DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4408 and CG12374

DIOPT Version :9

Sequence 1:	NP_651141.2	Gene:	CG4408 / 42762	FlyBaseID:	FBgn0039073	Length:	479	Species:	Drosophila melanogaster
Sequence 2:	NP_610819.1	Gene:	CG12374 / 36410	FlyBaseID:	FBgn0033774	Length:	422	Species:	Drosophila melanogaster

Alignment Length:	453	Identity:	137/453 - (30%)
Similarity:	223/453 - (49%)	Gaps:	49/453 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 LLLLLVSSVCVIQESKASSFCTKADQCALDEEIKTAADSVQARYDHTRIYQV----ELASEEHVR 98
            ||:.||:.|..                      |:|...:.|||||.||||:    .|..||..:
  Fly     6 LLITLVAMVAA----------------------KSAPGRMAARYDHFRIYQLTIETNLQMEELKK 48

  Fly    99 LFQALEQASDSCSFMGHARQPGQKLTIMVTGAKVADFDDLVHSYNVTHRVLNYNFQALIDANYLE 163
            :.:.:     |..|:......|.|..::|........:..:....:.:.|:..:.|.|||.:.:
  Fly    49 IHEHI-----SVHFLNELGAVGNKYNVIVGPLFHRALEKTLKFLEIVYEVIVDDLQKLIDESSV- 107

  Fly   164 VAPEDTKPEEFDWKRYHPLESINAWLKKLAETHPEVLLVELGVSAQGRPILGVQIAFDNENRTTV 228
              .:|:   :.:|:.||.|::|..|:.:....|..:....:|.|.:||.|..::::..:.|: .:
  Fly   108 --GDDS---QMEWETYHTLDTIYDWIDQECAAHDFLECKVIGQSYEGRDIKSIRLSKRSGNK-AI 166

  Fly   229 FVESGIHAREWIAPATATYIIDQLVNSKDSAVQALARSQRWYIFPTVNPDGYQYTFKGDRMWRKN 293
            |:|..|||.|||:.||.|::::||:||:|..:|.|:....|.:.|.|||||:.||.:.:|:||||
  Fly   167 FLEGNIHAMEWISSATVTFLLNQLINSEDPEMQRLSEEYDWIVVPMVNPDGFVYTHEVERLWRKN 231

  Fly   294 RALFGI------CRGVDLNRNFPFHWNVTGASGD-PCRYDYSGPSAASEVETQRMIEFIRHRVES 351
            |...|.      |.|:|:||||.:||...|.:.| ||.:.:.|....:|||...:..|: ...|.
  Fly   232 RRPNGYRNESGDCYGIDMNRNFDYHWGGAGWNIDEPCDHWFGGEEPNTEVEIISLQNFV-SSFED 295

  Fly   352 ERIRTFISLHSYSQMIMFPYGHS-AERVDNYHDLTDIGKLAANKIKDVSGRIYKSGSIYETIYPS 415
            ..||::::.|:|.|.::.||||| .|...||..:..|....::...||.|..:..|:.....|..
  Fly   296 GYIRSYMAYHAYGQYVLLPYGHSNTEFPPNYEQMKRIAAAFSDAAADVYGSTFTYGASGLLNYVV 360

  Fly   416 SGGSKDWAHGQLKIPITFSYELRGPADSEDLFILSAKEIEPTAAEAFASIQTIVQEAGKRGYY 478
            ||.:||||:|..|||.|.:.|||......  |.|.:.:|.....|..|.::.:|.:|.:.|.:
  Fly   361 SGAAKDWAYGVKKIPFTCTVELRDKGTFG--FFLPSNQITEVGLEVTAGLKALVNKAAEEGIF 421

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4408	NP_651141.2	Propep_M14	88..159	CDD:280416	13/74 (18%)
CG4408	NP_651141.2	M14_CP_A-B_like	179..472	CDD:199844	104/300 (35%)
CG12374	NP_610819.1	Propep_M14	34..104	CDD:280416	13/74 (18%)
CG12374	NP_610819.1	M14_CP_A-B_like	118..415	CDD:199844	104/300 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467022
Domainoid	1	1.000	158	1.000	Domainoid score	I1007
eggNOG	1	0.900	-	-		E1_COG2866
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D208397at33208
OrthoFinder	1	1.000	-	-		FOG0000056
OrthoInspector	1	1.000	-	-		otm46992
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11705
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X86
	9	8.850