Protein Alignment PolE1 and pold-1

DIOPT Version :10

• Sequence 1: NP_524462.2
• Gene: PolE1 / 42758
• FlyBaseID: FBgn0264326
• Length: 2236
• Species: Drosophila melanogaster
• Sequence 2: NP_506017.1
• Gene: pold-1 / 179652
• WormBaseID: WBGene00008645
• Length: 1081
• Species: Caenorhabditis elegans
• Alignment Length: 1396
• Identity: 263/1396 - (18%)
• Similarity: 432/1396 - (30%)
• Gaps: 514/1396 - (36%)

  Fly    17 VSENRTEGDDFFNEAGYRQSRENDKIDSKY--GFDRVKDSQ---ERTGYLINMHSNEVLDEDRRL 76
            ::..|..|..|..|.  ::.||:|:.:..|  .|:....|.   ::||:     :...:|:|..:
 Worm     1 MTSKRPGGSSFQPEV--KRKRESDEFEQCYVSRFENELPSVPTIDKTGW-----ARPAVDKDLGI 58

  Fly    77 IAALDLFFIQM-----DGSRFK------------------CTVA--YQPYLLIRPEDNMHLE--- 113
            ..::....:::     |||...                  |.:.  |.|:...:......:|
 Worm    59 SKSIACQILEVETYHEDGSATSYDRTNVKLYGVTKSGNSICVIVTDYFPHFYFQAPQGFGVEHIG 123

  Fly   114 ---------VARFLGRKYSGQ-------ISGLEHI-----------TKEDLDLPNHLSGLQQQYI 151
                     ||....|..|||       :..|.|:           ...|..:|         ::
 Worm   124 TAQSAICNMVAAAKRRGGSGQAQLPGKVVDNLVHVEIVHGENLYYFRGADTKVP---------FV 179

  Fly   152 KLSFLNQTAMTKVRRELMSAVKRNQERQKSNTYYMQMLATSLAQSSAGSEDATLGKRQQDYMDCI 216
            |:|...: |:.|.|.||.:.|                       :..|.....:|...:..::.|
 Worm   180 KVSGSTE-ALHKARMELKNGV-----------------------NLMGKGPVNVGNLYESNINVI 220

  Fly   217 VDIREHDVPYHVRVSIDLRIFCGQWYNIRCRSGVELPTITCRPDILDRPE-----------PV-- 268
                   |.:..:.:|   :.|| |        :|:|...||  ||...|           ||
 Worm   221 -------VMFLAKTNI---VGCG-W--------IEIPAGKCR--ILSNSEKSSRCQIEVTVPVKN 264

  Fly   269 -----------------VLAFDIETTKLPLKFPDAQTDQVMMISYMIDGQG----------YLIT 306
                             .|:.|||.......||:|..|.::.|:.::..:|          .|.|
 Worm   265 LIVHESDGEWAGIAPIRTLSLDIECIGRRGVFPEAIKDPIIQIANLVKIEGEAEPFVRNCFVLGT 329

  Fly   307 NREIISSNVDDFEYTPKPEFEGNFIVFNEENEMQLLQRFFDHIMEVRPHIIVTYNGDFFDWPFVE 371
            ...::.||                 :....||..||:::.:.:.||.|.||..||...||.|::.
 Worm   330 CAPVVGSN-----------------IIQCVNEKVLLEKWAEFVREVDPDIITGYNILNFDLPYIL 377

  Fly   372 TRAAVYDLDMKQEIGFSK-----LRDGNYLSRPA---------IH----MDCLCWVKRDSYLPVG 418
            .||.|..|.....:|..|     :||....|:..         ||    .|.|..|.||..|  .
 Worm   378 DRAKVLSLPQVSHLGRQKEKGSVVRDAAISSKQMGSRVNKSIDIHGRIIFDVLQVVLRDYKL--R 440

  Fly   419 SQGLKAVAKAKLRYDPVELDPE---DMCRMAVEQPQVLANYSVSDAVATYYLYMKYVHPFIFALN 480
            |..|.:|:...|.....:::..   |:.|...:..:.||.|.:.||    ||.::.:...:..:|
 Worm   441 SYTLNSVSYQFLSEQKEDVEHNIIPDLQRGDEQTRRRLAQYCLKDA----YLPLRLLDKLMSIIN 501

  Fly   481 TI-------IPMEPDEILRKGSGTLCETLLMVEAYHAQIVYPNKHQSELNKLSNEGHVLDSETYV 538
            .|       :||  :.:|.||......::::..........|...       :|.|   |.|.|.
 Worm   502 YIEMARVTGVPM--NFLLTKGQQIKILSMMLRRCKQNNFFLPVIE-------ANSG---DGEGYE 554

  Fly   539 GGHVEALESGVFRADIPCRFRLDPAMVKQLQEQVDAVLRHAIEVEEGIPLEKVLNLDEVRQEIVQ 603
            |..|                 :||
 Worm   555 GATV-----------------IDP----------------------------------------- 561

  Fly   604 GLQGLHDIPNRLEQPVIYHLDVGAMYPNIILTNRLQPSAMVSDLDCAACDFNKPGVRCKRSMDWL 668
             ::|.::.|       |..||..::||:|::.:.|          |.......|
 Worm   562 -IRGFYNEP-------IATLDFASLYPSIMIAHNL----------CYTTLLKSP----------- 597

  Fly   669 WRGEMLPASRNEFQRIQQQLETEKFPPLFPGGPQRAFHELSK---------EDQAAYEKKRLTDY 724
                             |.:|.|.:... |.|  :.|...||         ||..|..|:...|
 Worm   598 -----------------QGVENEDYIRT-PSG--QYFATKSKRRGLLPEILEDILAARKRAKND- 641

  Fly   725 CRKAYKKTKLTKLETRTSTICQKENSFYVDTVRAFRDRRYEYKGLTKVAKASVNAAVASGDAAEI 789
                                              .::.:.|:|
 Worm   642 ----------------------------------MKNEKDEFK---------------------- 650

  Fly   790 KAAKGREVLYDSLQLAHKCILNSFYGYVMRRGARWHSMPMAGI---VCLTGSNIITKAREIIERV 851
                  .::|:..|||.|...||.||:.   ||....:|...|   |...|..:|...:..:||:
 Worm   651 ------RMVYNGRQLALKISANSVYGFT---GATVGKLPCLEISQSVTAFGRKMIDMTKLEVERI 706

  Fly   852 GRPLELDTDGIWCILPGSFPQEFTIHTSHEKKKKINISYPNAVLNTMVKDHF---TNDQYHELRK 913
            .:...||         |..|.:          .|:.....::|   |||  |   |..|..|:..
 Worm   707 YKKGALD---------GKCPAD----------AKVIYGDTDSV---MVK--FGVETVAQAMEIGL 747

  Fly   914 DKENNLPKYDIRDENSIFFEVDGPYLAMVLPAAKEEGKKLKKRYAVFNFD----GTLAELKGFEV 974
            |....:.|.........|.:|..|||.:           .|||||...|.    ....:.||.|.
 Worm   748 DAAKEVSKIFTPPIKLEFEKVYSPYLLI-----------NKKRYAGLYFTKPDVHDKMDCKGLET 801

  Fly   975 KRRGELQLIKNFQSSVFEAFL----AGSTLEECYASVAKVADYWLDVLYSRGSNLPDSELFELIS 1035
            .||....|:........|..|    ..|.|:....:::.:....:|:              .|:.
 Worm   802 VRRDNCPLVAKVLGVCLEKLLIERDQQSALDFAKRTISDLLCNKIDI--------------SLLI 852

  Fly  1036 ENKSMSKKLEEYGAQKSTSISTAKRLAEFLGEQMVKDAGLACK------YIISKKPEGAPVTERA 1094
            .:|.::|..::|.| |...:..|.|:.:       :|||.|.:      |:.....:..|..|||
 Worm   853 ISKELTKSGDKYQA-KQAHVELAARMKK-------RDAGSAPRLGDRVPYVFVAAAKNVPAYERA 909

  Fly  1095 -IPLAIFQSE-PSVRRHHLRRWLK-------DNTMGD-----------ADIRDVLDWNYYIERLG 1139
             .|..:.|:. |...:|:|...|.       :..:||           ..:|.|:.     .::|
 Worm   910 EDPTFVLQNNIPLDTKHYLTNQLAKPLARIFEPILGDRAEKILVEGEHTRVRTVVQ-----SKVG 969

  Fly  1140 GTIQKIITIPAALQGLANPVPRVQHPDWLHKKMLEKNDVLKQRRINEMFTSRPKPKPLATEEDKL 1204
            | :....|..|...|..:.:||.:..:.:.|....|...:...|:|.|.........|.||....
 Worm   970 G-LAAFTTKSATCLGCKSVLPRAESENAVCKHCEPKLPTIFASRMNTMHELENHFGRLWTECQNC 1033

  Fly  1205 A-DMEDLAGKDGGEGAAGCPIVTKRKRIQLE 1234
            | .|:|....    .|..|||...|::::.|
 Worm  1034 AKTMQDKVNC----SARDCPIYYMREKVRNE 1060

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PolE1	NP_524462.2	DNA_polB_epsilon_exo	266..469	CDD:99822	61/263 (23%)
		POLBc_epsilon	529..1154	CDD:99918	120/673 (18%)
		DUF1744	1529..1930	CDD:462493
pold-1	NP_506017.1	PTZ00166	65..1072	CDD:240301	249/1325 (19%)