DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4408 and ZC434.9

DIOPT Version :9

Sequence 1:	NP_651141.2	Gene:	CG4408 / 42762	FlyBaseID:	FBgn0039073	Length:	479	Species:	Drosophila melanogaster
Sequence 2:	NP_001251356.1	Gene:	ZC434.9 / 172908	WormBaseID:	WBGene00013895	Length:	720	Species:	Caenorhabditis elegans

Alignment Length:	483	Identity:	148/483 - (30%)
Similarity:	239/483 - (49%)	Gaps:	80/483 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 WLLLLLVSSVCVIQESKASSFCTKADQCALDEEIKTAADSVQARYDHTRIYQVELASEEHVRLFQ 101
            |||:|:            |:|       |::.||   ||....::...|.:..::...:.:|  .
Worm    11 WLLILI------------SAF-------AINAEI---ADDKPPKFQVLRAHATDVPQLKALR--D 51

  Fly   102 ALEQASDSCSFMGHARQPGQKLTIMVTGAKVADFDDLVHSYNVTHRVLNYNFQALIDANYLEVAP 166
            ..|:......|.....:.|.:..|||...::...|.::.:.|:::.|:      :.|...|.:..
Worm    52 IHERTQHDLDFWQTPSKVGHRADIMVDEDRMEWLDSVLKNSNISYDVI------IEDVGKLILEK 110

  Fly   167 EDTKPE------------------EFDWKRYHPLESINAWLKKLAETHPEVLLV-ELGVSAQGRP 212
            |...|.                  .:.:..||..::|..|:|.:...:|:...| .:|.:::|||
Worm   111 EHGPPRFSNLLFSKRMHNEGGNRARYGFGEYHSYQTICDWMKDIERKYPDKAKVFTMGTTSEGRP 175

  Fly   213 ILGVQI---AFDNENRTTVFVESGIHAREWIAPATATYIIDQLV--NSKDSAVQALARSQRWYIF 272
            |.|::|   .:.|:.| ..:::.|||||||.|..||.:.||:|:  .:.||.|:|......:||.
Worm   176 IQGIKIGSQVWRNDKR-IFWIDGGIHAREWAAVHTALWFIDRLIADYNDDSLVRAAVDRLNFYIL 239

  Fly   273 PTVNPDGYQYTFKGD-----RMWRKNRALFGI------------CRGVDLNRNFPFHWNVTGASG 320
            |..|||||:|: :.|     |:||||||  |:            |.|||||||:.:|:..||:|.
Worm   240 PVANPDGYEYS-RSDVSPMIRLWRKNRA--GVVCKKDRWFRDRCCGGVDLNRNYDWHFGETGSST 301

  Fly   321 DPCRYDYSGPSAASEVETQRMIEFIRHRVESERIRTFISLHSYSQMIMFPYGHSAERVD-NYHDL 384
            |.|...|.|.||.||.||:.|.:|:.....:.:|..||:||:||||.:.||.|:.:.|. :..:|
Worm   302 DKCSEIYQGSSAFSESETRSMRDFLTSSELNGKIDAFITLHTYSQMWIHPYSHARKSVPADVAEL 366

  Fly   385 TDIGKLAANKIKDVSGRIYKSGSIYETIYPSSGGSKDWAHGQLKIPITFSYELRGPADSEDLFIL 449
            ..:|:.|...:::..|..||.|:..:.:|||:|||.|||.|.|:|...:..|||...|..|.|||
Worm   367 QRVGRAAVAALENTYGTKYKFGTGSDILYPSAGGSDDWAKGTLRIKYVYLLELRPGEDVWDGFIL 431

  Fly   450 SAKEIEPTAAEAFASIQTIV----QEAG 473
            ...::.|||.|.:..|:.::    ::||
Worm   432 DQHQLIPTAKETWNGIKVVIRAVTEQAG 459

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4408	NP_651141.2	Propep_M14	88..159	CDD:280416	10/70 (14%)
CG4408	NP_651141.2	M14_CP_A-B_like	179..472	CDD:199844	120/320 (38%)
ZC434.9	NP_001251356.1	Propep_M14	45..111	CDD:366995	12/73 (16%)
		M14_CP_A-B_like	141..454	CDD:349433	120/316 (38%)
		ShK	682..719	CDD:366702
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	220	1.000	Domainoid score	I1500
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D208397at33208
OrthoFinder	1	1.000	-	-		FOG0000056
OrthoInspector	1	1.000	-	-		mtm4737
orthoMCL	1	0.900	-	-		OOG6_100142
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X86
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.820