Protein Alignment DNApol-epsilon255 and POLE

DIOPT Version :9

• Sequence 1: NP_524462.2
• Gene: DNApol-epsilon255 / 42758
• FlyBaseID: FBgn0264326
• Length: 2236
• Species: Drosophila melanogaster
• Sequence 2: XP_011533097.1
• Gene: POLE / 5426
• HGNCID: 9177
• Length: 2298
• Species: Homo sapiens
• Alignment Length: 2267
• Identity: 1257/2267 - (55%)
• Similarity: 1624/2267 - (71%)
• Gaps: 118/2267 - (5%)

  Fly     1 MSDSSKGKVLQNTGKFVSENRTEGDDFFNEAGYR--QSRENDKIDSKYGFDRVKDSQERTGYLIN 63
            ||..|.|:...:.|.....:|.:|......|..|  :|:..||:|.::||:|:|:..|:||:|||
Human     1 MSLRSGGRRRADPGADGEASRDDGATSSVSALKRLERSQWTDKMDLRFGFERLKEPGEKTGWLIN 65

  Fly    64 MHSNEVLDEDRRLIAALDLFFIQMDGSRFKCTVAYQPYLLIRPEDNMHLEVARFLGRKYSGQISG 128
            ||..|:||||:||.:|:|.:|||.||||||..:.|:||..|........||:.||.:|:.|:|:.
Human    66 MHPTEILDEDKRLGSAVDYYFIQDDGSRFKVALPYKPYFYIATRKGCEREVSSFLSKKFQGKIAK 130

  Fly   129 LEHITKEDLDLPNHLSGLQQQYIKLSFLNQTAMTKVRRELMSAVKRNQERQKSNTYYMQMLATSL 193
            :|.:.||||||||||.||::.||:|||.....:.|||:|:..|||:|:|:..::..|..:|::.|
Human   131 VETVPKEDLDLPNHLVGLKRNYIRLSFHTVEDLVKVRKEISPAVKKNREQDHASDAYTALLSSVL 195

  Fly   194 AQSSAGSEDATLGKRQQDYMDCIVDIREHDVPYHVRVSIDLRIFCGQWYNIRCRSGVELPTITCR 258
            .:....:::....|:..|.:|.|||:||:|||||:|:||||:|....|||:|.|.......||.|
Human   196 QRGGVITDEEETSKKIADQLDNIVDMREYDVPYHIRLSIDLKIHVAHWYNVRYRGNAFPVEITRR 260

  Fly   259 PDILDRPEPVVLAFDIETTKLPLKFPDAQTDQVMMISYMIDGQGYLITNREIISSNVDDFEYTPK 323
            .|:::||:||||||||||||||||||||:|||:|||||||||||||||||||:|.:::|||:|||
Human   261 DDLVERPDPVVLAFDIETTKLPLKFPDAETDQIMMISYMIDGQGYLITNREIVSEDIEDFEFTPK 325

  Fly   324 PEFEGNFIVFNEENEMQLLQRFFDHIMEVRPHIIVTYNGDFFDWPFVETRAAVYDLDMKQEIGFS 388
            ||:||.|.||||.:|..|:||:|:|:.|.:|.|:||||||||||||||.||||:.|.|:|||||.
Human   326 PEYEGPFCVFNEPDEAHLIQRWFEHVQETKPTIMVTYNGDFFDWPFVEARAAVHGLSMQQEIGFQ 390

  Fly   389 KLRDGNYLSRPAIHMDCLCWVKRDSYLPVGSQGLKAVAKAKLRYDPVELDPEDMCRMAVEQPQVL 453
            |...|.|.:...||||||.||||||||||||..|||.|||||.|||||||||||||||.||||.|
Human   391 KDSQGEYKAPQCIHMDCLRWVKRDSYLPVGSHNLKAAAKAKLGYDPVELDPEDMCRMATEQPQTL 455

  Fly   454 ANYSVSDAVATYYLYMKYVHPFIFALNTIIPMEPDEILRKGSGTLCETLLMVEAYHAQIVYPNKH 518
            |.||||||||||||||||||||||||.|||||||||:||||||||||.||||:|:||.|::|||.
Human   456 ATYSVSDAVATYYLYMKYVHPFIFALCTIIPMEPDEVLRKGSGTLCEALLMVQAFHANIIFPNKQ 520

  Fly   519 QSELNKLSNEGHVLDSETYVGGHVEALESGVFRADIPCRFRLDPAMVKQLQEQVDAVLRHAIEVE 583
            :.|.|||:::|||||||||||||||||||||||:|||||||::||....|.::|:..||||:|.|
Human   521 EQEFNKLTDDGHVLDSETYVGGHVEALESGVFRSDIPCRFRMNPAAFDFLLQRVEKTLRHALEEE 585

  Fly   584 EGIPLEKVLNLDEVRQEIVQGLQGLHDIPNRLEQPVIYHLDVGAMYPNIILTNRLQPSAMVSDLD 648
            |.:|:|:|.|.:||..||...|..|.|:|:|:|.|:|||||||||||||||||||||||||.:..
Human   586 EKVPVEQVTNFEEVCDEIKSKLASLKDVPSRIECPLIYHLDVGAMYPNIILTNRLQPSAMVDEAT 650

  Fly   649 CAACDFNKPGVRCKRSMDWLWRGEMLPASRNEFQRIQQQLETEKFPPLFPGGPQRAFHELSKEDQ 713
            ||||||||||..|:|.|.|.||||.:||||:|:.|||.|||:||||||||.||.|||||||:|:|
Human   651 CAACDFNKPGANCQRKMAWQWRGEFMPASRSEYHRIQHQLESEKFPPLFPEGPARAFHELSREEQ 715

  Fly   714 AAYEKKRLTDYCRKAYKKTKLTKLETRTSTICQKENSFYVDTVRAFRDRRYEYKGLTKVAKASVN 778
            |.|||:||.|||||||||..:||:|.|.:||||:||||||||||||||||||:|||.||.|..::
Human   716 AKYEKRRLADYCRKAYKKIHITKVEERLTTICQRENSFYVDTVRAFRDRRYEFKGLHKVWKKKLS 780

  Fly   779 AAVASGDAAEIKAAKGREVLYDSLQLAHKCILNSFYGYVMRRGARWHSMPMAGIVCLTGSNIITK 843
            |||..|||||:|..|..||||||||||||||||||||||||:||||:||.||||||.||:||||:
Human   781 AAVEVGDAAEVKRCKNMEVLYDSLQLAHKCILNSFYGYVMRKGARWYSMEMAGIVCFTGANIITQ 845

  Fly   844 AREIIERVGRPLELDTDGIWCILPGSFPQEFTIHTSHEKKKKINISYPNAVLNTMVKDHFTNDQY 908
            |||:||::|||||||||||||:||.|||:.|...|::.||.|:.||||.|:||.|||:.||||||
Human   846 ARELIEQIGRPLELDTDGIWCVLPNSFPENFVFKTTNVKKPKVTISYPGAMLNIMVKEGFTNDQY 910

  Fly   909 HELRKDKENNLPKYDIRDENSIFFEVDGPYLAMVLPAAKEEGKKLKKRYAVFNFDGTLAELKGFE 973
            .||   .|.:...|..|.|||||||||||||||:|||:|||||||||||||||.||:||||||||
Human   911 QEL---AEPSSLTYVTRSENSIFFEVDGPYLAMILPASKEEGKKLKKRYAVFNEDGSLAELKGFE 972

  Fly   974 VKRRGELQLIKNFQSSVFEAFLAGSTLEECYASVAKVADYWLDVLYSRGSNLPDSELFELISENK 1038
            |||||||||||.||||||||||.||||||.|.|||||||||||||||:.:|:||||||||||||:
Human   973 VKRRGELQLIKIFQSSVFEAFLKGSTLEEVYGSVAKVADYWLDVLYSKAANMPDSELFELISENR 1037

  Fly  1039 SMSKKLEEYGAQKSTSISTAKRLAEFLGEQMVKDAGLACKYIISKKPEGAPVTERAIPLAIFQSE 1103
            |||:|||:||.|||||||||||||||||:||||||||:|:||||:||||:|||||||||||||:|
Human  1038 SMSRKLEDYGEQKSTSISTAKRLAEFLGDQMVKDAGLSCRYIISRKPEGSPVTERAIPLAIFQAE 1102

  Fly  1104 PSVRRHHLRRWLKDNTMGDADIRDVLDWNYYIERLGGTIQKIITIPAALQGLANPVPRVQHPDWL 1168
            |:||:|.||:|||.:::.|.|||.:|||:|||||||..||||||||||||.:.||||||:|||||
Human  1103 PTVRKHFLRKWLKSSSLQDFDIRAILDWDYYIERLGSAIQKIITIPAALQQVKNPVPRVKHPDWL 1167

  Fly  1169 HKKMLEKNDVLKQRRINEMFT------------SRPKPKPLATEEDKLADMEDLAGKDGGEGAAG 1221
            |||:||||||.||::|:|:||            |...|:|.|      .||||.........||
Human  1168 HKKLLEKNDVYKQKKISELFTLEGRRQVTMAEASEDSPRPSA------PDMEDFGLVKLPHPAA- 1225

  Fly  1222 CPIVTKRKRIQLEEHDDEEAQPQATTWRQALGAPPPIGETRKTIVEWVRFQKKKWKWQQDQR--Q 1284
             |:..||||:..|..::.:.......|::.||.||.:|.:::..:.|:||.||||:.|..||  :
Human  1226 -PVTVKRKRVLWESQEESQDLTPTVPWQEILGQPPALGTSQEEWLVWLRFHKKKWQLQARQRLAR 1289

  Fly  1285 RNRQASKRTRGEDPPVVRATGSTATLGGFLRRAQRTLLDQPWQIVQLVPVDDLGHFTVWALIGEE 1349
            |.||..:...|...|.....|....||.||||..|::||.||||||:......|.|.:|||:|.:
Human  1290 RKRQRLESAEGVLRPGAIRDGPATGLGSFLRRTARSILDLPWQIVQISETSQAGLFRLWALVGSD 1354

  Fly  1350 LHKIKLTVPRIFYVNQRSAAPPEEGQLWRKVNRVLPRSRPVFNLYRYSVPEQLFRDNSLGMLADL 1414
            ||.|:|::||:|||||| .|..|||..:||||||||||..|:|||.|||||.:::::...:.|:|
Human  1355 LHCIRLSIPRVFYVNQR-VAKAEEGASYRKVNRVLPRSNMVYNLYEYSVPEDMYQEHINEINAEL 1418

  Fly  1415 ATPDIEGIYETQMTLEFRALMDMGCICGVQREEARRLAQLATKDLETFSIEQLEQRPQTQVKYLA 1479
            :.|||||:||||:.|.||||:.:||:|.|.::..|.|:..   :.|||::|.||.|...|..||.
Human  1419 SAPDIEGVYETQVPLLFRALVHLGCVCVVNKQLVRHLSGW---EAETFALEHLEMRSLAQFSYLE 1480

  Fly  1480 SANNRLRKIYLYQHNTPTAKKEIWSLILMPSKKAFVFALDTVRANQMPNMRQLYTAERLALLKNL 1544
            ..:  :|.||||.|  ..|.|.::.:.:...::|.||.|||||:||||::..||:||...||:.:
Human  1481 PGS--IRHIYLYHH--AQAHKALFGIFIPSQRRASVFVLDTVRSNQMPSLGALYSAEHGLLLEKV 1541

  Fly  1545 TAEEQDKIPVEDYTFEVLIEVDVKQIYRHIQRALTTYKQEHQGPTILCLQTALSARKLSLAMPIL 1609
            ..|   .:|...:||||..|.|:|.|.|.|||.|..||:|.:|||::.:|::...::|:..:|:|
Human  1542 GPE---LLPPPKHTFEVRAETDLKTICRAIQRFLLAYKEERRGPTLIAVQSSWELKRLASEIPVL 1603

  Fly  1610 LEFPQAEIHISDDASLLSGLDWQRQGSRAVIRHFLNLNNVLDLMLDQCRYFHVPIGNMPPDTVLF 1674
            .|||...|.::|..: ...|||||.|:|.:|||:|||:..|....:..||||:||||:|.|...|
Human  1604 EEFPLVPICVADKIN-YGVLDWQRHGARRMIRHYLNLDTCLSQAFEMSRYFHIPIGNLPEDISTF 1667

  Fly  1675 GADLFFARLLQRHNFVLWWSASTRPDLGGREADDSRLLAEFEESISVVQNKAGFYPDVCVELALD 1739
            |:||||||.|||||.:||.|.:.||||||:||||:.|:.||::..:|..|.:|.|..|||||.|.
Human  1668 GSDLFFARHLQRHNHLLWLSPTARPDLGGKEADDNCLVMEFDDQATVEINSSGCYSTVCVELDLQ 1732

  Fly  1740 SLAVSALLQSTRIQEMEGASS-AITFDVMPQVSLEEMIGTVPAATLP-SYDETALCSAAFRVMRS 1802
            :|||:.:|||..:.:||||.| .|:|||:.|.|||:||....||:.| |||||||||..||:::|
Human  1733 NLAVNTILQSHHVNDMEGADSMGISFDVIQQASLEDMITGGQAASAPASYDETALCSNTFRILKS 1797

  Fly  1803 MVNGWLREVSINRNIFSDFQIVHFYRWVRSSNALLYDPALRRSLNNLMRKMFLRIIAEFKRLGAT 1867
            ||.||::|::...||::|.|::|||||:||.::||:||||.|:|:|:|:|:||::||||||||::
Human  1798 MVVGWVKEITQYHNIYADNQVMHFYRWLRSPSSLLHDPALHRTLHNMMKKLFLQLIAEFKRLGSS 1862

  Fly  1868 IIYADFNRIILSSGKKTVSDALGYVDYIVQSLRNKEMFHSIQLSFEQCWNFMLWMDQANFSGIRG 1932
            :|||:||||||.:.|:.|.||:.||:||..|:.:||.|||:.:||.:||.|:||||.:|:.||:|
Human  1863 VIYANFNRIILCTKKRRVEDAIAYVEYITSSIHSKETFHSLTISFSRCWEFLLWMDPSNYGGIKG 1927

  Fly  1933 KLPKGIDETVSSIVSTTMIRDSER--NQDDDEDEEEDSENRDPVESNEAEQDQEDELSLELNWTI 1995
            |        |||.:... ::||::  ..:|:::.|:|.|.||..|..|||:...::| ||.||.|
Human  1928 K--------VSSRIHCG-LQDSQKAGGAEDEQENEDDEEERDGEEEEEAEESNVEDL-LENNWNI 1982

  Fly  1996 GEHLPDENECREKFESLLTLFMQSLAE------------------------KKTTEQAI------ 2030
            .:.||....|:..|..:::.::.::..                        .:..|.|:
Human  1983 LQFLPQAASCQNYFLMIVSAYIVAVYHCMKDGLRRSAPGSTPVRRRGASQLSQEAEGAVGALPGM 2047

  Fly  2031 ---------KDISHCAFDFILKLHKNYGKGKPS-------------------PGLELIRTLIKAL 2067
                     .:::...|....|:.|.....:.|                   |.||.|:.:.|.|
Human  2048 ITFSQDYVANELTQSFFTITQKIQKKVTGSRNSTELSEMFPVLPGSHLLLNNPALEFIKYVCKVL 2112

  Fly  2068 SVDKTLAEQINELRRNMLRLVGIGEFSDLAEWEDPCDSHIINEVICKACNHCRDLDLCKDKHRAM 2132
            |:|..:..|:|:|.|::||||.:||||:.|::.|||.|:::.||||::||.|||||||||...:
Human  2113 SLDTNITNQVNKLNRDLLRLVDVGEFSEEAQFRDPCRSYVLPEVICRSCNFCRDLDLCKDSSFS- 2176

  Fly  2133 KDG--VPVWLCAQCYVAYDNEEIEMRMLDALQRKMMSYVLQDLR----CSRCSEIKR 2183
            :||  :|.|||:.|...||:..|||.:::.||:|:|::.|||||    ..:|.|.:|
Human  2177 EDGAVLPQWLCSNCQAPYDSSAIEMTLVEVLQKKLMAFTLQDLRKEADTPKCEEKER 2233

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DNApol-epsilon255	NP_524462.2	DNA_polB_epsilon_exo	266..469	CDD:99822	154/202 (76%)
		POLBc_epsilon	529..1154	CDD:99918	466/624 (75%)
		DUF1744	1529..1930	CDD:369900	205/402 (51%)
POLE	XP_011533097.1	PolB	99..1165	CDD:223494	745/1068 (70%)
		DNA_polB_epsilon_exo	268..471	CDD:99822	154/202 (76%)
		POLBc_epsilon	531..1153	CDD:99918	466/624 (75%)
		DUF1744	1529..1925	CDD:285663	205/399 (51%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158695
Domainoid	1	1.000	417	1.000	Domainoid score	I653
eggNOG	1	0.900	-	-		E1_COG0417
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4539
Inparanoid	1	1.050	2471	1.000	Inparanoid score	I32
Isobase	1	0.950	-	0	Normalized mean entropy	S834
OMA	1	1.010	-	-		QHG55019
OrthoDB	1	1.010	-	-		D16244at33208
OrthoFinder	1	1.000	-	-		FOG0004282
OrthoInspector	1	1.000	-	-		oto91852
orthoMCL	1	0.900	-	-		OOG6_101586
Panther	1	1.100	-	-	LDO	PTHR10670
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R346
SonicParanoid	1	1.000	-	-		X3018
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	18	17.750