DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4408 and Y18H1A.9

DIOPT Version :9

Sequence 1:	NP_651141.2	Gene:	CG4408 / 42762	FlyBaseID:	FBgn0039073	Length:	479	Species:	Drosophila melanogaster
Sequence 2:	NP_490776.2	Gene:	Y18H1A.9 / 171666	WormBaseID:	WBGene00021213	Length:	488	Species:	Caenorhabditis elegans

Alignment Length:	431	Identity:	137/431 - (31%)
Similarity:	225/431 - (52%)	Gaps:	40/431 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 SVQARYDHTRIYQVELASEEHVRLFQALEQASDSCSFMGHARQPGQKLTIMVTGAKVADFDDLVH 140
            ||.|......:::|:..:::.|.:...|........|.....:.|:::.:|::..|...|...:.
Worm    13 SVLAHQKKFTVWRVQPTTQDQVDILHNLYLNDVKLDFWKSPSEAGKEVHVMISDEKTQQFMKELD 77

  Fly   141 SYNVTHRVLNYNFQALI-------DANYLEVAPEDTKPE--EFDWKRYHPLESINAWLKKLAETH 196
            .:::.|.|:..:.|.:|       |....:|...|.:.:  :|:..:||....:..:|..||.|:
Worm    78 DHSIKHSVMIDDVQKVIVEQKEKRDKLRKQVRLHDWREQKVQFNLAQYHSFADVINYLNSLAITY 142

  Fly   197 PEVLLVE-LGVSAQGR--PILGVQIAFDNENRTTVFVESGIHAREWIAPATATYIIDQLVN--SK 256
            ||::.|: :|.:.:||  |::.:....:...:..::|:.|||||||::|:|..|.|.|||.  .|
Worm   143 PELVSVQPIGTTHEGRQIPLIKITNKRNGGTKRGIWVDGGIHAREWVSPSTVLYFIHQLVTQYDK 207

  Fly   257 DSAVQALARSQRWYIFPTVNPDGYQYTFKGD----RMWRKNRA----------LF-----GICRG 302
            |..::.......|||.|.:|||||:|:...:    |:|||||:          ||     ..|:|
Worm   208 DVQIKQFVDQLEWYIVPLLNPDGYEYSRSSNDPEIRLWRKNRSPPKCIQQATGLFQPPTTTCCQG 272

  Fly   303 VDLNRNFPFHWNVTGASGDPCRYDYSGPSAASEVETQRMIEFI-RHRVESERIRTFISLHSYSQM 366
            |||||||.:.:...|:|.|||...|.|..|.||.||..:.:|: ||     ||.||::.|||||:
Worm   273 VDLNRNFDWFFGQVGSSTDPCSEIYQGAYAFSEPETAAVRDFVQRH-----RISTFLTFHSYSQI 332

  Fly   367 IMFPYGHSAERVDN-YHDLTDIGKLAANKIKDVSGRIYKSGSIYETIYPSSGGSKDWAHGQLKIP 430
            :|:|:||......| .:||......||..:..|....||.|:..:|:||:||||:|||.|:..:.
Worm   333 LMYPFGHQVRTYSNDLNDLRSTALSAAQALNSVYNTQYKVGTGADTLYPASGGSEDWAKGKAHVK 397

  Fly   431 ITFSYELRGPADSEDLFILSAKEIEPTAAEAFASIQTIVQE 471
            .:|.:|||......|.|:|:..:|.|||.|.:.:::.|..:
Worm   398 YSFLFELRPEEQVWDGFLLAENQIIPTARETWEAVKVIASK 438

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4408	NP_651141.2	Propep_M14	88..159	CDD:280416	12/77 (16%)
CG4408	NP_651141.2	M14_CP_A-B_like	179..472	CDD:199844	118/319 (37%)
Y18H1A.9	NP_490776.2	Propep_M14	29..97	CDD:366995	11/67 (16%)
		M14_CP_A-B_like	125..436	CDD:349433	117/315 (37%)
		ShKT	454..487	CDD:214586
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2866
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	239	1.000	Inparanoid score	I2114
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47975
OrthoDB	1	1.010	-	-		D208397at33208
OrthoFinder	1	1.000	-	-		FOG0000056
OrthoInspector	1	1.000	-	-		mtm4737
orthoMCL	1	0.900	-	-		OOG6_100142
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X86
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.780