Protein Alignment DNApol-epsilon255 and DNApol-zeta

DIOPT Version :9

• Sequence 1: NP_524462.2
• Gene: DNApol-epsilon255 / 42758
• FlyBaseID: FBgn0264326
• Length: 2236
• Species: Drosophila melanogaster
• Sequence 2: NP_524881.2
• Gene: DNApol-zeta / 47186
• FlyBaseID: FBgn0002891
• Length: 2130
• Species: Drosophila melanogaster
• Alignment Length: 2165
• Identity: 408/2165 - (18%)
• Similarity: 676/2165 - (31%)
• Gaps: 842/2165 - (38%)

  Fly   100 PYLLIRPEDN--------------MHLEVARFLGRKYSGQ-ISGLEHITKEDL--DLPNH-LSGL 146
            |||.| |.|.              |||:.|..:.   .|| .|..:|:.|..|  .:|.: ...:
  Fly    69 PYLYI-PYDKKDFESLERGILQMAMHLDKAINIS---LGQGSSNAQHVFKIQLVKGIPFYGYHRV 129

  Fly   147 QQQYIKLSFLNQTAMTKVRRELMSAVKRNQERQKSNTYYMQMLATSLAQSSAGSEDATLGKRQQD 211
            :.|::|:...|...   |||                       |.:|.||.     |.|.|....
  Fly   130 EHQFLKIYMFNPRF---VRR-----------------------AANLLQSG-----AILSKNFSP 163

  Fly   212 YMDCIVDIREHDVPYHVRVSIDLRIFCGQWYNIRCRSGVELPTITCRPDILDRPEPVVLAFDIET 276
            :        |..|||.::..||        ||:...|.|.:|                    :|.
  Fly   164 H--------ESHVPYILQFMID--------YNLYGMSYVHVP--------------------LEV 192

  Fly   277 TKLPLKFPDAQTDQVMMISYMIDGQGYLI---TNREI--------ISSN--VDDFEYTPK----- 323
                |||.....|.|  |.|....|..|:   |.:::        :|||  ::.|:...|
  Fly   193 ----LKFRRNHDDDV--IPYANVKQAQLLDITTAKKVACSALEVDVSSNFILNRFQLVAKSKSNH 251

  Fly   324 --PEFEGNFIVFNEE--NEMQLLQRFFD----------HIMEVRP----HIIVTYNGDFFDWPFV 370
              |..|.   ::|:|  ...:|:::..|          .::|:.|    |.|.....|.|....:
  Fly   252 TNPGIEA---IWNDEKLRRQKLVEKHTDAGDEEKAEAVPVLELPPTQERHQIEIAESDIFYRTAL 313

  Fly   371 ETRAAVYDLDMKQEIGFSKLRDGNYLSRPAIHMDCLCWVKRDSYLPVGSQGLKAVAKAKLRYDPV 435
            |::....:.....|   ..|.|...|.:..:          .:.:|    |.||   .|.|::..
  Fly   314 ESKLMTLEQSTLSE---QTLSDQTILPQATM----------QTTMP----GTKA---QKRRFNLQ 358

  Fly   436 EL-----DPEDMCRMAVEQPQVLANYS-VSDAVATYYLYMKYVHPFIFALNTIIPMEPDEILRKG 494
            :|     .||:..:   :|.|:|.|.| :.:.|...|           :.:..:....||
  Fly   359 KLLANAVYPEECSQ---DQQQLLVNASFIQNHVTCGY-----------SSSVSLSTSKDE----- 404

  Fly   495 SGTLCET------LLMVEAYHAQIVYPNKHQSELNKLSNEGHVLDSETYVGGHVEALESGVFRAD 553
            |..|.||      :|.:...|..|.:....:.|..:|.:...:|:.:.....||: |:|.:....
  Fly   405 SDDLDETVVDEELILSLTQPHGAIPHDATLREEDLELLDALQLLEEQNESESHVD-LDSSLAPLS 468

  Fly   554 IPCRFRLDPAMVKQLQEQVDAVLRHAIEVEEGIPLE------KVL-NLDEVRQEIVQG------- 604
            ...:|.|.|.::.:......|:....::.:|....|      .|| ::||:..::.|.
  Fly   469 QHKKFELTPELLDKETAATAALFDEDVDSDEDADQETRHDFSTVLDDVDELLLKLTQSQPAESKE 533

  Fly   605 LQGLHDIP------NRLEQPVI------------------------------------------- 620
            |:....:|      :||::..|
  Fly   534 LKASSKLPQIDGADDRLQRTPIKSISSKSKSSPSKTPTTPIGQKSLPKSPRTPKTSAAKKYAPLA 598

  Fly   621 -------------------------YHLD----VGAMYPNIILTNRLQPSAM----------VSD 646
                                     ..||    .|.:.|.|.|..:|..|.|          :..
  Fly   599 LTIGSSSSKKSNDEFAGRPSNPRLSLQLDQGTGTGTLRPEISLRKKLAMSEMRRKSFEDSFVLLK 663

  Fly   647 LDC--------AACDFNKPGVRCKRSMDWLWRGEMLPASRNEFQRIQQQLETE---KFPPLFPGG 700
            .||        :..:.:|..:.|          .:.|..||  ..:....|||   :.||
  Fly   664 NDCTPVRSTRRSTSNLDKTHIIC----------SLTPRDRN--PGLSDMFETEDGKQLPP----- 711

  Fly   701 PQRAFHELSKEDQAAYEKKRLTDYCRKAYKKTKLTKLETRTSTICQKENSFYVDTVRAFRDRRYE 765
                             ||    ..||....|:...:|:.....|:.|           |..|.|
  Fly   712 -----------------KK----VVRKTRWSTRNQDIESLPKAGCEIE-----------RPHRSE 744

  Fly   766 YKGLTKV-----AKASVNAAVASGDAAEIKAAKGREVLYDSLQLAHKCILNSFYGYVMRRGARWH 825
            ...|.::     |:..||:|.....::||:.. |..|...||....|             .||..
  Fly   745 GSALDELKPRRSARHKVNSANPDECSSEIQTT-GPRVTTTSLDRPQK-------------KARLS 795

  Fly   826 SMP-------MAGIVCLTGS---------------NIITKAREIIERVGRPLELDTDGIWC---- 864
            ..|       |.|.|.|..:               |.:::..|.:|  .:|.:.|.....|
  Fly   796 QSPKENTKTSMNGTVALEKATKDSSSNSESPHQQENSVSEQIEYLE--SKPKKSDETARSCDEKL 858

  Fly   865 -----------ILPG---SFPQEFTIHTSHEKKKKINISYPNAVLNTMVKDHFTNDQYHELRKDK 915
                       |.||   :..:|.|....|::          |:.:....|:...    :|||..
  Fly   859 QRELIPQEPAGISPGDSANSTEEITFSPCHDE----------AIESDTESDYIVT----KLRKTP 909

  Fly   916 ENNLPKYDIRDE--NSIFFEVDGPYLAMVLPAAKEEGKKLKKRYAVFNFDGTLAELKGFEVKRRG 978
            .....::.||.|  |..|....|     :.|...|...:|..:   .|...|...::.|.
  Fly   910 NLKRLRWSIRSELLNKQFTPSSG-----IRPPETETTPQLSPK---SNESNTPELMRSFY----- 961

  Fly   979 ELQLIKNFQSSVFEAFL-------------------------------------AGS-------- 998
            |..||.| ..|||..||                                     :||
  Fly   962 EHSLIVN-SPSVFSDFLDSPEIHMDSPRSAPPSPDSNSFVIAPLELPPSYDEVVSGSRKMDIPEY 1025

  Fly   999 TLEECYAS----VAKVADYWLDVLYSRGSNLPDSELFELISENKSMSKKLEEYGAQKSTSISTAK 1059
            ..::.|.|    |:||.:....||:..|:.|.|.:.|:.|..|.                    :
  Fly  1026 EFQKPYYSNPSDVSKVTEVGFLVLHIPGNKLNDCDPFQSILGND--------------------R 1070

  Fly  1060 RLAEFLGEQMVKDAGLACKYIISKKPEGAPVTERAIPLAIFQSEPSVRRHHLRRWLKDNTMGDAD 1124
            .||.:...|::...|||                            .::||.          |:..
  Fly  1071 GLASWRRRQLIAIGGLA----------------------------MLQRHR----------GEQK 1097

  Fly  1125 IRDVLDWNYYIERLGGTIQKIITIPAALQGLANPVPRVQHPDWLHKKM-LEKNDVLKQRRINEMF 1188
            :|:     |:     .|.|:|...||.|.           |.|...|: |:..::|:||
  Fly  1098 VRE-----YF-----STQQRIAIEPAQLA-----------PTWQEAKIWLKAKELLRQR------ 1135

  Fly  1189 TSRPK------PKPLATEEDKLADMEDLAGKDGGEG--AAGCPIVTKRKRIQLEEHDDE-EAQPQ 1244
             ..||      ..|:..:..|:..|......|||.|  .||..:........|.:..|: :|.|.
  Fly  1136 -EEPKKSSDDIDSPIKIKRQKITMMLQAEEGDGGSGDEDAGEELDCSLSLTPLSQAKDKCKATPT 1199

  Fly  1245 ATTWRQALGAPPPIGETRKTIVEWVRFQKKKWKWQQDQRQRNRQASKRTRGEDPPVVRATGSTAT 1309
            ::..|          ||.|:.::  |..:..:...||:...:.|:|:::       |.::.:.|.
  Fly  1200 SSKAR----------ETGKSRLK--RGTRLSFIGSQDEEPPSSQSSEQS-------VSSSAAQAE 1245

  Fly  1310 L--GGFLRRAQRTLLDQPWQIVQLVPVDDLGHFTVWALIG-----EELHKIK-------LTVPRI 1360
            |  ..|||:.:.:..|:...:     ...|.|.|:....|     |.|.:.|       ||:..:
  Fly  1246 LDRSSFLRQLEGSSQDRQHDL-----SFGLSHATLDNTFGFKVNLENLQQAKADIDCNHLTIITL 1305

  Fly  1361 -FYVNQRSAAPPEEGQLWRKVNRVLPRSRPVFNLYRYSVPEQLFRDNSLGMLADLATPDIEGIYE 1424
             .:|:.|....|:.         :....|.:|....:|:|::.....:.|.:
  Fly  1306 EVFVSTRGDLQPDP---------MHDEIRCLFYAIEHSLPDEKLPSKACGYI------------- 1348

  Fly  1425 TQMTLEFRALMDMGCICGVQREEARRLAQLATKDLETFSIEQLEQRPQTQVKYLASANNRLRKIY 1489
              |....:.|:..|...|:.|:..   .|:.|.:.|.|  |.|          ||........||
  Fly  1349 --MVNTVQDLLSEGPFHGIDRDIE---VQVVTSEAEAF--EAL----------LALCERWDADIY 1396

  Fly  1490 LYQHNTPTAKKEI----WSLIL----------------MPSKKAFVFALDTVRANQMPNM----- 1529
                    |..||    |..::                :|::|...| :|..| .|..::
  Fly  1397 --------AGYEIEMSSWGYVIDRAKHLCFNIAPLLSRVPTQKVRDF-VDEDR-EQFTDLDVEMK 1451

  Fly  1530 ---RQLYTAERLALLKNLTAEEQDKIPVEDYTFE-VLIEVDVKQIYRHIQRALTT---------- 1580
               |.|....||.         :.:|.:..|||| |:..:..|:...|..::||.
  Fly  1452 LCGRILLDVWRLM---------RSEIALTSYTFENVMYHILHKRCPWHTAKSLTEWFGSPCTRWI 1507

  Fly  1581 ----YKQEHQGPTILCLQTALSARKLSLAMPILLEFPQAEIHISDDASLLSGLDWQRQGSRAVIR 1641
                |.:..:|...|..|..|..|...:|..|.::|.:          :||      :||:
  Fly  1508 VMEYYLERVRGTLTLLDQLDLLGRTSEMAKLIGIQFYE----------VLS------RGSQ---- 1552

  Fly  1642 HFLNLNNVLDLMLDQCRYFHVPIGNMPPDTVLFGADLFFARLLQRHNFV-LWWSASTRPDLGGRE 1705
                                            |..:....|:.:..|.| |..|...|..:...|
  Fly  1553 --------------------------------FRVESMMLRIAKPKNLVPLSPSVQARAHMRAPE 1585

  Fly  1706 ADDSRLLAEFEESISVVQNKAGFYPDVCVELALDSLAVSALLQ-----STRIQEME--GASSAIT 1763
                 .||      .:::.::.||.|..:.|...||..|.::.     ||.:..:|  |.||...
  Fly  1586 -----YLA------LIMEPQSRFYADPLIVLDFQSLYPSMIIAYNYCFSTCLGRVEHLGGSSPFE 1639

  Fly  1764 FDV--------MPQVSLEEMIGTVPAATLPSYDETALCSAAFRVMRSMVNGWLREVSINRNIFSD 1820
            |..        |.|..||..:.||           :.|...| |.|.:..|.|..:..
  Fly  1640 FGASQLRVSRQMLQKLLEHDLVTV-----------SPCGVVF-VKREVREGILPRMLT------- 1685

  Fly  1821 FQIVHFYRWVRSSNALLYD-PALRRSLNNLMRKMFLRIIAEFKRLGATIIY--ADFN-RI----- 1876
             :|:...:.|:.|..|..| .||:|.|::  |::.|:::|     ..|..|  |:|: |:
  Fly  1686 -EILDTRQMVKQSMKLHKDSSALQRILHS--RQLGLKLMA-----NVTYGYTAANFSGRMPSVEV 1742

  Fly  1877 ---ILSSGKKTVSDALGYVD 1893
               ::|.|::|:..|:..|:
  Fly  1743 GDSVVSKGRETLERAIKLVE 1762

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DNApol-epsilon255	NP_524462.2	DNA_polB_epsilon_exo	266..469	CDD:99822	49/244 (20%)
		POLBc_epsilon	529..1154	CDD:99918	142/833 (17%)
		DUF1744	1529..1930	CDD:369900	85/416 (20%)
DNApol-zeta	NP_524881.2	PTZ00166	20..>196	CDD:240301	44/201 (22%)
		DNA_polB_zeta_exo	1297..1518	CDD:99821	50/278 (18%)
		POLBc_zeta	1550..2000	CDD:99917	60/287 (21%)
		zf-C4pol	2041..2107	CDD:405022

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0417
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900