DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4393 and C11E4.6

DIOPT Version :9

Sequence 1:	NP_001287483.1	Gene:	CG4393 / 42764	FlyBaseID:	FBgn0039075	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_509620.2	Gene:	C11E4.6 / 181179	WormBaseID:	WBGene00007520	Length:	1170	Species:	Caenorhabditis elegans

Alignment Length:	1366	Identity:	292/1366 - (21%)
Similarity:	483/1366 - (35%)	Gaps:	314/1366 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 EFLEAARNGNISHIEKVLTQKAKRAGPLASLRRGTGVNV------------QDSGGYSALHHACL 58
            |.::|.:.|....:...|:.|..:     .:|.|.....            .:...::.||||.|
Worm    12 EVIDACKKGEYDKVALFLSSKKGK-----KIRSGLKFFTTRSDSHWLADYKDEKSDFTLLHHAVL 71

  Fly    59 NGHEDIVRLLLAHEASPNL---PDSRGSSPLHLAAWAGETEIVRLLLTHPY-RPAS-ANLQTIEQ 118
            .....|.:||:.:|  |.|   ..::...|:|||||.|..|||::||.... :||. .|...|..
Worm    72 ENQNQISKLLMDYE--PLLLLCKSTKNILPIHLAAWNGNLEIVKMLLLQTMEKPADILNAVNIFN 134

  Fly   119 ETPLHCAAQHGHTGALALLLHHDADPNMRNSRGETPLDLAAQYGRLQAVQMLIRAHPELIAHLGT 183
            |||||.|.|..|...:..|:..:|||.:||...|..:|:|::.|..:|::||.:..|:.......
Worm   135 ETPLHLAVQRCHLEVVFYLIKKNADPFIRNENKENVIDVASRIGSAEAIRMLCQKWPKFPVQSAY 199

  Fly   184 EALERGTPSPSSPASPSRAIFPHTCLHLASRNGHKSVVEVLLSAGVSVNLLTPSGTALHEAALCG 248
            |:|..|||....|..   ||:|   .|||::..|...::.|...|.|:|..|..|||||.|:.||
Worm   200 ESLRVGTPDIKRPFP---AIYP---FHLAAKYNHVECMQALREHGFSINYTTEDGTALHVASACG 258

  Fly   249 KENVVRTLLKAGINLNATDNEGRTALDILREFPPHVTKHIVAVINNFRNQMDTDEGDEVIYRQHS 313
            :...||.||:.|:|.:..:..|:|.|.::.:...:....|...:.|.....:.....|.:.|:.|
Worm   259 QAEAVRFLLEIGVNTDIKNQHGQTVLQMIIDLQENRRNEIAHFVKNPEGWKECRTIIEGMDRRDS 323

  Fly   314 GPPNSGRGQNKHHSQQQPPLSNHYHFNSNNHLLNHSHSMQQSGYSKQRLSAGNGGPYNGGKSLDS 378
            |....|...:........||.:............::||:.|......||               .
Worm   324 GRETEGSQSDNEREAIWQPLPSQASVQVYPDQRRNNHSIYQPPSISARL---------------R 373

  Fly   379 ALQPED--RFYQDLNAHSP--LHSQNEMGGGYSVSPSSSLSSFEPASVSPRSR---CSTGGLGQP 436
            .|.|:|  .....:.:..|  .||.|.......:..:.....|...|.|..|:   |.......|
Worm   374 DLSPDDSTEALNSVRSEGPYTTHSINRTWNSSMLDRAPRTGRFPLTSPSYHSKHYSCQRSSDTLP 438

  Fly   437 MHMSTFAPAGPPKKPPRRNLSVSPTHAG-----PGQQFSYSSPSSQSQSQSHGHGQNQVRRQPAS 496
            ..:              :|:...||...     ||...:|:|||..::.|.   .|..:..:|
Worm   439 TRL--------------KNVRTRPTEKQIASVLPGDNCAYNSPSKFNEWQK---SQLTISNRP-- 484

  Fly   497 ESPYSHQSHGSVGGMSFDETQLRERQRNDRLYASARQSTRSAIAGGMSLSSSNDMLDRQCSSSEL 561
            .:||.:..:                              .|||     ....|..:.|..|....
Worm   485 PAPYDNVPN------------------------------NSAI-----FVRPNSPIARSASLRRQ 514

  Fly   562 NSETSVPNSSGDSPATNSMKRPIPAPRSSTTKLSKELLKSAESATLKSYNPNR-KLKR---NRNS 622
            :...::|..:..||......||         .|:...::..:....:|.|.|: .:.|   :|..
Worm   515 SGYATLPKLATYSPRIPDHGRP---------DLNDAFIQDPDKTMDRSLNRNQFSISRTTCDREE 570

  Fly   623 SGANGAAKSNGGDENCEAKQQIPSSPTHYKQPPTPDHPPPSSSQAERTIHERIRPLSQEYKRRSA 687
            |  .|..:|...|....:   |.||.|:          ..|:...::...||        :|.:.
Worm   571 S--LGLTQSPRLDTRASS---ITSSLTY----------ACSTLDKDKFFRER--------ERDNG 612

  Fly   688 LLQLQAAQQLMIETGSSPSKLLPTLSTP------GYDYDDTVTVV--PRCPAPSSGSLSSSIS-- 742
            ...|...:::   |||....::.:....      .|:.|:.||.:  .....|||.|..|..|
Worm   613 RAPLAMPEEI---TGSVTGSVIYSQGNANQHLNGNYEKDNNVTAIFLEDVMRPSSNSAESPPSPN 674

  Fly   743 ----------CSDHSLSHSTDYVEEFVSDVPFAGLLKGASQQLKEQPEVKLKIQEES---KPQQT 794
                      |....|..||        :|.|......:|.......|...|:|..|   :|::.
Worm   675 TSKAFIFDALCGKSRLVDST--------NVDFFSGFSSSSNLSHRSTESTSKVQMNSSFTEPEEP 731

  Fly   795 LPRVRPPIPTKPAIPEKKFAKPPTTPTN---QSLEANGNSSSDVVIKPPRSPSKSPSKTSNKSPV 856
            : |:|....|                ||   .||....|.||....:...:.|:.||....:|..
Worm   732 V-RIRRQNGT----------------TNLMLNSLSPTDNLSSPSSDQKSDTTSEEPSWDRVESVF 779

  Fly   857 KSPGKSPAKSPGSGHSAARNSINLLSPFNAEEARKKISEIIENFGSGILNTSITPTHDIELDFED 921
            .|.|.:|.:.               |.| ..|...:::..:.:.||..|  |:|...|...|.:.
Worm   780 DSFGAAPCRE---------------SVF-VREYEPRVAVYLRDRGSKAL--SVTLVEDEFRDHKS 826

  Fly   922 MEVPNERRELATRLRAAGLL------HLERILFENGYDNYKFVNNVFEEPDIPLLHIPERDAPKL 980
            :.|..:.:.:...|.:..:|      .:..:|..:|||....:..:.....:..:.:.:....|:
Worm   827 LLVKKQPKTIIEWLESDVMLAPVAADSVGALLQTHGYDRMDQLKGIINRSILTEIGVDDVTKFKI 891

  Fly   981 LRFVQSLPPAEFQPQVPVKTQQENKQMGVAT------LQQWLNTIALPEYLEFF----NKHLYNT 1035
            :..::.|                  :..||:      :.:|||.|.|.:|:..|    .||:...
Worm   892 MSEIEKL------------------KDDVASAGRFFYVSEWLNFIGLQDYISNFVGAGYKHMAKL 938

  Fly  1036 IESVCGVWDVELQTVLEINKLGHRRRILQSLAYIRQMRDSDSKSQKTPLGENNETNQLTTNGNGT 1100
            .|.   .||......|.:.:.||..|:|.|   .::..|...|..      ||
Worm   939 TEI---DWDTARLMQLGVTRPGHIARMLHS---FKKAEDEKRKEY------NN------------ 979

  Fly  1101 AREAPPRLPANPVHHRNSITGYRKSRPAPPPPAPPARKTAALQIRAPSELLLGLPANLRTTEWRH 1165
                  ||...|:              ..|||.||..|....             |.....::..
Worm   980 ------RLQIKPL--------------MSPPPLPPRSKQNNC-------------AECPQGDFDK 1011

  Fly  1166 SAQTLLNEHINYEVQYLGSTVVKELRGTESTKKSIQKLKTS-ADGEVKSGSPLSLAICHRGVEFK 1229
            ....||..::.|...:||...:.|...::....::.::|.| .|.|......|.|. |: |:...
Worm  1012 IKNKLLQGNVVYRAHHLGVLEIGETECSDEAHAAMTRIKESIIDWETIPRVTLDLT-CN-GITIF 1074

  Fly  1230 DVNSKRTICEHEIQNINCACQDSEDLRHFAYITKE-QDLHYCHVFLVESTDLASEIILTLGQAFE 1293
            |...|..:..:.:..|...|||.:||..|.::.:: ::..:||.|.|.::.:|:|||.|:|..||
Worm  1075 DETFKTLLDGYGVYTIRVVCQDRKDLNFFCFVARDTENRFFCHTFCVLTSGIAAEIITTIGMMFE 1139

  Fly  1294 V 1294
            :
Worm  1140 L 1140

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4393	NP_001287483.1	Ank_2	<10..79	CDD:289560	17/83 (20%)
		ANK	43..171	CDD:238125	47/144 (33%)
		ANK repeat	49..79	CDD:293786	11/32 (34%)
		Ank_2	53..148	CDD:289560	39/99 (39%)
		ANK repeat	81..115	CDD:293786	15/35 (43%)
		ANK	112..257	CDD:238125	52/144 (36%)
		ANK repeat	117..148	CDD:293786	12/30 (40%)
		Ank_2	122..233	CDD:289560	35/110 (32%)
		ANK repeat	181..233	CDD:293786	16/51 (31%)
		Ank_5	224..276	CDD:290568	22/51 (43%)
		ANK repeat	237..267	CDD:293786	14/29 (48%)
		SAM_AIDA1AB-like_repeat2	1005..1069	CDD:188899	20/73 (27%)
		SAM	1009..1075	CDD:197735	20/75 (27%)
		PTB_Anks	1161..1305	CDD:269972	35/136 (26%)
C11E4.6	NP_509620.2	ANK	55..186	CDD:238125	46/132 (35%)
		ANK repeat	61..93	CDD:293786	11/33 (33%)
		Ank_2	66..164	CDD:289560	39/99 (39%)
		ANK repeat	95..131	CDD:293786	15/35 (43%)
		ANK	128..301	CDD:238125	60/178 (34%)
		ANK repeat	135..164	CDD:293786	12/28 (43%)
		Ank_2	138..277	CDD:289560	51/144 (35%)
		ANK repeat	166..245	CDD:293786	25/84 (30%)
		ANK repeat	247..277	CDD:293786	14/29 (48%)
		SAM	833..901	CDD:197735	8/85 (9%)
		SAM_1	907..965	CDD:278937	17/60 (28%)
		SAM	911..971	CDD:197735	18/65 (28%)
		PH-like	1007..1151	CDD:302622	35/136 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	57	1.000	Domainoid score	I7237
eggNOG	1	0.900	-	-		E2759_KOG0507
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	203	1.000	Inparanoid score	I2451
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D252573at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm14102
orthoMCL	1	0.900	-	-		OOG6_105646
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.770