DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4408 and CG8945

DIOPT Version :9

Sequence 1:	NP_651141.2	Gene:	CG4408 / 42762	FlyBaseID:	FBgn0039073	Length:	479	Species:	Drosophila melanogaster
Sequence 2:	NP_573190.1	Gene:	CG8945 / 32693	FlyBaseID:	FBgn0030815	Length:	1430	Species:	Drosophila melanogaster

Alignment Length:	509	Identity:	141/509 - (27%)
Similarity:	238/509 - (46%)	Gaps:	85/509 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 PKTWLLLL---LVSSVCVIQESKASSFCTKADQCALDEEIKTAADSVQAR--------YDHTRIY 87
            |:.|:.:|   :|:|......:..|:...:|....:.....|:..:..:|        ||..:|:
  Fly   923 PQNWIGILAHHIVNSTGSAISTSTSNPLLQALATRMTTRGTTSTTTTTSRPDVPRRISYDKYQIW 987

  Fly    88 QVELASEEHVRLFQALEQASDSCSFMGHARQPGQKLT-IMVTGAKVADFDDLVHSYNVTHRVLNY 151
            :::...||.||..:..::..|............:.|| ::|....:.||...::...:.|.||.:
  Fly   988 RLKPQDEEQVRALEEFKKGEDGVKLQWLKGPSLRGLTDVLVPPKMLVDFQGTLNYEGIAHEVLIF 1052

  Fly   152 NF-----QALIDANYLEVA----PEDTKPEEFDWKRYHPLESINAWLKKLAETHPEVL-LVELGV 206
            :.     ..|...:||:..    |..|.|....|.|||..:.|..:|:.:...||::: |:.:|.
  Fly  1053 DVGKAIAYELTKEDYLQTTRPSKPRPTAPPPMTWNRYHNHDEIVKYLETVRMRHPQLVELIHIGR 1117

  Fly   207 SAQGRPILGVQI-------AFDNENRTT---------------VFVESGIHAREWIAPATATYII 249
            |.:|||::.|:|       |.:|:...|               ||||:|.....||.||.||::|
  Fly  1118 SFEGRPLIVVKIESKQTAAAANNDGLHTIKRPKRKRKSGQANAVFVEAGAQGLAWIGPAAATWMI 1182

  Fly   250 DQLV-----NSKDSAVQALARSQRWYIFPTVNPDGYQYTFKGDRMWRKNRALF------------ 297
            .:|:     |..:..|:.: |:..|||.|.:|||||.|:.:.||.|:|:|:..
  Fly  1183 AELLRLMKTNKSNEDVEFI-RNTTWYIMPVLNPDGYAYSHEYDRFWKKSRSQHQTPPPSGLLDSA 1246

  Fly   298 -----------GICRGVDLNRNFPFHWNVTGASGDPCRYDYSGPSAASEVETQRMIEFIR-HRVE 350
                       .:|.||||:||:.:||...|:|..||...|:||:..||.||:.:.||:. :|.:
  Fly  1247 MTWLQQKRGPDKVCYGVDLDRNWLYHWGKRGSSKAPCNEFYAGPAPFSEPETKAVSEFLMDYRTQ 1311

  Fly   351 SERIRTFISLHSYSQMIMFPY----GHSAERVDNYHDLTDIGKLAANKIKDVSGRIYKSGSIYET 411
               |:.:|||.:|.|:|.:|.    ..::||:|::.|:..:|.....| |....| ||..:..:.
  Fly  1312 ---IKLYISLQAYGQVISYPVKANSTFNSERLDDFLDVAMVGTDGLRK-KGSKSR-YKVDASNDL 1371

  Fly   412 IYPSSGGSKDWAHGQLKIPITFSYELRGPADSEDLFILSAKEIEPTAAEAFASI 465
            |...||.:..:|..::.||  |||.|:...:....::|.:..|||||.:||..|
  Fly  1372 IEQRSGCADAFAAYEIGIP--FSYTLQLADNGVHGYLLPSSAIEPTARDAFEII 1423

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4408	NP_651141.2	Propep_M14	88..159	CDD:280416	14/76 (18%)
CG4408	NP_651141.2	M14_CP_A-B_like	179..472	CDD:199844	108/343 (31%)
CG8945	NP_573190.1	Propep_M14	988..1058	CDD:280416	13/69 (19%)
CG8945	NP_573190.1	M14_CP_A-B_like	1089..1430	CDD:199844	108/343 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2866
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D208397at33208
OrthoFinder	1	1.000	-	-		FOG0000056
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11705
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.920