|
Fly 40 DKIDSKYGFDR-----------VKDSQE---RTGYLINMH----SNEVL-----------DEDR- 74
|.|||..||:| .||..: |.|:|.||| |.|.| |.:|
Yeast 44 DDIDSMMGFERYVPPQYNGRFDAKDIDQIPGRVGWLTNMHATLVSQETLSSGSNGGGNSNDGERV 108
Fly 75 ---RLIAALDLFFIQMDGSRFKCTVAYQPYLLIRPEDNMHLEVARFLGRKY-SGQISGLEHITKE 135
:.|:.:|.:|:..:|..||.||.|.||..|...|...:.....|.:|| ...:..|:.|.||
Yeast 109 TTNQGISGVDFYFLDEEGGSFKSTVVYDPYFFIACNDESRVNDVEELVKKYLESCLKSLQIIRKE 173
Fly 136 DLDLPNHLSGLQQQYIKLSFLNQTAMTKVRRELMSAVKRNQERQKSNTYYMQMLATSLAQSSAGS 200
||.:.|||.|||:..|||||:|...:.:.|:.|...::.|.........|
Yeast 174 DLTMDNHLLGLQKTLIKLSFVNSNQLFEARKLLRPILQDNANNNVQRNIY--------------- 223
Fly 201 EDATLGKRQQDYMDCIVDIREHDVPYHVRVSIDLRIFCGQWYNIRCRSGVELPTITCRPDILDRP 265
..|..|..:.|....|.||||:|||||||||||..|..|:||.:..:..:|........|
Yeast 224 NVAANGSEKVDAKHLIEDIREYDVPYHVRVSIDKDIRVGKWYKVTQQGFIEDTRKIAFAD----- 283
Fly 266 EPVVLAFDIETTKLPLKFPDAQTDQVMMISYMIDGQGYLITNREIISSNVDDFEYTPKPEFEGNF 330
|||:||||||||.||||||:..||:|||||||||:|:|||||||||.:::|||||||||:.|.|
Yeast 284 -PVVMAFDIETTKPPLKFPDSAVDQIMMISYMIDGEGFLITNREIISEDIEDFEYTPKPEYPGFF 347
Fly 331 IVFNEENEMQLLQRFFDHIMEVRPHIIVTYNGDFFDWPFVETRAAVYDLDMKQEIGFSKLRDGNY 395
.:|||.:|:.||||||:||.:|||.:|.|:|||||||||:..|:.::.|||..||||:...:|.|
Yeast 348 TIFNENDEVALLQRFFEHIRDVRPTVISTFNGDFFDWPFIHNRSKIHGLDMFDEIGFAPDAEGEY 412
Fly 396 LSRPAIHMDCLCWVKRDSYLPVGSQGLKAVAKAKLRYDPVELDPEDMCRMAVEQPQVLANYSVSD 460
.|....||||..|||||||||.||||||||.::||.|:|:|||||.|...|.|:||.|:.|||||
Yeast 413 KSSYCSHMDCFRWVKRDSYLPQGSQGLKAVTQSKLGYNPIELDPELMTPYAFEKPQHLSEYSVSD 477
Fly 461 AVATYYLYMKYVHPFIFALNTIIPMEPDEILRKGSGTLCETLLMVEAYHAQIVYPNKHQSELNKL 525
|||||||||||||||||:|.||||:.|||.||||:|||||.||||:||...|:.||||...:.:.
Yeast 478 AVATYYLYMKYVHPFIFSLCTIIPLNPDETLRKGTGTLCEMLLMVQAYQHNILLPNKHTDPIERF 542
Fly 526 SNEGHVLDSETYVGGHVEALESGVFRADIPCRFRLDPAMVKQLQEQVDAVLRHAIEVEEGIPLEK 590
.:||:|:||||||||||:||:||||:|:...|::||:.:.:|.:::...|:.::|||....::|
Yeast 543 -YDGHLLESETYVGGHVESLEAGVFRSDLKNEFKIDPSAIDELLQELPEALKFSVEVENKSSVDK 606
Fly 591 VLNLDEVRQEIVQGLQGLHDIPNRLEQPVIYHLDVGAMYPNIILTNRLQPSAMVSDLDCAACDFN 655
|.|.:|::.:|.|.|..|.:...|.|.|:|||:||.:|||||:.||||||.::.::.|||:||||
Yeast 607 VTNFEEIKNQITQKLLELKENNIRNELPLIYHVDVASMYPNIMTTNRLQPDSIKAERDCASCDFN 671
Fly 656 KPGVRCKRSMDWLWRGEMLPASRNEFQRIQQQLETEKFP--PLFPGGPQRAFHELSKEDQAAYEK 718
:||..|.|.:.|.||||..|:..:|:..|::.|:.|.|| ..|.......|.|||..||..:.|
Yeast 672 RPGKTCARKLKWAWRGEFFPSKMDEYNMIKRALQNETFPNKNKFSKKKVLTFDELSYADQVIHIK 736
Fly 719 KRLTDYCRKAYKKTKLTKLETRTSTICQKENSFYVDTVRAFRDRRYEYKGLTKVAKASVNAAVAS 783
||||:|.||.|.:.|::::..|.:.:||:||.||||||::|||||||:|||.|..|.:::....|
Yeast 737 KRLTEYSRKVYHRVKVSEIVEREAIVCQRENPFYVDTVKSFRDRRYEFKGLAKTWKGNLSKIDPS 801
Fly 784 GDAAEIKAAKGREVLYDSLQLAHKCILNSFYGYVMRRGARWHSMPMAGIVCLTGSNIITKAREII 848
...|..:|.| ..|||||||||||.|||||||||||:|:||:||.||||.||||:.||..||.::
Yeast 802 DKHARDEAKK-MIVLYDSLQLAHKVILNSFYGYVMRKGSRWYSMEMAGITCLTGATIIQMARALV 865
Fly 849 ERVGRPLELDTDGIWCILPGSFPQE--FTIHTSHEKKKKINISYPNAVLNTMVKDHFTNDQYHEL 911
|||||||||||||||||||.|||:. ||: |..||:.:|||.::||..|...|||.||.||
Yeast 866 ERVGRPLELDTDGIWCILPKSFPETYFFTL----ENGKKLYLSYPCSMLNYRVHQKFTNHQYQEL 926
Fly 912 RKDKENNLPKYDIRDENSIFFEVDGPYLAMVLPAAKEEGKKLKKRYAVFNFDGTLAELKGFEVKR 976
||..|.: |:...||:|||||||||.||:||::|||||.:||||||||.||:||||||||:||
Yeast 927 -KDPLNYI--YETHSENTIFFEVDGPYKAMILPSSKEEGKGIKKRYAVFNEDGSLAELKGFELKR 988
Fly 977 RGELQLIKNFQSSVFEAFLAGSTLEECYASVAKVADYWLDVLYSRGSNLPDSELFELISENKSMS 1041
||||||||||||.:|:.||.|.|||.||::||.|.:.|||||.|.|..|.|.:|..||.||:|||
Yeast 989 RGELQLIKNFQSDIFKVFLEGDTLEGCYSAVASVCNRWLDVLDSHGLMLEDEDLVSLICENRSMS 1053
Fly 1042 KKLEEYGAQKSTSISTAKRLAEFLGEQMVKDAGLACKYIISKKPEGAPVTERAIPLAIFQSEPSV 1106
|.|:||..||||||:||:||.:||||.||||.||.||||||.||..|||||||||:|||.::..:
Yeast 1054 KTLKEYEGQKSTSITTARRLGDFLGEDMVKDKGLQCKYIISSKPFNAPVTERAIPVAIFSADIPI 1118
Fly 1107 RRHHLRRWLKDNTMGDADIRDVLDWNYYIERLGGTIQKIITIPAALQGLANPVPRVQHPDWLHKK 1171
:|..||||..|.::.|.|||.::||.||.||||..|||||||||||||::||||||:|||||.:|
Yeast 1119 KRSFLRRWTLDPSLEDLDIRTIIDWGYYRERLGSAIQKIITIPAALQGVSNPVPRVEHPDWLKRK 1183
Fly 1172 MLEKNDVLKQRRINEMFTSRPKPKPLATEEDKLADMEDLAGKDGGEGAAGCPI--------VTKR 1228
:..|.|..||..:.:.|: |.|.:.| ..|:.|:|||......|..|...| |:||
Yeast 1184 IATKEDKFKQTSLTKFFS---KTKNVPT-MGKIKDIEDLFEPTVEEDNAKIKIARTTKKKAVSKR 1244
Fly 1229 KRIQLEEHDDEEAQPQATTWRQALGAPPPIGETRKTIVEWVRFQKKKWKWQQDQRQRNRQASKRT 1293
||.||...:| .|..|..|....:..|.|:.:||.|||.|...|:|..|....|
Yeast 1245 KRNQLTNEED------------PLVLPSEIPSMDEDYVGWLNYQKIKWKIQARDRKRRDQLFGNT 1297
Fly 1294 RGEDPPVVRATGSTATLGGFLRRAQRTLLDQPWQIVQLVPVDDLGHFTVWALIGEELHKIKLTVP 1358
.::...:.||..:|:...:..:..|:::|.....:.|...|:..|..::..|...:|
Yeast 1298 --------NSSRERSALGSMIRKQAESYANSTWEVLQYKDSGEPGVLEVFVTINGKVQNITFHIP 1354
Fly 1359 RIFYVNQRSAAPPEE---GQLWRKVNRVLPRSRPVFN-----LYRYSVPEQLF---RDNSLGMLA 1412
:..|:..:|...|.: ..|..|.:..||.:....| |::.::||.:| ::|...:..
Yeast 1355 KTIYMKFKSQTMPLQKIKNCLIEKSSASLPNNPKTSNPAGGQLFKITLPESVFLEEKENCTSIFN 1419
Fly 1413 DLATPDIEGIYETQMTLEFRALMDMGCICGVQREEARRLAQLATKDLETFSIEQLEQRPQTQVKY 1477
| .::.|::|..:|...||:||:|.....:.:....|.:...:..|...:...|.. :|
Yeast 1420 D---ENVLGVFEGTITPHQRAIMDLGASVTFRSKAMGALGKGIQQGFEMKDLSMAENE-----RY 1476
Fly 1478 LASANNRLRKIYLYQHNTPTAKK-----EIWS-----LILMPSKKAFVFALDTVRANQMPNMRQL 1532
|:..:..:. ||....|....: :.|. |:|.||.:| ..:.|: ::.|:
Yeast 1477 LSGFSMDIG--YLLHFPTSIGYEFFSLFKSWGDTITILVLKPSNQA-----QEINAS---SLGQI 1531
Fly 1533 YTAERLALLKNLTAEEQDKIPV--------EDYTFEVLIEVDVKQIYRHIQRALTTYKQEHQGPT 1589
| |.:..:::.||.. ||..||.:...|:.::||.:.:..|..|:|.....
Yeast 1532 Y--------KQMFEKKKGKIETYSYLVDIKEDINFEFVYFTDISKLYRRLSQETTKLKEERGLQF 1588
Fly 1590 ILCLQTALSARKLSLAMPILLEFPQAEIHISDDASLLSGLDWQRQGSRAVIRHFLNLNNVLDLML 1654
:|.||:....:.|. .:.:|.:.|..::.::: .||..|:||....:.::.|.|:..:.:..::
Yeast 1589 LLLLQSPFITKLLG-TIRLLNQMPIVKLSLNE--VLLPQLNWQPTLLKKLVNHVLSSGSWISHLI 1650
Fly 1655 DQCRYFHVPIGNMPPDTVLFGADLFFARLLQRHNFVLWWS-ASTRPDLGGREADDSRLLAEFEES 1718
...:|.::||.|:..|::.:..|:.:||.|::.|.||||: .:..||.||.:.| |:.:
Yeast 1651 KLSQYSNIPICNLRLDSMDYIIDVLYARKLKKENIVLWWNEKAPLPDHGGIQND-------FDLN 1708
Fly 1719 ISVVQ--------NKAGFYPDVCVELALDSLAVSALLQSTRIQEMEGASSAITFDVMPQVSLEEM 1775
.|.:. |.:|.|.:|.:::.:|:|.|:.:|.|..|.:.||:.. |...:.:::.
Yeast 1709 TSWIMNDSEFPKINNSGVYDNVVLDVGVDNLTVNTILTSALINDAEGSDL-----VNNNMGIDDK 1768
Fly 1776 IGTVPAATLPS-YDETALCSAAFRVMRSMVNGWLREVSINRNIFSDFQIVHFYRWVRSSNALLYD 1839
...:.: || :...|..:.|..|:|.|:..|..| ::..|..:|..:.....||::.||.|:|
Yeast 1769 DAVINS---PSEFVHDAFSNDALNVLRGMLKEWWDE-ALKENSTADLLVNSLASWVQNPNAKLFD 1829
Fly 1840 PALRRSLNNLMRKMFLRIIAEFKRLGATIIYADFNRIILSSGKKTVSDALGYVDYIVQSLRNKEM 1904
..||..::||.:|..|:::.||..||:||:|||.|:|::.:.|.:..:...|..|:::::|...|
Yeast 1830 GLLRYHVHNLTKKALLQLVNEFSALGSTIVYADRNQILIKTNKYSPENCYAYSQYMMKAVRTNPM 1894
Fly 1905 FHSIQLSFEQCWNFMLWMDQANFSGI-----------------RGKLPKGID-------ETVSSI 1945
|..:.|:.::.|:.::|||:.||||: :.:|.|.:. |....|
Yeast 1895 FSYLDLNIKRYWDLLIWMDKFNFSGLACIEIEEKENQDYTAVSQWQLKKFLSPIYQPEFEDWMMI 1959
Fly 1946 VSTTMIRDSERNQDDDEDEEEDSENRDPVE-SNEAEQDQEDELSLELNWTIGEHLPDENECREKF 2009
:..:|::..:... :.:|..:.|.: .|..:||:||.:...|| .|
Yeast 1960 ILDSMLKTKQSYL------KLNSGTQRPTQIVNVKKQDKEDSVENSLN---------------GF 2003
Fly 2010 ESLLTLFMQSLAEK--KTTEQAIKDISHCAFDFILKLHKNYGKGKPSPGLELIRTLIKALSVDKT 2072
..|.:..:....:| |..::.|.|..:.| |:::.:.........:|.|||:::|...:.:.|:
Yeast 2004 SHLFSKPLMKRVKKLFKNQQEFILDPQYEA-DYVIPVLPGSHLNVKNPLLELVKSLCHVMLLSKS 2067
Fly 2073 LAEQINELRRNMLRLVGIGEFSDLAEWEDPCDSHIINEVICKACNHCRDLDLCKDKHRAMKDGVP 2137
...:|..||:.:|::..:.||:.:||::||..|.::.:.:|:.|....|:|.||....:
Yeast 2068 TILEIRTLRKELLKIFELREFAKVAEFKDPSLSLVVPDFLCEYCFFISDIDFCKAAPES------ 2126
Fly 2138 VWLCAQCYVAYDNEEIEMRMLDALQRKMMSYVLQDLRCSRCSEIKRENLAEFCTCAGNFVPLISG 2202
::.|.:|:.|::...::..::..|:..:.||::||||||||.::||:.::..|.|||.:...:..
Yeast 2127 IFSCVRCHKAFNQVLLQEHLIQKLRSDIESYLIQDLRCSRCHKVKRDYMSAHCPCAGAWEGTLPR 2191
Fly 2203 KDIQTLLGTFNKVAANHKMQLL 2224
:.|...|..|.:||..:...:|
Yeast 2192 ESIVQKLNVFKQVAKYYGFDIL 2213
| 
