DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG4393 and ANKS1A

DIOPT Version :10

Sequence 1:NP_651143.2 Gene:CG4393 / 42764 FlyBaseID:FBgn0039075 Length:1325 Species:Drosophila melanogaster
Sequence 2:XP_011512733.1 Gene:ANKS1A / 23294 HGNCID:20961 Length:1166 Species:Homo sapiens


Alignment Length:1417 Identity:414/1417 - (29%)
Similarity:576/1417 - (40%) Gaps:444/1417 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MGKDQEFLEAARNGNISHIEKVLTQKAKRAG----------------------------PLASLR 37
            |||:||.|||||.|::..:||:|:.|...:|                            ||:||.
Human     1 MGKEQELLEAARTGHLPAVEKLLSGKRLSSGFGGGGGGGSGGGGGGSGGGGGGLGSSSHPLSSLL 65

  Fly    38 ---RGTGVNVQDSGGYSALHHACLNGHEDIVRLLLAHEASPNLPDSRGSSPLHLAAWAGETEIVR 99
               ||..||..||.||:.||||.||||:|:|.:||.::|..|:.||:|..|||||||.|:.:|||
Human    66 SMWRGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIVR 130

  Fly   100 LLL----TH------------------PYRPASANLQTIEQETPLHCAAQHGHTGALALLLHHDA 142
            ||:    :|                  |:.| ..|.:..:.||.||||||:|||..:.:||....
Human   131 LLIHQGPSHTRVNEQNALEIKELKKYGPFDP-YINAKNNDNETALHCAAQYGHTEVVKVLLEELT 194

  Fly   143 DPNMRNSRGETPLDLAAQYGRLQAVQMLIRAHPELIAHLGTEALERGTPSPSSPASPSRAIFPHT 207
            ||.|||::.||||||||.||||:.|:||:.|||.|:: ..|:                    .||
Human   195 DPTMRNNKFETPLDLAALYGRLEVVKMLLNAHPNLLS-CNTK--------------------KHT 238

  Fly   208 CLHLASRNGHKSVVEVLLSAGVSVNLLTPSGTALHEAALCGKENVVRTLLKAGINLNATDNEGRT 272
            .||||:|||||:||:|||.||:..|..|..|:|||||||.||.:||:.||.||.::|..||.|.|
Human   239 PLHLAARNGHKAVVQVLLDAGMDSNYQTEMGSALHEAALFGKTDVVQILLAAGTDVNIKDNHGLT 303

  Fly   273 ALDILREFPPHVTKHIVAVI-NNFRNQMDTDEGDEVIYRQHSGPPNSGRGQNKHHSQQQPPLSNH 336
            |||.:||.|...::.|.|:| ::...:..|.|.|:.       ||            .||||   
Human   304 ALDTVRELPSQKSQQIAALIEDHMTGKRSTKEVDKT-------PP------------PQPPL--- 346

  Fly   337 YHFNSNNHLLNHSHSMQQSGYSKQRL----SAGNGGPYNGGKSLDSALQPEDRFYQDLNAHSPLH 397
              .:|.:.:...|....:...::..:    :|...|||   ::|.:|:.              .|
Human   347 --ISSMDSISQKSQGDVEKAVTELIIDFDANAEEEGPY---EALYNAIS--------------CH 392

  Fly   398 SQNEMGGGYSVSPSSS-----LSSFEPASVSPRSRCSTGGLGQPMHMSTFAPAGPPKKPPRRNLS 457
            |.:.|..|.|....|:     .:..:||.|.||.|                |..|.|.||     
Human   393 SLDSMASGRSSDQDSTNKEAEAAGVKPAGVRPRER----------------PPPPAKPPP----- 436

  Fly   458 VSPTHAGPGQQFSYSSPSSQSQSQSHGHGQNQVRRQPASESPYSHQSHGSVGGMSFDETQLRERQ 522
                                                                    ||   .|..
Human   437 --------------------------------------------------------DE---EEED 442

  Fly   523 RNDRLY----ASARQSTRSAIAGGMSLSSSNDMLDRQCSSSELNSETSVPNSSGDSPATNSMKRP 583
            ..|:.|    ||...|.|..|.|                                |.|....:.|
Human   443 HIDKKYFPLTASEVLSMRPRIHG--------------------------------SAAREEDEHP 475

  Fly   584 IPAPRSSTTKLSKELLKSAESATLKSYNPNRKLKRNRNSSGANGAAKSNGGDENCEAKQQIP--- 645
            .            |||.:||  |.|....:.|.|.:|.||.:.....:.|.|      .|:|   
Human   476 Y------------ELLLTAE--TKKVVLVDGKTKDHRRSSSSRSQDSAEGQD------GQVPEQF 520

  Fly   646 SSPTHYKQPPTPDHPPPSSSQAERTIHERIRPLSQEYKRRSALLQLQAAQQLMIETGSSPSKLLP 710
            |...|...|                                           :.|.|..|.:|  
Human   521 SGLLHGSSP-------------------------------------------VCEVGQDPFQL-- 540

  Fly   711 TLSTPGYDYDDTVTVVPRCPAPSSGSLSSSISCSDHSLSHSTDYVEEFVSDVPFAGLLKGASQ-- 773
             |.|.|..:.|        .:|..|      :|...|:.     :||.....|      ||||  
Human   541 -LCTAGQSHPD--------GSPQQG------ACHKASMQ-----LEETGVHAP------GASQPS 579

  Fly   774 QLKEQPEV----KLKIQEESKPQQTLPRVRPPIPTKPAIPEKKFAKPPTTPTNQSLEANGNSSSD 834
            .|.:...|    .|.........:||.....|.|......::..|:....||         |...
Human   580 ALDQSKRVGYLTGLPTTNSRSHPETLTHTASPHPGGAEEGDRSGARSRAPPT---------SKPK 635

  Fly   835 VVIKPPRSPSKSPSKTSNKSPVKSPGKSPAKSPGSGHSAARNSINLLSPFNAEEARKKISEIIEN 899
            ..:|..||.|||.|.....||.:...........|..|..:..:.....|.:|  ..:|.:|:.:
Human   636 AELKLSRSLSKSDSDLLTCSPTEDATMGSRSESLSNCSIGKKRLEKSPSFASE--WDEIEKIMSS 698

  Fly   900 FGSGILNTSITPTHDIELDF--EDMEVPNER---RELATRLRAAGLLHLERILFENGYDNYKFV- 958
            .|.||             ||  |..::...|   :.:...|.:.||...|..|..||:|:..|: 
Human   699 IGEGI-------------DFSQERQKISGLRTLEQSVGEWLESIGLQQYESKLLLNGFDDVHFLG 750

  Fly   959 NNVFEEPDIPLLHIPE-RDAPKLLRFVQSLPPAE-------FQPQVPVKTQQENKQMGVATLQQW 1015
            :||.||.|:..:.|.: :...|||:..:|||..:       ..|.||                .|
Human   751 SNVMEEQDLRDIGISDPQHRRKLLQAARSLPKVKALGYDGNSPPSVP----------------SW 799

  Fly  1016 LNTIALPEYLEFFNKHLYNTIESVCGVWDVELQTVLEINKLGHRRRILQSLA------------Y 1068
            |:::.|.:|:..|....|::|::|..:|::||..||::..||||:||:.|||            .
Human   800 LDSLGLQDYVHSFLSSGYSSIDTVKNLWELELVNVLKVQLLGHRKRIIASLADRPYEEPPQKPPR 864

  Fly  1069 IRQMRDSDSKSQ-KTPLGENNETNQLTTNGNGTAREAPPRLPANPVHHRNSITGYRKSRPAPPPP 1132
            ..|:|..|..|| .:||.:|:..         |.|.|...||...       || |:...:...|
Human   865 FSQLRCQDLLSQTSSPLSQNDSC---------TGRSADLLLPPGD-------TG-RRRHDSLHDP 912

  Fly  1133 APPAR----------KTAALQIRAPSELLLGLPANLRTTEWRHSAQTLLNEHINYEVQYLGSTVV 1187
            |.|:|          :.|.|.:|.||......|..    .|:|..:.|:.|...||..||||.::
Human   913 AAPSRAERFRIQEEHREAKLTLRPPSLAAPYAPVQ----SWQHQPEKLIFESCGYEANYLGSMLI 973

  Fly  1188 KELRGTESTKKSIQKLKTSADGEVKSGSPLSLAICHRGVEFKDVNSKR-TICEHEIQNINCACQD 1251
            |:|||||||:.:..|::.|.: .:|....:.|:|.::||:|.|.::|: .|.||||:||:||.||
Human   974 KDLRGTESTQDACAKMRKSTE-HMKKIPTIILSITYKGVKFIDASNKQNVIAEHEIRNISCAAQD 1037

  Fly  1252 SEDLRHFAYITKEQDL--HYCHVFLVESTDLASEIILTLGQAFEVAYQLALR 1301
            .|||..||||||:...  ||||||.....:|..||||||||||||||||||:
Human  1038 PEDLCTFAYITKDLQTSHHYCHVFSTVDVNLTYEIILTLGQAFEVAYQLALQ 1089

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG4393NP_651143.2 ANKYR <36..274 CDD:440430 122/262 (47%)
ANK repeat 49..79 CDD:293786 16/29 (55%)
ANK repeat 81..115 CDD:293786 18/55 (33%)
ANK repeat 117..148 CDD:293786 16/30 (53%)
ANK repeat 181..233 CDD:293786 19/51 (37%)
ANK repeat 237..267 CDD:293786 17/29 (59%)
SAM_AIDA1AB-like_repeat2 1005..1069 CDD:188899 22/75 (29%)
PTB_Anks 1161..1305 CDD:269972 73/144 (51%)
ANKS1AXP_011512733.1 ANK repeat 7..77 CDD:293786 19/69 (28%)
ANKYR 72..306 CDD:440430 120/255 (47%)
ANK repeat 80..110 CDD:293786 16/29 (55%)
ANK repeat 112..167 CDD:293786 18/55 (33%)
ANK repeat 169..200 CDD:293786 16/30 (53%)
ANK repeat 202..233 CDD:293786 19/31 (61%)
ANK repeat 235..265 CDD:293786 19/49 (39%)
ANK repeat 268..298 CDD:293786 17/29 (59%)
SAM_AIDA1AB-like_repeat1 718..784 CDD:188898 21/65 (32%)
SAM_AIDA1AB-like_repeat2 789..853 CDD:188899 25/79 (32%)
PTB_Anks 947..1093 CDD:269972 73/148 (49%)

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