Protein Alignment DNApol-epsilon255 and rev-3

DIOPT Version :9

• Sequence 1: NP_524462.2
• Gene: DNApol-epsilon255 / 42758
• FlyBaseID: FBgn0264326
• Length: 2236
• Species: Drosophila melanogaster
• Sequence 2: NP_001299851.1
• Gene: rev-3 / 175809
• WormBaseID: WBGene00021344
• Length: 1303
• Species: Caenorhabditis elegans
• Alignment Length: 1552
• Identity: 286/1552 - (18%)
• Similarity: 493/1552 - (31%)
• Gaps: 577/1552 - (37%)

  Fly     3 DSSKGKVLQNTGKFVSENRTEGDDFFNEA--GYRQSRENDKIDSKYGFDRVKDSQERTGYLIN-M 64
            ::|.||    |.||..:...:.:.|.:.:  ||:...|:        |.||..|.  ..||.. .
 Worm    86 ETSTGK----TNKFSVDYVYKMESFSSRSLYGYQDEEED--------FVRVYFSS--PWYLKKAT 136

  Fly    65 HS--NEVLDE------------------DRRLIAALDLFF----IQMDGSRFKCTVAYQPY---- 101
            ||  .||:|:                  |..:....:::.    .:||......|:.|:..
 Worm   137 HSLGKEVIDKPLFQPYEAHLPFHLQFFIDNSIFGMDNIYLKKVKFRMDSRDEDATLIYKDLSVGD 201

  Fly   102 -----LLIRP---EDNMHLE----VARFLGRKYS-----GQISGLEHITKEDLDLPNHLSGLQQQ 149
                 ||:.|   :...|:|    |...|..:..     ....|||::.:|:.:..:.| |::.:
 Worm   202 IRNNELLLSPYEKKTTCHVECDALVTDILNMEMQADNVHSSNPGLEYLWREEKERCDAL-GIELK 265

  Fly   150 YIKLSF--------LNQTAMTKVRRELMSAVKRNQERQKSNTYYMQMLATSLAQ-----SSAGSE 201
            .:..|:        ..:..|.:..|::  |.|..|||..|. ....::.|.:|:     ||.|:.
 Worm   266 DVFNSYEPRKSTICPQERDMLRTARKM--AKKFRQERCMSE-QLDDLMVTRIAESQQTTSSVGAS 327

  Fly   202 DATLGKRQQDYMDCIVDIREHDVPYHVRVSIDLRIFCGQWYNIRCRSGVELPTITCRPDILDRPE 266
            |.|:.::..:      |..|.|     |:.             |.::..||.....:.:  ||.|
 Worm   328 DTTIWEQPGE------DPMEED-----RIG-------------REKTPEELDAERQKEE--DREE 366

  Fly   267 PVVLAFD---------IETTKLPLKFPDAQ----TDQVMMISYMID--------GQGYLITNREI 310
               .|.|         .|.|    .|.|:|    .|:.|.:...::        |.|.:|   ||
 Worm   367 ---AAEDDDNDPKNQEAEMT----MFADSQKPVERDEAMDVDEEVEDDEELNDKGTGEVI---EI 421

  Fly   311 ISSNVDDFE----YTPKPEFEGNFIVFNEENEMQLLQRFFDHIMEVRPHIIVTYNGDFFDWPFVE 371
            .|...||.:    .|.|..::.|||..||
 Worm   422 SSDGDDDQDIVQWITTKSAYDQNFISMNE------------------------------------ 450

  Fly   372 TRAAVYDLDMKQEIGFSKLRDGNYLSRPAIHMDCLCWVKRDSYLPVGSQGLKAVAKAKLRY---- 432
                 :..|.|      |:.:....||..    ..|.|..|..:...::..:.|.:.:|..
 Worm   451 -----FLFDAK------KIENQRQFSREM----TACSVMTDETVVAAAEHSQPVEQTRLLSQTSI 500

  Fly   433 -DP------VELDPEDMCRMAVE--------QPQVLANYSVSDAVATYYLYMKYVHPFIFALNTI 482
             :|      ||.|...:|..::|        .|...::..||.::|.|....:...|.:..|.|.
 Worm   501 GEPSTSEKSVESDIVGLCVASLELLVDTKMPMPDAASSEIVSVSLAIYNDVCRCSSPKLHVLLTT 565

  Fly   483 IPMEPDEILRKGSGTLCETLLMVEAY-HAQIVYPNKHQSELNKLSNEGHVLDSETYVGGHVEALE 546
            :|:.|                   || ..::|:.......|.:::......|.:..:|.....|.
 Worm   566 LPVGP-------------------AYSDRRVVHMETELEMLEEVAKWIVQYDVDVMIGYETIRLS 611

  Fly   547 SGVFRADIP---CRFRLDPAMVKQLQEQVDAVLRHAIEVEEG------------IPLEKVLNLDE 596
            .|.|...|.   .|..:|.|:       :||...| |||::.            :.:.||:..|.
 Worm   612 WGFFFRRIKLLGSRISMDRAL-------IDAYEDH-IEVDDQEITVAPPKGRLLVSVWKVVRSDL 668

  Fly   597 VRQEIVQGLQGLHDIPNRLEQPVIYHLDVGAMYPNIILTNRL--QPSAMVSDLDCAACDFNKPGV 659
            ..:....|    ..:.|.|.:.:       .|..|..|..|:  :.||:.:|:.......:...:
 Worm   669 ALRNYDLG----SAVANVLRKKI-------PMLDNAALMRRIKGERSAIRNDVHLHLLKLSSLNI 722

  Fly   660 RCKRSMDW-LWRGEMLPASRNEFQRI---QQQLETEKF------------PPL------FPGGPQ 702
            .....|:| |...||......:|..:   ..||..|..            |.:      ..|.|:
 Worm   723 SLLTEMNWFLKNAEMARVYGIQFHEVWTRGSQLRVESMLLRLAHRMNFVAPSITHLQRNMMGSPE 787

  Fly   703 RAFHELSKEDQAAYEKKRLTD-------------YCRKAYKKTKLTKLETRTSTICQKENSFYV- 753
            :....|..:.:..::...:.|             ||    ..|.|.|:........:..|...:
 Worm   788 QLQLILEPQSKVYFDPVIVLDFQSLYPSMVIAYNYC----YSTILGKIGNLVQMNDESRNREEIV 848

  Fly   754 -----------DTVR--AFRD-----------RRYEYKGLTKVAKASVNAAVASGDAAEIKAAKG 794
                       |.|:  |:::           ::.:.:|:..:....:.||.....:| :|..|.
 Worm   849 LGAIKYHPSKDDIVKLVAYKEVCASPLASMFVKKSKREGVMPLLLREILAARIMVKSA-MKRTKN 912

  Fly   795 REV--LYDSLQLAHKCILNSFYGYVMRRGARWHS-MPMAGIVCLTGSNIITKAREIIERVGRPLE 856
            :::  :.|:.|||.|.:.|..|||.   .|.|.. ||.|.:    ...|:.|.||.:|   |.:|
 Worm   913 KKLKRILDARQLALKLVANVSYGYT---AANWSGRMPCAEL----ADAILGKGRETLE---RSIE 967

  Fly   857 L--------------DTDGIWCILPGSFPQE-FTIHTSHEKKKKINISYPNAVLNTMVKDHFTND 906
            :              |||.::.::.|:..:| |.|                   ...:.|..||.
 Worm   968 MVQRGDYGGAEVIYGDTDSMFVLVRGASVEEAFEI-------------------GRRIVDDVTNS 1013

  Fly   907 QYHELRKDKENNLPKYDIRDENSIFFEVDGPYLAMVLPAAKEEGKKLKKRYAVF-----NFDGTL 966
                               :.:.:..:::..|...||        :.|||||.:     |.:|:|
 Worm  1014 -------------------NPDPVVLKLEKVYKGCVL--------ETKKRYAGWMYEHENDEGSL 1051

  Fly   967 AELKGFEVKRRGELQLIKNFQSSVFEAFLAGSTLEECYASVAKVADYWLDVLYSRG--------- 1022
             :.||.|..||....:                        ||:|.:..|.:::|:.
 Worm  1052 -DAKGIETVRRDTCPI------------------------VAEVLEKSLGLIFSQNWKTFITYLN 1091

  Fly  1023 ---SNLPDSELFELISENKSMSKKLEEY-GAQKSTSISTAKRLAE-----------FLGEQMVKD 1072
               .|||        .||.|.....:|| |...:.::...|::||           ..||::
 Worm  1092 TVVLNLP--------QENFSKFVFCKEYRGDYSARAMVPQKKIAEARIRKCPSHITLRGERV--- 1145

  Fly  1073 AGLACKYIISKKPEGAPVTERAIPLAIFQSEPSVRRHHLRRWLKDNTMGDADIRDVLDWNYYIER 1137
                 .|:|.....|:.|......:..|...|.         .|.||.            ||:.
 Worm  1146 -----PYVIIDGVTGSTVYSCVRSIDQFARNPE---------YKINTF------------YYLN- 1183

  Fly  1138 LGGTIQKIITIPAALQGLANPVPRVQHPDWLHKKMLEKNDVLKQRRINEMFTSRPKPKPLATEED 1202
                    ..|.|||:.:.:.:|.             |.|.|                |.|.|:.
 Worm  1184 --------AHILAALRRVTDLIPM-------------KIDFL----------------PFAAEQC 1211

  Fly  1203 KLADMEDLAGKDGGEGAAGCPIVTKRKRIQLEEHDDEEAQPQATTWRQALGAPPPIGETRKTIVE 1267
            .::|...: ||     ...|        |:.|::.:|.|.......|::        ..|..|::
 Worm  1212 FVSDCSRI-GK-----TPWC--------IECEQNPEELALALVQLGRES--------RARSQIIQ 1254

  Fly  1268 WVRFQKKKWKWQQDQRQRNRQASKRTRGEDPPVVRATGSTATLGGFLRRAQRTLLDQ 1324
            :.               .:.|:|.:..||| .||.....|..|     |...:::|:
 Worm  1255 YC---------------TSCQSSSQRLGED-QVVDCANFTCLL-----RQTMSIMDR 1290

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DNApol-epsilon255	NP_524462.2	DNA_polB_epsilon_exo	266..469	CDD:99822	46/246 (19%)
		POLBc_epsilon	529..1154	CDD:99918	138/748 (18%)
		DUF1744	1529..1930	CDD:369900
rev-3	NP_001299851.1	DnaQ_like_exo	517..725	CDD:299142	44/245 (18%)
		POLBc_zeta	752..1201	CDD:99917	105/593 (18%)
		DNA_pol_B	752..1193	CDD:278562	104/572 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0417
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900