Protein Alignment PolE1 and Rev3l

DIOPT Version :10

• Sequence 1: NP_524462.2
• Gene: PolE1 / 42758
• FlyBaseID: FBgn0264326
• Length: 2236
• Species: Drosophila melanogaster
• Sequence 2: XP_006256586.1
• Gene: Rev3l / 309812
• RGDID: 1307087
• Length: 3133
• Species: Rattus norvegicus
• Alignment Length: 2493
• Identity: 446/2493 - (17%)
• Similarity: 751/2493 - (30%)
• Gaps: 921/2493 - (36%)

  Fly   173 KRNQERQKSNTYYMQMLATSLAQSSAGSE---DATLGKR--QQDYMDC----IVDI-REHDVPYH 227
            ||.||..|.|.:.::.|:.|:..||...|   :.||...  ..:.:.|    :::: |::|
  Rat   303 KRLQEILKQNDFSVRTLSGSVDYSSGSQEFSAELTLHSEILSPEMLPCSPANMIEVHRDND---- 363

  Fly   228 VRVSIDLRIFCGQWYNIRCRSGVELPTITCRPDILDRPEPVVLAFDIETTKLPLK--------FP 284
                         |.....:..||        :.|...|.::...:...|..||.        |.
  Rat   364 -------------WSKGNTKHKVE--------EALINEEAILNLIENSQTFQPLTQRLSETPVFM 407

  Fly   285 DAQTDQVMM-ISYMIDGQGYL-ITNREII----------SSNVDDFEYTPKPEFEGNFIVFNEEN 337
            |:..|:.:: :...::..||. ..||..:          ..|.||.|..|:.|        .||.
  Rat   408 DSSPDESLVHLLAGLESDGYQGEKNRMPLPRHTFGESQNPQNSDDEENAPQME--------KEEM 464

  Fly   338 EMQLL--QRFFDHIMEV---------RPHIIVTYNGDF-----FDWPFVETRAAVYDLDMKQEIG 386
            |:.:|  ||:.....|.         ..|...|...|.     .:|  .:......:|.:.|..|
  Rat   465 ELSVLMSQRWDSDTEEQCAKKRSLCRNAHRSSTEEDDSSSEEEMEW--TDNSLLFANLSIPQLDG 527

  Fly   387 FSKLRDGNYLS--RPAIHMDCLCWVK---RDSYLPVGSQGLKAVAKAKLRYDPVE--------LD 438
            .:.....|.|:  ....|...:...|   |.|.....:..|:..:.||:.:....        |:
  Rat   528 TADENSDNPLNNENSRAHSSVIATSKLSVRPSVFHKDAATLEPPSSAKITFQCKHTSALSSHGLN 592

  Fly   439 PEDMCRMAVEQPQVLANYSVSDAV----ATYYLYMKY-------VH---------------PFIF 477
            .:|:.. .:.||........|...    :||  .|||       ||               |...
  Rat   593 KDDLIE-GLSQPNNTEKGRDSSVTFTKESTY--SMKYSGSLSSTVHSDNSHKEICKKDKSLPVPS 654

  Fly   478 ALNTIIPMEPD--EILRKGSGTLCETLLMVEAYHAQIVYPNKHQSE----------------LNK 524
            ..:::...|.|  .:.|:........:..:|. .|..::.|:|.||                .||
  Rat   655 CESSVFDYEEDIPSVTRQAPSRKYSNMRKIEK-DAPFIHANRHTSESTLGKNSFNFADLNHSKNK 718

  Fly   525 LSNEGHVLDSETYVGGHVEALESGVFRADIPCRFRLDPAMVKQLQEQVDAV--------LRHAIE 581
            ||:||:...:.|       ||.| ||.:              .|.|..|.:        :.|::
  Rat   719 LSSEGNERGNST-------ALNS-VFPS--------------SLAESCDLLSSSGENRSVAHSL- 760

  Fly   582 VEEGIPLEKVLNLDEVRQEIVQGLQGLHDIPNRLEQPVIYHLDVGAM-YPNIILTNRLQPSAMVS 645
              :.|..|...:..::|.|..|        .:::|:|.:.......| :|:::|:|.|.....:|
  Rat   761 --DSITDESGRSKLKIRYEEFQ--------EHKMERPSLSQQAAHYMFFPSVVLSNCLTRPQKLS 815

  Fly   646 DLDCAACDFNKPGVRCKRSMDWLWRGEMLPASRNEFQRIQQQLE------------TEKFPPLFP 698
            .:....    :||.:..|          |..::.:...:|:...            |...|  :.
  Rat   816 PVTYKL----QPGSKTSR----------LKLNKKKLISLQETSTKSSETGAAKDSCTHNHP--YS 864

  Fly   699 GGPQR---AFHELSKEDQAAYEKKRLTDY---CRKAYKKTKLTKLETRTSTICQKENSF------ 751
            |.|::   ...:|.|.....:|.|..|::   |....     ..|||        |.||
  Rat   865 GTPEKESGLSSDLIKATHGTFENKTPTEHFIDCHFGD-----GSLET--------EQSFGLYGNK 916

  Fly   752 YVDTVRAFRDRRYEYKG-----LTKVAKASVNAAVASGDAAE--IKAAKGREVLYDSLQLAHK-C 808
            |  |:||.|...||.:.     :|..:|.|:...:..|:..:  :|:.|.|::......:..| .
  Rat   917 Y--TLRAKRKVNYETEDSESSFVTHNSKISLPHPMEIGENLDGTLKSRKRRKMSKKLPPVIIKYI 979

  Fly   809 ILNSFYGYVMRRGARWHSMPMAGIVCLTGSNIITKAREIIERVGRPLELDTDGIWCILPGSFPQE 873
            |:|.|      ||.:...:.:..|.......|:|:.:..:.:...||:    ..|..:|.|...:
  Rat   980 IINRF------RGRKNMLVKLGKIDSKEKQVILTEEKMELYKKLAPLK----DFWPKVPDSPATK 1034

  Fly   874 FTIH-----TSHEKKKK---------------------------------INISYPNAVLNTMVK 900
            :.|:     .||.:|.|                                 ::...|:.:..|...
  Rat  1035 YPIYPLTPKKSHRRKSKHKSAKRKPGKQHRASSENIKRTLSFRKKRTHAVLSPPSPSYIAETEDC 1099

  Fly   901 DHFTNDQYHELRKDKE------NNLP-----KYDIR--------DENSIFFEVDGPYLAMVLPAA 946
            |...:|...:|....|      |:.|     ..|.|        ::.|:.|:  ||.:......:
  Rat  1100 DLNYSDVMSKLGFLSERSTSPVNSSPPRCWSPTDPRAEEIMAAAEKESVLFK--GPNVCNTKTVS 1162

  Fly   947 KEEGKKLKKRYAVFNFDGTLAE---LKGFEVKRRGELQLIKN----------------------- 985
            ...||..:.|..|......||:   :.....||....||:.|
  Rat  1163 PRVGKASRARAQVKKSKARLAKSSVVTNKRNKRNQTNQLVDNGKKKPRAKQKQRANEKGISRKPV 1227

  Fly   986 -----------------FQSSVFE---------------------------------AFLAGSTL 1000
                             .|.||.|                                 ...|...|
  Rat  1228 IPTDETTKPPSEAELTPSQRSVPELTSSSGIHTLSKQKEMTQTGPAMDHPLPPCQPTGINAQQRL 1292

  Fly  1001 EECYASVAKVADYWLDVLYSRGS----NLPDSELFELISENKSMSKKLEEYGAQKSTSIS---TA 1058
            ..|::|          .|.||.|    ..|.|......|...|:...:.:...|:|.|.|   |.
  Rat  1293 SNCFSS----------FLESRKSVQFPTFPSSRGDSRSSVYSSIGPGVSKVNTQRSHSQSAMFTR 1347

  Fly  1059 KR----------LAEFLGEQMVKDAGLACKYIISKKPEGAPVTERAIPLAIFQSEPSVRRHHLRR 1113
            |.          |:..|.:  |..:...|..|||.|.|.:..|::
  Rat  1348 KETTLIQKSIFDLSNHLSQ--VAQSTQLCSGIISPKTEESSNTQK-------------------- 1390

  Fly  1114 WLKDNTMGDADIRDVLDWNYYIERLGGTIQKIITIPAALQGLANPVPRVQHPDWLHKKMLEKNDV 1178
                                   ..|.:|.|:....::|:  :.| .:|..|::||.:..:
  Rat  1391 -----------------------NCGSSIGKLNEYRSSLE--SKP-EKVCAPNFLHCRDSQ---- 1425

  Fly  1179 LKQRRINEMFTSRP----KPKPLATEEDKLADMEDLAGKDGGEGAAGCPIVTKRKRIQLEEHDDE 1239
              |:.:|....|:|    .|...|:||.:               ...|.:.:.|..|
  Rat  1426 --QQTVNVSEQSKPSETCSPGNAASEESQ---------------TPNCFVTSLRSPI-------- 1465

  Fly  1240 EAQPQATTWRQALGAPPPIGETRKTIVEWVRFQKKKWKWQQDQRQRNRQASK-------RTRGED 1297
                :..||.|         ..|..|:|...|:.:|.|    ||..:...|:       :.:...
  Rat  1466 ----KQITWEQ---------RQRGCILEMSSFKPEKVK----QRSLSEAISQTKALSQCKNQNVS 1513

  Fly  1298 PPVVRATGST--ATLGGFLRRAQRTLLDQPWQIVQLVPVDDLG-------HFTVWALIGEELHKI 1353
            .|.|...|.:  |.|...|::.|        |..|...|.|..       ..:|.|       :.
  Rat  1514 TPSVFGEGQSGLAVLKELLQKRQ--------QKAQTTNVQDSASSHQPDKDISVSA-------EH 1563

  Fly  1354 KLTVPRIFYVNQRSAAPPEEGQLWR--KVNRVLPRSRPV--FNLYRYSVPEQLFRDNSLGMLADL 1414
            |.|..|     .|:.|.|.:.:..|  |.....||...|  .||......:....|:|..:.:|
  Rat  1564 KKTNKR-----TRAVASPRKPRAPRRTKPKEQTPRRLKVDPLNLQTSGHLDNSLSDDSPILFSD- 1622

  Fly  1415 ATPDIEGIY--ETQMTLEFRALMDMGCI-----CGVQREEARRLAQLATKDLETFSIEQLEQRPQ 1472
              |..|..|  |..::.|.....|:..|     |.:...     :|....|         :..||
  Rat  1623 --PGFESCYSLEDSLSPEHNYNFDINTIGQTGFCSLYSG-----SQFVPAD---------QNLPQ 1671

  Fly  1473 TQVKYLASA------NNRLRKIYLYQHNTPTAKKE--------IWSLILMPSKKAFVFALDTVRA 1523
               |:|:.|      ...:.|..|..|:..:..:|        .|                 |||
  Rat  1672 ---KFLSDAVQDLFPGQAIEKNELLSHDRQSCTEEKHHVSDSGPW-----------------VRA 1716

  Fly  1524 NQMPNMRQLYTAERLALLKNLTAEEQDKIPVEDYTFEVLIEVDVKQIYRHIQRALTTYKQEHQGP 1588
            :                  .|..|..:|           :.:|..:.:||.|...:.:.......
  Rat  1717 S------------------TLNPELFEK-----------VGIDNNENHRHSQWKTSFHPLTSHSN 1752

  Fly  1589 TIL---CLQTALSA-------RKLSLAMPILLEFPQAEIHISDDASLLSGLDWQRQGSRAVIRHF 1643
            :|:   |:|.|.|.       .:.|::..:.|..|||           |..|| .||..
  Rat  1753 SIMESFCVQQAESCLPEKSRLNRSSVSKEVFLSLPQA-----------SSSDW-IQGHN------ 1799

  Fly  1644 LNLNNVLDLMLDQCRYFHVPIGNMPPDTVLFGADLFFARLLQRHNFVLWWSASTRPDLGGREADD 1708
               ...::..||........:.:.|...::..|.......:.|:|.||    :..||...|...
  Rat  1800 ---GKEIEQSLDSANTSFTTVLSSPDGELVDAASEDLELYVSRNNDVL----TPTPDSSPRSTS- 1856

  Fly  1709 SRLLAEFEESISVVQNKAG-FYPDVCVELALDSLAVSALLQSTRIQEMEGASSAITFDVMPQVSL 1772
                       |.:|:|.| |.|                           .::.|...:|...|.
  Rat  1857 -----------SPLQSKNGSFTP---------------------------RTAHILKPLMSPPSR 1883

  Fly  1773 EEMIGTVPAATLPSYD------ETALCSAAFRVMRS--MVNGWLR--EVSINRNIF---SDFQIV 1824
            ||::     |||..:|      :...||....|...  .:.|.|.  |..:..::.   .||.:.
  Rat  1884 EEIV-----ATLLDHDLSEAIYQEPFCSNPSDVPEKPREIGGRLLMVETRLPNDLIEFEGDFSLE 1943

  Fly  1825 HFYRWVRSSNALLYDPALRRSLNNLMRKMFLRIIAEFKRLGATIIYADFNRIILSSGKKTVSDAL 1889
            ....|..:.:|:..:|.....|.|                |..::..:     .|:..|||.|.
  Rat  1944 GLRLWKTAFSAMTQNPRPGSPLRN----------------GPAVVNKE-----SSNSHKTVEDK- 1986

  Fly  1890 GYVDYIVQSLRNKEMFHSIQLSFEQCWNFMLWMDQANFSGIRGK-LPK----------------- 1936
               ..::...|.......:|          .|: ||....:|.| ||:
  Rat  1987 ---KIVIMPCRYAPSRQLVQ----------AWL-QAKEEYVRSKRLPRTESTPVIKSADNVSPSL 2037

  Fly  1937 -----------------------------------------GIDETVSSIVSTTMIRDSERNQDD 1960
                                                     |..:|||:  |.|::..:.....:
  Rat  2038 NPGDTRAVAPQMDTCPHTLSSTAHAKEEVCQSQIALQTSRTGCGQTVSA--SQTLLPAASAAVPE 2100

  Fly  1961 DEDEEEDSENRDPVESNEAEQDQEDELSLELNWTIGEHLPD--------------------ENEC 2005
            :|:|||:.|          |:::|||     |..:....||                    |:.|
  Rat  2101 EEEEEEEEE----------EEEEEDE-----NGYVSYSSPDSPGIPPWQQAASPDFRALNGEHRC 2150

  Fly  2006 REKFESLLTLFMQSLAEKKTTEQAIKDISHCAFDFILKLHKNYGKGK------------PSPGLE 2058
            ....|.|.:..:::..  |..:..|:..|.|....|..:|......|            |...||
  Rat  2151 SSPVEELCSRAVENFL--KPIKDGIQKASCCESQVISPIHARTRTEKCEPLCLHSTPVMPRKFLE 2213

  Fly  2059 LI--RTLIKALSVDKTLAEQINE-------LRRNMLRLVGIGEFS-------DLAEWEDPCDSH- 2106
            .:  .|.:..|||:....:..|:       |||.:|......:|:       :.::.:.|..::
  Rat  2214 KLPEATGLSPLSVEPKTQKLYNKKGSDTDHLRRVLLTTQVENQFAAVNTPKKETSQIDGPSLNNT 2278

  Fly  2107 ------IINEVICKACNHCRDLDLCK-DKH-RAMKDGVP----VWLCAQCYVAY------DNEEI 2153
                  |.|....||.:..::|.|.. :.| |..:|..|    ..:||..|...      |.|:.
  Rat  2279 YGFKVSIQNLQEAKALHEIQNLTLISVELHARTRRDLQPDPEFDPICALFYCISSDTPLPDTEKT 2343

  Fly  2154 EMRMLDALQR-KMMSYVLQDLRC 2175
            |:..:..:.: |.:::  ||:||
  Rat  2344 ELTGVIVIDKDKTVTH--QDIRC 2364

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PolE1	NP_524462.2	DNA_polB_epsilon_exo	266..469	CDD:99822	47/255 (18%)
		POLBc_epsilon	529..1154	CDD:99918	139/815 (17%)
		DUF1744	1529..1930	CDD:462493	72/424 (17%)
Rev3l	XP_006256586.1	PTZ00166	41..>195	CDD:240301
		DUF4683	753..1133	CDD:464832	76/431 (18%)
		REV3L_RBD	1869..1891	CDD:412083	7/26 (27%)
		DNA_polB_zeta_exo	2297..2535	CDD:99821	17/70 (24%)
		POLBc_zeta	2561..3009	CDD:99917
		zf-C4pol	3045..3112	CDD:464119