DRSC/TRiP Functional Genomics Resources

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Protein Alignment DNApol-epsilon255 and POL2

DIOPT Version :9

Sequence 1:NP_524462.2 Gene:DNApol-epsilon255 / 42758 FlyBaseID:FBgn0264326 Length:2236 Species:Drosophila melanogaster
Sequence 2:NP_014137.1 Gene:POL2 / 855459 SGDID:S000005206 Length:2222 Species:Saccharomyces cerevisiae


Alignment Length:2297 Identity:896/2297 - (39%)
Similarity:1308/2297 - (56%) Gaps:239/2297 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly    40 DKIDSKYGFDR-----------VKDSQE---RTGYLINMH----SNEVL-----------DEDR- 74
            |.|||..||:|           .||..:   |.|:|.|||    |.|.|           |.:| 
Yeast    44 DDIDSMMGFERYVPPQYNGRFDAKDIDQIPGRVGWLTNMHATLVSQETLSSGSNGGGNSNDGERV 108

  Fly    75 ---RLIAALDLFFIQMDGSRFKCTVAYQPYLLIRPEDNMHLEVARFLGRKY-SGQISGLEHITKE 135
               :.|:.:|.:|:..:|..||.||.|.||..|...|...:.....|.:|| ...:..|:.|.||
Yeast   109 TTNQGISGVDFYFLDEEGGSFKSTVVYDPYFFIACNDESRVNDVEELVKKYLESCLKSLQIIRKE 173

  Fly   136 DLDLPNHLSGLQQQYIKLSFLNQTAMTKVRRELMSAVKRNQERQKSNTYYMQMLATSLAQSSAGS 200
            ||.:.|||.|||:..|||||:|...:.:.|:.|...::.|.........|               
Yeast   174 DLTMDNHLLGLQKTLIKLSFVNSNQLFEARKLLRPILQDNANNNVQRNIY--------------- 223

  Fly   201 EDATLGKRQQDYMDCIVDIREHDVPYHVRVSIDLRIFCGQWYNIRCRSGVELPTITCRPDILDRP 265
            ..|..|..:.|....|.||||:|||||||||||..|..|:||.:..:..:|........|     
Yeast   224 NVAANGSEKVDAKHLIEDIREYDVPYHVRVSIDKDIRVGKWYKVTQQGFIEDTRKIAFAD----- 283

  Fly   266 EPVVLAFDIETTKLPLKFPDAQTDQVMMISYMIDGQGYLITNREIISSNVDDFEYTPKPEFEGNF 330
             |||:||||||||.||||||:..||:|||||||||:|:|||||||||.:::|||||||||:.|.|
Yeast   284 -PVVMAFDIETTKPPLKFPDSAVDQIMMISYMIDGEGFLITNREIISEDIEDFEYTPKPEYPGFF 347

  Fly   331 IVFNEENEMQLLQRFFDHIMEVRPHIIVTYNGDFFDWPFVETRAAVYDLDMKQEIGFSKLRDGNY 395
            .:|||.:|:.||||||:||.:|||.:|.|:|||||||||:..|:.::.|||..||||:...:|.|
Yeast   348 TIFNENDEVALLQRFFEHIRDVRPTVISTFNGDFFDWPFIHNRSKIHGLDMFDEIGFAPDAEGEY 412

  Fly   396 LSRPAIHMDCLCWVKRDSYLPVGSQGLKAVAKAKLRYDPVELDPEDMCRMAVEQPQVLANYSVSD 460
            .|....||||..|||||||||.||||||||.::||.|:|:|||||.|...|.|:||.|:.|||||
Yeast   413 KSSYCSHMDCFRWVKRDSYLPQGSQGLKAVTQSKLGYNPIELDPELMTPYAFEKPQHLSEYSVSD 477

  Fly   461 AVATYYLYMKYVHPFIFALNTIIPMEPDEILRKGSGTLCETLLMVEAYHAQIVYPNKHQSELNKL 525
            |||||||||||||||||:|.||||:.|||.||||:|||||.||||:||...|:.||||...:.:.
Yeast   478 AVATYYLYMKYVHPFIFSLCTIIPLNPDETLRKGTGTLCEMLLMVQAYQHNILLPNKHTDPIERF 542

  Fly   526 SNEGHVLDSETYVGGHVEALESGVFRADIPCRFRLDPAMVKQLQEQVDAVLRHAIEVEEGIPLEK 590
             .:||:|:||||||||||:||:||||:|:...|::||:.:.:|.:::...|:.::|||....::|
Yeast   543 -YDGHLLESETYVGGHVESLEAGVFRSDLKNEFKIDPSAIDELLQELPEALKFSVEVENKSSVDK 606

  Fly   591 VLNLDEVRQEIVQGLQGLHDIPNRLEQPVIYHLDVGAMYPNIILTNRLQPSAMVSDLDCAACDFN 655
            |.|.:|::.:|.|.|..|.:...|.|.|:|||:||.:|||||:.||||||.::.::.|||:||||
Yeast   607 VTNFEEIKNQITQKLLELKENNIRNELPLIYHVDVASMYPNIMTTNRLQPDSIKAERDCASCDFN 671

  Fly   656 KPGVRCKRSMDWLWRGEMLPASRNEFQRIQQQLETEKFP--PLFPGGPQRAFHELSKEDQAAYEK 718
            :||..|.|.:.|.||||..|:..:|:..|::.|:.|.||  ..|.......|.|||..||..:.|
Yeast   672 RPGKTCARKLKWAWRGEFFPSKMDEYNMIKRALQNETFPNKNKFSKKKVLTFDELSYADQVIHIK 736

  Fly   719 KRLTDYCRKAYKKTKLTKLETRTSTICQKENSFYVDTVRAFRDRRYEYKGLTKVAKASVNAAVAS 783
            ||||:|.||.|.:.|::::..|.:.:||:||.||||||::|||||||:|||.|..|.:::....|
Yeast   737 KRLTEYSRKVYHRVKVSEIVEREAIVCQRENPFYVDTVKSFRDRRYEFKGLAKTWKGNLSKIDPS 801

  Fly   784 GDAAEIKAAKGREVLYDSLQLAHKCILNSFYGYVMRRGARWHSMPMAGIVCLTGSNIITKAREII 848
            ...|..:|.| ..|||||||||||.|||||||||||:|:||:||.||||.||||:.||..||.::
Yeast   802 DKHARDEAKK-MIVLYDSLQLAHKVILNSFYGYVMRKGSRWYSMEMAGITCLTGATIIQMARALV 865

  Fly   849 ERVGRPLELDTDGIWCILPGSFPQE--FTIHTSHEKKKKINISYPNAVLNTMVKDHFTNDQYHEL 911
            |||||||||||||||||||.|||:.  ||:    |..||:.:|||.::||..|...|||.||.||
Yeast   866 ERVGRPLELDTDGIWCILPKSFPETYFFTL----ENGKKLYLSYPCSMLNYRVHQKFTNHQYQEL 926

  Fly   912 RKDKENNLPKYDIRDENSIFFEVDGPYLAMVLPAAKEEGKKLKKRYAVFNFDGTLAELKGFEVKR 976
             ||..|.:  |:...||:|||||||||.||:||::|||||.:||||||||.||:||||||||:||
Yeast   927 -KDPLNYI--YETHSENTIFFEVDGPYKAMILPSSKEEGKGIKKRYAVFNEDGSLAELKGFELKR 988

  Fly   977 RGELQLIKNFQSSVFEAFLAGSTLEECYASVAKVADYWLDVLYSRGSNLPDSELFELISENKSMS 1041
            ||||||||||||.:|:.||.|.|||.||::||.|.:.|||||.|.|..|.|.:|..||.||:|||
Yeast   989 RGELQLIKNFQSDIFKVFLEGDTLEGCYSAVASVCNRWLDVLDSHGLMLEDEDLVSLICENRSMS 1053

  Fly  1042 KKLEEYGAQKSTSISTAKRLAEFLGEQMVKDAGLACKYIISKKPEGAPVTERAIPLAIFQSEPSV 1106
            |.|:||..||||||:||:||.:||||.||||.||.||||||.||..|||||||||:|||.::..:
Yeast  1054 KTLKEYEGQKSTSITTARRLGDFLGEDMVKDKGLQCKYIISSKPFNAPVTERAIPVAIFSADIPI 1118

  Fly  1107 RRHHLRRWLKDNTMGDADIRDVLDWNYYIERLGGTIQKIITIPAALQGLANPVPRVQHPDWLHKK 1171
            :|..||||..|.::.|.|||.::||.||.||||..|||||||||||||::||||||:|||||.:|
Yeast  1119 KRSFLRRWTLDPSLEDLDIRTIIDWGYYRERLGSAIQKIITIPAALQGVSNPVPRVEHPDWLKRK 1183

  Fly  1172 MLEKNDVLKQRRINEMFTSRPKPKPLATEEDKLADMEDLAGKDGGEGAAGCPI--------VTKR 1228
            :..|.|..||..:.:.|:   |.|.:.| ..|:.|:|||......|..|...|        |:||
Yeast  1184 IATKEDKFKQTSLTKFFS---KTKNVPT-MGKIKDIEDLFEPTVEEDNAKIKIARTTKKKAVSKR 1244

  Fly  1229 KRIQLEEHDDEEAQPQATTWRQALGAPPPIGETRKTIVEWVRFQKKKWKWQQDQRQRNRQASKRT 1293
            ||.||...:|            .|..|..|....:..|.|:.:||.|||.|...|:|..|....|
Yeast  1245 KRNQLTNEED------------PLVLPSEIPSMDEDYVGWLNYQKIKWKIQARDRKRRDQLFGNT 1297

  Fly  1294 RGEDPPVVRATGSTATLGGFLRRAQRTLLDQPWQIVQLVPVDDLGHFTVWALIGEELHKIKLTVP 1358
                    .::...:.||..:|:...:..:..|:::|.....:.|...|:..|..::..|...:|
Yeast  1298 --------NSSRERSALGSMIRKQAESYANSTWEVLQYKDSGEPGVLEVFVTINGKVQNITFHIP 1354

  Fly  1359 RIFYVNQRSAAPPEE---GQLWRKVNRVLPRSRPVFN-----LYRYSVPEQLF---RDNSLGMLA 1412
            :..|:..:|...|.:   ..|..|.:..||.:....|     |::.::||.:|   ::|...:..
Yeast  1355 KTIYMKFKSQTMPLQKIKNCLIEKSSASLPNNPKTSNPAGGQLFKITLPESVFLEEKENCTSIFN 1419

  Fly  1413 DLATPDIEGIYETQMTLEFRALMDMGCICGVQREEARRLAQLATKDLETFSIEQLEQRPQTQVKY 1477
            |   .::.|::|..:|...||:||:|.....:.:....|.:...:..|...:...|..     :|
Yeast  1420 D---ENVLGVFEGTITPHQRAIMDLGASVTFRSKAMGALGKGIQQGFEMKDLSMAENE-----RY 1476

  Fly  1478 LASANNRLRKIYLYQHNTPTAKK-----EIWS-----LILMPSKKAFVFALDTVRANQMPNMRQL 1532
            |:..:..:.  ||....|....:     :.|.     |:|.||.:|     ..:.|:   ::.|:
Yeast  1477 LSGFSMDIG--YLLHFPTSIGYEFFSLFKSWGDTITILVLKPSNQA-----QEINAS---SLGQI 1531

  Fly  1533 YTAERLALLKNLTAEEQDKIPV--------EDYTFEVLIEVDVKQIYRHIQRALTTYKQEHQGPT 1589
            |        |.:..:::.||..        ||..||.:...|:.::||.:.:..|..|:|.....
Yeast  1532 Y--------KQMFEKKKGKIETYSYLVDIKEDINFEFVYFTDISKLYRRLSQETTKLKEERGLQF 1588

  Fly  1590 ILCLQTALSARKLSLAMPILLEFPQAEIHISDDASLLSGLDWQRQGSRAVIRHFLNLNNVLDLML 1654
            :|.||:....:.|. .:.:|.:.|..::.:::  .||..|:||....:.::.|.|:..:.:..::
Yeast  1589 LLLLQSPFITKLLG-TIRLLNQMPIVKLSLNE--VLLPQLNWQPTLLKKLVNHVLSSGSWISHLI 1650

  Fly  1655 DQCRYFHVPIGNMPPDTVLFGADLFFARLLQRHNFVLWWS-ASTRPDLGGREADDSRLLAEFEES 1718
            ...:|.::||.|:..|::.:..|:.:||.|::.|.||||: .:..||.||.:.|       |:.:
Yeast  1651 KLSQYSNIPICNLRLDSMDYIIDVLYARKLKKENIVLWWNEKAPLPDHGGIQND-------FDLN 1708

  Fly  1719 ISVVQ--------NKAGFYPDVCVELALDSLAVSALLQSTRIQEMEGASSAITFDVMPQVSLEEM 1775
            .|.:.        |.:|.|.:|.:::.:|:|.|:.:|.|..|.:.||:..     |...:.:::.
Yeast  1709 TSWIMNDSEFPKINNSGVYDNVVLDVGVDNLTVNTILTSALINDAEGSDL-----VNNNMGIDDK 1768

  Fly  1776 IGTVPAATLPS-YDETALCSAAFRVMRSMVNGWLREVSINRNIFSDFQIVHFYRWVRSSNALLYD 1839
            ...:.:   || :...|..:.|..|:|.|:..|..| ::..|..:|..:.....||::.||.|:|
Yeast  1769 DAVINS---PSEFVHDAFSNDALNVLRGMLKEWWDE-ALKENSTADLLVNSLASWVQNPNAKLFD 1829

  Fly  1840 PALRRSLNNLMRKMFLRIIAEFKRLGATIIYADFNRIILSSGKKTVSDALGYVDYIVQSLRNKEM 1904
            ..||..::||.:|..|:::.||..||:||:|||.|:|::.:.|.:..:...|..|:::::|...|
Yeast  1830 GLLRYHVHNLTKKALLQLVNEFSALGSTIVYADRNQILIKTNKYSPENCYAYSQYMMKAVRTNPM 1894

  Fly  1905 FHSIQLSFEQCWNFMLWMDQANFSGI-----------------RGKLPKGID-------ETVSSI 1945
            |..:.|:.::.|:.::|||:.||||:                 :.:|.|.:.       |....|
Yeast  1895 FSYLDLNIKRYWDLLIWMDKFNFSGLACIEIEEKENQDYTAVSQWQLKKFLSPIYQPEFEDWMMI 1959

  Fly  1946 VSTTMIRDSERNQDDDEDEEEDSENRDPVE-SNEAEQDQEDELSLELNWTIGEHLPDENECREKF 2009
            :..:|::..:...      :.:|..:.|.: .|..:||:||.:...||               .|
Yeast  1960 ILDSMLKTKQSYL------KLNSGTQRPTQIVNVKKQDKEDSVENSLN---------------GF 2003

  Fly  2010 ESLLTLFMQSLAEK--KTTEQAIKDISHCAFDFILKLHKNYGKGKPSPGLELIRTLIKALSVDKT 2072
            ..|.:..:....:|  |..::.|.|..:.| |:::.:.........:|.|||:::|...:.:.|:
Yeast  2004 SHLFSKPLMKRVKKLFKNQQEFILDPQYEA-DYVIPVLPGSHLNVKNPLLELVKSLCHVMLLSKS 2067

  Fly  2073 LAEQINELRRNMLRLVGIGEFSDLAEWEDPCDSHIINEVICKACNHCRDLDLCKDKHRAMKDGVP 2137
            ...:|..||:.:|::..:.||:.:||::||..|.::.:.:|:.|....|:|.||....:      
Yeast  2068 TILEIRTLRKELLKIFELREFAKVAEFKDPSLSLVVPDFLCEYCFFISDIDFCKAAPES------ 2126

  Fly  2138 VWLCAQCYVAYDNEEIEMRMLDALQRKMMSYVLQDLRCSRCSEIKRENLAEFCTCAGNFVPLISG 2202
            ::.|.:|:.|::...::..::..|:..:.||::||||||||.::||:.::..|.|||.:...:..
Yeast  2127 IFSCVRCHKAFNQVLLQEHLIQKLRSDIESYLIQDLRCSRCHKVKRDYMSAHCPCAGAWEGTLPR 2191

  Fly  2203 KDIQTLLGTFNKVAANHKMQLL 2224
            :.|...|..|.:||..:...:|
Yeast  2192 ESIVQKLNVFKQVAKYYGFDIL 2213

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DNApol-epsilon255NP_524462.2 DNA_polB_epsilon_exo 266..469 CDD:99822 134/202 (66%)
POLBc_epsilon 529..1154 CDD:99918 359/628 (57%)
DUF1744 1529..1930 CDD:369900 110/418 (26%)
POL2NP_014137.1 DNA_pol_B_exo1 121..442 CDD:397292 166/341 (49%)
DNA_polB_epsilon_exo 283..486 CDD:99822 135/208 (65%)
POLBc_epsilon 545..1166 CDD:99918 359/628 (57%)
DUF1744 1528..1920 CDD:400678 110/418 (26%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C157346029
Domainoid 1 1.000 314 1.000 Domainoid score I199
eggNOG 1 0.900 - - E1_COG0417
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H4539
Inparanoid 1 1.050 1488 1.000 Inparanoid score I10
Isobase 1 0.950 - 0 Normalized mean entropy S834
OMA 1 1.010 - - QHG55019
OrthoFinder 1 1.000 - - FOG0004282
OrthoInspector 1 1.000 - - oto100395
orthoMCL 1 0.900 - - OOG6_101586
Panther 1 1.100 - - LDO PTHR10670
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R346
SonicParanoid 1 1.000 - - X3018
TreeFam 1 0.960 - -
1615.740

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