DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bb8 and gdh-1

DIOPT Version :9

Sequence 1:	NP_651140.1	Gene:	bb8 / 42756	FlyBaseID:	FBgn0039071	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	NP_502267.1	Gene:	gdh-1 / 178130	WormBaseID:	WBGene00014095	Length:	536	Species:	Caenorhabditis elegans

Alignment Length:	527	Identity:	235/527 - (44%)
Similarity:	341/527 - (64%)	Gaps:	13/527 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 RQVLKRS-------AH-QVPEKLKKVETDKDPEFSEMVLYYYHKAAQTMEPALLKEMEKYPHMKP 74
            |.|..||       || ||.::.|.:|...:|.|.:||.:|::|.|:.:.|.|.:|: |...:..
Worm    10 RSVAVRSYSAATLDAHSQVLDEQKPMEEQVNPSFYKMVDFYFNKGAEVIAPKLAEEL-KSNSLSQ 73

  Fly    75 EERQARVTAILNLLGSVSTSVEVNFPIVRKNGTYEIISGYRSHHVRHRLPLKGGIRYALDVNESE 139
            ::::..|:.||..:..|:..:.:.|||.|.||.:|:|..:|:.|..||.|.||||||:|||.|.|
Worm    74 KDKKNLVSGILGAIKPVNKVLYITFPIRRDNGEFEVIEAWRAQHSEHRTPTKGGIRYSLDVCEDE 138

  Fly   140 VKALAAIMTFKCACVNVPYGGSKGGICIDPKKYTVDELQTITRRYTMELLKRNMIGPGIDVPAPD 204
            ||||:|:||:|||.|:||:||:|||:.||||:||..|::.||||..:|..|:..:|||:||||||
Worm   139 VKALSALMTYKCAVVDVPFGGAKGGVKIDPKQYTDYEIEKITRRIAIEFAKKGFLGPGVDVPAPD 203

  Fly   205 VNTGPREMSWIVDQYQKTFGYKDINSSAIVTGKPVHNGGINGRHSATGRGVWKAGDLFLKDKEWM 269
            :.||.|||.||.|.|.:|.|:.|.::||.:||||:.:|||:||.|||||||||..::|..|.::|
Worm   204 MGTGEREMGWIADTYAQTIGHLDRDASACITGKPIVSGGIHGRVSATGRGVWKGLEVFTNDADYM 268

  Fly   270 DLLKWKTGWKDKTVIVQGFGNVGSFAAKYVHEAGAKVIGIKEFDVSLVNKDGIDINDLFEYTEEK 334
            .::...||...||.|:|||||||....:|:|.||:|||||:|:|.::.|.|||...:|.::.:..
Worm   269 KMVGLDTGLAGKTAIIQGFGNVGLHTHRYLHRAGSKVIGIQEYDCAVYNPDGIHPKELEDWKDAN 333

  Fly   335 KTIKGYPKAQ--ESKEDLLVAETDILMPCATQKVITTDNAKDIKAKLILEGANGPTTPSGEKILL 397
            .|||.:|.|:  :...:|:..:.||.:|.|.:|.|..:||..|:||:|.|.|||||||:.::|||
Worm   334 GTIKNFPGAKNFDPFTELMYEKCDIFVPAACEKSIHKENASRIQAKIIAEAANGPTTPAADRILL 398

  Fly   398 DKG-VLLVPDLYCNAGGVTVSYFEYLKNINHVSYGKMNSKSTSELIIELMNSINESLHECPDSQL 461
            .:| .|::||:|.|:|||||||||:|||:||||||::..|...|....|:.|:.|||.:......
Worm   399 ARGDCLIIPDMYVNSGGVTVSYFEWLKNLNHVSYGRLTFKYDEEANKMLLASVQESLSKAVGKDC 463

  Fly   462 PNICPNKKLKRIQQCTTEADIVDSALQTVMESAARGIKEMAHKFELCNDLRRAAYVWSSFKIFQA 526
            | :.||..........:|.|||.|.|:..|:.:...|...|||:.|..|:|.|||..|..|::..
Worm   464 P-VEPNAAFAAKIAGASEKDIVHSGLEYTMQRSGEAIIRTAHKYNLGLDIRTAAYANSIEKVYNT 527

  Fly   527 MESSGIS 533
            ..::|.:
Worm   528 YRTAGFT 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bb8	NP_651140.1	GdhA	72..532	CDD:223411	213/462 (46%)
		ELFV_dehydrog_N	95..221	CDD:280903	73/125 (58%)
		NAD_bind_1_Glu_DH	242..517	CDD:133445	124/277 (45%)
gdh-1	NP_502267.1	GdhA	75..533	CDD:223411	213/458 (47%)
		ELFV_dehydrog_N	91..218	CDD:280903	72/126 (57%)
		NAD_bind_1_Glu_DH	241..526	CDD:133445	127/285 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160162760
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0334
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.917438	Normalized mean entropy	S1271
OMA	1	1.010	-	-		QHG54967
OrthoDB	1	1.010	-	-		D217293at33208
OrthoFinder	1	1.000	-	-		FOG0001473
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100455
Panther	1	1.100	-	-	O	PTHR11606
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R306
SonicParanoid	1	1.000	-	-		X1737
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.740