DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4393 and Caskin1

DIOPT Version :9

Sequence 1:	NP_001287483.1	Gene:	CG4393 / 42764	FlyBaseID:	FBgn0039075	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	XP_006245957.1	Gene:	Caskin1 / 140722	RGDID:	620191	Length:	1437	Species:	Rattus norvegicus

Alignment Length:	1377	Identity:	313/1377 - (22%)
Similarity:	506/1377 - (36%)	Gaps:	392/1377 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGKDQEFLEAARNGNISHIEKVLTQ----KAKRAGPLASLRRGTGVNVQDSGG-------YSALH 54
            |||:||.::|.:..::...:::|.:    |||..|....:    .||.||..|       :||||
  Rat     1 MGKEQELVQAVKAEDVGTAQRLLQRPRPGKAKLLGSTKKI----NVNFQDPDGPVLHLPSFSALH 61

  Fly    55 HACLNGHEDIVRLLLAHEASPNLPDSRGSSPLHLAAWAGETEIVRLLLTHPYRPASA-NLQTIEQ 118
            ||.|||:.:::.|||..:|:.::.|::|..|||.|||.|..|.::|:|    :..|| |:.:.|.
  Rat    62 HAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVL----KAGSAVNVPSDEG 122

  Fly   119 ETPLHCAAQHGHTGALALLLHHDADPNMRNSRGETPLDLAAQYGRLQAVQMLIRAHPELIAHLGT 183
            ..|||.||||||.....:||.|.::|.|.::.|:||||||.::||:..||:|      |.:::..
  Rat   123 HIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVGVVQLL------LSSNMCA 181

  Fly   184 EALERGTPSPSSPASPSRAIFPHTCLHLASRNGHKSVVEVLLSAGVSVNLLTPSGTALHEAALCG 248
            ..||   |.|.....|:..    :.||||::|||..::.:||.||:.:|..|.||||||||||||
  Rat   182 ALLE---PRPGDTTDPNGT----SPLHLAAKNGHIDIIRLLLQAGIDINRQTKSGTALHEAALCG 239

  Fly   249 KENVVRTLLKAGINLNATDNEGRTALDILREF-PPHVTKHIVAVI----------------NNF- 295
            |..|||.||.:|||....:...:|||||:.:| ....:|.|..::                ||:
  Rat   240 KTEVVRLLLDSGINAQVRNTYSQTALDIVHQFTTSQASKEIKQLLREASAALQVRATKDYCNNYD 304

  Fly   296 RNQMDTDEGDEV-IYRQHSGPPNSGRGQNKHHSQQQPPLSNHYHFNSNNHLLNHSHSMQQSGYSK 359
            ...::...||.: :..||.    .||.:...|..:          ..|:.:.....|:.::...:
  Rat   305 LTSLNVKAGDIITVLEQHP----DGRWKGCIHDNR----------TGNDRVGYFPSSLGEAIVKR 355

  Fly   360 QRLSAGN-GGPYNGGKSLDSALQPEDRFYQDLNAHSPLHSQNEMGGGYSVSPSSSLSSFEPASVS 423
            .....|: ..|..||.||..:..||:.:.          .:....||   ..|.|||:.....
  Rat   356 AGSRTGSEPSPPQGGGSLGPSAPPEEIWV----------LRKPFAGG---DRSGSLSNVAGGR-- 405

  Fly   424 PRSRCSTGGLGQPMH-----------------MSTFAPAGPPKKPPRRNLSVS---PTHAGPGQQ 468
                 |||  |..:|                 :|..:|...|.|||..:...:   |..|..||.
  Rat   406 -----STG--GHALHAGAEGVKLLATVLSQKSVSESSPGDSPVKPPEGSSGAARSQPPAAHAGQV 463

  Fly   469 FSYSSPSS-QSQSQSHGHGQNQVRRQPASESPYSHQSHGSVGGMSFDETQLRERQRNDRLYASAR 532
            :....|.. :|.|.|.|.....|.:..|:.....:..:.:..|  :|            |...:|
  Rat   464 YGEQPPKKLESSSASEGKSAEAVSQWLATFQLQLYAPNFTSAG--YD------------LPTISR 514

  Fly   533 QSTRSAIAGGMSLSSSNDMLDRQCSSSELNSETSVPNSSGDSPATNSMKRPI------------- 584
            .:.....|.|::.......:..:.|.  ||....:|.   ..||..::...:
  Rat   515 MTPEDLTAIGVTKPGHRKKITAEISG--LNIPDCLPE---HKPANLAVWLSMIGLAQYYKVLVDN 574

  Fly   585 --------------PAPRSSTTKL--SKELLKSAESATLKSYNPNRKLKRNRNSSGANGAAKSNG 633
                          .......|||  .|:|:.:.           |||...:.:.    .:|..|
  Rat   575 GYENIDFITDITWEDLQEIGITKLGHQKKLMLAV-----------RKLAELQKAE----YSKYEG 624

  Fly   634 GDENCEAKQQIPSSPTHYKQPPTPDHPPPSSSQAERTIHERIRPLSQEYKRRSALLQLQAAQQLM 698
            |....:|.|.:.....   :.|.|..|..:..|:.:....:...||.|         ||||....
  Rat   625 GPLRRKAPQSLEMMAI---ESPPPSEPAAAECQSPKMTTFQDSELSGE---------LQAALSGP 677

  Fly   699 IETGSSPSKLLPTLSTPGYDYDDTVTVVPRCPAPSSGSLSSSISCSDHSLSHSTDYVEEFVSDVP 763
            .|.|::.:             :.:...:|..|..:|.. .||:|.....:|.|    :|.:.|.|
  Rat   678 AEAGAAAA-------------EKSSNHLPATPRTTSRQ-ESSLSGRARHMSSS----QELLGDGP 724

  Fly   764 FAGLLKGASQQLKEQPEVKLKIQEESKPQQTLPR-VR-------------PPIPTKP--AIPE-- 810
                 :|....:....|..|   :|.....|.|: ||             ||:|.||  .:|.
  Rat   725 -----QGPGSPMSRSQEYLL---DEGPAPGTPPKEVRSSRHGHSVKRASVPPVPGKPRQVLPSGV 781

  Fly   811 KKFAKPPTTPTNQ---SLEANG--NSSSDVVIKP----------PRSPSKSPSKTSNK------- 853
            ..|. ||.|||..   |.:|.|  :..:...:||          |.||...|...:::
  Rat   782 SHFT-PPQTPTKAQPGSPQALGGPHGPATAKVKPTPQLLPPTDRPMSPRSLPQSPTHRGFAYVLP 845

  Fly   854 SPVK------SPGKSPAKSPGSGHSAARNSINLLSPFNAEEAR-KKISEIIENFGSGILNTSITP 911
            .||:      :||..|...|     ||..::.|....:.|..| ||.:..:..:.:.
  Rat   846 QPVEGEAGPPAPGPVPPPVP-----AAVPTLCLPPEADVEPGRPKKRAHSLNRYAAS-------- 897

  Fly   912 THDIELDFEDMEVPNERRELATRLRAAGLLHLERILFENGYDNYKFVNNVFEEPDIPLLHIPERD 976
              |.|.:.:::.||......||..|..|..|..|.  ..|.|  |.||........|....|...
  Rat   898 --DSEPERDELLVPAAAGPYATVQRRVGRSHSVRA--PAGTD--KNVNRSQSFAVRPRKKGPPPP 956

  Fly   977 APKLLRFVQSLPPAEFQPQVPVKTQQENKQMGVATLQQWLNTIALPEYLEFFNKHLYNTIESVCG 1041
            .||  |...::..|....:.....:.|:.::||...::..:.:|             .::::...
  Rat   957 PPK--RSSSAMASANLADEPSPDVETEDGRLGVRAQRRRASDLA-------------GSVDTGSA 1006

  Fly  1042 VWDVELQTVLEINKLGHRRRILQSLAYIRQMRDSDSKSQKTPLGENNETNQLTTNGNGTAREAPP 1106
            .....:..:||::.:|                                       |.|.|...||
  Rat  1007 GSVKSIAAMLELSSIG---------------------------------------GGGRAIRRPP 1032

  Fly  1107 R-----LPANP-----------VHHRNSI------TGYRKSRPAPPP---------PAPPARK-- 1138
            .     .||:|           |.|:.:|      ...|::...|..         |..||.:
  Rat  1033 EGHPTPRPASPDPGRVATVLASVKHKEAIGPDGEVVNRRRTLSGPVTGLLATARRGPGEPAEQSH 1097

  Fly  1139 -----TAALQIRAPSELLLGL--PANLRTTEWRHSAQTLLNEHINYEVQYLGSTVVKELRGTEST 1196
                 ||..::|.|::...|:  |...|..                    ..:|:.:.:|..:|.
  Rat  1098 FMEDGTARQRLRGPAKGEAGVEGPPLARVE--------------------ASATLKRRIRAKQSQ 1142

  Fly  1197 KKSIQKLKTSAD 1208
            :::::.:.|.:|
  Rat  1143 QENVKFILTESD 1154

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4393	NP_001287483.1	Ank_2	<10..79	CDD:289560	24/79 (30%)
		ANK	43..171	CDD:238125	58/135 (43%)
		ANK repeat	49..79	CDD:293786	14/36 (39%)
		Ank_2	53..148	CDD:289560	41/95 (43%)
		ANK repeat	81..115	CDD:293786	14/34 (41%)
		ANK	112..257	CDD:238125	63/144 (44%)
		ANK repeat	117..148	CDD:293786	15/30 (50%)
		Ank_2	122..233	CDD:289560	42/110 (38%)
		ANK repeat	181..233	CDD:293786	16/51 (31%)
		Ank_5	224..276	CDD:290568	30/51 (59%)
		ANK repeat	237..267	CDD:293786	21/29 (72%)
		SAM_AIDA1AB-like_repeat2	1005..1069	CDD:188899	6/63 (10%)
		SAM	1009..1075	CDD:197735	5/65 (8%)
		PTB_Anks	1161..1305	CDD:269972	5/48 (10%)
Caskin1	XP_006245957.1	ANK	43..175	CDD:238125	59/141 (42%)
		ANK repeat	56..86	CDD:293786	13/29 (45%)
		Ank_2	60..152	CDD:289560	41/95 (43%)
		ANK repeat	88..119	CDD:293786	14/34 (41%)
		ANK	116..248	CDD:238125	63/144 (44%)
		ANK repeat	121..152	CDD:293786	15/30 (50%)
		Ank_2	126..225	CDD:289560	43/111 (39%)
		ANK repeat	154..193	CDD:293786	17/47 (36%)
		ANK repeat	195..225	CDD:293786	12/33 (36%)
		Ank_5	215..268	CDD:290568	31/52 (60%)
		ANK repeat	228..258	CDD:293786	21/29 (72%)
		ANK repeat	260..294	CDD:293786	8/33 (24%)
		SH3_Caskin1	291..352	CDD:212995	11/74 (15%)
		Caskin1-CID	380..428	CDD:293208	12/69 (17%)
		SAM	479..541	CDD:197735	10/77 (13%)
		SAM_caskin1,2_repeat1	480..545	CDD:188896	12/80 (15%)
		SAM_caskin1,2_repeat2	547..616	CDD:188897	11/82 (13%)
		SAM	558..613	CDD:197735	8/65 (12%)
		Caskin-Pro-rich	884..955	CDD:293512	19/84 (23%)
		Caskin-tail	1375..1437	CDD:293238
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0507
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810