Protein Alignment DNApol-epsilon255 and POL3

DIOPT Version :9

• Sequence 1: NP_524462.2
• Gene: DNApol-epsilon255 / 42758
• FlyBaseID: FBgn0264326
• Length: 2236
• Species: Drosophila melanogaster
• Sequence 2: NP_010181.2
• Gene: POL3 / 851456
• SGDID: S000002260
• Length: 1097
• Species: Saccharomyces cerevisiae
• Alignment Length: 1059
• Identity: 197/1059 - (18%)
• Similarity: 357/1059 - (33%)
• Gaps: 407/1059 - (38%)

  Fly    67 NEVLDEDRRLIAALDLFFIQMDGSRFKCTV-AYQPYLLI----RPEDNMHLEVARF---LGRKYS 123
            |.:.||:...:  :..|.:..:|....|.| .::.||.:    ..:.|...::.:|   |...:.
Yeast   126 NGIKDENTSTV--VRFFGVTSEGHSVLCNVTGFKNYLYVPAPNSSDANDQEQINKFVHYLNETFD 188

  Fly   124 GQISGLEHITKE-------DLDLPNHLSGLQQQYIKLSFLNQTAMTKVRRELMSAVKRNQERQKS 181
            ..|..:|.::|:       |..||         :.|:.......:.|:|    :|.:|.  ....
Yeast   189 HAIDSIEVVSKQSIWGYSGDTKLP---------FWKIYVTYPHMVNKLR----TAFERG--HLSF 238

  Fly   182 NTYYMQMLATSLAQSSAGSEDATLGKRQQDYMDCIVDIREHDVPYHVRVSIDLRIFCGQWYNI-- 244
            |:::..                  |....|           ::.|.:|:.:|..|....|..:
Yeast   239 NSWFSN------------------GTTTYD-----------NIAYTLRLMVDCGIVGMSWITLPK 274

  Fly   245 -------------RCRSGVELPTITCRPDILDRP--------EPV-VLAFDIETTKLPLKFPDAQ 287
                         .|:..|   :|..| :::..|        .|: :::||||.......||:.:
Yeast   275 GKYSMIEPNNRVSSCQLEV---SINYR-NLIAHPAEGDWSHTAPLRIMSFDIECAGRIGVFPEPE 335

  Fly   288 TDQVMMISYMIDGQG----YLITNREIISSNVDDFEYTPKPEFEGNFIVFNEENEMQLLQRFFDH 348
            .|.|:.|:.::...|    ::   |.:.:.|      |..| ..|: ::|:...|.::|..:.:.
Yeast   336 YDPVIQIANVVSIAGAKKPFI---RNVFTLN------TCSP-ITGS-MIFSHATEEEMLSNWRNF 389

  Fly   349 IMEVRPHIIVTYNGDFFDWPFVETRAAVYDLD----------MKQEIGFSKLRDGNYLSRPA--- 400
            |::|.|.:|:.||...||.|::..||....::          :||||..|......|.:|..
Yeast   390 IIKVDPDVIIGYNTTNFDIPYLLNRAKALKVNDFPYFGRLKTVKQEIKESVFSSKAYGTRETKNV 454

  Fly   401 -----IHMDCLCWVKRDSYLPVGSQGLKAVA-------KAKLRY----DPVELDPEDMCRMAVEQ 449
                 :.:|.|.:::|:..|  .|..|.||:       |..:.|    |....|.|...|:||
Yeast   455 NIDGRLQLDLLQFIQREYKL--RSYTLNAVSAHFLGEQKEDVHYSIISDLQNGDSETRRRLAV-- 515

  Fly   450 PQVLANYSVSDAVATYYLYMKYVHPFIFALNTIIPMEPDEILRKGSGTLCETLLMVEAYHAQIVY 514
                  |.:.||    ||.::                           |.|.|:.:..|
Yeast   516 ------YCLKDA----YLPLR---------------------------LMEKLMALVNY------ 537

  Fly   515 PNKHQSELNKLSNEGHVLDSETYVGGHVEALESGVFRADIPCRFRLDPAMVKQLQEQVDAVLRHA 579
                 :|:.:::.                          :|..:.|  |..:|: :.|..:.|..
Yeast   538 -----TEMARVTG--------------------------VPFSYLL--ARGQQI-KVVSQLFRKC 568

  Fly   580 IEVEEGIP-LEKVLNLDEVR-QEIVQGLQGLHDIPNRLEQPVIYHLDVGAMYPNIILTNRLQPSA 642
            :|::..|| ::...:.|:.. ..:::.::|.:|:|       |..||..::||:|::.:.|
Yeast   569 LEIDTVIPNMQSQASDDQYEGATVIEPIRGYYDVP-------IATLDFNSLYPSIMMAHNL---- 622

  Fly   643 MVSDLDCAACDFNKPGVRCKRSMDWLWRGEMLPASRNEFQRIQQQLETEKFPPLFPGGPQRAFHE 707
                  |.....||..|                      :|:..:::.:..  :.|.|
Yeast   623 ------CYTTLCNKATV----------------------ERLNLKIDEDYV--ITPNG------- 650

  Fly   708 LSKEDQAAYEKKR------LTDYCRKAYKKTKLTKLETRTSTICQKENSFYVDTVRAFRDRRYEY 766
                |.....|:|      :.|....|.|:.|                       :..||.:..:
Yeast   651 ----DYFVTTKRRRGILPIILDELISARKRAK-----------------------KDLRDEKDPF 688

  Fly   767 KGLTKVAKASVNAAVASGDAAEIKAAKGREVLYDSLQLAHKCILNSFYGYVMRRGARWHSMPMAG 831
            |                           |:|| :..|||.|...||.||:.   ||....:|
Yeast   689 K---------------------------RDVL-NGRQLALKISANSVYGFT---GATVGKLP--- 719

  Fly   832 IVCLTGSNIITKAREIIERVGRPLELDTDGIWCILPGSFPQEFTIHTSHEKKKKINISYP-NAVL 895
              ||..|:.:|       ..||.:.|.|                 .|:.::|..|...|. :||:
Yeast   720 --CLAISSSVT-------AYGRTMILKT-----------------KTAVQEKYCIKNGYKHDAVV 758

  Fly   896 ------NTMVKDHFTNDQYHELRK--DKENNLPKY---------DIRDENSIFFEVDGPYLAMVL 943
                  :.|||...|     :|::  |......||         ::..|.:.|     |||.:
Yeast   759 VYGDTDSVMVKFGTT-----DLKEAMDLGTEAAKYVSTLFKHPINLEFEKAYF-----PYLLI-- 811

  Fly   944 PAAKEEGKKLKKRYA-VF-----NFDGTLAELKGFEVKRRGELQLIKNFQSSVFEAFLAGSTLEE 1002
                     .||||| :|     .||  ..:.||....||....|:....:.|.:..|....::.
Yeast   812 ---------NKKRYAGLFWTNPDKFD--KLDQKGLASVRRDSCSLVSIVMNKVLKKILIERNVDG 865

  Fly  1003 CYASVAKVADYWLDVLYSR 1021
            ..|.|.:..:   |:|::|
Yeast   866 ALAFVRETIN---DILHNR 881

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DNApol-epsilon255	NP_524462.2	DNA_polB_epsilon_exo	266..469	CDD:99822	58/236 (25%)
		POLBc_epsilon	529..1154	CDD:99918	98/525 (19%)
		DUF1744	1529..1930	CDD:369900
POL3	NP_010181.2	PTZ00166	90..1095	CDD:240301	197/1059 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0417
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900