Protein Alignment PolE1 and Pold1

DIOPT Version :10

• Sequence 1: NP_524462.2
• Gene: PolE1 / 42758
• FlyBaseID: FBgn0264326
• Length: 2236
• Species: Drosophila melanogaster
• Sequence 2: NP_035261.3
• Gene: Pold1 / 18971
• MGIID: 97741
• Length: 1105
• Species: Mus musculus
• Alignment Length: 1170
• Identity: 217/1170 - (18%)
• Similarity: 375/1170 - (32%)
• Gaps: 443/1170 - (37%)

  Fly   221 EHDVPYHVRVSIDLRIFCGQWYNIRCRSGV---ELPTITCR-------PDILDRP--------EP 267
            |.:|.:.:|..:|..|....|..:.....|   |.....|:       .|::..|        .|
Mouse   243 EANVDFEIRFMVDADIVGCNWLELPAGKYVRRAEKKATLCQLEVDVLWSDVISHPPEGQWQRIAP 307

  Fly   268 V-VLAFDIETTKLPLKFPDAQTDQVMMISYM----IDGQGYL---ITNR---EIISSNVDDFEYT 321
            : ||:||||.......||:.:.|.|:.|..:    .:.:.:|   :|.|   .|:.:.|..:
Mouse   308 LRVLSFDIECAGRKGIFPEPERDPVIQICSLGLRWGEPEPFLRLALTLRPCAPILGAKVQSY--- 369

  Fly   322 PKPEFEGNFIVFNEENEMQLLQRFFDHIMEVRPHIIVTYNGDFFDWPFVETRAAVYDLDMKQEIG 386
                          |.|..|||.:.|.|:.:.|.:|..||...||.|::.:||....:|....:|
Mouse   370 --------------EREEDLLQAWADFILAMDPDVITGYNIQNFDLPYLISRAQALKVDRFPFLG 420

  Fly   387 -----FSKLRDGNYLSRPA-------------IHMDCLCWVKRDSYLPVGSQGLKAVA------- 426
                 .|.:||.::.||..             :.||.|..:.|:..|  .|..|.||:
Mouse   421 RVTGLRSNIRDSSFQSRQVGRRDSKVISMVGRVQMDMLQVLLREHKL--RSYTLNAVSFHFLGEQ 483

  Fly   427 KAKLRYDPVELDPEDMCRMAVEQPQVLANYSVSDAVATYYLYMKYVHPFIFALNTI-------IP 484
            |..:::..:    .|:.....:..:.||.|.:.||    :|.::.:...:..:|.:       :|
Mouse   484 KEDVQHSII----TDLQNGNEQTRRRLAVYCLKDA----FLPLRLLERLMVLVNNVEMARVTGVP 540

  Fly   485 MEPDEILRKGSGTLCETLLMVEAYHAQIVYPNKHQSELNKLSNEGHVLDSETYVGGHVEALESGV 549
            :  ..:|.:|......:.|:.:|....::.|        .:..||    ||.|.|.
Mouse   541 L--GYLLTRGQQVKVVSQLLRQAMRQGLLMP--------VVKTEG----SEDYTGA--------- 582

  Fly   550 FRADIPCRFRLDPAMVKQLQEQVDAVLRHAIEVEEGIPLEKVLNLDEVRQEIVQGLQGLHDIPNR 614
                                                              .:::.|:|.:|:|
Mouse   583 --------------------------------------------------TVIEPLKGYYDVP-- 595

  Fly   615 LEQPVIYHLDVGAMYPNIILTNRLQPSAMVSDLDCAACDFNKPGVRCKRSMDWLWRGEMLPASRN 679
                 |..||..::||:|::.:.|..:.::           :||.           .:.|....:
Mouse   596 -----IATLDFSSLYPSIMMAHNLCYTTLL-----------RPGA-----------AQKLGLKPD 633

  Fly   680 EFQRIQQQLETEKFPPLFPGGPQRAFHELSKEDQAAYEKKRLTDYCRKAYKKTKLTKLETRTSTI 744
            ||      ::|       |.|                     .::.:.:.:|..|.::
Mouse   634 EF------IKT-------PTG---------------------DEFVKSSVRKGLLPQI------- 657

  Fly   745 CQKENSFYVDTVRAFRDRRYEYKGLTKVAKASVNAAVASGDAAEIKAAKGREVLYDSLQLAHKCI 809
                    ::.:.:.|.|          |||.:        |.|....: |:|| |..|||.|..
Mouse   658 --------LENLLSARKR----------AKAEL--------AQETDPLR-RQVL-DGRQLALKVS 694

  Fly   810 LNSFYGYVMRRGARWHSMPMAGIVCLTGSNIITK-AREIIERVGRPLEL---------------- 857
            .||.||:.   ||:...:|     ||..|..:|. .|::||:..:.:|.
Mouse   695 ANSVYGFT---GAQVGKLP-----CLEISQSVTGFGRQMIEKTKQLVESKYTVENGYDANAKVVY 751

  Fly   858 -DTDGIWCILPGSFPQEFTIHTSHEKKKKINISYPNAVLNTMVKDHFTNDQYHELRKDKENNLPK 921
             |||.:.|        .|.:.:..|.     :|......| .|..||.:....|..|
Mouse   752 GDTDSVMC--------RFGVSSVAEA-----MSLGREAAN-WVSSHFPSPIRLEFEK-------- 794

  Fly   922 YDIRDENSIFFEVDGPYLAMVLPAAKEEGKKLKKRYAVFNFDG-----TLAELKGFEVKRRGELQ 981
                    ::|    |||.:           .|||||...|..     ...:.||.|..||....
Mouse   795 --------VYF----PYLLI-----------SKKRYAGLLFSSRSDAHDKMDCKGLEAVRRDNCP 836

  Fly   982 LIKNFQSSVFEAFLAGSTLEECYASVAKVADYWLDVLYSRGSNLPDSELFELISENKSMSKKLEE 1046
            |:.|..:|.....|.....:   .:||...|...|:|.:|      .::.:|:. .|.:::...:
Mouse   837 LVANLVTSSLRRILVDRDPD---GAVAHAKDVISDLLCNR------IDISQLVI-TKELTRAAAD 891

  Fly  1047 YGAQKSTSISTAKRLAEFLGEQMVKDAGLACKYIISKKPEGAPVTERAIPLAIFQSEPSVRRHHL 1111
            | |.|...:..|:|:.:                   :.|..||.....:|..|..:...|..:
Mouse   892 Y-AGKQAHVELAERMRK-------------------RDPGSAPSLGDRVPYVIIGAAKGVAAY-- 934

  Fly  1112 RRWLKDNTMGDADIRDVL------DWNYYIER-------------LG-GTIQKII---------- 1146
                    |...|...||      |..||:|:             || |..:.::
Mouse   935 --------MKSEDPLFVLEHSLPIDTQYYLEQQLAKPLLRIFEPILGEGRAESVLLRGDHTRCKT 991

  Fly  1147 TIPAALQGLANPVPR----------VQHPDWLHKKMLEKNDVLKQRRINEMFTSRPKPKPLATE- 1200
            .:.:.:.||.....|          :.|...:.|....:...|.|:.::.:.....:...|.|:
Mouse   992 VLTSKVGGLLAFTKRRNCCIGCRSVIDHQGAVCKFCQPRESELYQKEVSHLNALEERFSRLWTQC 1056

  Fly  1201 --------EDKLADMEDLAGKDGGEGAAGCPIVTKRKRIQLEEHDDEEAQPQATTWRQALGAPPP 1257
                    ||.:....|            |||...||:::.:..|.|..       .|..|.|.|
Mouse  1057 QRCQGSLHEDVICTSRD------------CPIFYMRKKVRKDLEDQERL-------LQRFGPPGP 1102

  Fly  1258  1257
            Mouse  1103  1102

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PolE1	NP_524462.2	DNA_polB_epsilon_exo	266..469	CDD:99822	57/238 (24%)
		POLBc_epsilon	529..1154	CDD:99918	118/677 (17%)
		DUF1744	1529..1930	CDD:462493
Pold1	NP_035261.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..31
		Nuclear localization signal. /evidence=ECO:0000255	4..19
		PTZ00166	78..1098	CDD:240301	214/1164 (18%)
		CysB motif	1056..1074		3/29 (10%)