DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DNApol-epsilon255 and pole

DIOPT Version :9

Sequence 1:	NP_524462.2	Gene:	DNApol-epsilon255 / 42758	FlyBaseID:	FBgn0264326	Length:	2236	Species:	Drosophila melanogaster
Sequence 2:	XP_004910692.2	Gene:	pole / 100498309	XenbaseID:	XB-GENE-1011589	Length:	2286	Species:	Xenopus tropicalis

Alignment Length:	2298	Identity:	1273/2298 - (55%)
Similarity:	1682/2298 - (73%)	Gaps:	103/2298 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 VLQNTGKFVSENRTEGDDFFNEAG-------YRQSRENDKIDSKYGFDRVKDSQERTGYLINMHS 66
            ||||:||..:|.|.:|::..::|.       ..:|:..||||::|||:|:::..|:||:|:|||.
Frog     2 VLQNSGKLRAEPRGDGENQQDDASASSAAKRLERSQWTDKIDAQYGFERIREPGEKTGWLLNMHP 66

  Fly    67 NEVLDEDRRLIAALDLFFIQMDGSRFKCTVAYQPYLLIRPEDNMHLEVARFLGRKYSGQISGLEH 131
            ||:||||:||::|:|.:|||.||||||..:.|:||..:..:.....||:.||.:|:.|:::.||.
Frog    67 NEILDEDKRLVSAVDYYFIQEDGSRFKVALPYKPYFYVATKKGCEREVSSFLSKKFQGKLAKLET 131

  Fly   132 ITKEDLDLPNHLSGLQQQYIKLSFLNQTAMTKVRRELMSAVKRNQERQKSNTYYMQMLATSLAQS 196
            |.||||||||||.||::.||||||.:...:.|||:|:..||::|:||..::..|..||:::|..:
Frog   132 IPKEDLDLPNHLVGLKRGYIKLSFHSVDDLIKVRKEISPAVRKNKERDHASDTYTAMLSSALTGN 196

  Fly   197 SAGSEDATLGKRQQDYMDCIVDIREHDVPYHVRVSIDLRIFCGQWYNIRCRSGVELPTITCRPDI 261
            :.|:|:....|:..|.|:.|||:||:||||||||||||:|....|||||.|.....|.||.|.|:
Frog   197 NMGAEEEGPSKKISDQMENIVDMREYDVPYHVRVSIDLKIHVAHWYNIRYRGSSSPPEITRRDDL 261

  Fly   262 LDRPEPVVLAFDIETTKLPLKFPDAQTDQVMMISYMIDGQGYLITNREIISSNVDDFEYTPKPEF 326
            ::||:||||||||||||||||||||:|||:|||||||||||||||||||:|.:::|||:|||||:
Frog   262 VERPDPVVLAFDIETTKLPLKFPDAETDQIMMISYMIDGQGYLITNREIVSEDIEDFEFTPKPEY 326

  Fly   327 EGNFIVFNEENEMQLLQRFFDHIMEVRPHIIVTYNGDFFDWPFVETRAAVYDLDMKQEIGFSKLR 391
            ||.|.:|||.:|..|:||:|:|:.|.:|:|||||||||||||||||||:|:.:.|.|||||.|..
Frog   327 EGPFCIFNEPDEAHLIQRWFEHMQETKPNIIVTYNGDFFDWPFVETRASVHGMSMLQEIGFQKDN 391

  Fly   392 DGNYLSRPAIHMDCLCWVKRDSYLPVGSQGLKAVAKAKLRYDPVELDPEDMCRMAVEQPQVLANY 456
            .|.|.|.|.||||||.||||||||||||..|||.|||||.|||||||||:|||||.|:|||||.|
Frog   392 QGEYKSPPCIHMDCLRWVKRDSYLPVGSHNLKAAAKAKLGYDPVELDPEEMCRMATEEPQVLATY 456

  Fly   457 SVSDAVATYYLYMKYVHPFIFALNTIIPMEPDEILRKGSGTLCETLLMVEAYHAQIVYPNKHQSE 521
            ||||||||||:||||||||||||.|||||||||:||||||||||.||||:||||.|::|||.::.
Frog   457 SVSDAVATYYMYMKYVHPFIFALCTIIPMEPDEVLRKGSGTLCEALLMVQAYHANIIFPNKQEAV 521

  Fly   522 LNKLSNEGHVLDSETYVGGHVEALESGVFRADIPCRFRLDPAMVKQLQEQVDAVLRHAIEVEEGI 586
            .|||:::|||||||||||||||||||||||:||||||:::||....|.::|:..||||||.||.|
Frog   522 FNKLTSDGHVLDSETYVGGHVEALESGVFRSDIPCRFKMNPAAFDFLLQRVELTLRHAIEEEEKI 586

  Fly   587 PLEKVLNLDEVRQEIVQGLQGLHDIPNRLEQPVIYHLDVGAMYPNIILTNRLQPSAMVSDLDCAA 651
            |||:|.|..||.:||.:.|..|.::|||:|.|:|||||||||||||||||||||||||.::.|||
Frog   587 PLEQVTNFQEVCEEIKKKLNSLKEVPNRIECPLIYHLDVGAMYPNIILTNRLQPSAMVDEVTCAA 651

  Fly   652 CDFNKPGVRCKRSMDWLWRGEMLPASRNEFQRIQQQLETEKFPPLFPGGPQRAFHELSKEDQAAY 716
            |||||||..|:|.|.|.||||.:||||:|:.|||||||:|||||||||.|.||||||::|:||.|
Frog   652 CDFNKPGATCQRQMTWQWRGEFMPASRSEYHRIQQQLESEKFPPLFPGKPPRAFHELTREEQAKY 716

  Fly   717 EKKRLTDYCRKAYKKTKLTKLETRTSTICQKENSFYVDTVRAFRDRRYEYKGLTKVAKASVNAAV 781
            |||||.|||||||||..:|:||.:.:||||:||||||||||||||||||:|||.||.|..:::|.
Frog   717 EKKRLADYCRKAYKKIHVTRLEEKVTTICQRENSFYVDTVRAFRDRRYEFKGLHKVWKKKLSSAC 781

  Fly   782 ASGDAAEIKAAKGREVLYDSLQLAHKCILNSFYGYVMRRGARWHSMPMAGIVCLTGSNIITKARE 846
            .||||||||..|..|:||:|||||||||||||||||||:||||:||.||||||.||:||||:|||
Frog   782 ESGDAAEIKRCKNMEILYESLQLAHKCILNSFYGYVMRKGARWYSMEMAGIVCYTGANIITQARE 846

  Fly   847 IIERVGRPLELDTDGIWCILPGSFPQEFTIHTSHEKKKKINISYPNAVLNTMVKDHFTNDQYHEL 911
            ::|::|||||||||||||:||.|||:.|.|.:::.||.|:.||||.|:||.:||:.|||.||.||
Frog   847 LVEQIGRPLELDTDGIWCVLPNSFPENFVIKSTNAKKPKVTISYPGAMLNILVKEGFTNHQYQEL 911

  Fly   912 RKDKENNLPKYDIRDENSIFFEVDGPYLAMVLPAAKEEGKKLKKRYAVFNFDGTLAELKGFEVKR 976
               .:.....|..|.|||||||||||||||:|||:|||||||||||||||.||:|||||||||||
Frog   912 ---SDPATLTYITRSENSIFFEVDGPYLAMILPASKEEGKKLKKRYAVFNEDGSLAELKGFEVKR 973

  Fly   977 RGELQLIKNFQSSVFEAFLAGSTLEECYASVAKVADYWLDVLYSRGSNLPDSELFELISENKSMS 1041
            ||||||||.||||||||||.||||||.|||||||||||||||||:.:|:||:|||||||||:|||
Frog   974 RGELQLIKIFQSSVFEAFLKGSTLEEVYASVAKVADYWLDVLYSKAANMPDAELFELISENRSMS 1038

  Fly  1042 KKLEEYGAQKSTSISTAKRLAEFLGEQMVKDAGLACKYIISKKPEGAPVTERAIPLAIFQSEPSV 1106
            ::||:||.|||||||||||||||||:||||||||:|:|:||:||||:|||||||||||||:|..|
Frog  1039 RRLEDYGEQKSTSISTAKRLAEFLGDQMVKDAGLSCRYVISRKPEGSPVTERAIPLAIFQAEVGV 1103

  Fly  1107 RRHHLRRWLKDNTMGDADIRDVLDWNYYIERLGGTIQKIITIPAALQGLANPVPRVQHPDWLHKK 1171
            :||:||:|||:.::.|.|||.:|||:|||||||..||||||||||||.:.||||||:||||||||
Frog  1104 KRHYLRKWLKNPSLQDLDIRSILDWDYYIERLGSAIQKIITIPAALQQVKNPVPRVRHPDWLHKK 1168

  Fly  1172 MLEKNDVLKQRRINEMFTSRPKPKPLA----TEEDKLADMEDLAGKDGGEGAAGCPIVTKRKRIQ 1232
            :|||||:.||:||||:|||..|.:..|    .:..:..||||..  .|.......||.|||||:.
Frog  1169 LLEKNDIYKQKRINELFTSEGKRQITAQMQQPDSSQTPDMEDFG--IGKRLQPAVPISTKRKRVP 1231

  Fly  1233 LEEHDDEEAQPQATT--WRQALGAPPPIGETRKTIVEWVRFQKKKWKWQQDQRQRNRQASKRTRG 1295
            ..|....::|..|.|  ||:.||.|||:|.|::..:.|:|:.||||:.|..||:..::..:...|
Frog  1232 TAEDSQGDSQNLALTQSWREVLGPPPPLGTTKEERLVWLRYHKKKWELQARQRKERQKKRRLEDG 1296

  Fly  1296 EDPP----VVRATGSTATLGGFLRRAQRTLLDQPWQIVQLVPVDDLGHFTVWALIGEELHKIKLT 1356
            :..|    |:|.| ..|.||.||||..|::||.||||||:......|.|.:||:||.:||.|||.
Frog  1297 DVAPGAGGVIRET-QAAGLGSFLRRTARSILDMPWQIVQIGESSQPGLFRLWAVIGNDLHCIKLN 1360

  Fly  1357 VPRIFYVNQRSAAPPEEGQLWRKVNRVLPRSRPVFNLYRYSVPEQLFRDNSLGMLADLATPDIEG 1421
            :||:|:|||| ...||||.::|||||:||||.||::||.|:|||.:::::...:.|||:.|||||
Frog  1361 IPRVFFVNQR-IPKPEEGAVYRKVNRILPRSNPVYHLYEYTVPEDMYQEHINEINADLSAPDIEG 1424

  Fly  1422 IYETQMTLEFRALMDMGCICGVQREEARRLAQLATKDLETFSIEQLEQRPQTQVKYLASANNRLR 1486
            :||||:.|..||:..:||:|.|.::..|   .|:.::.:||.:|.||.:...|..||...:  :|
Frog  1425 VYETQVPLIMRAVSQLGCVCMVNKQLVR---HLSGREADTFDLEHLEMKSLAQYSYLEPGS--IR 1484

  Fly  1487 KIYLYQHNTPTAKKEIWSLILMPSKKAFVFALDTVRANQMPNMRQLYTAERLALLKNLTAEEQDK 1551
            .|||| ||: ...|.::.|.:...:|:.||.:||||:|||||:..:||||..|:.:.:   :.:.
Frog  1485 HIYLY-HNS-QGHKALFGLFIPSQRKSAVFVVDTVRSNQMPNLSNMYTAEHTAMQERV---DPEL 1544

  Fly  1552 IPVEDYTFEVLIEVDVKQIYRHIQRALTTYKQEHQGPTILCLQTALSARKLSLAMPILLEFPQAE 1616
            :|.|.:.|||..|.|:|.:||.|||.|.:||.|.:|||::.:|:..:.|:|:..||:|.|||...
Frog  1545 LPPEKHIFEVRAETDLKTVYRGIQRLLLSYKDERRGPTLIAVQSNWNLRRLAAGMPVLEEFPLVP 1609

  Fly  1617 IHISDDASLLSGLDWQRQGSRAVIRHFLNLNNVLDLMLDQCRYFHVPIGNMPPDTVLFGADLFFA 1681
            :.|:||.| ...|||||.|:|.:|||:|||::.|....:..||:|:|:||:|.|...||:||||:
Frog  1610 VRITDDIS-YGVLDWQRHGARRMIRHYLNLDSCLSQAFEMARYYHLPVGNLPDDVSTFGSDLFFS 1673

  Fly  1682 RLLQRHNFVLWWSASTRPDLGGREADDSRLLAEFEESISVVQNKAGFYPDVCVELALDSLAVSAL 1746
            |.|:|||.:||.|.|.||||||:||||:||:.||:|..||..|..|.|..|||||.:.||||:::
Frog  1674 RHLRRHNHLLWLSPSARPDLGGKEADDNRLVMEFDEKASVEINNPGCYNTVCVELDIQSLAVNSI 1738

  Fly  1747 LQSTRIQEMEGASS-AITFDVMPQVSLEEMIGTVPAATLPSYDETALCSAAFRVMRSMVNGWLRE 1810
            |||..|.::|||.| .|:|||:.|.|||:|:....|:::.|||||||||..||:::|||.||::|
Frog  1739 LQSHHINDLEGAGSMGISFDVLQQASLEDMVTGNQASSVASYDETALCSNTFRILKSMVVGWVKE 1803

  Fly  1811 VSINRNIFSDFQIVHFYRWVRSSNALLYDPALRRSLNNLMRKMFLRIIAEFKRLGATIIYADFNR 1875
            ::...|:::|.|::|||||:||.::|||||||.|:|:|:|:|:||:::|||||||::::||:|||
Frog  1804 ITQYHNVYADNQVMHFYRWLRSPSSLLYDPALHRTLHNMMKKLFLQLVAEFKRLGSSVVYANFNR 1868

  Fly  1876 IILSSGKKTVSDALGYVDYIVQSLRNKEMFHSIQLSFEQCWNFMLWMDQANFSGIRGKLPKGIDE 1940
            |||.:.|:.|.||:.||:||.||:.::|:|||:.:|..:||.|:||||.||:.|::||||..:..
Frog  1869 IILCTKKRRVEDAVAYVEYITQSIHSREIFHSLTISVSRCWEFLLWMDPANYGGVKGKLPSSVHY 1933

  Fly  1941 TVSSIVSTTMIRDSERNQDDDEDEEEDSENRDPVESNEAEQDQEDELSLELNWTIGEHLPDENEC 2005
            ..|:.....:  |.| ..|..||||||.:   ||.|::.:.:.:.|.|||.||.|.::||....|
Frog  1934 GESAKKKKAL--DGE-GDDGSEDEEEDDQ---PVNSDDEQSEDQVEESLENNWNIVQYLPQAASC 1992

  Fly  2006 REKFESLLTLFM----QSLAEK-----------------KTTEQAIKD----------------- 2032
            :..|..:::.::    .|:.|:                 :.:::|..|
Frog  1993 QSYFLMIVSAYIVAVYHSMREEMRRNAPGNTPIKRRQNSQVSQEANADGGAMPGLITFSQDYVAN 2057

  Fly  2033 -ISHCAFDFILKLHKNY-----------------GKGKP--SPGLELIRTLIKALSVDKTLAEQI 2077
             ::...|....|:.|..                 |...|  :|.||.|:.:.:.|::|..:..|:
Frog  2058 ELTQNFFTITQKIQKKVTGTRHATEPSEMFPILPGSHLPLNNPALEFIKYVCEVLALDSNITNQV 2122

  Fly  2078 NELRRNMLRLVGIGEFSDLAEWEDPCDSHIINEVICKACNHCRDLDLCKDKHRAMKDG--VPVWL 2140
            |:|:|::||||.:||||:.|::.|||.|:|:.|:||::||.|||||||||. ...:||  :|.|:
Frog  2123 NKLKRDLLRLVDVGEFSEDAQFRDPCRSYILPEIICRSCNFCRDLDLCKDP-AINQDGSVLPQWV 2186

  Fly  2141 CAQCYVAYDNEEIEMRMLDALQRKMMSYVLQDLRCSRCSEIKRENLAEFCTCAGNFVPLISGKDI 2205
            |..|...||::.|||.:::|||:|||::.||||.|.:|..:|..|:..:|.|||:|...||.|.:
Frog  2187 CTNCQAEYDSDGIEMALVEALQKKMMAFTLQDLVCMKCKGVKEANMPVYCNCAGDFTLTISVKVL 2251

  Fly  2206 QTLLGTFNKVAANHKMQLLQQTV 2228
            ...:..|..:|.::.|..|.:|:
Frog  2252 LEQINVFRNIAQHYNMAHLLETI 2274

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNApol-epsilon255	NP_524462.2	DNA_polB_epsilon_exo	266..469	CDD:99822	153/202 (76%)
		POLBc_epsilon	529..1154	CDD:99918	459/624 (74%)
		DUF1744	1529..1930	CDD:369900	202/401 (50%)
pole	XP_004910692.2	DNA_polB_epsilon_exo	266..469	CDD:99822	153/202 (76%)
		POLBc_epsilon	529..1151	CDD:99918	459/624 (74%)
		DUF1744	1525..1923	CDD:400678	202/401 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	436	1.000	Domainoid score	I564
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4539
Inparanoid	1	1.050	2384	1.000	Inparanoid score	I33
OMA	1	1.010	-	-		QHG55019
OrthoDB	1	1.010	-	-		D16244at33208
OrthoFinder	1	1.000	-	-		FOG0004282
OrthoInspector	1	1.000	-	-		oto105610
Panther	1	1.100	-	-	LDO	PTHR10670
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R346
SonicParanoid	1	1.000	-	-		X3018
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110