DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bb8 and glud1b

DIOPT Version :9

Sequence 1:	NP_651140.1	Gene:	bb8 / 42756	FlyBaseID:	FBgn0039071	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	NP_955839.2	Gene:	glud1b / 373092	ZFINID:	ZDB-GENE-030828-1	Length:	542	Species:	Danio rerio

Alignment Length:	501	Identity:	232/501 - (46%)
Similarity:	335/501 - (66%)	Gaps:	6/501 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 ETDKDPEFSEMVLYYYHKAAQTMEPALLKEMEKYPHMKPEERQARVTAILNLLGSVSTSVEVNFP 100
            :.:.||.|..||..::.:.|..:|..|:::::  ....||::::||..||.::...:..:.|:||
Zfish    43 DKEDDPNFFRMVEGFFDRGATIVENKLVEDLK--TRETPEQKRSRVRGILKIIKPCNHVLSVSFP 105

  Fly   101 IVRKNGTYEIISGYRSHHVRHRLPLKGGIRYALDVNESEVKALAAIMTFKCACVNVPYGGSKGGI 165
            |.|.||.:|:|.|||:.|.:||.|.||||||::||:..||||||::||:|||.|:||:||:|.|:
Zfish   106 IKRDNGEWEVIEGYRAQHSQHRTPCKGGIRYSMDVSVDEVKALASLMTYKCAVVDVPFGGAKAGV 170

  Fly   166 CIDPKKYTVDELQTITRRYTMELLKRNMIGPGIDVPAPDVNTGPREMSWIVDQYQKTFGYKDINS 230
            .|:|:.|:.:||:.||||:|:||.|:..|||||||||||::||.||||||.|.|..|..:.|||:
Zfish   171 KINPRNYSDNELEKITRRFTIELAKKGFIGPGIDVPAPDMSTGEREMSWIADTYANTIAHTDINA 235

  Fly   231 SAIVTGKPVHNGGINGRHSATGRGVWKAGDLFLKDKEWMDLLKWKTGWKDKTVIVQGFGNVGSFA 295
            .|.|||||:..|||:||.|||||||:...:.|:.:..:|..|....|:.|||.|:|||||||..:
Zfish   236 HACVTGKPISQGGIHGRISATGRGVFHGIENFINEASYMSKLGLTPGFADKTFIIQGFGNVGLHS 300

  Fly   296 AKYVHEAGAKVIGIKEFDVSLVNKDGIDINDLFEYTEEKKTIKGYPKAQESKEDLLVAETDILMP 360
            .:|:|..|||.:||.|.|.|:.|.:|:|..:|.:|..:..||.|:|.:|..:.::|.|:.|||:|
Zfish   301 MRYLHRYGAKCVGIAEIDGSIWNPNGMDPKELEDYKLQHGTIVGFPNSQPYEGNILEAQCDILIP 365

  Fly   361 CATQKVITTDNAKDIKAKLILEGANGPTTPSGEKILLDKGVLLVPDLYCNAGGVTVSYFEYLKNI 425
            .|.:|.:|..||.:||||:|.|||||||||..:||.:::.|:::||:|.|||||||||||:|||:
Zfish   366 AAGEKQLTRKNAHNIKAKIIAEGANGPTTPDADKIFIERNVMVIPDMYLNAGGVTVSYFEWLKNL 430

  Fly   426 NHVSYGKMNSKSTSELIIELMNSINESLHECPDSQ---LPNICPNKKLKRIQQCTTEADIVDSAL 487
            ||||||::..|...:....|:.|:.|||......|   :| |.|....:......:|.|||.|.|
Zfish   431 NHVSYGRLTFKYERDSNYHLLMSVQESLERKFGKQGGPIP-IVPTADFQARVAGASEKDIVHSGL 494

  Fly   488 QTVMESAARGIKEMAHKFELCNDLRRAAYVWSSFKIFQAMESSGIS 533
            ...||.:||.|...|:|:.|..|||.||||.:..|:|:....:|::
Zfish   495 AYTMERSARQIMRTANKYNLGLDLRTAAYVNAIEKVFKVYNEAGLT 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bb8	NP_651140.1	GdhA	72..532	CDD:223411	223/462 (48%)
		ELFV_dehydrog_N	95..221	CDD:280903	76/125 (61%)
		NAD_bind_1_Glu_DH	242..517	CDD:133445	127/277 (46%)
glud1b	NP_955839.2	ELFV_dehydrog_N	97..224	CDD:280903	75/126 (60%)
		NAD_bind_1_Glu_DH	247..532	CDD:133445	130/285 (46%)
		ELFV_dehydrog	247..530	CDD:278631	129/283 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170588143
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54967
OrthoDB	1	1.010	-	-		D217293at33208
OrthoFinder	1	1.000	-	-		FOG0001473
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100455
Panther	1	1.100	-	-	O	PTHR11606
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R306
SonicParanoid	1	1.000	-	-		X1737
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.890