DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4408 and CPO

DIOPT Version :9

Sequence 1:	NP_651141.2	Gene:	CG4408 / 42762	FlyBaseID:	FBgn0039073	Length:	479	Species:	Drosophila melanogaster
Sequence 2:	NP_775100.1	Gene:	CPO / 130749	HGNCID:	21011	Length:	374	Species:	Homo sapiens

Alignment Length:	319	Identity:	109/319 - (34%)
Similarity:	187/319 - (58%)	Gaps:	16/319 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   163 EVAPEDTKP---EEFDWKRYHPLESINAWLKKLAETHPEVLLVE-LGVSAQGRPILGVQIAFDNE 223
            |:..:...|   |.:.:..|||:..|..|:::::|.:.||:... |||:.:..|:..::|:..:.
Human    31 EIVDKSVSPWSLETYSYNIYHPMGEIYEWMREISEKYKEVVTQHFLGVTYETHPMYYLKISQPSG 95

  Fly   224 N-RTTVFVESGIHAREWIAPATATYIIDQLV-NSKD-SAVQALARSQRWYIFPTVNPDGYQYTFK 285
            | :..::::.|||||||||||...:.:.::: |.|| |:::.|.|:..:|:.|.:|.|||.||:.
Human    96 NPKKIIWMDCGIHAREWIAPAFCQWFVKEILQNHKDNSSIRKLLRNLDFYVLPVLNIDGYIYTWT 160

  Fly   286 GDRMWRKNRALF--GICRGVDLNRNFPFHWNVTGASGDPCRYDYSGPSAASEVETQRMIEFIRHR 348
            .||:|||:|:..  |.|.|.||||||...|...|||.:.....:.|....||.||:.:..||..:
Human   161 TDRLWRKSRSPHNNGTCFGTDLNRNFNASWCSIGASRNCQDQTFCGTGPVSEPETKAVASFIESK 225

  Fly   349 VESERIRTFISLHSYSQMIMFPYGHSAERVDNYHDLTDIGKLAANKIKDVSGRIYKSGSIYETIY 413
              .:.|..|:::|||.|:|:.|||::..:..|:.::..:|:.|||.:|...|..|:.||..:.:|
Human   226 --KDDILCFLTMHSYGQLILTPYGYTKNKSSNHPEMIQVGQKAANALKAKYGTNYRVGSSADILY 288

  Fly   414 PSSGGSKDWAHGQLKIPITFSYELRGPADSEDL-FILSAKEIEPTAAEAFASIQTIVQE 471
            .|||.|:|||. .:.||.::::|||   ||... |:|...:|:||..|...::.:::.:
Human   289 ASSGSSRDWAR-DIGIPFSYTFELR---DSGTYGFVLPEAQIQPTCEETMEAVLSVLDD 343

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4408	NP_651141.2	Propep_M14	88..159	CDD:280416
CG4408	NP_651141.2	M14_CP_A-B_like	179..472	CDD:199844	106/300 (35%)
CPO	NP_775100.1	M14_CPO	47..344	CDD:133105	106/303 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157711
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2866
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D208397at33208
OrthoFinder	1	1.000	-	-		FOG0000056
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X86
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.750