DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pnt and Ets1

DIOPT Version :9

Sequence 1:	NP_524461.2	Gene:	pnt / 42757	FlyBaseID:	FBgn0003118	Length:	718	Species:	Drosophila melanogaster
Sequence 2:	NP_001359463.1	Gene:	Ets1 / 23871	MGIID:	95455	Length:	484	Species:	Mus musculus

Alignment Length:	625	Identity:	209/625 - (33%)
Similarity:	270/625 - (43%)	Gaps:	199/625 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 KEEPIHGCKD---LCS----------LSDISDHEASLEVPTAL------------PPLTPGTNRK 157
            ::.||:..:|   .|.          |..:.|..|:.||||.|            |.|||.:...
Mouse    24 RQGPINAFEDPRMTCGFQSNYHQQRPLYPLWDETATQEVPTGLEHCGSDMECADVPLLTPSSKEM 88

  Fly   158 VNEVLKASFASWEKEVQKCNITKDPREWTEEHVIYWLNWAKNEFSLVSMNLDPFYKMKGRAMVDL 222
            :::.|||:|:.:.||.|:..|.||||:|||.||..|:.||.|||||..::...|. |.|.|:..|
Mouse    89 MSQALKATFSGFTKEQQRLGIPKDPRQWTETHVRDWVMWAVNEFSLKGVDFQKFC-MSGAALCAL 152

  Fly   223 GKEKFLAITPPFTGDILWEHLDILQKDCEKPNEDIVHGNSFESATTASVCGSDHQVANYPNETHA 287
            |||.||.:.|.|.||||||||:||||:..||                      :|| |..|.|:.
Mouse   153 GKECFLELAPDFVGDILWEHLEILQKEDVKP----------------------YQV-NGANPTYP 194

  Fly   288 NSNNSSINSRLSMDYVTSAGNSDNKNFHRATPHSHNGYNTSNTHDRINNSTPPQQQQSQQPTVNG 352
            .|..:|       ||..|.|          ..|:              ...||.:...
Mouse   195 ESCYTS-------DYFISYG----------IEHA--------------QCVPPSEFSE------- 221

  Fly   353 SGSASSNNNNSMLPPAVQQSNNENNNTSSSNTNNSSNNNNNSGGSNNSNAGSNNNNNNNNNINFM 417
                         |..:.:|....:..||....:....|:
Mouse   222 -------------PSFITESYQTLHPISSEELLSLKYEND------------------------- 248

  Fly   418 AAAAIFQHHLKEEPGTQNGNIGGYGGGSNSQNDPTDLSSYGLPAHLAAYGGGSGSGPTG---GRS 479
            ..:.|.|..|                    |.|......:.:...:..        |..   ||:
Mouse   249 YPSVILQDPL--------------------QTDTLQTDYFAIKQEVLT--------PDNMCLGRA 285

  Fly   480 SGG--GGDESDYHSTISAQDHQSQQSSGGNGSGGASGGSTGNSNGYLDSSSEFYGSYAGRNRFHD 542
            |.|  ||.:|          .:|.:|                    .||......|::.::.|:.
Mouse   286 SRGKLGGQDS----------FESVES--------------------YDSCDRLTQSWSSQSSFNS 320

  Fly   543 -GYPPEFTPYDAQSFQSMGPQPTAMDQWGAAHAHQHPAAYMSTLGLDKGLLGGYTTQGGVPCFTG 606
             ...|.:..:|.:.:      |.|:.........:......:.|..||.::......|    :||
Mouse   321 LQRVPSYDSFDYEDY------PAALPNHKPKGTFKDYVRDRADLNKDKPVIPAAALAG----YTG 375

  Fly   607 SGPIQLWQFLLELLLDKTCQSFISWTGDGWEFKLTDPDEVARRWGIRKNKPKMNYEKLSRGLRYY 671
            ||||||||||||||.||:||||||||||||||||:||||||||||.|||||||||||||||||||
Mouse   376 SGPIQLWQFLLELLTDKSCQSFISWTGDGWEFKLSDPDEVARRWGKRKNKPKMNYEKLSRGLRYY 440

  Fly   672 YDKNIIHKTAGKRYVYRFVCDLQNLVGHTPEELVAKYDLK 711
            |||||||||||||||||||||||:|:|:|||||.|..|:|
Mouse   441 YDKNIIHKTAGKRYVYRFVCDLQSLLGYTPEELHAMLDVK 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pnt	NP_524461.2	SAM_PNT-ETS-1,2	179..250	CDD:188879	41/70 (59%)
pnt	NP_524461.2	ETS	609..693	CDD:197710	79/83 (95%)
Ets1	NP_001359463.1	SAM_PNT-ETS-1	95..182	CDD:176092	47/87 (54%)
Ets1	NP_001359463.1	ETS	378..462	CDD:197710	79/83 (95%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	168	1.000	Domainoid score	I3823
eggNOG	1	0.900	-	-		E1_KOG3806
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	326	1.000	Inparanoid score	I2460
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D243757at33208
OrthoFinder	1	1.000	-	-		FOG0003547
OrthoInspector	1	1.000	-	-		otm42562
orthoMCL	1	0.900	-	-		OOG6_107578
Panther	1	1.100	-	-	O	PTHR11849
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R10367
SonicParanoid	1	1.000	-	-		X2422
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.860