DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG4393 and Caskin1

DIOPT Version :10

Sequence 1:NP_651143.2 Gene:CG4393 / 42764 FlyBaseID:FBgn0039075 Length:1325 Species:Drosophila melanogaster
Sequence 2:XP_006524376.1 Gene:Caskin1 / 268932 MGIID:2442952 Length:1438 Species:Mus musculus


Alignment Length:1416 Identity:321/1416 - (22%)
Similarity:497/1416 - (35%) Gaps:454/1416 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MGKDQEFLEAARNGNISHIEKVLTQ----KAKRAGPLASLRRGTGVNVQDSGG-------YSALH 54
            |||:||.::|.:..::...:::|.:    |||..|....:    .||.||..|       :||||
Mouse     1 MGKEQELVQAVKAEDVGTAQRLLQRPRPGKAKLLGSTKKI----NVNFQDPDGSVLPLPSFSALH 61

  Fly    55 HACLNGHEDIVRLLLAHEASPNLPDSRGSSPLHLAAWAGETEIVRLLLTHPYRPASA-NLQTIEQ 118
            ||.|||:.:::.|||..:|:.::.|::|..|||.|||.|..|.::|:|    :..|| |:.:.|.
Mouse    62 HAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVL----KAGSAVNVPSDEG 122

  Fly   119 ETPLHCAAQHGHTGALALLLHHDADPNMRNSRGETPLDLAAQYGRLQAVQMLIRAHPELIAHLGT 183
            ..|||.||||||.....:||.|.::|.|.::.|:||||||.::||:..||:|      |.:::..
Mouse   123 HIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVGVVQLL------LSSNMCA 181

  Fly   184 EALERGTPSPSSPASPSRAIFPHTCLHLASRNGHKSVVEVLLSAGVSVNLLTPSGTALHEAALCG 248
            ..||   |.|.....|:..    :.||||::|||..::.:||.||:.:|..|.||||||||||||
Mouse   182 ALLE---PRPGDTTDPNGT----SPLHLAAKNGHIDIIRLLLQAGIDINRQTKSGTALHEAALCG 239

  Fly   249 KENVVRTLLKAGINLNATDNEGRTALDILREF-PPHVTKHIVAVI----------------NNF- 295
            |..|||.||.:|||....:...:|||||:.:| ....:|.|..::                ||: 
Mouse   240 KTEVVRLLLDSGINAQVRNTYSQTALDIVHQFTTSQASKEIKQLLREASAALQVRATKDYCNNYD 304

  Fly   296 RNQMDTDEGDEV-IYRQHSGPPNSGRGQNKHHSQQQPPLSNHYHFNSNNHLLNHSHSMQQSGYSK 359
            ...::...||.: :..||.    .||.:...|..:          ..|:.:.....|:.::...:
Mouse   305 LTSLNVKAGDIITVLEQHP----DGRWKGCIHDNR----------TGNDRVGYFPSSLGEAIVKR 355

  Fly   360 QRLSAGN-GGPYNGGKSLDSALQPEDRFYQDLNAHSPLHSQNEMGGGYSVSPSSSLSSFEPASVS 423
            .....|: ..|..||.||..:..||:.:.          .:....||   ..|.|||:.....  
Mouse   356 AGSRTGSEPSPPQGGGSLGPSAPPEEIWV----------LRKPFAGG---DRSGSLSNVAGGR-- 405

  Fly   424 PRSRCSTGGLGQPMH-----------------MSTFAPAGPPKKPPRRNLSVS---PTHAGPGQQ 468
                 |||  |..:|                 :|..:|...|.|||..:...:   |..|..||.
Mouse   406 -----STG--GHALHAGSEGVKLLATVLSQKSVSESSPGDSPVKPPEGSSGAARSQPPAAHAGQV 463

  Fly   469 FSYSSP---SSQSQSQSHGHGQNQV---------------------------RRQP-------AS 496
            :....|   .|.|.|.|.|.....|                           |..|       .:
Mouse   464 YGEQPPKKLESASASASEGKSAEAVSQWLATFQLQLYAPNFTSAGYDLPTISRMTPEDLTAIGVT 528

  Fly   497 ESPYSHQSHGSVGGMSFDE---------------------------------------------- 515
            :..:..:....:.|::..:                                              
Mouse   529 KPGHRKKITAEISGLNIPDWLPEHKPANLAVWLSMIGLAQYYKVLVDNGYENIDFITDITWEDLQ 593

  Fly   516 ----TQLRERQR---NDRLYASARQSTRSAIAGG------------MSLSS--SNDMLDRQCSS- 558
                |:|..:::   ..|..|..:::..|...||            |::.|  .::....:|.| 
Mouse   594 EIGITKLGHQKKLMLAVRKLAELQKAEYSKYEGGPLRRKTPQSLEMMAIESPPPSEPAAAECQSP 658

  Fly   559 -------SELNSE----TSVPNSSGDSPATNSMKRPIPAPRSSTTK-----------LSKELL-- 599
                   |||:.|    .|.|..:|.:....|.....|.||:::.:           .|:|||  
Mouse   659 KMTTFQDSELSGELQAALSGPAEAGAAAVEKSSNHLPPTPRTTSRESSLSGRARHISSSQELLGD 723

  Fly   600 ----------KSAESATLKSYNPNRKLKRNRNSSGANGAAKSNGGDENCEAKQQIPSSPTHYKQP 654
                      :|.|....:...|....|..|:|...:...:::......:.:|.:||..:|:..|
Mouse   724 GPPGPGSPMSRSQEYLLDEGMAPGTPPKEVRSSRHGHSVKRASVPPVPGKPRQVLPSGASHFTPP 788

  Fly   655 PTPDHPPPSSSQAERTIHERIRPLSQEYKRRSALLQLQAAQQLMIETG--SSPSKLLPTLSTPGY 717
            .||....|.|.||....|            ..|..:::...||:..|.  .||..|..:.:..|:
Mouse   789 QTPTKAQPGSPQALGGPH------------GPATAKVKPTPQLLPPTDRPMSPRSLPQSPTHRGF 841

  Fly   718 DYDDTVTVVPR---------CPAPSSGSLSSSIS--CSDHSLSHSTDYVEEFVSDVPFAGLLKGA 771
            .|     |:|:         .|.|:...:.:::.  |    |...|| ||        .|..|..
Mouse   842 AY-----VLPQPVEGEVGPPAPGPAPPPVPAAVPTLC----LPPETD-VE--------PGRPKKR 888

  Fly   772 SQQLK------EQPE-VKLKIQEESKPQQTLPR-------VRPPIPTKPAI---------PEKKF 813
            :..|.      .:|| .:|.:...:.|..|:.|       ||.|..|...:         |.||.
Mouse   889 AHSLNRYAASDSEPERDELLVPAAAGPYATVQRRVGRSHSVRAPAGTDKNVNRSQSFAVRPRKKG 953

  Fly   814 AKPPTTPTNQSLEANGN----SSSDVVIKPPRSPSKSPSK----------TSNKSPVKS------ 858
            ..||....:.|..|:.|    .:.||..:..|...::..:          |.:...|||      
Mouse   954 PPPPPPKRSSSAMASANLADEPAPDVEAEDGRLGVRAQRRRASDLAGSVDTGSAGSVKSIAAMLE 1018

  Fly   859 -----PGKSPAKSPGSGHSAARNSINLLSPFNAEEARKKISEIIENFGSGILNTSITPTHDIELD 918
                 .|....:.|..||...|       |.:.|..|              :.|.:......|..
Mouse  1019 LSSIGGGGRAIRRPPEGHPTPR-------PASPEPGR--------------VATVLASVKHKEAI 1062

  Fly   919 FEDMEVPNERRE--------LATRLRAAGLLHLERILFENGYDNYKFVNNVFEEPDIPLLHIPER 975
            ..|.||.|.||.        |||..|.:|....:....|:|....:...        |.......
Mouse  1063 GPDGEVVNRRRTLSGPVTGLLATARRGSGEPAEQSHFMEDGTARQRLRG--------PAKGEASA 1119

  Fly   976 DAPKLLRFVQSLPPAEFQPQVPVK-TQQENKQMGVATLQQWLNTIALPEYLEFFNKHLYNTIESV 1039
            :.|.|.|...|   |..:.::..| :||||.:. :.|                            
Mouse  1120 EGPPLARVEAS---ATLKRRIRAKQSQQENVKF-ILT---------------------------- 1152

  Fly  1040 CGVWDVELQTVLEINKLGHRRRILQSLAYIRQMRDSDSKSQKTPLGENNETNQLTTNGNGTAREA 1104
                  |..||        :||        .:.::.|:..:..|      ...:..||..|.|..
Mouse  1153 ------ESDTV--------KRR--------PKAKEPDTGPEPPP------PLSVYQNGTATVRRR 1189

  Fly  1105 PPRLPANPVHHRNSITGYRKSRPAPPPPAPPARKTAALQIRAPSELLLGLP 1155
            |....|.|              |..|||.|||....|..::.|.   |.||
Mouse  1190 PTSEQAGP--------------PELPPPPPPAEPPPADLMQLPP---LPLP 1223

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG4393NP_651143.2 ANKYR <36..274 CDD:440430 101/245 (41%)
ANK repeat 49..79 CDD:293786 14/36 (39%)
ANK repeat 81..115 CDD:293786 14/34 (41%)
ANK repeat 117..148 CDD:293786 15/30 (50%)
ANK repeat 181..233 CDD:293786 16/51 (31%)
ANK repeat 237..267 CDD:293786 21/29 (72%)
SAM_AIDA1AB-like_repeat2 1005..1069 CDD:188899 6/63 (10%)
PTB_Anks 1161..1305 CDD:269972
Caskin1XP_006524376.1 Ank_2 7..86 CDD:463710 24/82 (29%)
ANK repeat 56..86 CDD:293786 13/29 (45%)
ANKYR 59..298 CDD:440430 102/255 (40%)
ANK repeat 88..119 CDD:293786 14/34 (41%)
ANK repeat 121..152 CDD:293786 15/30 (50%)
ANK repeat 154..193 CDD:293786 17/47 (36%)
ANK repeat 195..225 CDD:293786 12/33 (36%)
ANK repeat 228..258 CDD:293786 21/29 (72%)
ANK repeat 260..294 CDD:293786 8/33 (24%)
SH3_Caskin1 291..352 CDD:212995 11/74 (15%)
Caskin1-CID 380..428 CDD:465190 12/69 (17%)
SAM_caskin1,2_repeat1 482..547 CDD:188896 5/64 (8%)
SAM_caskin1,2_repeat2 548..618 CDD:188897 4/69 (6%)
PTZ00449 <694..>836 CDD:185628 32/153 (21%)
Caskin-Pro-rich 885..956 CDD:465308 15/70 (21%)
Caskin-tail 1376..1438 CDD:465209
Blue background indicates that the domain is not in the aligned region.

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