DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG4393 and Caskin2

DIOPT Version :9

Sequence 1:NP_001287483.1 Gene:CG4393 / 42764 FlyBaseID:FBgn0039075 Length:1325 Species:Drosophila melanogaster
Sequence 2:NP_542374.2 Gene:Caskin2 / 140721 MGIID:2157062 Length:1201 Species:Mus musculus


Alignment Length:1422 Identity:335/1422 - (23%)
Similarity:499/1422 - (35%) Gaps:458/1422 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MGKDQEFLEAARNGNISHIEKVLTQ-KAKRAGPLASLRRGTGVNVQDSGGYSALHHACLNGHEDI 64
            ||::|:.:.|.:||:::.::|::.: ||.:...|.|.:| ..:|.||:.|:||||||.|.|..::
Mouse     1 MGREQDLILAVKNGDVTCVQKLVAKVKAAKTKLLGSTKR-LNINYQDADGFSALHHAALGGSLEL 64

  Fly    65 VRLLLAHEASPNLPDSRGSSPLHLAAWAGETEIVRLLLTHPYRPASANLQTIEQETPLHCAAQHG 129
            :.|||..:|:.::.||.|..|||.|||.|..|.|||||.   ..|:.|..:::.:.|||.|||:|
Mouse    65 IALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLLLR---ASAAVNAASLDGQIPLHLAAQYG 126

  Fly   130 HTGALALLLHHDADPNMRNSRGETPLDLAAQYGRLQAVQMLIRAHPELIAHLGTEALERGTPSPS 194
            |.....:||.|.::|.:.|...:||||||.::|||:..|:|:.:| ..:|.|..||.:...|:.:
Mouse   127 HYEVSEMLLQHQSNPCLVNKLKKTPLDLACEFGRLKVAQLLLNSH-LCVALLEGEAKDPCDPNYT 190

  Fly   195 SPASPSRAIFPHTCLHLASRNGHKSVVEVLLSAGVSVNLLTPSGTALHEAALCGKENVVRTLLKA 259
            :|            ||||::|||:.|:..||.||:.:|..|.:|||||||||.||..|||.||:.
Mouse   191 TP------------LHLAAKNGHREVIRQLLKAGIEINRQTKTGTALHEAALYGKTEVVRLLLEG 243

  Fly   260 GINLNATDNEGRTALDILREF-PPHVTKHI------------VAVINNFRN-----QMDTDEGDE 306
            |:::|..:...:|||||:.:| ....::.|            |..:.:|.|     .::...||.
Mouse   244 GVDVNIRNTYNQTALDIVNQFTTSQASREIKQLLREASGILKVRALKDFWNLHDPTALNVRAGDV 308

  Fly   307 V-IYRQHSGPPNSGRGQNKHHSQQQPPLSNHYHFNSNNHLLNHSHSMQQSGYSK----QRLSAGN 366
            : :..||.    .||.:...|..|:                    ...:.||..    :.:|...
Mouse   309 ITVLEQHP----DGRWKGHIHESQR--------------------GTDRVGYFPPGIVEVVSKRV 349

  Fly   367 GGPYNGGKSLDSALQPEDRFYQDLNAHSPLHS-------------QNEMGGGYSVSPSSSLSSFE 418
            |.|.....|..:.|:|.........|..||.|             .:..|...||....|:.|..
Mouse   350 GIPVARLPSAPTPLRPSFSRISQPAADDPLPSVPYGQLPRVGLSPDSPAGDRNSVGSEGSVGSIR 414

  Fly   419 PASVSPRSRCSTG-GLG------QPMHMST--------FAPAGPPKKPPRRNLSVSPTHAG---- 464
            .|.....|..:.| |.|      ||:..::        .||:      |..|||..|. ||    
Mouse   415 SAGSGQSSEGTNGHGTGLLIENAQPLPSASEDQGLPGLHAPS------PADNLSHRPL-AGYRSG 472

  Fly   465 --------PGQ---------------------------QFSYSSPSSQSQSQSH---------GH 485
                    |.|                           |..|..|:....:...         ||
Mouse   473 EIFTQDVRPEQLLEGKDAQAIHNWLSEFQLEGYTAHFLQAGYDVPTISRMTPEDLTAIGVTKPGH 537

  Fly   486 GQNQVRRQPASE--------------------------SPYSHQ--------SHGSVGGMSFDET 516
                 |::.|||                          .|..|:        |.|.|..::::|.
Mouse   538 -----RKKIASEIAQLSIAEWLPNYIPVDLLEWLCALGLPQYHKQLVSSGYDSMGLVADLTWEEL 597

  Fly   517 Q---LRERQRNDRLYASARQ--STRSAIAGGMSLSSSNDMLDRQCSSSELNSETSVPNSSGDSPA 576
            |   :.:.....:|....::  ..|..:..|.:|......:.|   ..||.:...:.|  |:.|.
Mouse   598 QEIGVNKLGHQKKLMLGVKRLAELRRGLLHGEALGEGGRRMTR---GPELMAIEGLEN--GEGPT 657

  Fly   577 TNSMKRPIPAPRSST---TKLSKELLKSAESATLKSYNPNRKLKRNRNSSGANGAAKSNGGDENC 638
            |       ..||..|   ::||.||                            .||.:.||.|  
Mouse   658 T-------AGPRLLTFQGSELSPEL----------------------------QAAMAGGGSE-- 685

  Fly   639 EAKQQIPSSPTHYKQPPTPDHPPPSSSQAERTI--------HERIRPLSQEYKRRSALLQLQAAQ 695
                            |.|  .||:.|.::.:|        |.:.:|:.|     .::....|.|
Mouse   686 ----------------PLP--LPPARSPSQESIGARSRGSGHSQEQPVPQ-----PSVGDPSAPQ 727

  Fly   696 QLMIETGSS-PSKLLPTLSTPGYDYDDTVTVVPR------CPAPSSG------SLSSSISC---- 743
            :..:..|:. ||||...|  ||......|.:.|:      .|.|..|      .|:.|.:.    
Mouse   728 ERNLPEGTERPSKLCSPL--PGQGPAPYVFMCPQNLPSSPAPGPPPGVPRAFSYLAGSPAAPPDP 790

  Fly   744 -----SDHSLSH--STDYVEEFVSDVPFAGLLKGASQQLKEQPEVKLKIQEESKPQQTLPRVRPP 801
                 ..||||.  ..:...|..::.|....| |:...|..:|           .:.||.|..|.
Mouse   791 PRPKRRSHSLSRPGPAEGEAEGEAEGPVGSAL-GSYATLTRRP-----------GRSTLARTSPS 843

  Fly   802 I-PTKPAIPEKKFA------KPPTTPTNQSLEANGNS---SSDVVIKP--------------PRS 842
            : ||:.....:.||      .||..|..:....:|::   |.|....|              |..
Mouse   844 LTPTRGTPRSQSFALRARRKGPPPPPPKRLSSVSGSTEPPSLDGTSGPKEGATGPRRRTLSEPTG 908

  Fly   843 PSKSPSKTSNKSPVKSPGKSPAKSPGSGHSAARNSINLLSPFNAEEARKKISEIIENFGSGILNT 907
            ||:||..::...||....:.|..   .|...:|.|.....|| |||....|.:..:..|.....|
Mouse   909 PSESPGPSAPTGPVSDTEEEPGP---EGTPPSRGSSGEGLPF-AEEGNLTIKQRPKPAGPPPRET 969

  Fly   908 SITPTHDIELDFED--MEVP--NERRELATRLRAAGLLHLERILFENGYDNYKFVNNVFEEPDIP 968
            .:.|..|..|...|  ...|  .||..|.|.|.|.|::         |.|.        ..|..|
Mouse   970 PVPPGLDFNLTESDTVKRRPKCKEREPLQTALLAFGVV---------GSDT--------PGPSNP 1017

  Fly   969 LLHIPERDAPKLLRFVQSLPPAEFQPQVPVKTQQENKQMGVATLQQWLNTIALPEYLEFFNKHLY 1033
            |......|.|.    ..|.||...:|.|                        ||.         .
Mouse  1018 LSTQAPCDPPS----ASSNPPQRSEPSV------------------------LPS---------Q 1045

  Fly  1034 NTIESVCGVWDVELQTVLEINKLGHRRRILQSLAYIRQMRDSDSKSQKTPLGE------NNETNQ 1092
            .|..|                          ||:.:.|.......|....|..      |.||..
Mouse  1046 GTSAS--------------------------SLSSVTQSPGHPGPSAGPALANSTGSKPNVETEP 1084

  Fly  1093 -------LTTNGNGTAREAPPRLPANPVHHRNSITGYRKS-----RPAPPP------PAPPARKT 1139
                   |...|.|||    |: |.:....:.:.:|.:.:     ||.|||      |..|.|..
Mouse  1085 PAPPAALLKVPGAGTA----PK-PVSVACTQLAFSGPKLAPRLGPRPVPPPRPENTGPVCPGRAQ 1144

  Fly  1140 AALQIRAPSELLLGLPANLRT------TEWRHSAQTLLNEHINYEVQYLGSTVVKEL 1190
            ..|:..:.|     |.|.||.      ||.|........:||..::..:...:..:|
Mouse  1145 QRLEQTSSS-----LEAALRAAEKSIGTEERDGPTGTSTKHILDDISTMFDALADQL 1196

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG4393NP_001287483.1 Ank_2 <10..79 CDD:289560 25/69 (36%)
ANK 43..171 CDD:238125 57/127 (45%)
ANK repeat 49..79 CDD:293786 13/29 (45%)
Ank_2 53..148 CDD:289560 40/94 (43%)
ANK repeat 81..115 CDD:293786 16/33 (48%)
ANK 112..257 CDD:238125 60/144 (42%)
ANK repeat 117..148 CDD:293786 12/30 (40%)
Ank_2 122..233 CDD:289560 42/110 (38%)
ANK repeat 181..233 CDD:293786 17/51 (33%)
Ank_5 224..276 CDD:290568 27/51 (53%)
ANK repeat 237..267 CDD:293786 18/29 (62%)
SAM_AIDA1AB-like_repeat2 1005..1069 CDD:188899 6/63 (10%)
SAM 1009..1075 CDD:197735 7/65 (11%)
PTB_Anks 1161..1305 CDD:269972 6/30 (20%)
Caskin2NP_542374.2 ANK 7..135 CDD:238125 51/131 (39%)
Ank_4 7..61 CDD:290365 20/54 (37%)
ANK repeat 7..46 CDD:293786 10/39 (26%)
ANK repeat 48..79 CDD:293786 13/30 (43%)
ANK 1 48..77 13/28 (46%)
Ank_2 53..145 CDD:289560 40/94 (43%)
ANK 76..209 CDD:238125 57/148 (39%)
ANK 2 81..110 15/31 (48%)
ANK repeat 85..112 CDD:293786 15/29 (52%)
ANK repeat 114..145 CDD:293786 12/30 (40%)
ANK 3 114..143 12/28 (43%)
ANK 4 147..176 12/29 (41%)
Ank_2 152..251 CDD:289560 48/111 (43%)
ANK repeat 158..219 CDD:293786 25/73 (34%)
ANK 183..311 CDD:238125 46/139 (33%)
ANK 5 188..217 13/40 (33%)
ANK 6 220..249 17/28 (61%)
ANK repeat 221..251 CDD:293786 18/29 (62%)
SH3_Caskin2 284..345 CDD:212996 13/84 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 355..466 25/116 (22%)
SAM_caskin1,2_repeat1 487..552 CDD:188896 9/69 (13%)
SAM 493..548 CDD:197735 9/59 (15%)
SAM_caskin1,2_repeat2 553..623 CDD:188897 8/69 (12%)
SAM 561..620 CDD:197735 8/58 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 675..1103 118/583 (20%)
Caskin-Pro-rich 797..881 CDD:293512 22/95 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1115..1179 18/68 (26%)
Caskin-tail 1144..1201 CDD:293238 12/58 (21%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0507
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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