Protein Alignment PolE1 and ICU2

DIOPT Version :10

• Sequence 1: NP_524462.2
• Gene: PolE1 / 42758
• FlyBaseID: FBgn0264326
• Length: 2236
• Species: Drosophila melanogaster
• Sequence 2: NP_201511.2
• Gene: ICU2 / 836845
• AraportID: AT5G67100
• Length: 1524
• Species: Arabidopsis thaliana
• Alignment Length: 1306
• Identity: 251/1306 - (19%)
• Similarity: 439/1306 - (33%)
• Gaps: 426/1306 - (32%)

  Fly    39 NDKIDSKYGF----DRVKDS----QERTGYLINMHS---NEVLDEDRRLIAALDLFFIQMDGSRF 92
            ||.|...:..    ..||||    :...|.|..|.|   ||:..|           .:|::.|.|
plant   395 NDSIFPSHELIMLEQEVKDSRLSPESFRGKLHEMASKLKNEIAQE-----------LLQLNVSNF 448

  Fly    93 KCTVAYQPYLLIRPEDNMHLEVARFLGRKYSGQISGLEHITKEDLDLPNHLSGLQQQYIKLSFLN 157
            ......:.|...||:..        .|.:|..:|    :.:.:|..||..|.|  :.:..|...:
plant   449 SMAPVKRNYAFERPDVP--------AGEQYVLKI----NYSFKDRPLPEDLKG--ESFSALLGSH 499

  Fly   158 QTAMTK--VRRELMSAVKRNQERQKSNTYYMQMLATSLAQSSAGSEDATLGKRQQDYMDCIVDIR 220
            .:|:..  ::|::|...            ::::.:.|....|.|..........|...|..:.:.
plant   500 TSALEHFILKRKIMGPC------------WLKISSFSTCSPSEGVSWCKFEVTVQSPKDITILVS 552

  Fly   221 EHDV--PYHVRVSIDLRIFCGQWYNIRCRSGVELPTITCRPDILDRPEPVVLAFDIETTKLPLKF 283
            |..|  |..|..:|:|:....:..||.     |:.:.:            ||.|......:|:..
plant   553 EEKVVHPPAVVTAINLKTIVNEKQNIS-----EIVSAS------------VLCFHNAKIDVPMPA 600

  Fly   284 PDAQTDQVMMISYMI---DGQGYLI-TNREIISSNVDDFEYTPKPEFEGNFIVFNEENEMQLLQR 344
            |:.:...::....::   :|.||.| ..:|:...|..:          |..::..|.:|..||.|
plant   601 PERKRSGILSHFTVVRNPEGTGYPIGWKKEVSDRNSKN----------GCNVLSIENSERALLNR 655

  Fly   345 FFDHIMEVRPHIIVTYNGDFFDWPFVETRAAVYDL--DMKQEIG------FSKLR-DGNYLS--R 398
            .|..:.::...|:|.:|...||...:..||....:  .|..:||      ..||: :.||.|  .
plant   656 LFLELNKLDSDILVGHNISGFDLDVLLQRAQACKVQSSMWSKIGRLKRSFMPKLKGNSNYGSGAT 720

  Fly   399 PAIHMDC----------LCWVKRDSYLPVGSQGLKAVAKAKLRYDPVELDPEDMCRMAVEQPQV- 452
            |.: |.|          ||  .||....| |..|..::|.:|..|..|:.|.|:.:|......:
plant   721 PGL-MSCIAGRLLCDTDLC--SRDLLKEV-SYSLTDLSKTQLNRDRKEIAPNDIPKMFQSSKTLV 781

  Fly   453 -LANYSVSDAVATYYLYMKYVHPFIFALNTIIPMEPDEILRKGSGTLCETLL-----------MV 505
             |.....:||    :|.|:    .:|.| :::|:...  |...||.|....|           ::
plant   782 ELIECGETDA----WLSME----LMFHL-SVLPLTLQ--LTNISGNLWGKTLQGARAQRIEYYLL 835

  Fly   506 EAYHA-QIVYPNKHQSELNKLSNEGHVLDSETYVGGHVEALESGVFRADIPCRFRLDPAMVKQLQ 569
            ..:|: :.:.|:|....:.::.:.                            :.|:|.|...:..
plant   836 HTFHSKKFILPDKISQRMKEIKSS----------------------------KRRMDYAPEDRNV 872

  Fly   570 EQVDAVLRHAIEVEEGIPLEK------VLNLDEVRQEIVQGLQGLHDIPNRLEQPVIYHLDVGAM 628
            :::||.|....:..:|...:|      .|.|:..|        ||:|       ..:..||..::
plant   873 DELDADLTLENDPSKGSKTKKGPAYAGGLVLEPKR--------GLYD-------KYVLLLDFNSL 922

  Fly   629 YPNIILTNRLQPSAMVSDLDCAACDFNKPGVRCKRSMDWLWRGEMLPASRNEFQRIQQQLETEKF 693
            ||:||.                  ::|.......||.|.:.|   ||:|:.
plant   923 YPSIIQ------------------EYNICFTTIPRSEDGVPR---LPSSQT-------------- 952

  Fly   694 PPLFPGGPQRAFHELSKEDQAAYEKKRLTDYCRKAYKKTKLTKLETRTSTICQKENSFYVDTVRA 758
            |.:.|                     :|.::.....|..|| |::..|.
plant   953 PGILP---------------------KLMEHLVSIRKSVKL-KMKKETG---------------- 979

  Fly   759 FRDRRYEYKGLTKVAKASVNAAVASGDAAEIKAAKGREVLYDSLQLAHKCILNSFYGYVMRRGAR 823
                 .:|..|                              |..|.|.|...||.||.:....:|
plant   980 -----LKYWEL------------------------------DIRQQALKLTANSMYGCLGFSNSR 1009

  Fly   824 WHSMPMAGIVCLTGSNIITKAREIIERVGRPLEL---DTDGIWCILPGSFPQEFTIHTSHEKKKK 885
            :::.|:|.::.|.|.:|:.:..::::. ...||:   |||.|            .||:..:
plant  1010 FYAKPLAELITLQGRDILQRTVDLVQN-HLNLEVIYGDTDSI------------MIHSGLD---- 1057

  Fly   886 INISYPNAVLNTMVKDHFTNDQYHELRKDKENNLPKYDIRDENSIFFEVDGPYLAMVLPAAKEEG 950
             :|....|:.:.::::  .|.:|..|:.|                   .||.|..|:|
plant  1058 -DIEEVKAIKSKVIQE--VNKKYRCLKID-------------------CDGIYKRMLL------- 1093

  Fly   951 KKLKKRYAVFNF---DGTLA---ELKGFEVKRRGELQLIKNFQSSVFEAFLAGSTLEECYASVAK 1009
             ..||:||....   ||...   |.||.::.||....|.|..........|.|.:.|:...::
plant  1094 -LRKKKYAAVKLQFKDGKPCEDIERKGVDMVRRDWSLLSKEIGDLCLSKILYGGSCEDVVEAI-- 1155

  Fly  1010 VADYWLDVLYSRGSNLPDSELFELISENKSMSKKLEEYGAQKSTS--------------ISTAKR 1060
                             .:||.::..|.::....||:|...|:.:              :..|.|
plant  1156 -----------------HNELMKIKEEMRNGQVALEKYVITKTLTKPPAAYPDSKSQPHVQVALR 1203

  Fly  1061 LAEFLGEQMVKDAGLACKYII------SKKPEGAPVTERAIPLAIFQSEPSVRRHHLRRWLKDNT 1119
            :.: .|.:...:|.....|||      :.....|.:.|||......:||.|       |||
plant  1204 MRQ-RGYKEGFNAKDTVPYIICYEQGNASSASSAGIAERARHPDEVKSEGS-------RWL---- 1256

  Fly  1120 MGDADIRDVLDWNYYIERLGGTIQKIIT-IPAALQGLANPVPRVQHPDWLHKKMLEKNDVLKQR- 1182
                     :|.:||   |...|..::: :.|.:||.:        |:.|.:.:  ..|..|.|
plant  1257 ---------VDIDYY---LAQQIHPVVSRLCAEIQGTS--------PERLAECL--GLDPSKYRS 1299

  Fly  1183 RINEMFTSRPKPKPL--ATEEDKLADMEDLA-GKDGGEGAAGCPIVTKR--KRIQLEEHDDEEAQ 1242
            :.|:..:|.|....|  .::|::....|.|| .......|..||.:...  ..|..:....|..:
plant  1300 KSNDATSSDPSTSLLFATSDEERYKSCEPLALTCPSCSTAFNCPSIISSVCASISKKPATPETEE 1364

  Fly  1243 PQATTW 1248
            ..:|.|
plant  1365 SDSTFW 1370

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PolE1	NP_524462.2	DNA_polB_epsilon_exo	266..469	CDD:99822	54/229 (24%)
		POLBc_epsilon	529..1154	CDD:99918	117/660 (18%)
		DUF1744	1529..1930	CDD:462493
ICU2	NP_201511.2	pol2	53..1275	CDD:273159	228/1199 (19%)
		zf-DNA_Pol	1318..1522	CDD:462651	11/53 (21%)