DRSC/TRiP Functional Genomics Resources

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Protein Alignment DNApol-epsilon255 and POLA1

DIOPT Version :9

Sequence 1:NP_524462.2 Gene:DNApol-epsilon255 / 42758 FlyBaseID:FBgn0264326 Length:2236 Species:Drosophila melanogaster
Sequence 2:NP_001317289.1 Gene:POLA1 / 5422 HGNCID:9173 Length:1468 Species:Homo sapiens


Alignment Length:1178 Identity:228/1178 - (19%)
Similarity:386/1178 - (32%) Gaps:411/1178 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   241 WYNIRCRSGVELPTITC-------RPDILD-----RPEP-VVLAFDIETTKLPLKFPDAQTDQVM 292
            |..::....:..|...|       :||:::     .|.| ||:||.::|.:      :|:..|..
Human   504 WLEVKSPQLLNQPVSWCKVEAMALKPDLVNVIKDVSPPPLVVMAFSMKTMQ------NAKNHQNE 562

  Fly   293 MI--------SYMIDGQGYLITNREIISSNVDDFEYTPKPEFEGNFIV------------FNE-- 335
            :|        |:.:|                   :..|||.|:.:|.|            |.|  
Human   563 IIAMAALVHHSFALD-------------------KAAPKPPFQSHFCVVSKPKDCIFPYAFKEVI 608

  Fly   336 ----------ENEMQLLQRFFDHIMEVRPHIIVTYNGDFFDWPFVETRAAVYDLDMKQEIGFSKL 390
                      ..|..||..|...:.::.|.|||.:|...|:...:..|..|.......:||  :|
Human   609 EKKNVKVEVAATERTLLGFFLAKVHKIDPDIIVGHNIYGFELEVLLQRINVCKAPHWSKIG--RL 671

  Fly   391 RDGN---------YLSRPAI--HMDCLCWVKRDSYLPVGSQGLKAVAKAKLRYDPVELDPEDMCR 444
            :..|         :..|.|.  .|.|...:.....:...|..|..:.:..|:.:.|.:..|::..
Human   672 KRSNMPKLGGRSGFGERNATCGRMICDVEISAKELIRCKSYHLSELVQQILKTERVVIPMENIQN 736

  Fly   445 MAVEQPQV--LANYSVSDAVATYYLYMKYVHPFIFALNTIIPME----------PDEILRKGSGT 497
            |..|..|:  |..::..||        |::...:..|| ::|:.          ....|..|...
Human   737 MYSESSQLLYLLEHTWKDA--------KFILQIMCELN-VLPLALQITNIAGNIMSRTLMGGRSE 792

  Fly   498 LCETLLMVEAYHAQIVYPNKH--QSELNKLSNEGHVLDSET--YVGGHVEALESGVFRADIPCRF 558
            ..|.||:...|....:.|:|.  :....||.:|...:|.:|  |..|..:|..:|        ..
Human   793 RNEFLLLHAFYENNYIVPDKQIFRKPQQKLGDEDEEIDGDTNKYKKGRKKAAYAG--------GL 849

  Fly   559 RLDPAMVKQLQEQVDAVLRHAIEVEEGIPLEKVLNLDEVRQEIVQGLQGLHDIPNRLEQPVIYHL 623
            .|||.:                                          |.:|       ..|..|
Human   850 VLDPKV------------------------------------------GFYD-------KFILLL 865

  Fly   624 DVGAMYPNIILTNRLQPSAMVSDLDCAACDFNKPGVRCKRSMDWLWRGEMLPASRNEFQRIQQQL 688
            |..::||:||.                  :||......:|             ..:|.|::.:..
Human   866 DFNSLYPSIIQ------------------EFNICFTTVQR-------------VASEAQKVTEDG 899

  Fly   689 ETEKFPPLFPGGPQRAFHELSKEDQAAYEKKRLTDYCRKAYKKTKLTKLETRTSTICQKENSFYV 753
            |.|:.|.|  ..|......|.:|                                          
Human   900 EQEQIPEL--PDPSLEMGILPRE------------------------------------------ 920

  Fly   754 DTVRAFRDRRYEYKGLTKVAKASVNAAVASGDAAEIKAAKGREVLYDSLQLAHKCILNSFYGYVM 818
              :|...:||.:.|.|.|  :..:|..:.              :.||..|.|.|...||.||.:.
Human   921 --IRKLVERRKQVKQLMK--QQDLNPDLI--------------LQYDIRQKALKLTANSMYGCLG 967

  Fly   819 RRGARWHSMPMAGIVCLTGSNIITKAREIIERVGRPLEL---DTDGIWCILPGSFPQEFTIHTSH 880
            ...:|:::.|:|.:|...|..|:...:|:::::.  ||:   |||.|                  
Human   968 FSYSRFYAKPLAALVTYKGREILMHTKEMVQKMN--LEVIYGDTDSI------------------ 1012

  Fly   881 EKKKKINISYPNAVLNTMVKDHFTN-DQYHELR---KDKENNLPKYDIRDENSIFFEVDGPYLAM 941
                             |:..:.|| ::..:|.   |.:.|.|.|.       :..::||.:.::
Human  1013 -----------------MINTNSTNLEEVFKLGNKVKSEVNKLYKL-------LEIDIDGVFKSL 1053

  Fly   942 VLPAAKEEGKKLKKRYAVF----NFDG---TLAELKGFEVKRRGELQLIKNFQSSVFEAFLAGST 999
            :|        ..||:||..    ..||   |..||||.::.||....|.|:..:.|....|:..:
Human  1054 LL--------LKKKKYAALVVEPTSDGNYVTKQELKGLDIVRRDWCDLAKDTGNFVIGQILSDQS 1110

  Fly  1000 LEECYASVAK-VADYWLDVLYSRGSNLPDSELFELISENKSMSKKLEEYGAQKSTSISTAKRLAE 1063
            .:....::.| :.:...:||   ..::|.|: ||:   ||:::|..::|..:||...........
Human  1111 RDTIVENIQKRLIEIGENVL---NGSVPVSQ-FEI---NKALTKDPQDYPDKKSLPHVHVALWIN 1168

  Fly  1064 FLGEQMVKDAGLACKYIISKKPEGAPVTERAIPLAIFQSEPSVRRHHLRRWLKDNTMGDADIRDV 1128
            ..|.:.|| ||....|:|.:.......::||......|.:             ||.        .
Human  1169 SQGGRKVK-AGDTVSYVICQDGSNLTASQRAYAPEQLQKQ-------------DNL--------T 1211

  Fly  1129 LDWNYYI-ERLGGTIQKI--------ITIPAALQGLANPVPRVQHPDWLHKKMLEKNDVL----- 1179
            :|..||: :::...:.:|        ..:.|...||.....||.|   .||.  |:||.|     
Human  1212 IDTQYYLAQQIHPVVARICEPIDGIDAVLIATWLGLDPTQFRVHH---YHKD--EENDALLGGPA 1271

  Fly  1180 -----KQRRINEMFTSRPKPKPLATEEDKLADMEDLAGKDGGEGAAGCPIVTKRKRIQLEEHDDE 1239
                 ::.|..|.|..   |.|....|:...::.|.:|.|.......|..:            |.
Human  1272 QLTDEEKYRDCERFKC---PCPTCGTENIYDNVFDGSGTDMEPSLYRCSNI------------DC 1321

  Fly  1240 EAQPQATTWRQALGAPPPIGETRKTIVEWVRFQKK---KWKWQQDQRQRNRQAS-----KRTRGE 1296
            :|.|...|          :..:.|.|::..||.||   .|...::...|||...     .||...
Human  1322 KASPLTFT----------VQLSNKLIMDIRRFIKKYYDGWLICEEPTCRNRTRHLPLQFSRTGPL 1376

  Fly  1297 DPPVVRAT 1304
            .|..::||
Human  1377 CPACMKAT 1384

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DNApol-epsilon255NP_524462.2 DNA_polB_epsilon_exo 266..469 CDD:99822 50/248 (20%)
POLBc_epsilon 529..1154 CDD:99918 117/650 (18%)
DUF1744 1529..1930 CDD:369900
POLA1NP_001317289.1 DNA_pol_alpha_N 41..101 CDD:289058
pol2 56..1231 CDD:273159 187/993 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 104..129
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 238..257
DNA_polB_alpha_exo 541..773 CDD:99819 54/267 (20%)
DNA-binding. /evidence=ECO:0000255 656..721 12/66 (18%)
POLBc_alpha 838..1248 CDD:99915 115/640 (18%)
DNA-binding. /evidence=ECO:0000255 1251..1382 36/160 (23%)
zf-DNA_Pol 1271..1461 CDD:286132 29/139 (21%)
CysB motif. /evidence=ECO:0000250|UniProtKB:P15436 1354..1380 6/25 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0417
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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