DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6763 and Tll1

DIOPT Version :9

Sequence 1:	NP_001262871.1	Gene:	CG6763 / 42754	FlyBaseID:	FBgn0039069	Length:	354	Species:	Drosophila melanogaster
Sequence 2:	NP_001099551.1	Gene:	Tll1 / 678743	RGDID:	1306120	Length:	1013	Species:	Rattus norvegicus

Alignment Length:	379	Identity:	114/379 - (30%)
Similarity:	158/379 - (41%)	Gaps:	91/379 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LVLALALSSCQALPY--------------VSYDD------------VDDTEVIELPGNGIEEIPP 45
            :|.:..|..|..|.|              :.|.|            :||.::      .|.:|..
  Rat    19 IVFSRELWVCTGLDYDYTFDGNEEDKTEPIDYKDPCKAAVFWGDIALDDEDL------NIFQIDR 77

  Fly    46 TLGKDIIDLT--PLG-----TALFGKPDEELTANRVGNFSADADEMNPEELGSYLEGD------- 96
            |     ||||  |.|     |..||  |..:...| |......|.:  ..:||.||.:
  Rat    78 T-----IDLTQGPFGKLGHITGGFG--DHGMPKKR-GALYQLIDRI--RRIGSGLEQNNTTKGKA 132

  Fly    97 --MLVPQTDLIMKNGLP-TQSSR----WPNGVVPYEIRGNFNARDMATIENAIGEYHRRTCIRFV 154
              .|..|.:   ||.:| ..:||    ||.||:||.|.|||.....|..:.|:..:.:.||:.|.
  Rat   133 PPKLSEQNE---KNRVPRAATSRTERIWPGGVIPYVIGGNFTGSQRAMFKQAMRHWEKHTCVTFT 194

  Fly   155 KRSSERDYISIRGDNSGCWSSVGRVG-GKQEVNLQSPGCLSRPGTAMHELMHALGFLHEQNRMER 218
            :||.|..||.......||.|.|||.| |.|.::: ...| .:.|..:|||.|.:||.||..|.:|
  Rat   195 ERSDEESYIVFTYRPCGCCSYVGRRGNGPQAISI-GKNC-DKFGIVVHELGHVIGFWHEHTRPDR 257

  Fly   219 DGYVAIQYNNVQSSAMNNFEK--AARTEAFGVPYDYGSVMHYSKNAFSINGQ--PTIL-AMQANG 278
            |.:|.|...|:|.....||.|  .....:.|..||:.|:|||::|.|| .|.  .||| :...||
  Rat   258 DNHVTIIRENIQPGQEYNFLKMEPGEVNSLGERYDFDSIMHYARNTFS-RGMFLDTILPSRDDNG 321

  Fly   279 -ADKMGQRNGFSDYDIQKLNRMYDC-----------GTVNAVPVAPGLPAPAPA 320
             ...:|||...|..||.:..::|.|           |.::    :||.|...|:
  Rat   322 IRPAIGQRTRLSKGDIAQARKLYRCPACGETLQESSGNLS----SPGFPNGYPS 371

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6763	NP_001262871.1	Astacin	116..304	CDD:279708	74/209 (35%)
CG6763	NP_001262871.1	ZnMc_astacin_like	119..300	CDD:239807	69/187 (37%)
Tll1	NP_001099551.1	ZnMc_BMP1_TLD	148..347	CDD:239808	74/201 (37%)
		Astacin	155..348	CDD:279708	73/195 (37%)
		CUB	349..458	CDD:278839	5/27 (19%)
		CUB	462..571	CDD:278839
		FXa_inhibition	582..614	CDD:291342
		CUB	618..727	CDD:278839
		FXa_inhibition	734..769	CDD:291342
		CUB	774..883	CDD:278839
		CUB	887..1000	CDD:278839
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810