLAAQYGRLQAVQMLIRAHPELIAHLGTEALERGTPSPS 194
            |.....:||.|.::|.:.|...:||||||.::|||:..|:|:.:| ..:|.|..||.:...|:.:
  Rat   127 HYEVSEMLLQHQSNPCLVNKLKKTPLDLACEFGRLKVAQLLLNSH-LCVALLEGEAKDPCDPNYT 190

  Fly   195 SPASPSRAIFPHTCLHLASRNGHKSVVEVLLSAGVSVNLLTPSGTALHEAALCGKENVVRTLLKA 259
            :|            ||||::|||:.|:..||.||:.:|..|.:|||||||||.||..|||.||:.
  Rat   191 TP------------LHLAAKNGHREVIRQLLKAGIEINRQTKTGTALHEAALYGKTEVVRLLLEG 243

  Fly   260 GINLNATDNEGRTALDILREF-PPHVTKHI------------VAVINNFRNQMDTD-----EGDE 306
            |:::|..:...:|||||:.:| ....::.|            |..:.:|.|..|..     .||.
  Rat   244 GVDVNIRNTYNQTALDIVNQFTTSQASREIKQLLREASGILKVRALKDFWNLHDPTALNIRAGDV 308

  Fly   307 V-IYRQHSGPPNSGRGQNKHHSQQQ--------PP-----LSNHY-----HFNSNNHLLNHSHS- 351
            : :..||.    .||.:...|..|:        ||     :|...     ...|...||..|.|
  Rat   309 ITVLEQHP----DGRWKGHIHESQRGTDRVGYFPPGIVEVVSKRVGIPVTRLPSAPTLLRPSFSR 369

  Fly   352 -----------------MQQSGYSK-----QRLSAGNGGPYNGGKSLDSALQPEDRFYQDLNAHS 394
                             :.:.|.|.     .|.|.|:.|.....:|..|....|     ..|.||
  Rat   370 ISQPSADDPLPSLTYGQLPRVGLSPDSPAGDRNSVGSEGSVGSIRSAGSGQSSE-----GTNGHS 429

  Fly   395 ---------PLHSQNE---MGGGYSVSPSSSLSSFEPAS----------VSPRSRCSTGGLGQPM 437
                     ||.|.||   :.|.::.||:.:||....||          |.| .:...|...|.:
  Rat   430 TGLLIENAQPLPSANEDQVLPGLHAPSPADNLSHRPLASYRSGEIFTQDVRP-EQLLEGKDAQAI 493

  Fly   438 H-----------MSTFAPAGPPKKPPRRNLSVSPTHAG---PGQQFSYSSPSSQSQSQSH----- 483
            |           .:.|..||.......|......|..|   ||.:...:|..:|......
  Rat   494 HNWLSEFQLEGYTAHFLQAGYDVPTISRMTPEDLTAIGVTKPGHRKKIASEIAQLSIAEWLPNYI 558

  Fly   484 ---------GHGQNQVRRQPASESPYSHQSHGSVGGMSFDETQ---LRERQRNDRLYASARQ--S 534
                     ..|..|..:|..|.   .:.|.|.|..::::|.|   :.:.....:|....::  .
  Rat   559 PVDLLEWLCALGLPQYHKQLVSS---GYDSMGLVADLTWEELQEIGVNKLGHQKKLMLGVKRLAE 620

  Fly   535 TRSAIAGGMSLSSSNDMLDRQCSSSELNSETSVPNSSGDSPATNSMKRPIPAPRSST---TKLSK 596
            .|..:..|.:|......:.|   ..||.:...:.|  ||||||       ..||..|   ::||.
  Rat   621 LRRGLLHGEALGEGGRRMTR---GPELMAIEGLEN--GDSPAT-------AGPRLLTFQGSELSP 673

  Fly   597 EL-------------LKSAESATLKSYNPNRKLKRNRNSSGANG--AAKSNGGDENCEAKQQIPS 646
            ||             |..|.|.:.:|..     .|:|.|..:.|  .::.|.|:.:...::.:|.
  Rat   674 ELQAAMAGGGPEPLPLPPARSPSQESIG-----ARSRGSGHSQGQPGSQPNAGEPSAPQERNLPE 733

  Fly   647 SPTHYKQPPTPDHPPPSSSQAERTIHERIRPLSQEYKRRSALLQLQAAQQLMIETGSSPSKLLPT 711
            ..   ::|..|..|.|....|...                    ....|.|    .|||:...|
  Rat   734 GT---ERPFKPCSPLPGQGPAPYV--------------------FMCPQSL----PSSPAPAPP- 770

  Fly   712 LSTPGYDYDDTVTVVPRCPAPSSGSLSSSISCSD--------HSLSH--STDYVEEFVSDVPFAG 766
               ||         |||..:..:|   ||.:..|        ||||.  ..:...|..::.|...
  Rat   771 ---PG---------VPRAFSYLAG---SSAAPPDPPRPKRRSHSLSRPGPAEGEAEGEAEGPVGS 820

  Fly   767 LLKGASQQLKEQPEVKLKIQEESKPQQTLPRVRPPI-PTKPAIPEKKFA----------KPP--- 817
            .| |:...|..:|           .:.||.|..|.: ||:.....:.||          .||
  Rat   821 AL-GSYATLTRRP-----------GRSTLARTSPSLTPTRGTPRSQSFALRARRKGPPPPPPKRL 873

  Fly   818 ------TTPTNQSLEANGNSSSDV------VIKPPRSPSKSPSKTSNKSPVKS--------PGKS 862
                  |.||  |||.........      .:..|..||:||:.::...||..        .|..
  Rat   874 SSVSGSTEPT--SLEGTSGPKEGAAGPRRRTLSEPTGPSESPAPSAPTGPVSDTEEEEPVLEGTP 936

  Fly   863 PAK-SPGSGHSAARNSINLLSPFNAEEARKKISEIIENFGSGILNTSITPTHDIELDFED--MEV 924
            |:: |.|.|           .|| |||....|.:..:..|.....|::.|..|..|...|  ...
  Rat   937 PSRGSSGEG-----------LPF-AEEGNLTIKQRPKPAGPPPRETTVPPGLDFNLTESDTVKRR 989

  Fly   925 P--NERRELATRLRAAGLLHLERILFENGYDNYKFVNNVFEEPDIPLLHIPERDAPKLLRFVQSL 987
            |  .||..|.|.|.|.|::         |.|.        ..|..||......:||.    ..|.
  Rat   990 PKCKEREPLRTALLAFGVV---------GSDT--------PGPSTPLSSQAPCEAPS----APSN 1033

  Fly   988 PPAEFQPQVPVKTQQENKQMGVATLQQWLNTIALPEYLEFFNKHLYNTIESVCGVWDVELQTVLE 1052
            ||......:|       .|...|.    |:.:..|.
  Rat  1034 PPRSEPSSLP-------SQEAPAP----LSPVTQPP----------------------------- 1058

  Fly  1053 INKLGHRRRI----LQSLAYIRQMRDSDSKSQKTPLGENNETNQLTTNGNGTAREAPPRLPANPV 1113
                ||....    |::....||..|::..:....|        |...|.|||    |: |.:..
  Rat  1059 ----GHPGPSAGPGLETSTGSRQNVDTEPPAPPAAL--------LKVPGAGTA----PK-PVSVA 1106

  Fly  1114 HHRNSITGYRKS-----RPAPPP------PAPPARKTAALQIRAPSELLLGLPANLRTTEWRHSA 1167
            ..:.:.:|.:.:     ||.|||      |..|.|....|:..:.|     |.|.||..|
  Rat  1107 CTQLAFSGPKLAPRLGPRPVPPPRPENTGPVCPGRAQQRLEQTSSS-----LEAALRAAE----- 1161

  Fly  1168 QTLLNEHINYEVQYLGSTVVKELRGTESTKKSIQKLKTSAD 1208
                 ::|..|.|. |.|       ..|||..:..:.|..|
  Rat  1162 -----KNIGSEEQD-GPT-------GPSTKHILDDISTMFD 1189

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4393	NP_001287483.1	Ank_2	<10..79	CDD:289560	25/69 (36%)
		ANK	43..171	CDD:238125	56/127 (44%)
		ANK repeat	49..79	CDD:293786	13/29 (45%)
		Ank_2	53..148	CDD:289560	39/94 (41%)
		ANK repeat	81..115	CDD:293786	15/33 (45%)
		ANK	112..257	CDD:238125	60/144 (42%)
		ANK repeat	117..148	CDD:293786	12/30 (40%)
		Ank_2	122..233	CDD:289560	42/110 (38%)
		ANK repeat	181..233	CDD:293786	17/51 (33%)
		Ank_5	224..276	CDD:290568	27/51 (53%)
		ANK repeat	237..267	CDD:293786	18/29 (62%)
		SAM_AIDA1AB-like_repeat2	1005..1069	CDD:188899	7/67 (10%)
		SAM	1009..1075	CDD:197735	8/69 (12%)
		PTB_Anks	1161..1305	CDD:269972	11/48 (23%)
Caskin2	NP_001100535.1	ANK	7..135	CDD:238125	50/131 (38%)
		Ank_4	7..61	CDD:290365	20/54 (37%)
		ANK repeat	7..46	CDD:293786	10/39 (26%)
		ANK repeat	48..79	CDD:293786	13/30 (43%)
		Ank_2	53..145	CDD:289560	39/94 (41%)
		ANK	76..209	CDD:238125	56/148 (38%)
		ANK repeat	85..112	CDD:293786	14/29 (48%)
		ANK repeat	114..145	CDD:293786	12/30 (40%)
		Ank_2	152..251	CDD:289560	48/111 (43%)
		ANK repeat	158..219	CDD:293786	25/73 (34%)
		ANK	183..>258	CDD:238125	35/86 (41%)
		ANK repeat	221..251	CDD:293786	18/29 (62%)
		SH3_Caskin2	284..345	CDD:212996	14/64 (22%)
		SAM_caskin1,2_repeat1	487..552	CDD:188896	13/64 (20%)
		SAM	493..548	CDD:197735	10/54 (19%)
		SAM_caskin1,2_repeat2	553..623	CDD:188897	10/72 (14%)
		SAM	561..620	CDD:197735	10/61 (16%)
		Caskin-Pro-rich	797..881	CDD:293512	20/95 (21%)
		Draxin	899..>1067	CDD:292187	49/244 (20%)
		Caskin-tail	1143..1200	CDD:293238	17/70 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0507
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810