Protein Alignment DNApol-epsilon255 and TIL2

DIOPT Version :9

• Sequence 1: NP_524462.2
• Gene: DNApol-epsilon255 / 42758
• FlyBaseID: FBgn0264326
• Length: 2236
• Species: Drosophila melanogaster
• Sequence 2: NP_001325161.1
• Gene: TIL2 / 817254
• AraportID: AT2G27120
• Length: 2141
• Species: Arabidopsis thaliana
• Alignment Length: 2269
• Identity: 900/2269 - (39%)
• Similarity: 1319/2269 - (58%)
• Gaps: 235/2269 - (10%)

  Fly    40 DKIDSKYGFDRVKDSQERTGYLINMHSNEVLDEDR-RLIAALDLFFIQMDGSRFKCTVAYQPYLL 103
            |::::|.||......:.|.|:|:...|:...|.|. :..:.:||||:..|||.||....::|||.
plant    19 DELETKLGFGLFSQGETRLGWLLTFASSSWEDADTGKTFSCVDLFFVTQDGSSFKTKYKFRPYLY 83

  Fly   104 IRPEDNMHLEVARFLGRKYSGQISGLEHITKEDLDLPNHLSGLQQQYIKLSFLNQTAMTKVRREL 168
            ...:|||.|||..:|.|:|..|::.::.:.||||.|.|||||||::|:|:||.....:.:|:|:|
plant    84 AATKDNMELEVEAYLRRRYERQVADIQIVHKEDLYLKNHLSGLQKKYLKVSFDTVQQLVEVKRDL 148

  Fly   169 MSAVKRNQERQKSNTYYMQMLATSLAQSSAGSEDATLGKRQ---QDYMDCIVDIREHDVPYHVRV 230
            :..|:||..:..:...|..:|:               |||:   ||.:|.:||:||:|||||||.
plant   149 LHIVERNLAKFNALEAYESILS---------------GKREQRPQDCLDSVVDLREYDVPYHVRF 198

  Fly   231 SIDLRIFCGQWYNIRCRSGVELPTITCRPDILDRPEPVVLAFDIETTKLPLKFPDAQTDQVMMIS 295
            :||..:..|||||:...|...:  :..|.|:|.|.|..|.||||||.|||||||||:.||:||||
plant   199 AIDNDVRSGQWYNVSISSTDVI--LEKRTDLLQRAEVRVCAFDIETVKLPLKFPDAEYDQIMMIS 261

  Fly   296 YMIDGQGYLITNREIISSNVDDFEYTPKPEFEGNFIVFNEENEMQLLQRFFDHIMEVRPHIIVTY 360
            ||:||||:||||||.:..:::|.||||||||||.|.|.|..||::||:::|.|:.|::|.|.|||
plant   262 YMVDGQGFLITNRECVGKDIEDLEYTPKPEFEGYFKVTNVTNEVELLRKWFSHMQELKPGIYVTY 326

  Fly   361 NGDFFDWPFVETRAAVYDLDMKQEIGF-SKLRDGNYLSRPAIHMDCLCWVKRDSYLPVGSQGLKA 424
            |||||||||:|.||:.:.:.|.:|:|| .....|...::...|:||..|||||||||.|||||||
plant   327 NGDFFDWPFIERRASHHGIKMNEELGFRCDQNQGECRAKFVCHLDCFSWVKRDSYLPQGSQGLKA 391

  Fly   425 VAKAKLRYDPVELDPEDMCRMAVEQPQVLANYSVSDAVATYYLYMKYVHPFIFALNTIIPMEPDE 489
            |.|.||.|||:|::||||.|.|:|:||.:|:||||||||||||||.|||||:|:|.|||||.|||
plant   392 VTKVKLGYDPLEVNPEDMVRFAMEKPQTMASYSVSDAVATYYLYMTYVHPFVFSLATIIPMVPDE 456

  Fly   490 ILRKGSGTLCETLLMVEAYHAQIVYPNKHQSELNKLSNEGHVLDSETYVGGHVEALESGVFRADI 554
            :||||||||||.|||||||.|.:|.|||:|::..|. .:|.:|:||||:|||||.|:|||||:||
plant   457 VLRKGSGTLCEMLLMVEAYKANVVCPNKNQADPEKF-YQGKLLESETYIGGHVECLQSGVFRSDI 520

  Fly   555 PCRFRLDPAMVKQLQEQVDAVLRHAIEVEEGIPLEKVLNLDEVRQEIVQGLQGLHDIPNRLEQPV 619
            |..|:||.:..:||.:.:...|.:||.||..:.::.|.|.|||::.|.:.|:.|.|.|.|.|.|:
plant   521 PTSFKLDASAYQQLIDNLGRDLEYAITVEGKMRMDSVSNFDEVKEVIREKLEKLRDDPIREEGPL 585

  Fly   620 IYHLDVGAMYPNIILTNRLQPSAMVSDLDCAACDFNKPGVRCKRSMDWLWRGEMLPASRNEFQRI 684
            ||||||.||||||||||||||.::|:|..|.|||||.|...|.|.::|:|||.....:::|:..:
plant   586 IYHLDVAAMYPNIILTNRLQPPSIVTDEVCTACDFNGPEKTCLRKLEWVWRGVTFKGNKSEYYHL 650

  Fly   685 QQQLETEKFPPLFPGGPQRAFHELSKEDQAAYEKKRLTDYCRKAYKKTKLTK--LETRTSTICQK 747
            ::|:|:|...........:.|.:|.|.:|.:..|:||..||:|||.:. |.|  .|.|.:.||.:
plant   651 KKQIESESVDAGANMQSSKPFLDLPKVEQQSKLKERLKKYCQKAYSRV-LDKPITEVREAGICMR 714

  Fly   748 ENSFYVDTVRAFRDRRYEYKGLTKVAKASVNAAVASGDAAEIKAAKGREVLYDSLQLAHKCILNS 812
            ||.|||||||:|||||||||.|.||.|..::.|.|||:..:|:.|....|:||||||||||||||
plant   715 ENPFYVDTVRSFRDRRYEYKTLNKVWKGKLSEAKASGNLIKIQEAHDMVVVYDSLQLAHKCILNS 779

  Fly   813 FYGYVMRRGARWHSMPMAGIVCLTGSNIITKAREIIERVGRPLELDTDGIWCILPGSFPQEFTIH 877
            |||||||:||||:||.|||:|..||:.||..||.:|||:|:|||||||||||.||||||:.||..
plant   780 FYGYVMRKGARWYSMEMAGVVTYTGAKIIQNARLLIERIGKPLELDTDGIWCALPGSFPENFTFK 844

  Fly   878 TSHEKKKKINISYPNAVLNTMVKDHFTNDQYHEL----RKDKENNLPKYDIRDENSIFFEVDGPY 938
            |.  ..||..||||..:||..|..:.:||||..|    ||       .|:.|.|.||.|||||||
plant   845 TI--DMKKFTISYPCVILNVDVAKNNSNDQYQTLVDPVRK-------TYNSRSECSIEFEVDGPY 900

  Fly   939 LAMVLPAAKEEGKKLKKRYAVFNFDGTLAELKGFEVKRRGELQLIKNFQSSVFEAFLAGSTLEEC 1003
            .||::||:||||..:||||||||.|||:|||||||:||||||:|||.||:.:|:.||.|||||||
plant   901 KAMIIPASKEEGILIKKRYAVFNHDGTIAELKGFEMKRRGELKLIKVFQAELFDKFLHGSTLEEC 965

  Fly  1004 YASVAKVADYWLDVLYSRGSNLPDSELFELISENKSMSKKLEEYGAQKSTSISTAKRLAEFLGEQ 1068
            |::||.||:.|||:|..:|.::.||||.:.|||:.:|||.|.:||.|||.:::||||||:|||:.
plant   966 YSAVAAVANRWLDLLEGQGKDIADSELLDYISESSTMSKSLADYGQQKSCAVTTAKRLADFLGDT 1030

  Fly  1069 MVKDAGLACKYIISKKPEGAPVTERAIPLAIFQSEPSVRRHHLRRWLKDNTMGDADIRDVLDWNY 1133
            ||||.||.|:||::::|||.||:|||:|:||||::...::.:|::|.|.::.  ..||.::||.|
plant  1031 MVKDKGLRCQYIVAREPEGTPVSERAVPVAIFQTDDPEKKFYLQKWCKISSY--TGIRSIIDWMY 1093

  Fly  1134 YIERLGGTIQKIITIPAALQGLANPVPRVQHPDWLHKKMLEKNDVLKQRRINEMFTSRPKPKPLA 1198
            |.:||...|||:||||||:|.:||||.||:||.||.||:.:|   .:|.:|.:||:|..|... .
plant  1094 YKQRLHSAIQKVITIPAAMQKVANPVLRVRHPYWLEKKVCDK---FRQGKIVDMFSSANKDHS-T 1154

  Fly  1199 TEEDKLADMEDLAGKDGGEGAAGCPIVTKRKRIQLEEHDDEEAQPQATTWRQALGAPPPIGETRK 1263
            |:::.:||:|:...::........|:.   :..:::.:..|..|.:  :|      .|...:...
plant  1155 TQDNVVADIEEFCKENRPSVKGPKPVA---RSFEVDRNHSEGKQQE--SW------DPEFHDISL 1208

  Fly  1264 TIVE-------WVRFQKKKWKWQQDQRQRNRQAS-------------KRTRGEDPPVVRATGSTA 1308
            ..|:       |:..:|:|||.....:::.|.:|             |..:|.           .
plant  1209 QNVDKNVDYQGWLELEKRKWKMTLTNKKKRRYSSSLFGFDLEQNINKKVCKGR-----------V 1262

  Fly  1309 TLGGFLRRAQRTLLDQPWQIVQLVPVDDLGHFTVWALIGEELHKIKLTVPRIFYVNQRSAAPPEE 1373
            .:|.:.||.:..|.....||:|||.....|.|..|.::...:.||.||:||:||:|.:::.   .
plant  1263 GVGSYFRRPEEALTSSYLQIIQLVQSPQSGQFFAWVVVEGLMLKIPLTIPRVFYINSKASI---A 1324

  Fly  1374 GQLWRK-VNRVLPRSRPVFNLYRYSVPEQLFRDNSLGMLADLATPDIEGIYETQMTLEFRALMDM 1437
            |....| :|::||..:|.:||...::.|..|...|..:.|.||.|:|||||||:|.|||.|:..:
plant  1325 GNFTGKCINKILPHGKPCYNLMEVNIQEDQFIKESKKLAALLADPEIEGIYETKMPLEFSAICQI 1389

  Fly  1438 GCICGVQREEARRLAQLATKDLETFSIEQLEQRPQTQVKYLASANNRLRKIYLYQHNTPTAKKEI 1502
            ||:|.::.....|..|      :.:.:.:|.:...|:.:||   .|.:..:||| |:|.|. :.:
plant  1390 GCVCKIEDTAKHRNTQ------DGWKLGELHRITTTECRYL---ENSIPLVYLY-HSTSTG-RAV 1443

  Fly  1503 WSLILMPSKKAFVFALDTVRANQMPNMRQLYTAERLALLKNLTAEEQDKIPVEDYTFE-VLIEVD 1566
            :.|....||     .:..|..|...:...|.:|     |:....:...::..|.:::: :|.:|:
plant  1444 YVLYCHASK-----LMSVVVVNPYGDKELLSSA-----LERQFRDRCQELSPEPFSWDGILFQVE 1498

  Fly  1567 V----KQIYRHIQRALTTYKQEHQGPTILCLQTALSARKLSLAMPILLEFPQAEIHISDDASLLS 1627
            .    :...:.:|:||..|::|:.|.|:..::.. ........:..|.:||...|..:||.:...
plant  1499 YVDHPEAATKFLQKALCEYREENCGATVAVIECP-DFNTTKEGVKALEDFPCVRIPFNDDDNSYQ 1562

  Fly  1628 GLDWQRQGSRAVIRHFLNLNNVLDLMLDQCRYFHVPIGNMPPDTVLFGADLFFARLLQRHNFVLW 1692
            .:.|||..::..:....:....||..:.|.||.|||:||...|.:.|..|:|.:|.|:....|||
plant  1563 PVSWQRPAAKIAVLRCASAIQWLDRRIAQSRYAHVPLGNFGRDWLTFTVDIFLSRALRDQQQVLW 1627

  Fly  1693 WSASTRPDLGGREADDSRLLAEFEESISVVQNKAGFYPDVCVELALDSLAVSALLQSTRIQEMEG 1757
            .|.:..||||....:::.|..|.:|:..:.   .|.|..|.|||.:..|||:|||:|..:.||||
plant  1628 VSDNGVPDLGDINNEETFLADELQETSLLF---PGAYRKVSVELKVHRLAVNALLKSDLVSEMEG 1689

  Fly  1758 ASSAITFDVMPQVSLEEMIGTVPAATL----PSYDETALCSAAFRVMRSMVNGWLREVSINRNIF 1818
            ..               .:|.....:.    .|:||...|:.||||::.::...|.:...:.||:
plant  1690 GG---------------FLGVNSRGSSLNDNGSFDENNGCAQAFRVLKQLIKRLLHDACNSGNIY 1739

  Fly  1819 SDFQIVHFYRWVRSSNALLYDPALRRSLNNLMRKMFLRIIAEFKRLGATIIYADFNRIILSSGKK 1883
            :|..:.|...|:||.::.|:||||...|:.:|:|:|..::.:.:||||.||||||:::|:.:||.
plant  1740 ADSILQHLSWWLRSPSSKLHDPALHLMLHKVMQKVFALLLTDLRRLGAIIIYADFSKVIIDTGKF 1804

  Fly  1884 TVSDALGYVDYIVQSLRNKEMFHSIQLSFEQCWNFMLWMDQANFSGIRGKLPKGIDETVSSIVST 1948
            .:|.|..|.:.::..:.::::|..|.|.....|:.:|:|||.|::|||.
plant  1805 DLSAAKTYCESLLTVMGSRDIFKLILLEPVHYWHSLLFMDQHNYAGIRA---------------- 1853

  Fly  1949 TMIRDSERNQDDDEDEEEDSENRDPVESNEAEQDQEDELSLELNWTIGEHLPD------------ 2001
                                 ..|.:..|        |:::|..|::..|||:
plant  1854 ---------------------TGDEISGN--------EVTIEPKWSVARHLPEYIQKDFIIIVAT 1889

  Fly  2002 --------------------ENECREKF-ESLLTLFMQSLAEK-KTTEQAIKDISHCAFDFILKL 2044
                                |.|..|.. |.:.|.|:..:.|| ......||||:        ..
plant  1890 FIFGPWKFALEKKRGSAESLEAEMVEYLKEQIGTRFISMIVEKIGNIRSHIKDIN--------VS 1946

  Fly  2045 HKNYGKGKPSPG---LELIRTLIKALSVDKTLAEQINELRRNMLRLVGIGEFSDLAEWEDPCDSH 2106
            ..::..|:...|   .|.|:.:...|::|:.:.:.:..:|:.:|:.:.:.|.:..||:.||..|.
plant  1947 DASWASGQAPKGDYTFEFIQIITAVLALDQNVQQDVLVMRKILLKYIKVKECAAEAEFIDPGPSF 2011

  Fly  2107 IINEVICKACNHCRDLDLCKDKHRAMKDGVPVWLCA--QCYVAYDNEEIEMRMLDALQRKMMSYV 2169
            |:..|.|..|...||||.|:|.....:   ..|.||  ||...||.|:||..::..::::...|.
plant  2012 ILPNVACSNCGAYRDLDFCRDSALLTE---KEWSCADPQCVKIYDKEQIESSIIQMVRQRERMYQ 2073

  Fly  2170 LQDLRCSRCSEIKRENLAEFCTCAGNFVPLISGKDIQTLLGTFNKVAANHKMQLLQQTV 2228
            ||||.|:||:::|..:|.|.|.|:|:|....||.|....:..|..:|...|.:||::.:
plant  2074 LQDLVCNRCNQVKAAHLTEQCECSGSFRCKESGSDFHKRIEIFLDIAKRQKFRLLEECI 2132

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DNApol-epsilon255	NP_524462.2	DNA_polB_epsilon_exo	266..469	CDD:99822	127/203 (63%)
		POLBc_epsilon	529..1154	CDD:99918	342/630 (54%)
		DUF1744	1529..1930	CDD:369900	117/409 (29%)
TIL2	NP_001325161.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	336	1.000	Domainoid score	I252
eggNOG	1	0.900	-	-		E1_COG0417
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4539
Inparanoid	1	1.050	1610	1.000	Inparanoid score	I8
OMA	1	1.010	-	-		QHG55019
OrthoDB	1	1.010	-	-		D39650at2759
OrthoFinder	1	1.000	-	-		FOG0004282
OrthoInspector	1	1.000	-	-		otm2849
orthoMCL	1	0.900	-	-		OOG6_101586
Panther	1	1.100	-	-	O	PTHR10670
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3018
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.840