Protein Alignment DNApol-epsilon255 and pole-1

DIOPT Version :9

• Sequence 1: NP_524462.2
• Gene: DNApol-epsilon255 / 42758
• FlyBaseID: FBgn0264326
• Length: 2236
• Species: Drosophila melanogaster
• Sequence 2: NP_493616.1
• Gene: pole-1 / 173368
• WormBaseID: WBGene00009368
• Length: 2144
• Species: Caenorhabditis elegans
• Alignment Length: 2248
• Identity: 968/2248 - (43%)
• Similarity: 1366/2248 - (60%)
• Gaps: 196/2248 - (8%)

  Fly    29 NEAGYRQS----RENDKIDSKYGFDRVKDSQERTGYLINMHSNEVLDEDRR-LIAALDLFFIQMD 88
            |::.|::.    |.||:||:|.||.|....||:.|:|||:..:|::||..: :|:.:|.|||...
 Worm    14 NDSNYKERLALIRSNDEIDAKLGFSRYTGLQEKKGFLINIQPSELVDEQTKVIISVVDYFFISDM 78

  Fly    89 GSRFKCTVAYQPYLLIRPEDNMHLEVARFLGRKYSGQISGLEHITKEDLDLPNHLSGLQQQYIKL 153
            ..|||.:..::||..|...|....:|:.:|.:||..| :.:||:.:|||||.:|||||::.||||
 Worm    79 DERFKISYPFRPYFYIATLDGFEFQVSSYLSKKYGAQ-TAVEHMDREDLDLKDHLSGLKKTYIKL 142

  Fly   154 SFLNQTAMTKVRRELMSAVKRNQERQKSNTYYMQMLATSLAQSSAGSEDATLGKRQQDYMDCIVD 218
            ||.:...:.|:|:|||..|::|.:|.|..:.|...||.:|:.....|:|..|   ..|.::.|||
 Worm   143 SFTSTVELIKIRKELMPLVRKNTDRIKKESAYADYLARNLSGKGGDSKDQQL---NGDILNQIVD 204

  Fly   219 IREHDVPYHVRVSIDLRIFCGQWYNIRCRSGVELPTITCRPDI-LDRPEPVVLAFDIETTKLPLK 282
            |||:|||:|:|||||.:||.|.||:::......:|||. |.|: |...:|.||||||||||||||
 Worm   205 IREYDVPFHMRVSIDEKIFVGLWYDVKGIGPNRVPTIK-RKDLPLFHAKPKVLAFDIETTKLPLK 268

  Fly   283 FPDAQTDQVMMISYMIDGQGYLITNREIISSNVDDFEYTPKPEFEGNFIVFNEENEMQLLQRFFD 347
            |||.::|::||||||:||:|:||.||||:|::::.||||||.|:.|.|.|:||::|..|:::|||
 Worm   269 FPDRESDEIMMISYMVDGRGFLIINREIVSADINAFEYTPKAEYIGEFTVWNEKDEAALIRKFFD 333

  Fly   348 HIMEVRPHIIVTYNGDFFDWPFVETRAAVYDLDMKQEIGFSKLRDGNYLSRPAIHMDCLCWVKRD 412
            |.::|||:|:||||||||||||||.||.:...:|::||||||.....|.||..||||...|||||
 Worm   334 HFLQVRPNIVVTYNGDFFDWPFVEARAKIRGFNMEREIGFSKDSADEYKSRNCIHMDAFRWVKRD 398

  Fly   413 SYLPVGSQGLKAVAKAKLRYDPVELDPEDMCRMAVEQPQVLANYSVSDAVATYYLYMKYVHPFIF 477
            ||||||||.||||.||||||||||::||.||:||.||||.||||||||||:||||||||||.|||
 Worm   399 SYLPVGSQNLKAVTKAKLRYDPVEVEPELMCKMAREQPQQLANYSVSDAVSTYYLYMKYVHQFIF 463

  Fly   478 ALNTIIPMEPDEILRKGSGTLCETLLMVEAYHAQIVYPNKHQS-ELNKLSNEGHVLDSETYVGGH 541
            ||.||||:..|::||||||||||.||||||:|..||:|||:.. |..:.|.:||.::||||||||
 Worm   464 ALCTIIPLGADDVLRKGSGTLCEALLMVEAFHNNIVFPNKYTGPEETRFSKDGHRVESETYVGGH 528

  Fly   542 VEALESGVFRADIPCRFRLDPAMVKQLQEQVDAVLRHAIEVEEGIPLEKVLNLDEVRQEIVQGLQ 606
            |||||:||||||||.:|||....::||:.::...||..:..|..:.|::|::.||...|:.....
 Worm   529 VEALEAGVFRADIPAKFRLSVPALEQLKSEIQETLRKELAREFEVTLDQVVDFDEQCAEVQDAFD 593

  Fly   607 GLHDIPNRLEQPVIYHLDVGAMYPNIILTNRLQPSAMVSDLDCAACDFNKPGVRCKRSMDWLWRG 671
            |:.::|.|||.|.|||||||||||||||||||||.|||::..|..|.:|||...|||:|.|.|||
 Worm   594 GMINVPTRLENPRIYHLDVGAMYPNIILTNRLQPCAMVTEEICMGCSYNKPDAECKRTMAWEWRG 658

  Fly   672 EMLPASRNEFQRIQQQLETEKFPPLFPGGPQRAFHELSKEDQAAYEKKRLTDYCRKAYKKTKLTK 736
            |:.||:|.|:|:|.||||.|.|     |.|.:.||.|.:.::.|.|.||:.||.|:.|.||.||:
 Worm   659 ELTPATRGEYQQIMQQLEAESF-----GKPPKHFHMLERSEREAIEMKRIKDYSRRVYGKTHLTR 718

  Fly   737 LETRTSTICQKENSFYVDTVRAFRDRRYEYKGLTKVAKASVNAAVASGDAAEIKAAKGREVLYDS 801
            ||.|.:||||:||.|||:||:||||||||||.:.|.||...:.|.|:.|.|.:..:|...|||:|
 Worm   719 LEMRETTICQRENHFYVETVKAFRDRRYEYKDMLKKAKGRFDQAQATNDLATMTTSKLEMVLYES 783

  Fly   802 LQLAHKCILNSFYGYVMRRGARWHSMPMAGIVCLTGSNIITKAREIIERVGRPLELDTDGIWCIL 866
            ||||||||||||||||||:|:||.||.||||||.||:|||.:||:::|::|.|||||||||||::
 Worm   784 LQLAHKCILNSFYGYVMRKGSRWFSMEMAGIVCHTGANIIREARKLVEQIGTPLELDTDGIWCLI 848

  Fly   867 PGSFPQEFTIHTSHEKKKKINISYPNAVLNTMVKDHFTNDQYHELRKDKENNLPKYDIRDENSIF 931
            |.|||:..|....:.|:..:.:|||.|:||.:|.:.|||.|||.|.||     ..|....||||:
 Worm   849 PASFPENVTFKLKNHKRSSVTVSYPGAMLNALVYEGFTNHQYHTLEKD-----GSYSKSSENSIY 908

  Fly   932 FEVDGPYLAMVLPAAKEEGKKLKKRYAVFNFDGTLAELKGFEVKRRGELQLIKNFQSSVFEAFLA 996
            |||||||..|:|||:|||||||||||||||.||:|||:||||:||||||.:||:||..||:.||.
 Worm   909 FEVDGPYQCMILPASKEEGKKLKKRYAVFNLDGSLAEMKGFELKRRGELNIIKHFQGCVFKTFLN 973

  Fly   997 GSTLEECYASVAKVADYWLDVLYSRGSNLPDSELFELISENKSMSKKLEEYGAQKSTSISTAKRL 1061
            |.||||.|.:||..||:|||:|:|.|::|.|.|||:|||||:|||:|||:|||||||||||||||
 Worm   974 GKTLEETYKAVAADADHWLDILHSHGADLTDEELFDLISENRSMSRKLEDYGAQKSTSISTAKRL 1038

  Fly  1062 AEFLGEQMVKDAGLACKYIISKKPEGAPVTERAIPLAIFQSEPSVRRHHLRRWLKDNTMG-DADI 1125
            |||||:.|||||||||.:||||.|.||||||||||:|||:|:..||.|::|:|.|..... |.||
 Worm  1039 AEFLGDDMVKDAGLACMFIISKHPIGAPVTERAIPVAIFKSDAKVRSHYIRKWTKQVDFNEDTDI 1103

  Fly  1126 RDVLDWNYYIERLGGTIQKIITIPAALQGLANPVPRVQHPDWLHKKMLEKNDVLKQRRINEMFTS 1190
            ||:|||:||:||.|..|||||||||||||::||||||.|||||..|:..|.|..:|.|||::|.:
 Worm  1104 RDMLDWDYYLERFGSCIQKIITIPAALQGISNPVPRVPHPDWLQNKIRNKFDAHRQPRINQIFAA 1168

  Fly  1191 RPKPKPL--------------ATEEDKLADMEDLAGKDGGEGAAGCPIVTKRKRIQLEEHDDEEA 1241
            ..||...              ...||.:...:|:...|..|..|      ||::...:.|..|
 Worm  1169 CQKPSTSQMDNGKRRRTPDDDVASEDAMDSQDDIIIDDDKENGA------KRQKNTKKVHTTE-- 1225

  Fly  1242 QPQATTWRQALGAPPPIGETRKTIV-----EWVRFQKKKWKWQQDQRQRNRQASKRTRGEDPPVV 1301
                            :...:||:|     ||:.|.||||:.|  :::|..|.|.:    |..||
 Worm  1226 ----------------VVLEKKTLVEHGFDEWMGFLKKKWRVQ--RKERKTQLSSK----DSDVV 1268

  Fly  1302 RATGSTATLGGFLRRAQRTLLDQPWQIVQLVPVDDLGHFTVWALIGEELHKIKLTVPRIFYVNQR 1366
            .|         .:|.|:....|:.|.|:.:.|..|...|.||..:..::||:.:.:.|...|:.|
 Worm  1269 EA---------IVRGAREAEHDKEWHILSVEPTADASFFNVWLAVQGQMHKVIMKIGRRIIVDSR 1324

  Fly  1367 SAAPPEEGQLWRKVNRVLPRSRPVFNLYRYSVPEQLFRDNSLGMLAD-----LATPDIEGIYETQ 1426
            :.....:     .:.|:||..:....||.:...|     |.|..|.|     ..:..|:||||::
 Worm  1325 APRGDRD-----TIRRILPHHKTPGFLYEFRTDE-----NQLTALMDKLYSETCSSTIDGIYESE 1379

  Fly  1427 MTLEFRALMDMGCICGVQREEARRLA--QLATKDLETFSIEQLEQRPQTQVKYLASANNRLRKIY 1489
            :...|||::.:|.|  |:.:....|.  ||..::|          :|..:..|| ..:.::|.|:
 Worm  1380 VPTSFRAVLQLGSI--VRPDHGISLGGHQLTLENL----------KPMEKAPYL-PLDQKIRTIF 1431

  Fly  1490 LYQHNTPTAKKEIWSLILMPSKKAFVFALDTVRANQMPNMRQLYTAERLALLKNLTAEE------ 1548
            ||:.:..:  :.::|||......|:.:.::|... |||||..|||:   |..|.::.|.
 Worm  1432 LYKFSQDS--RHVYSLIDSSGSAAYFYIVNTGDV-QMPNMDSLYTS---AYTKMMSTERGQLCHT 1490

  Fly  1549 QDKIPVEDYTFEVLIEVDVKQIYRHIQRALTTYKQEHQGPTILCLQTALSARKLSLAMPILLEFP 1613
            .:.:|.....|....|.:     |.:.|||..|::......|:.|.:.....:|:..:|.|..||
 Worm  1491 SESMPFTVKRFSSNTECE-----RQLGRALRVYREVSSKTAIVLLLSDTDPFRLARKLPNLGLFP 1550

  Fly  1614 QAEIHISDDASLLSGLDWQRQGSRAVIRHFLNLNNVLDLMLDQCRYFHVPIGNMPPDTVLFGADL 1678
            ..::||::.:|||:.:|||:..:|.|::|:.|....|...|:..||..|||||:|.|..|||.||
 Worm  1551 NVQLHITEPSSLLNQIDWQKVVARRVLQHYFNSFFFLADYLEWARYLRVPIGNLPADHALFGLDL 1615

  Fly  1679 FFARLLQRHNFVLWWSASTRPDLGGREADDSRLLAEFEE-SI--SVVQNKAGFYPDVCVELALDS 1740
            .|||.||:....||.:.::||||||:|.||.||..::.. ||  :|:.|:..|....||||.|.:
 Worm  1616 LFARNLQKSGHALWATRASRPDLGGKEMDDVRLSVDWNPLSIDDTVLLNRETFCETACVELQLSA 1680

  Fly  1741 LAVSALLQSTRIQEMEGASSAITFDVMPQVSLEEMIGTVPAATLPSYDETALCSAAFRVMRSMVN 1805
            :||:||:|.:|:.|.|||...:|||.|..::.:.:.|.. ..::..|||.|...|..:|::.|:.
 Worm  1681 VAVTALVQRSRVLEAEGADDVVTFDSMNTIAQQSVTGGA-VNSIACYDEGAAVDATIKVLKQMLT 1744

  Fly  1806 GWLREVSINRNIFSDFQIVHFYRWVRSSNALLYDPALRRSLNNLMRKMFLRIIAEFKRLGATIIY 1870
            ..:|.::...|..:|..::...||:.:.:|||:|.||.||::.|..|:.|.:.||.:|:||.:|:
 Worm  1745 ECVRHIAHQGNARADEVVMTVSRWLNTRSALLFDAALTRSVSVLESKLVLLLCAECERIGAKVIH 1809

  Fly  1871 ADFNRIILSSGKKTVSDALGYVDYIVQSLRNKEMFHSIQLSFEQCWNFMLWMDQANFSGIRGKLP 1935
            |...:::|::||.|..:|.|:.:.::|||....:|.::.::..:.::.|||||..|.:|||
 Worm  1810 ATAQKLVLNTGKSTSEEAKGFAEMLIQSLSTNVVFAALHITPVKFFDAMLWMDAHNHTGIR---- 1870

  Fly  1936 KGIDETVSSIVSTTMIRDSERNQDDDEDEEEDSENRDPVESNEAEQDQEDELSLELNWTIGEHLP 2000
              |.|            .:|.:.|...||||.|..               |......|.|.|.:|
 Worm  1871 --ISE------------KTESSPDVIADEEESSCT---------------EFETTAIWKIAEEMP 1906

  Fly  2001 DENECREKFESLLTLFMQSLAEKK-------------TTEQAIKDISHCAFDFILKL-HKNYGKG 2051
            .|...:|:|..::..::....|..             .::...:.|||..:..:.|: |.|....
 Worm  1907 TEANIQEEFLQMIGAYILEFLETNRKMHFDSESGATFRSDCISQKISHRLYRIVNKMVHNNADIA 1971

  Fly  2052 KPSPGLELIRTLIKALSVDKTLAEQINELRRNMLRLVGIGEFSDLAEWE-DPCDSH--IINEVIC 2113
            ..|  :.|...|.:|||.|:|....:..:|.|..||:    .:.:.|.: .|..|.  .::.|.|
 Worm  1972 HCS--VYLANALCRALSCDQTSQLAVEGIRDNAKRLL----HNSVVEADMTPLRSTTLFVSNVFC 2030

  Fly  2114 KACNHCRDLDLCKDKHRAMKDGVPVWLCAQCYVAYDNEEIEMRMLDALQRKMMSYVLQDLRCSRC 2178
            .:|:...::.|.....        :..||.|....:::.|:|.:.|.|.:.:.:|.:||.:|::|
 Worm  2031 NSCSQASNVFLSSTDE--------ILTCATCQSKLNSDVIDMMICDRLNQLLTAYQIQDHQCTKC 2087

  Fly  2179 SEIKRENLAEFCTCAGNFVPLISGKDIQTLLGTFNKVA 2216
            ..::.:.|:.:|.|...|:|.|:...::....|...|:
 Worm  2088 KSVRHDTLSMYCECCSQFIPQITPAQLKHEASTVETVS 2125

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DNApol-epsilon255	NP_524462.2	DNA_polB_epsilon_exo	266..469	CDD:99822	138/202 (68%)
		POLBc_epsilon	529..1154	CDD:99918	380/625 (61%)
		DUF1744	1529..1930	CDD:369900	139/409 (34%)
pole-1	NP_493616.1	PolB	69..1144	CDD:223494	644/1089 (59%)
		DNA_polB_epsilon_exo	253..455	CDD:99822	138/201 (69%)
		POLBc_epsilon	516..1132	CDD:99918	380/625 (61%)
		DUF1744	1470..1869	CDD:285663	138/407 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166260
Domainoid	1	1.000	354	1.000	Domainoid score	I519
eggNOG	1	0.900	-	-		E1_COG0417
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4539
Inparanoid	1	1.050	1717	1.000	Inparanoid score	I29
Isobase	1	0.950	-	0	Normalized mean entropy	S834
OMA	1	1.010	-	-		QHG55019
OrthoDB	1	1.010	-	-		D16244at33208
OrthoFinder	1	1.000	-	-		FOG0004282
OrthoInspector	1	1.000	-	-		oto17507
orthoMCL	1	0.900	-	-		OOG6_101586
Panther	1	1.100	-	-	LDO	PTHR10670
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R346
SonicParanoid	1	1.000	-	-		X3018
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	17	16.750