DRSC/TRiP Functional Genomics Resources

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Protein Alignment DNApol-epsilon255 and REV3

DIOPT Version :9

Sequence 1:NP_524462.2 Gene:DNApol-epsilon255 / 42758 FlyBaseID:FBgn0264326 Length:2236 Species:Drosophila melanogaster
Sequence 2:NP_015158.1 Gene:REV3 / 855936 SGDID:S000006088 Length:1504 Species:Saccharomyces cerevisiae


Alignment Length:1528 Identity:271/1528 - (17%)
Similarity:494/1528 - (32%) Gaps:562/1528 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 GKVLQNTGKFVSENRTEGDDFFNEAGYRQSRENDK-------IDSKYGFDRVKDSQERTGYL--- 61
            |...|::|:|        :.|:.:|.::.|..:.:       ||....|..:....|....|   
Yeast   340 GHQWQSSGEF--------EAFYKKAQHKTSTFDGQIPNFENFIDKNQKFSAINTPYEALPQLWPR 396

  Fly    62 ---INMHSNEVLDE--DRRLIAALDLFFI--------QMDGSRFKC-TVAYQPYLLIRPEDNMHL 112
               |.:::|.:.|:  |.::.|:...:.|        .:.||..|. :.::.|..:..|:|:..|
Yeast   397 LPQIEINNNSMQDKKNDDQVNASFTEYEICGVDNENEGVKGSNIKSRSYSWLPESIASPKDSTIL 461

  Fly   113 EVARFLGRKYSGQISGLEHITKEDLDLPNHLSGLQQQYIKLSFLNQTAMTK---VRRELMSAVKR 174
                            |:|.||              .:..::|....|||:   .:|:|.|:|..
Yeast   462 ----------------LDHQTK--------------YHNTINFSMDCAMTQNMASKRKLRSSVSA 496

  Fly   175 N------QERQKSNTYYMQMLATSL---------AQSSAGSEDATLGKRQQ------DYMDCI-- 216
            |      ::|:|       ::|..|         .:...|.:| .|.|.:.      ||.|..  
Yeast   497 NKTSLLSRKRKK-------VMAAGLRYGKRAFVYGEPPFGYQD-ILNKLEDEGFPKIDYKDPFFS 553

  Fly   217 --VDIREHDVPY----------HVRVSIDLRIFCGQ----------------------------- 240
              ||:......|          ||...|.:: |.|:                             
Yeast   554 NPVDLENKPYAYAGKRFEISSTHVSTRIPVQ-FGGETVSVYNKPTFDMFSSWKYALKPPTYDAVQ 617

  Fly   241 -WY-------NIRCRSGVELPTITCR------PDILDRPEPVVLAFDIETTKLPL---------K 282
             ||       |.:..|.:.:.|...:      .|:..:.:....:.....|.|.|         |
Yeast   618 KWYNKVPSMGNKKTESQISMHTPHSKFLYKFASDVSGKQKRKKSSVHDSLTHLTLEIHANTRSDK 682

  Fly   283 FPDAQTDQVMMISYMIDG-----------QGYLITNREIISSNVDDFEYTPKPEFEGNFI-VFNE 335
            .||...|:|.||.:.::.           :|.:|.::.     .:|..:..|.:...|.| |...
Yeast   683 IPDPAIDEVSMIIWCLEEETFPLDLDIAYEGIMIVHKA-----SEDSTFPTKIQHCINEIPVMFY 742

  Fly   336 ENEMQLLQRFFDHIMEVRPHIIVTYNGDFFDWPFVETRA-AVYDLDMKQEIGFSKLRDGNYLSRP 399
            |:|.::.:...|.::.:.|.|:..:....|.|.::..|. .::..|:.:|:...|          
Yeast   743 ESEFEMFEALTDLVLLLDPDILSGFEIHNFSWGYIIERCQKIHQFDIVRELARVK---------- 797

  Fly   400 AIHMDCLCWVK---RDSYLPVGSQGLKAVAKAKLRYDPVELDPEDMCRMAVEQPQVLANYSVSDA 461
                   |.:|   .|::....|.|:....:..:          ::.| |:.....|..|::..|
Yeast   798 -------CQIKTKLSDTWGYAHSSGIMITGRHMI----------NIWR-ALRSDVNLTQYTIESA 844

  Fly   462 VATYYLYMKYVHPFIFALNTIIPMEPDEILRKGSGTLCETLLMVEAYHAQIVYPNKHQSELNKLS 526
             |...|:.:..|   |:..::..|..    .|.|.|..:|:|......|||              
Yeast   845 -AFNILHKRLPH---FSFESLTNMWN----AKKSTTELKTVLNYWLSRAQI-------------- 887

  Fly   527 NEGHVLDSETYVGGHVEA-------LESGVFRADIPCRFRLDPAMVKQLQEQVDAVLRHAIEVEE 584
             ...:|..:.|:..::|.       ..|..:|..   :|:::..:::..:.:...:|.       
Yeast   888 -NIQLLRKQDYIARNIEQARLIGIDFHSVYYRGS---QFKVESFLIRICKSESFILLS------- 941

  Fly   585 GIPLEKVLNLDEVRQEIVQGLQGLHDIPNRLE-------QPVIYHLDVGAMYPNIILTNRLQPSA 642
              |.:|     :||::     :.|..:|..:|       .|:|. ||..::||:|::......|.
Yeast   942 --PGKK-----DVRKQ-----KALECVPLVMEPESAFYKSPLIV-LDFQSLYPSIMIGYNYCYST 993

  Fly   643 MVSDLDCAACDFNKPGVRCKRSMDWLWRGEMLPASRNEFQRIQQQLETEKFPPLFPGGPQRAFHE 707
            |:..:                               .|....:..|...||.  .|    |....
Yeast   994 MIGRV-------------------------------REINLTENNLGVSKFS--LP----RNILA 1021

  Fly   708 LSKEDQAAYEKKRLTDYCRKAYKKTKLTKLETRTSTICQKENSFYVDTVRAFRDRRYEYKGLTKV 772
            |.|.|........:  |.:.:.:|:.|:|:.|                         :...:..:
Yeast  1022 LLKNDVTIAPNGVV--YAKTSVRKSTLSKMLT-------------------------DILDVRVM 1059

  Fly   773 AKASVNAAVASGDAAEIKAAKGREVLYDSLQLAHKCILNSFYGYVMRR-GARWHSMPMAGIVCLT 836
            .|.::|.  ...|...:|.      |.::.|||.|.:.|..|||.... ..|.....:|..:..|
Yeast  1060 IKKTMNE--IGDDNTTLKR------LLNNKQLALKLLANVTYGYTSASFSGRMPCSDLADSIVQT 1116

  Fly   837 GSNIITKAREIIER----VGRPLELDTDGIWCILPGSFPQE-FTIHTSHEKKKKINISYPNAVLN 896
            |...:.||.:|||:    ..:.:..|||.::..|||....| |:|  .|...:::.         
Yeast  1117 GRETLEKAIDIIEKDETWNAKVVYGDTDSLFVYLPGKTAIEAFSI--GHAMAERVT--------- 1170

  Fly   897 TMVKDHFTNDQYHELRKDKENNLPKYDIRDENSIFFEVDGPYLAMVLPAAKEEGKKLKKRYAVFN 961
                               :|| ||       .||.:.:..|...:|.:        ||||..|:
Yeast  1171 -------------------QNN-PK-------PIFLKFEKVYHPSILIS--------KKRYVGFS 1200

  Fly   962 FDG-----TLAELKGFEVKRRG--------------------ELQLIKNFQSSVFEAFLAG--ST 999
            ::.     .:.:.||.|..||.                    :|..||.:..:.|.....|  |.
Yeast  1201 YESPSQTLPIFDAKGIETVRRDGIPAQQKIIEKCIRLLFQTKDLSKIKKYLQNEFFKIQIGKVSA 1265

  Fly  1000 LEECYASVAKVADYWLDVLYSRGSNLPDSELFELISENKSMSKKLEEYGAQKSTSISTAKRLAE- 1063
            .:.|:|...|:..|                          .|:|....||     :...:|:.| 
Yeast  1266 QDFCFAKEVKLGAY--------------------------KSEKTAPAGA-----VVVKRRINED 1299

  Fly  1064 FLGEQMVKDAGLACKYIISKKPEGAPVTERAIPLAIFQSEPSVRRHHLRRWLKDNTMGDADIRDV 1128
            ...|...|:   ...|::.|..:|..:.||.:     ..|..:...:|.                
Yeast  1300 HRAEPQYKE---RIPYLVVKGKQGQLLRERCV-----SPEEFLEGENLE---------------- 1340

  Fly  1129 LDWNYYIERLGGTIQKIITIPAALQGLANPVPRVQHPDWLHKKMLEKNDVLKQRRINEMFTSRPK 1193
            ||..|||.:        |.|| .|..|.|.: .:...:|       ..:::|.:|          
Yeast  1341 LDSEYYINK--------ILIP-PLDRLFNLI-GINVGNW-------AQEIVKSKR---------- 1378

  Fly  1194 PKPLATEEDKLADMEDLAGKDGGEGAAGCPI---VTKRKRIQLEEHDDEEAQPQATTWRQALGAP 1255
               .:|...|:.::..:     |..|..|..   :||...:||   .|:..:.::||        
Yeast  1379 ---ASTTTTKVENITRV-----GTSATCCNCGEELTKICSLQL---CDDCLEKRSTT-------- 1424

  Fly  1256 PPIGETRKTIVEWVRFQKK-----------KWKWQQDQRQRNRQASKRTRGEDPPVVRATGSTAT 1309
                 |...:::.::.||:           .:::..|....|...:.:....|.||         
Yeast  1425 -----TLSFLIKKLKRQKEYQTLKTVCRTCSYRYTSDAGIENDHIASKCNSYDCPV--------- 1475

  Fly  1310 LGGFLRR--AQRTLLDQPWQIVQ----LVPVDD 1336
               |..|  |:|.|.|.  |.||    |:.::|
Yeast  1476 ---FYSRVKAERYLRDN--QSVQREEALISLND 1503

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DNApol-epsilon255NP_524462.2 DNA_polB_epsilon_exo 266..469 CDD:99822 40/227 (18%)
POLBc_epsilon 529..1154 CDD:99918 121/672 (18%)
DUF1744 1529..1930 CDD:369900
REV3NP_015158.1 PTZ00166 12..>221 CDD:240301
PolB 398..1376 CDD:223494 226/1285 (18%)
POLBc_zeta 919..1366 CDD:99917 118/652 (18%)
zf-C4pol 1398..1479 CDD:405022 17/108 (16%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0417
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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