DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4408 and AGBL2

DIOPT Version :9

Sequence 1:	NP_651141.2	Gene:	CG4408 / 42762	FlyBaseID:	FBgn0039073	Length:	479	Species:	Drosophila melanogaster
Sequence 2:	NP_079059.2	Gene:	AGBL2 / 79841	HGNCID:	26296	Length:	902	Species:	Homo sapiens

Alignment Length:	229	Identity:	49/229 - (21%)
Similarity:	80/229 - (34%)	Gaps:	78/229 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   225 RTTVFVESGIHARE----WIAPATATYIIDQLVNSKDSAVQALARSQRWYIFPTVNPDGYQYTFK 285
            :..|.:.:.:|..|    |:......:|   |.||.|:  |.|.....:.:.|.:||||
Human   452 KKAVVLSARVHPGESNGSWVMKGFLDFI---LSNSPDA--QLLRDIFVFKVLPMLNPDG------ 505

  Fly   286 GDRMWRKNRALFGICR----GVDLNRNFPFHWNVTGASGDPCRYDYSGPSAASEVETQRMIEFIR 346
                     .:.|..|    |.||||    |:........||.:           .|:.|   |:
Human   506 ---------VIVGNYRCSLAGRDLNR----HYKTILKESFPCIW-----------YTRNM---IK 543

  Fly   347 HRVESERIRTFISLHSYSQM-IMFPYG----------HSAERV------------DNYHDLTDIG 388
            ..:|...:..:...|.:|:. .:|.||          |  |||            .::|..
Human   544 RLLEEREVLLYCDFHGHSRKNNIFLYGCNNNNRKYWLH--ERVFPLMLCKNAPDKFSFHSC---- 602

  Fly   389 KLAANKIKDVSGRI--YKSGSIYE-TIYPSSGGS 419
            .....|.|:.:||:  ::.|.:.. |:..:.|||
Human   603 NFKVQKCKEGTGRVVMWRMGILNSYTMESTFGGS 636

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4408	NP_651141.2	Propep_M14	88..159	CDD:280416
CG4408	NP_651141.2	M14_CP_A-B_like	179..472	CDD:199844	49/229 (21%)
AGBL2	NP_079059.2	GVQW	105..>120	CDD:290611
		M14_AGBL2-3_like	407..666	CDD:133117	49/229 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	746..770
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	796..879
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2866
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900