DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pnt and ETS1

DIOPT Version :9

Sequence 1:	NP_524461.2	Gene:	pnt / 42757	FlyBaseID:	FBgn0003118	Length:	718	Species:	Drosophila melanogaster
Sequence 2:	NP_001137292.1	Gene:	ETS1 / 2113	HGNCID:	3488	Length:	485	Species:	Homo sapiens

Alignment Length:	591	Identity:	202/591 - (34%)
Similarity:	265/591 - (44%)	Gaps:	180/591 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   136 DHEASLEVPTAL------------PPLTPGTNRKVNEVLKASFASWEKEVQKCNITKDPREWTEE 188
            |..|:.||||.|            |.|||.:...:::.|||:|:.:.||.|:..|.||||:|||.
Human    55 DEMATQEVPTGLEHCVSDMECADVPLLTPSSKEMMSQALKATFSGFTKEQQRLGIPKDPRQWTET 119

  Fly   189 HVIYWLNWAKNEFSLVSMNLDPFYKMKGRAMVDLGKEKFLAITPPFTGDILWEHLDILQKDCEKP 253
            ||..|:.||.|||||..::...|. |.|.|:..|||:.||.:.|.|.||||||||:||||:..||
Human   120 HVRDWVMWAVNEFSLKGVDFQKFC-MNGAALCALGKDCFLELAPDFVGDILWEHLEILQKEDVKP 183

  Fly   254 NEDIVHGNSFESATTASVCGSDHQVANYPNETHANSNNSSINSRLSMDYVTSAGNSDNKNFHRAT 318
            .:  |:|.:                ..||            .||.:.||..|.|          .
Human   184 YQ--VNGVN----------------PAYP------------ESRYTSDYFISYG----------I 208

  Fly   319 PHSHNGYNTSNTHDRINNSTPPQQQQSQQPTVNGSGSASSNNNNSMLPPAVQQSNNENNNTSSSN 383
            .|:              ...||.:...                    |..:.:|....:..||..
Human   209 EHA--------------QCVPPSEFSE--------------------PSFITESYQTLHPISSEE 239

  Fly   384 TNNSSNNNNNSGGSNNSNAGSNNNNNNNNNINFMAAAAIFQHHLKEEPGTQNGNIGGYGGGSNSQ 448
            ..:....|:...........::...|     ::.|        :|:|..|
Human   240 LLSLKYENDYPSVILRDPLQTDTLQN-----DYFA--------IKQEVVT--------------- 276

  Fly   449 NDPTDLSSYGLPAHLAAYGGGSGSGPTGGRSSGG--GGDESDYHSTISAQDHQSQQSSGGNGSGG 511
                       |.::..           ||:|.|  ||.:|          .:|.:|
Human   277 -----------PDNMCM-----------GRTSRGKLGGQDS----------FESIES-------- 301

  Fly   512 ASGGSTGNSNGYLDSSSEFYGSYAGRNRFHD-GYPPEFTPYDAQSFQSMGPQPTAMDQWGAAHAH 575
                        .||......|::.::.|:. ...|.:..:|::.:      |.|:.........
Human   302 ------------YDSCDRLTQSWSSQSSFNSLQRVPSYDSFDSEDY------PAALPNHKPKGTF 348

  Fly   576 QHPAAYMSTLGLDKGLLGGYTTQGGVPCFTGSGPIQLWQFLLELLLDKTCQSFISWTGDGWEFKL 640
            :......:.|..||.::......|    :||||||||||||||||.||:||||||||||||||||
Human   349 KDYVRDRADLNKDKPVIPAAALAG----YTGSGPIQLWQFLLELLTDKSCQSFISWTGDGWEFKL 409

  Fly   641 TDPDEVARRWGIRKNKPKMNYEKLSRGLRYYYDKNIIHKTAGKRYVYRFVCDLQNLVGHTPEELV 705
            :||||||||||.||||||||||||||||||||||||||||||||||||||||||:|:|:|||||.
Human   410 SDPDEVARRWGKRKNKPKMNYEKLSRGLRYYYDKNIIHKTAGKRYVYRFVCDLQSLLGYTPEELH 474

  Fly   706 AKYDLK 711
            |..|:|
Human   475 AMLDVK 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pnt	NP_524461.2	SAM_PNT-ETS-1,2	179..250	CDD:188879	40/70 (57%)
pnt	NP_524461.2	ETS	609..693	CDD:197710	79/83 (95%)
ETS1	NP_001137292.1	SAM_PNT-ETS-1	95..182	CDD:176092	46/87 (53%)
ETS1	NP_001137292.1	ETS	378..462	CDD:197710	79/83 (95%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	168	1.000	Domainoid score	I3832
eggNOG	1	0.900	-	-		E1_KOG3806
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	325	1.000	Inparanoid score	I2492
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D243757at33208
OrthoFinder	1	1.000	-	-		FOG0003547
OrthoInspector	1	1.000	-	-		otm40489
orthoMCL	1	0.900	-	-		OOG6_107578
Panther	1	1.100	-	-	O	PTHR11849
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R10367
SonicParanoid	1	1.000	-	-		X2422
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.860