DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DNApol-epsilon255 and pold1

DIOPT Version :9

Sequence 1:	NP_524462.2	Gene:	DNApol-epsilon255 / 42758	FlyBaseID:	FBgn0264326	Length:	2236	Species:	Drosophila melanogaster
Sequence 2:	NP_001034899.1	Gene:	pold1 / 556456	ZFINID:	ZDB-GENE-060429-1	Length:	1105	Species:	Danio rerio

Alignment Length:	1272	Identity:	251/1272 - (19%)
Similarity:	409/1272 - (32%)	Gaps:	475/1272 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   140 PN-----HLSGLQQQYIKLSFLNQTAMTKVRRELMSAVKRNQERQKSNTYYMQMLATSLAQSSAG 199
            ||     ||:|.|                  |||.|.|.::....|.|     :..|.||.....
Zfish   146 PNGFTNAHLAGFQ------------------RELNSVVLKDMRSNKDN-----IAVTVLAVDITK 187

  Fly   200 SEDA--TLGKRQQDYMDCIVDIR---------------------------EHDVPYHVRVSIDLR 235
            .|..  ..|.:..|::...:.:.                           |.::.:.:|..:|..
Zfish   188 KESMYNYHGNKPHDFLRITMAMPRLVAPAKRLLEQGFKFANFATQSYQAFEANIDFEIRFMVDSN 252

  Fly   236 IFCGQW-------YNIR------------------CRSGVEL--PTITCRP--DILDRPEPV-VL 270
            :....|       |.:|                  |:..|::  .::...|  ....|..|: ||
Zfish   253 VVGCCWIELPKGKYQLREERREGQTDSKYPGKVSLCQYEVDVAWDSLISHPAEGEWQRIAPLRVL 317

  Fly   271 AFDIETTKLPLKFPDAQTDQVMMISYMIDGQG----------YLITNREIISSNVDDFEYTPKPE 325
            :||||.......||:.:.|.|:.|:.|:..||          .|.:...|:.|.:
Zfish   318 SFDIECAGRKGVFPEPEVDPVIQIASMVQRQGEKEPFIRTVFTLQSCASIVGSQI---------- 372

  Fly   326 FEGNFIVFNEENEMQLLQRFFDHIMEVRPHIIVTYNGDFFDWPFVETRAAVYDLDMKQEIG---- 386
                 :.|.:|..|  ||.:.:.:..|.|.||..||...||.|::..|||...::|...:|
Zfish   373 -----LCFTQEKLM--LQSWAEFMRTVDPDIITGYNIQNFDLPYLLNRAATLKVNMFPYLGRVWG 430

  Fly   387 -FSKLRDGNYLSRP-------------AIHMDCLCWVKRDSYLPVGSQGLKAVAKAKLRYDPVEL 437
             .|.|:|.::.|:.             .:..|.|..:.||..|  .|..|.||:     :..::.
Zfish   431 CKSVLKDSSFQSKQMGRRENKTINMEGRVQFDLLQVLLRDYKL--RSYTLNAVS-----FHFLQE 488

  Fly   438 DPEDMCRMAVEQPQ--------VLANYSVSDAVATYYLYMKYVHPFIFALN-------TIIPMEP 487
            ..||:....:...|        .||.|.:.||    ||.::.:...:..:|       |.:|:
Zfish   489 QKEDVQHSIITDLQNGNEQTRRRLAVYCLKDA----YLPLRLLQKLMCVINYMEMARVTGVPL-- 547

  Fly   488 DEILRKGSGTLCETLLMVEAYHAQIVYPNKHQSELNKLSNEGHVLDSETYVGGHVEALESGVFRA 552
            ..:|.:|......:.|:.:|....:|.|        .:..||    .|.|.|..|
Zfish   548 TYLLSRGQQIKVVSQLLRQAMKQDLVMP--------VVKTEG----GEDYTGATV---------- 590

  Fly   553 DIPCRFRLDPAMVKQLQEQVDAVLRHAIEVEEGIPLEKVLNLDEVRQEIVQGLQGLHDIPNRLEQ 617
                                       ||.|                      :|.:.:|
Zfish   591 ---------------------------IEPE----------------------KGYYSVP----- 601

  Fly   618 PVIYHLDVGAMYPNIIL------TNRLQPSAMVSDLDCAACDFNKP---GVRCKRSMDWLWRGEM 673
              |..||..::||:|::      |..||.| .:..|.....||.|.   .:..|.|:    |..:
Zfish   602 --IATLDFSSLYPSIMMAHNLCYTTLLQKS-QIEKLGLGPDDFIKTPTGDLFVKSSV----RKGL 659

  Fly   674 LPASRNEFQRIQQQLETEKFPPLFPGGPQRAFHELSKEDQAAYEKKRLTDYCRKAYKKTKLTKLE 738
            ||      :.::..|...|          ||..||.||          ||    .:||..|
Zfish   660 LP------EILENLLSARK----------RAKAELKKE----------TD----PFKKQVL---- 690

  Fly   739 TRTSTICQKENSFYVDTVRAFRDRRYEYKGLTKVAKASVNAAVASGDAAEIKAAKGREVLYDSLQ 803
                                                                         |..|
Zfish   691 -------------------------------------------------------------DGRQ 694

  Fly   804 LAHKCILNSFYGYVMRRGARWHSMPMAGIVCLTGSNIITK-AREIIERVGRPLELDTDGIWCILP 867
            ||.|...||.||:.   ||:...:|     ||..|..:|. .|::||:..:.:|
Zfish   695 LALKISANSVYGFT---GAQVGKLP-----CLEISQSVTGFGRQMIEQTKQLVE----------- 740

  Fly   868 GSFPQEFTIHTSHEKKKKINISYPNAVLNTMVKDHFTNDQYHELRKDKE-------NNLPKYDIR 925
                ..:|:...::...|:.....::|   |||......| ..:.:.||       :.:|...:.
Zfish   741 ----SRYTLDNGYQADAKVIYGDTDSV---MVKLGVATVQ-EAMNQGKEAAEWVSSHFVPPIKLE 797

  Fly   926 DENSIFFEVDGPYLAMVLPAAKEEGKKLKKRYAVFNFDGTL-----AELKGFEVKRRGELQLIKN 985
                 |.:|..|||.:           .|||||...|..:.     .:.||.|..||....|:.|
Zfish   798 -----FEKVYYPYLLI-----------NKKRYAGLYFSSSAEHHDKMDCKGIETVRRDNCPLVAN 846

  Fly   986 FQSSVFEAFLAGSTLEECYASVAKVADYWLDVLYSRGSNLPDSELFELISENKSMSKKLEEYGAQ 1050
            ..::..:..|.....:   .:|....:...|:|.:|      .::.:|:. .|.:::..:|| |.
Zfish   847 LINTCLQNILIDRDPD---GAVTHAKEVISDLLCNR------IDISQLVI-TKELTRTAQEY-AG 900

  Fly  1051 KSTSISTAKRLAEFLGEQMVKDAGLA------CKYIISKKPEG-APVTERAIPLAIFQSE-PSVR 1107
            |...:..|:|:.:       :|||.|      ..|:|.|..:| |...:...|:.:.::. |...
Zfish   901 KQAHVELAERMRK-------RDAGSAPNLGDRVPYVIIKAAKGVAAYMKSEDPIYVLENNIPIDT 958

  Fly  1108 RHHLRRWLK-------DNTMGDADIRDVL---DW----NYYIERLGGTI---QKIITIPAALQGL 1155
            :::|.:.|.       :..:|::....||   |.    .....|:||.:   ||..|.......|
Zfish   959 QYYLEQQLSKPLLRIFEPILGESKAESVLLKGDHTRCKTVLTSRVGGLMAFAQKRSTCIGCRAVL 1023

  Fly  1156 ANPVPRVQHPDWLHKKMLEKNDVLKQRRINEMFTSRPKPKPLATE---------EDKLADMEDLA 1211
            ...|...   |:..|:..|    |.|:.|..:.|...|...|.|:         ||.|....|
Zfish  1024 KTDVAVC---DFCKKRESE----LYQKEIAHLSTLEEKFSRLWTQCQRCQGSLHEDVLCTSRD-- 1079

  Fly  1212 GKDGGEGAAGCPIVTKRKRIQLEEHDDEEAQPQATTW 1248
                      |||...||::| ::.||:|.......|
Zfish  1080 ----------CPIFYMRKKVQ-KDLDDQEKLVSRFGW 1105

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNApol-epsilon255	NP_524462.2	DNA_polB_epsilon_exo	266..469	CDD:99822	60/239 (25%)
		POLBc_epsilon	529..1154	CDD:99918	126/671 (19%)
		DUF1744	1529..1930	CDD:369900
pold1	NP_001034899.1	PTZ00166	59..1104	CDD:240301	250/1269 (20%)
		DNA_polB_delta_exo	308..537	CDD:99820	62/256 (24%)
		POLBc_delta	583..978	CDD:99916	115/621 (19%)
		zf-C4pol	1016..1086	CDD:290959	19/88 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0417
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900