DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4393 and si:dkeyp-9d4.3

DIOPT Version :9

Sequence 1:	NP_001287483.1	Gene:	CG4393 / 42764	FlyBaseID:	FBgn0039075	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	XP_009304428.1	Gene:	si:dkeyp-9d4.3 / 100148061	ZFINID:	ZDB-GENE-110914-175	Length:	1558	Species:	Danio rerio

Alignment Length:	1403	Identity:	334/1403 - (23%)
Similarity:	522/1403 - (37%)	Gaps:	423/1403 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGKDQEFLEAARNGNISHIEKVLTQKAKRAGPLASLRRGTGVNVQDSGGYSALHHACLNGHEDIV 65
            |||:||.|:|.:..::..::::|.:..:....|....:...||.||:.|.||||||.|||:.:::
Zfish     1 MGKEQELLQAVKTEDLVTVQRLLQRPKQGKAKLLGAAKKVNVNFQDTDGLSALHHAALNGNVELI 65

  Fly    66 RLLLAHEASPNLPDSRGSSPLHLAAWAGETEIVRLLLTHPYRPASANLQTIEQETPLHCAAQHGH 130
            .|||..::..::.|.:|..|||.|||.|:.|.:::||.   ..:|.|.|:.|.:.|||.::||||
Zfish    66 SLLLESQSVVDIKDQKGMRPLHYAAWQGKCEPMKMLLK---AGSSVNSQSDEGQIPLHLSSQHGH 127

  Fly   131 TGALALLLHHDADPNMRNSRGETPLDLAAQYGRLQAVQMLIRAHPELIAHLGTEALERGTPSPSS 195
            .....:||.|.::|.:|:..|:||||||.::||:..||:|:.      :::....||   |.||.
Zfish   128 YEGSEMLLQHQSNPCLRDHAGKTPLDLACEFGRVTVVQLLLN------SNMCAAMLE---PKPSD 183

  Fly   196 PASPSRAIFPHTCLHLASRNGHKSVVEVLLSAGVSVNLLTPSGTALHEAALCGKENVVRTLLKAG 260
            |    ..|.|   ||||::|||..::::|:.||:.:|..|.|||||||||||||...||.||.:|
Zfish   184 P----NGISP---LHLAAKNGHIEIIKLLIQAGIDINRQTKSGTALHEAALCGKTEAVRLLLDSG 241

  Fly   261 INLNATDNEGRTALDILREF-PPHVTKHI------------VAVINNFRNQMDTDE-----GDEV 307
            |:....:...:|||||:.:| ....:|.|            |..:.::.|..|...     ||.:
Zfish   242 ISAGVRNTYCQTALDIVNQFTTTQASKEIKQMLRDASAAMQVRALKDYCNNYDLTSLNIKAGDII 306

  Fly   308 -IYRQHSGPPNSGRGQNKHHSQQQPPLSNHYHFNSNNHL----LNHSHSMQQSGYSKQRL----- 362
             :..|||    .||.:...|..:          ..|:.:    .|....::::|.|.|:.
Zfish   307 TVLEQHS----DGRWKGCIHDNR----------TGNDRVGYFPSNMVEVIKRAGPSTQQYLKIHI 357

  Fly   363 ---SAGNGGPYNGGKS--LDSALQPEDRFYQDLNAHSPLHSQNEMGGGYSVSPSSSLSSFEPASV 422
               :.|:....||..|  ....|.|.......| .|.||.:    ..||:: |:.|...||||
Zfish   358 RPPAIGSVIMVNGDSSHIFSLPLTPPPPPALPL-THQPLFT----SFGYNM-PTCSTIGFEPA-- 414

  Fly   423 SPRSRCSTGGLGQPMHMSTFAPAGPPKKPPRRNLSVSPTHAGPGQQFSYSSPSSQSQSQSHGHGQ 487
               |.||.                .|:|......|||..|..|          :.|..||..:.:
Zfish   415 ---SSCSE----------------EPQKDTGSRGSVSSPHGSP----------TLSGQQSGANEE 450

  Fly   488 NQVRRQPASESPYSHQSHGSVGGMSFDETQLRERQRNDRLYASARQSTRSAIAGGMSLSSSNDML 552
            ..|.|:|.:       :.||||.|.                ::...|.||:.:|    .|||
Zfish   451 IWVLRKPLA-------AGGSVGSMG----------------STGSLSGRSSASG----QSSN--- 485

  Fly   553 DRQCSSSELNSETSVPNSSGDSPATNSMKRPIPA--PRSSTTKLSKELLKSAESATLKSYNPNRK 615
               .::...||...||.:...||..|:....:|.  .::...||...:|  ::||..|.:    .
Zfish   486 ---ANAHLTNSPVPVPTTPTHSPGVNTHGLNVPGLHAQAEGVKLLATVL--SQSAKAKEH----L 541

  Fly   616 LKRNRNSSGANGAAKSNGGDENCEAKQQIPSSPTHYKQPPTPDHPPPSSSQAERTIHERIRPLSQ 680
            :.::::.|..|.|:.        :..|.:.:.|...::.|..|           .:.:|....|.
Zfish   542 MDQSQSVSDPNSASP--------QRPQSVSAVPRQQRKKPFVD-----------PLLQRKDEASA 587

  Fly   681 EYKRRSALLQLQAAQQLMIETGS------------------------------------------ 703
            |.|...|:::...:.||...|.:
Zfish   588 ESKSSEAVVEWLTSAQLQFYTTNFLTAGYDLQTISRMTPEDLTAIGVTKPGHRKKMLSEISKMNI 652

  Fly   704 -------SPSKL------------LPTLSTPGYDYDDTVT-----------------------VV 726
                   .||.|            ..||...|||..|.::                       .:
Zfish   653 PDWIPQEKPSSLAEWLSAIGLNQYYQTLVQNGYDNMDFISDITLEDLKEIGFTKLGHQKKLMLAI 717

  Fly   727 PR-CPAPSSGSLSSSISCSDHSLSHSTD-------YVEEFVSDVPFAGLLKGASQQLKEQPEVKL 783
            .| ..:|.:.|||     .:..|..|||       ..|..|:.||.|.:.|.|..:.:.:||.:.
Zfish   718 KRLSESPEAESLS-----KESQLEESTDAKQPLETSTEPDVNSVPSARIRKRAEGRSEGRPEGRP 777

  Fly   784 KIQEE--SKPQQT-----LPRVRPPIP-TKPAIPEKKFAKPPTTPTNQSLEANGNSSSDVVIKPP 840
            ..:.|  |.|:.:     :.|...|.| .||:..:.....||.|||      .|.:||.....|.
Zfish   778 DGRSEGRSSPRHSTQGRGIQRANAPPPLKKPSSIDSPTPTPPHTPT------KGRTSSSSSNSPS 836

  Fly   841 RSPSKSPSKTSNKSPVKSPGKSPAKSPGSGHSAARNSINLLSPFNAEEARKKISEIIENFGSGIL 905
            ..|| ||.||.::.      :.|..||.| |:.||....|..|...|..        |:.|.
Zfish   837 HIPS-SPLKTQSRP------RGPCDSPRS-HAHARTVPVLCLPHEGETE--------ESNGQ--- 882

  Fly   906 NTSITPT-----HDIELDFEDMEVPNERRELAT----------RLRAAGLLHLERILFENGYDNY 955
                ||:     ..|..| .|:.:|:...:.||          ..|.:|
Zfish   883 ----TPSQPRRGQSINTD-ADLPMPDSSVKYATLGGHKTTSSSSTRTSG---------------- 926

  Fly   956 KFVNNVFEEPDIPLLHIPERDAPKLLRFVQSLPPAEFQPQVPVKTQQENKQMGVATLQQWLNTIA 1020
                   |..||       ....:...|..:.|....:|..|.|....:...|..|.:...:...
Zfish   927 -------ESLDI-------NSVNRSQSFATARPRRRTRPPTPPKRSCSSISTGNLTDEAVADDAR 977

  Fly  1021 LPEYLEFFNKHLYNTI-----ESVCGVWDV---------ELQTVLEINKLGHR--------RRIL 1063
            |.|  ...|..|.|..     .|.||:...         ::..:||::.||:.        .::.
Zfish   978 LSE--NRANNLLLNVTYRERRRSDCGIASEKTSSGGSVRDIAAMLEMSNLGNSGKGSGSGYTQVS 1040

  Fly  1064 QSLAYIRQMRD---SDSKSQKTPLGENNETNQLTTNGNGTAREAPPRLPANPVHHRNS--ITGYR 1123
            |::  :||.|:   .|:.|::..:.|..::.:.:.:    .:||..|  .:..||:..  .|...
Zfish  1041 QNV--LRQNREVLNLDADSRRRTISEFYDSQKQSAD----VQEAEMR--QDTAHHKPEPRETHLL 1097

  Fly  1124 KSRPAPPPPAPPARKTAALQIRAPSELLLGLPANLRTTEW-RHSAQTLL----------NEHINY 1177
            |..|.|.|             |:....|.|..::|...|| |..|...|          .||.|
Zfish  1098 KQAPEPRP-------------RSMITHLEGGVSSLPQEEWSRMDATATLRRPRPPHHTDGEHFN- 1148

  Fly  1178 EVQYLGSTVVKELRGTESTKKSIQKLK------TSADG 1209
                        |..|.:.|:..:.|.      |..||
Zfish  1149 ------------LTETSTIKRRPKALAQPQSNGTDGDG 1174

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4393	NP_001287483.1	Ank_2	<10..79	CDD:289560	20/68 (29%)
		ANK	43..171	CDD:238125	55/127 (43%)
		ANK repeat	49..79	CDD:293786	13/29 (45%)
		Ank_2	53..148	CDD:289560	37/94 (39%)
		ANK repeat	81..115	CDD:293786	13/33 (39%)
		ANK	112..257	CDD:238125	62/144 (43%)
		ANK repeat	117..148	CDD:293786	12/30 (40%)
		Ank_2	122..233	CDD:289560	41/110 (37%)
		ANK repeat	181..233	CDD:293786	18/51 (35%)
		Ank_5	224..276	CDD:290568	27/51 (53%)
		ANK repeat	237..267	CDD:293786	19/29 (66%)
		SAM_AIDA1AB-like_repeat2	1005..1069	CDD:188899	15/85 (18%)
		SAM	1009..1075	CDD:197735	17/90 (19%)
		PTB_Anks	1161..1305	CDD:269972	15/66 (23%)
si:dkeyp-9d4.3	XP_009304428.1	Ank_4	7..69	CDD:290365	19/61 (31%)
		ANK repeat	7..46	CDD:293786	6/38 (16%)
		ANK	43..168	CDD:238125	55/127 (43%)
		ANK repeat	48..79	CDD:293786	13/30 (43%)
		Ank_2	53..145	CDD:289560	37/94 (39%)
		ANK repeat	81..112	CDD:293786	13/33 (39%)
		ANK	109..238	CDD:238125	62/144 (43%)
		ANK repeat	114..145	CDD:293786	12/30 (40%)
		Ank_2	119..215	CDD:289560	42/111 (38%)
		ANK repeat	148..183	CDD:293786	16/43 (37%)
		ANK repeat	185..216	CDD:293786	13/33 (39%)
		Ank_5	205..258	CDD:290568	28/52 (54%)
		ANK repeat	218..248	CDD:293786	19/29 (66%)
		SH3	281..342	CDD:302595	13/74 (18%)
		Caskin1-CID	449..533	CDD:293208	26/118 (22%)
		SAM	587..650	CDD:197735	6/62 (10%)
		SAM_caskin1,2_repeat1	590..654	CDD:188896	5/63 (8%)
		SAM_caskin1,2_repeat2	655..722	CDD:188897	10/66 (15%)
		SAM	661..723	CDD:197735	10/61 (16%)
		Caskin-tail	1501..1558	CDD:293238
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910