DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4408 and Y47G6A.19

DIOPT Version :9

Sequence 1:	NP_651141.2	Gene:	CG4408 / 42762	FlyBaseID:	FBgn0039073	Length:	479	Species:	Drosophila melanogaster
Sequence 2:	NP_001379340.1	Gene:	Y47G6A.19 / 171921	WormBaseID:	WBGene00021645	Length:	509	Species:	Caenorhabditis elegans

Alignment Length:	422	Identity:	138/422 - (32%)
Similarity:	213/422 - (50%)	Gaps:	63/422 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 VRLFQALEQASDSCSFMGHARQPGQKLTIMVTGAKVADFDDLVHSYNVTHRVLNYNFQ-ALIDAN 160
            :|||:..:  :|...|..........:.|||    ..:..|....|...|   .|.|| |:.|.:
Worm    40 IRLFETAD--TDRADFWHAPSVVNGTVDIMV----APEHTDQFRQYLEKH---GYTFQVAIDDLH 95

  Fly   161 YLEVAPE-----DTKPEEFDWKR---------------YHPLESINAWLKKLAETHPEVL-LVEL 204
            .|.:..|     .:..:.|..||               |:....::.||:::||..|::. |:::
Worm    96 KLLIEKEGNLSTHSNDDAFFLKRLHDDVGFHSRLRMGEYYSYSVLSTWLERIAENMPDIAKLIKV 160

  Fly   205 GVSAQGRPILGVQIAFDNENRTTVFVESGIHAREWIAPATATYIIDQLVNSK--DSAVQALARSQ 267
            |.:.:||.|||::...|..::..|.:::|||||||.|..||:|.|:.:||.:  |..:|....:.
Worm   161 GTTIEGRDILGLKFGKDTPDKKIVVIDAGIHAREWAAIHTASYFINLIVNGREEDPQIQNYLDNI 225

  Fly   268 RWYIFPTVNPDGYQYTFKGD------RMWRKNR-----ALFGI----CRGVDLNRNFPFHWNVTG 317
            ..||.|.:|||||:|| :.|      |||||:|     |..|:    |.||||||||.|.::..|
Worm   226 VLYIIPVLNPDGYEYT-RTDKTNPRARMWRKSRSPKACAFDGVRNSCCMGVDLNRNFDFRFSEIG 289

  Fly   318 ASGDPCRYDYSGPSAASEVETQRMIEFIRHRVESERIRTFISLHSYSQMIMFPYGHSAERVDNY- 381
            ||..||...|.||||.||.|::...:|:...  ..|:..:|:||||||:.::.|.|   |...|
Worm   290 ASRYPCSEIYHGPSAFSEPESKAYSQFLTSL--KGRLEAYITLHSYSQLWIYSYSH---RKFTYA 349

  Fly   382 HDLTDIGKLAANKIKDVS---GRIYKSGSIYETIYPSSGGSKDWAHGQLKIPITFSYELRGPADS 443
            .|:.:..::||..::::.   |..|:.|:..|.||..||||.|||...|||..:::.||| |...
Worm   350 PDIEETRRVAAKAVQELGRMYGTKYRHGTGPEIIYAFSGGSTDWAKETLKIKYSYTIELR-PGYE 413

  Fly   444 EDL----FILSAKEIEPTAAEAFASIQTIVQE 471
            ..:    |:|...::.|||.|.:|.:..::.|
Worm   414 GIIEWNGFVLDKNQLIPTAKETWAGVTVVLDE 445

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4408	NP_651141.2	Propep_M14	88..159	CDD:280416	15/62 (24%)
CG4408	NP_651141.2	M14_CP_A-B_like	179..472	CDD:199844	117/319 (37%)
Y47G6A.19	NP_001379340.1	Propep_M14	32..102	CDD:396700	17/70 (24%)
		M14_CP_A-B_like	134..446	CDD:349433	117/319 (37%)
		ShK	467..504	CDD:396228
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47975
OrthoDB	1	1.010	-	-		D208397at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100142
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.830