Protein Alignment DNApol-epsilon255 and POLD1

DIOPT Version :9

• Sequence 1: NP_524462.2
• Gene: DNApol-epsilon255 / 42758
• FlyBaseID: FBgn0264326
• Length: 2236
• Species: Drosophila melanogaster
• Sequence 2: NP_001295561.1
• Gene: POLD1 / 5424
• HGNCID: 9175
• Length: 1133
• Species: Homo sapiens
• Alignment Length: 1197
• Identity: 215/1197 - (17%)
• Similarity: 376/1197 - (31%)
• Gaps: 471/1197 - (39%)

  Fly   221 EHDVPYHVRVSIDLRIFCGQW-------YNIRCR---SGVELPTITCRPDILDRP--------EP 267
            |.:|.:.:|..:|..|....|       |.:|.:   :..:|.......|::..|        .|
Human   245 EANVDFEIRFMVDTDIVGCNWLELPAGKYALRLKEKATQCQLEADVLWSDVVSHPPEGPWQRIAP 309

  Fly   268 V-VLAFDIETTKLPLKFPDAQTDQVMMISYM----IDGQGYL---ITNR---EIISSNVDDFEYT 321
            : ||:||||.......||:.:.|.|:.|..:    .:.:.:|   :|.|   .|:.:.|..:
Human   310 LRVLSFDIECAGRKGIFPEPERDPVIQICSLGLRWGEPEPFLRLALTLRPCAPILGAKVQSY--- 371

  Fly   322 PKPEFEGNFIVFNEENEMQLLQRFFDHIMEVRPHIIVTYNGDFFDWPFVETRAAVYDLDMKQEIG 386
                          |.|..|||.:...|..:.|.:|..||...||.|::.:||....:.....:|
Human   372 --------------EKEEDLLQAWSTFIRIMDPDVITGYNIQNFDLPYLISRAQTLKVQTFPFLG 422

  Fly   387 -----FSKLRDGNYLSRPA-------------IHMDCLCWVKRDSYLPVGSQGLKAVA------- 426
                 .|.:||.::.|:..             :.||.|..:.|:..|  .|..|.||:
Human   423 RVAGLCSNIRDSSFQSKQTGRRDTKVVSMVGRVQMDMLQVLLREYKL--RSYTLNAVSFHFLGEQ 485

  Fly   427 KAKLRYDPVELDPEDMCRMAVEQPQVLANYSVSDAVATYYLYMKYVHPFIFALNTI-------IP 484
            |..:::..:    .|:.....:..:.||.|.:.||    ||.::.:...:..:|.:       :|
Human   486 KEDVQHSII----TDLQNGNDQTRRRLAVYCLKDA----YLPLRLLERLMVLVNAVEMARVTGVP 542

  Fly   485 MEPDEILRKGSGTLCETLLMVEAYHAQIVYPNKHQSELNKLSNEGHVLDSETYVGGHVEALESGV 549
            :  ..:|.:|......:.|:.:|.|..::.|        .:.:||    .|.|.|..|
Human   543 L--SYLLSRGQQVKVVSQLLRQAMHEGLLMP--------VVKSEG----GEDYTGATV------- 586

  Fly   550 FRADIPCRFRLDPAMVKQLQEQVDAVLRHAIEVEEGIPLEKVLNLDEVRQEIVQGLQGLHDIPNR 614
                      ::|....:.|::..|.                       .|::....|....|.|
Human   587 ----------IEPLKGVRPQDRAGAA-----------------------WELLALTPGRGCSPPR 618

  Fly   615 LEQPVIYHLDVGAMYPNIILTNRLQPSAMVSDLDCAACDFNKPGVRCKRSMDWLWRGEMLPASRN 679
            .....|..||..::||:|::.:.|..:.::           :||.           .:.|..:.:
Human   619 YYDVPIATLDFSSLYPSIMMAHNLCYTTLL-----------RPGT-----------AQKLGLTED 661

  Fly   680 EFQRIQQQLETEKFPPLFPGGPQRAFHELSKEDQAAYEKKRLTDYCRKAYKKTKLTKLETRTSTI 744
            :|.|.             |.|                     .::.:.:.:|..|.::
Human   662 QFIRT-------------PTG---------------------DEFVKTSVRKGLLPQI------- 685

  Fly   745 CQKENSFYVDTVRAFRDRRYEYKGLTKVAKASVNAAVASGDAAEIKAAKGREVLYDSLQLAHKCI 809
                    ::.:.:.|.|          |||.:        |.|....: |:|| |..|||.|..
Human   686 --------LENLLSARKR----------AKAEL--------AKETDPLR-RQVL-DGRQLALKVS 722

  Fly   810 LNSFYGYVMRRGARWHSMPMAGIVCLTGSNIITK-AREIIERVGRPLEL---------------- 857
            .||.||:.   ||:...:|     ||..|..:|. .|::||:..:.:|.
Human   723 ANSVYGFT---GAQVGKLP-----CLEISQSVTGFGRQMIEKTKQLVESKYTVENGYSTSAKVVY 779

  Fly   858 -DTDGIWCILPGSFPQEFTIHTSHEKKKKINISYPNAVLNTM---------VKDHFTNDQYHELR 912
             |||.:.|                    :..:|   :|...|         |..||.:....|..
Human   780 GDTDSVMC--------------------RFGVS---SVAEAMALGREAADWVSGHFPSPIRLEFE 821

  Fly   913 KDKENNLPKYDIRDENSIFFEVDGPYLAMVLPAAKEEGKKLKKRYAVFNFDG-----TLAELKGF 972
            |                ::|    |||.:           .|||||...|..     ...:.||.
Human   822 K----------------VYF----PYLLI-----------SKKRYAGLLFSSRPDAHDRMDCKGL 855

  Fly   973 EVKRRGELQLIKNFQSSVFEAFLAGSTLEECYASVAKVADYWLDVLYSRGSNLPDSELFELISEN 1037
            |..||....|:.|..::.....|.....|   .:||...|...|:|.:|      .::.:|:. .
Human   856 EAVRRDNCPLVANLVTASLRRLLIDRDPE---GAVAHAQDVISDLLCNR------IDISQLVI-T 910

  Fly  1038 KSMSKKLEEYGAQKSTSISTAKRLAEFLGEQMVKDAGLACKYIISKKPEGAPVTERAIPLAIFQS 1102
            |.:::...:| |.|...:..|:|:.:                   :.|..||.....:|..|..:
Human   911 KELTRAASDY-AGKQAHVELAERMRK-------------------RDPGSAPSLGDRVPYVIISA 955

  Fly  1103 EPSVRRHHLRRWLKDNTMGDADIRDVL------DWNYYIERLGGTIQKIITIPAALQGLANPVPR 1161
            ...|..:          |...|...||      |..||:|                |.||.|:.|
Human   956 AKGVAAY----------MKSEDPLFVLEHSLPIDTQYYLE----------------QQLAKPLLR 994

  Fly  1162 VQHP------------------------------------------------------------- 1165
            :..|
Human   995 IFEPILGEGRAEAVLLRGDHTRCKTVLTGKVGGLLAFAKRRNCCIGCRTVLSHQGAVCEFCQPRE 1059

  Fly  1166 DWLHKKMLEKNDVLKQRRINEMFTSRPKPKPLATEEDKLADMEDLAGKDGGEGAAGCPIVTKRKR 1230
            ..|::|.:...:.|:: |.:.::|...:.:. :..||.:....|            |||...||:
Human  1060 SELYQKEVSHLNALEE-RFSRLWTQCQRCQG-SLHEDVICTSRD------------CPIFYMRKK 1110

  Fly  1231 IQLEEHDDEEAQPQATTWRQALGAPPP 1257
            ::.:..|.|:.       .:..|.|.|
Human  1111 VRKDLEDQEQL-------LRRFGPPGP 1130

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DNApol-epsilon255	NP_524462.2	DNA_polB_epsilon_exo	266..469	CDD:99822	55/238 (23%)
		POLBc_epsilon	529..1154	CDD:99918	116/662 (18%)
		DUF1744	1529..1930	CDD:369900
POLD1	NP_001295561.1	PTZ00166	81..1126	CDD:240301	212/1191 (18%)
		DNA_polB_delta_exo	304..533	CDD:99820	56/255 (22%)
		POLBc_delta	579..1000	CDD:99916	121/669 (18%)
		zf-C4pol	1038..1108	CDD:290959	11/83 (13%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0417
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900