Protein Alignment DNApol-epsilon255 and Pola1

DIOPT Version :9

• Sequence 1: NP_524462.2
• Gene: DNApol-epsilon255 / 42758
• FlyBaseID: FBgn0264326
• Length: 2236
• Species: Drosophila melanogaster
• Sequence 2: NP_445931.1
• Gene: Pola1 / 85241
• RGDID: 621816
• Length: 1468
• Species: Rattus norvegicus
• Alignment Length: 1054
• Identity: 203/1054 - (19%)
• Similarity: 346/1054 - (32%)
• Gaps: 360/1054 - (34%)

  Fly   241 WYNIRCRSGVELPTITC-------RPDILD-----RPEP-VVLAFDIETTKLPLKFPDAQTDQVM 292
            |..::....:..|...|       :||:::     .|.| ||::|.::|
  Rat   505 WLEVKNPQLLNQPISWCKFEAMALKPDLVNVIKDVSPPPLVVMSFSMKT---------------- 553

  Fly   293 MISYMIDGQGYLITNREIISSNVDDFEYTPKPEFEGNFIV------------FNE---------- 335
             :..:.:.|..:|....::..|....:..|||.|:.:|.|            |.|
  Rat   554 -MQNVQNHQHEIIAMAALVHHNFPLDKAPPKPPFQTHFCVVSKPKDCIFPCAFKEVIKKKNMEVE 617

  Fly   336 --ENEMQLLQRFFDHIMEVRPHIIVTYNGDFFDWPFVETRAAVYDLDMKQEIGFSKLRDGN---- 394
              ..|..||..|...:.::.|.|:|.:|...|:...:..|.....:....:||  :||..|
  Rat   618 VAATERTLLGFFLAKVHKLDPDILVGHNICGFELEVLLQRINECKVPFWSKIG--RLRRSNMPKL 680

  Fly   395 -----YLSRPAI--HMDCLCWVKRDSYLPVGSQGLKAVAKAKLRYDPVELDPEDMCRMAVEQPQV 452
                 :..|.|.  .|.|...:.....:...|..|..:.:..|:.:.:.:..|::..|..|...:
  Rat   681 GSRSGFGERNATCGRMICDVEISVKELIHCKSYHLSELVQQILKTERIVIPTENIRNMYSEPSHL 745

  Fly   453 --LANYSVSDAVATYYLYMKYVHPFIFALNTIIPME----------PDEILRKGSGTLCETLLMV 505
              |..:...||        :::...:..|| ::|:.          ....|..|.....|.||:.
  Rat   746 LYLLEHIWKDA--------RFILQIMCELN-VLPLALQITNIAGNIMSRTLMGGRSERNEFLLLH 801

  Fly   506 EAYHAQIVYPNKH--QSELNKLSNEGHVLDSET--YVGGHVEALESGVFRADIPCRFRLDPAMVK 566
            ..|....:.|:|.  :....|..:|...:|.:|  |..|..:|..:|        ...|||.:
  Rat   802 AFYENNYIVPDKQIFRKPQQKPGDEDEEIDGDTNKYKKGRKKAAYAG--------GLVLDPKV-- 856

  Fly   567 QLQEQVDAVLRHAIEVEEGIPLEKVLNLDEVRQEIVQGLQGLHDIPNRLEQPVIYHLDVGAMYPN 631
                                                    |.:|       ..|..||..::||:
  Rat   857 ----------------------------------------GFYD-------KFILLLDFNSLYPS 874

  Fly   632 IILTNRLQPSAMVSDLDCAACDFNKPGVRCKRSMDWLWRGEMLPASRNEFQRIQQQLETEKFPPL 696
            ||.                  :||......:|.     ..|.|.|:.:|        |.|:.|.|
  Rat   875 IIQ------------------EFNICFTTVQRV-----ASETLKATEDE--------EQEQIPEL 908

  Fly   697 FPGGPQRAFHELSKEDQAAYEKKRLTDYCRKAYKKTKLTKLETRTSTICQKENSFYVDTVRAFRD 761
              ..|......|.:|                                            :|...:
  Rat   909 --PDPNLDMGILPRE--------------------------------------------IRKLVE 927

  Fly   762 RRYEYKGLTKVAKASVNAAVASGDAAEIKAAKGREVLYDSLQLAHKCILNSFYGYVMRRGARWHS 826
            ||.:.|.|.|  :..:|..:.              :.||..|.|.|...||.||.:....:|:::
  Rat   928 RRKQVKQLMK--QQDLNPDLV--------------LQYDIRQKALKLTANSMYGCLGFSYSRFYA 976

  Fly   827 MPMAGIVCLTGSNIITKAREIIERVGRPLEL---DTDGIWCILPGSFPQEFTIHTSHEKKKKINI 888
            .|:|.:|...|..|:...:|:::::.  ||:   |||.|
  Rat   977 KPLAALVTYKGREILMHTKEMVQKMN--LEVIYGDTDSI-------------------------- 1013

  Fly   889 SYPNAVLNTMVKDHFTN-DQYHELRKDKENNLPK-YDIRDENSIFFEVDGPYLAMVLPAAKEEGK 951
                     |:..:.|| ::..:|....:|.:.| |.:.:     .::||.:.:::|
  Rat  1014 ---------MINTNSTNLEEVFKLGNKVKNEVNKLYKLLE-----IDIDGVFKSLLL-------- 1056

  Fly   952 KLKKRYAVF----NFDG---TLAELKGFEVKRRGELQLIKNFQSSVFEAFLAGSTLEECYASVAK 1009
            ..||:||..    ..||   |..||||.::.||....|.|:..:.|....|:..:.:....::.|
  Rat  1057 LKKKKYAALVVEPTSDGNYITKQELKGLDIVRRDWCDLAKDTGNFVIGQILSDQSRDTIVENIQK 1121

  Fly  1010 -VADYWLDVLYSRGSNLPDSELFELISENKSMSKKLEEYGAQKSTSISTAKRLAEFLGEQMVKDA 1073
             :.:...:||   ..::|.|: ||:   ||:::|..::|..:||.............|.:.|| |
  Rat  1122 RLIEIGENVL---NGSVPVSQ-FEI---NKALTKDPQDYPDKKSLPHVHVALWINSQGGRKVK-A 1178

  Fly  1074 GLACKYIISKKPEGAPVTERAIPLAIFQSEPSVRRHHLRRWLKDNTMGDADIRDVLDWNYY---- 1134
            |....|:|.:.....|.|:||......|.:             ||.        .:|..||
  Rat  1179 GDTVSYVICQDGSNLPATQRAYAPEQLQKQ-------------DNL--------AIDTQYYLAQQ 1222

  Fly  1135 ----IERLGGTIQKIITIPAAL-QGLANPVPRVQHPDWLHKKMLEKNDVLKQRRINEMFTSRPKP 1194
                :.|:...|..|..:..|| .||.:...||..   .||.  |:||.|           ...|
  Rat  1223 IHPVVARICEPIDGIDAVLIALWLGLDSTQFRVHQ---YHKD--EENDAL-----------LGGP 1271

  Fly  1195 KPLATEEDKLADME 1208
            ..| |:|:|..|.|
  Rat  1272 AQL-TDEEKYKDCE 1284

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DNApol-epsilon255	NP_524462.2	DNA_polB_epsilon_exo	266..469	CDD:99822	44/240 (18%)
		POLBc_epsilon	529..1154	CDD:99918	123/648 (19%)
		DUF1744	1529..1930	CDD:369900
Pola1	NP_445931.1	DNA_pol_alpha_N	41..101	CDD:289058
		pol2	56..1232	CDD:273159	182/983 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	105..135
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	174..226
		DNA_polB_alpha_exo	542..774	CDD:99819	47/259 (18%)
		DNA-binding. /evidence=ECO:0000255	657..722		12/66 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	816..836		4/19 (21%)
		POLBc_alpha	839..1249	CDD:99915	121/638 (19%)
		DNA-binding. /evidence=ECO:0000255	1252..1383		15/50 (30%)
		zf-DNA_Pol	1272..1461	CDD:286132	6/14 (43%)
		CysB motif	1355..1381

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0417
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900