DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG6763 and TLL1

DIOPT Version :10

Sequence 1:NP_651138.1 Gene:CG6763 / 42754 FlyBaseID:FBgn0039069 Length:354 Species:Drosophila melanogaster
Sequence 2:NP_036596.3 Gene:TLL1 / 7092 HGNCID:11843 Length:1013 Species:Homo sapiens


Alignment Length:341 Identity:104/341 - (30%)
Similarity:149/341 - (43%) Gaps:59/341 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    16 CQALPY---VSYDDVDDTEVIELPGNGIEEIPPTLGKDIIDLTP-----LGTALFGKPDEELTAN 72
            |:|..:   ::.|| :|..:.::...             ||||.     ||....|..|..::..
Human    54 CKAAVFWGDIALDD-EDLNIFQIDRT-------------IDLTQNPFGNLGHTTGGLGDHAMSKK 104

  Fly    73 RVGNFSADADEMNPEELGSYLEGDMLVP---------QTDLIMKNGLP-TQSSR----WPNGVVP 123
            | |......|.:  ..:|..||.:..|.         |.:   ||.:| ..:||    ||.||:|
Human   105 R-GALYQLIDRI--RRIGFGLEQNNTVKGKVPLQFSGQNE---KNRVPRAATSRTERIWPGGVIP 163

  Fly   124 YEIRGNFNARDMATIENAIGEYHRRTCIRFVKRSSERDYISIRGDNSGCWSSVGRVG-GKQEVNL 187
            |.|.|||.....|..:.|:..:.:.||:.|::||.|..||.......||.|.|||.| |.|.:::
Human   164 YVIGGNFTGSQRAMFKQAMRHWEKHTCVTFIERSDEESYIVFTYRPCGCCSYVGRRGNGPQAISI 228

  Fly   188 QSPGCLSRPGTAMHELMHALGFLHEQNRMERDGYVAIQYNNVQSSAMNNFEK--AARTEAFGVPY 250
             ...| .:.|..:|||.|.:||.||..|.:||.:|.|...|:|.....||.|  .....:.|..|
Human   229 -GKNC-DKFGIVVHELGHVIGFWHEHTRPDRDNHVTIIRENIQPGQEYNFLKMEPGEVNSLGERY 291

  Fly   251 DYGSVMHYSKNAFSINGQ--PTIL-AMQANG-ADKMGQRNGFSDYDIQKLNRMYDCGTV------ 305
            |:.|:|||::|.|| .|.  .||| :...|| ...:|||...|..||.:..::|.|...      
Human   292 DFDSIMHYARNTFS-RGMFLDTILPSRDDNGIRPAIGQRTRLSKGDIAQARKLYRCPACGETLQE 355

  Fly   306 -NAVPVAPGLPAPAPA 320
             |....:||.|...|:
Human   356 SNGNLSSPGFPNGYPS 371

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG6763NP_651138.1 ZnMc_astacin_like 119..300 CDD:239807 69/187 (37%)
TLL1NP_036596.3 ZnMc_BMP1_TLD 148..347 CDD:239808 74/201 (37%)
CUB 349..458 CDD:395345 5/23 (22%)
CUB 462..571 CDD:395345
FXa_inhibition 582..614 CDD:464251
CUB 618..727 CDD:395345
FXa_inhibition 734..769 CDD:464251
CUB 774..883 CDD:395345
CUB 887..1000 CDD:395345
Blue background indicates that the domain is not in the aligned region.

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