DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4408 and CG14820

DIOPT Version :9

Sequence 1:	NP_651141.2	Gene:	CG4408 / 42762	FlyBaseID:	FBgn0039073	Length:	479	Species:	Drosophila melanogaster
Sequence 2:	NP_648060.1	Gene:	CG14820 / 38754	FlyBaseID:	FBgn0035718	Length:	416	Species:	Drosophila melanogaster

Alignment Length:	393	Identity:	139/393 - (35%)
Similarity:	220/393 - (55%)	Gaps:	24/393 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 QARYDHTRIYQVELASEEHVRLFQALEQASDSCSFMGHARQPGQKLTIMVTGAKVADFDDLVHSY 142
            |.|||:.::|.|.:...|..:|....|::....|:. .||..|:...||:.......|:.|:..:
  Fly    20 QVRYDNYKVYNVRIDDLEQFKLLHTQERSLKLSSWR-EARHLGESSDIMLPPEYQKTFESLLTKH 83

  Fly   143 NVTHRVLNYNFQALIDANYLEVAPEDTKPEE----FDWKRYHPLESINAWLKKLAETHPEVLL-V 202
            |.|:.:...|.|..|||.         :|::    .:|.::|.||.|.|||..:.:.:|:::. .
  Fly    84 NFTYNLKIDNVQTHIDAQ---------RPKQRITSMEWTQFHTLEEIYAWLDVIEDRYPDIVTPF 139

  Fly   203 ELGVSAQGRPILGVQIAFDNENRTTVFVESGIHAREWIAPATATYIIDQLVNSKDSAVQALARSQ 267
            .:|.|.:||||.||:|:: .|....||:||.|||||||..||.||.||:|:..::.||:.:|::.
  Fly   140 TIGNSYEGRPIRGVKISY-KEGNPAVFIESNIHAREWITSATITYFIDELLVPRNPAVRDIAQNV 203

  Fly   268 RWYIFPTVNPDGYQYTFKGDRMWRKNRA---LFGICRGVDLNRNFPFHWNVTGASGDPCRYDYSG 329
            .|||.|.:|.||:.|:.:.:|:|||:|.   ..|.|.|.||||||.:.|.:|||..|||...|:|
  Fly   204 DWYIIPVLNTDGFAYSHEVERLWRKSRLPSDPTGECIGTDLNRNFDYLWMLTGAESDPCSQLYAG 268

  Fly   330 PSAASEVETQRMIEFIRHRVESERIRTFISLHSYSQMIMFPYGHSA-ERVDNYHDLTDIGKLAAN 393
            ||..|:.|..::..:|.:.:....|:.:||||||.|.::.|:||:| |..::|..:..:.|..::
  Fly   269 PSPESDPEISQLTAYINNSIPEGTIKIYISLHSYGQYVLSPWGHTALEFPEHYPQMMHVAKGFSD 333

  Fly   394 KIKDVSGRIYKSGSIYETIYPSSGGSKDWAHGQLKIPITFSYELRGPADSEDL-FILSAKEIEPT 457
            .:....|.::..||...|:|..||..|:||:....|.|.::.|||   |..:| |:|..::|.|.
  Fly   334 ALYRRYGTVFTYGSSATTLYEVSGSGKEWAYAVKNIKIHYTIELR---DKGELGFVLPPEDIIPV 395

  Fly   458 AAE 460
            |.|
  Fly   396 ARE 398

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4408	NP_651141.2	Propep_M14	88..159	CDD:280416	17/70 (24%)
CG4408	NP_651141.2	M14_CP_A-B_like	179..472	CDD:199844	113/288 (39%)
CG14820	NP_648060.1	Propep_M14	31..100	CDD:280416	17/69 (25%)
CG14820	NP_648060.1	M14_CP_A-B_like	115..410	CDD:199844	113/288 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467019
Domainoid	1	1.000	158	1.000	Domainoid score	I1007
eggNOG	1	0.900	-	-		E1_COG2866
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	239	1.000	Inparanoid score	I2114
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D208397at33208
OrthoFinder	1	1.000	-	-		FOG0000056
OrthoInspector	1	1.000	-	-		mtm4737
orthoMCL	1	0.900	-	-		OOG6_100142
Panther	1	1.100	-	-	P	PTHR11705
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X86
	11	10.800