DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6763 and astl2c

DIOPT Version :9

Sequence 1:	NP_001262871.1	Gene:	CG6763 / 42754	FlyBaseID:	FBgn0039069	Length:	354	Species:	Drosophila melanogaster
Sequence 2:	NP_001037864.1	Gene:	astl2c / 594901	XenbaseID:	XB-GENE-6449741	Length:	496	Species:	Xenopus tropicalis

Alignment Length:	343	Identity:	101/343 - (29%)
Similarity:	156/343 - (45%)	Gaps:	75/343 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSLKVFLVLALALSSCQ-------ALPYVSYDDVDDTEVIELPGNGIEEIPPTLGKDIIDLTPLG 58
            ||..:..:|...|..|.       ..|:|..:|.      |:|.|..:
Frog     1 MSSTISFILLFGLFVCATSFPIQIVFPHVEQNDT------EVPDNDDD----------------- 42

  Fly    59 TALFGKPDEELTANR-VGNFSADADEMNPEELGSYLEGDMLVPQTDLIMKNGLPTQSSRWP---N 119
              :||:   .|.||: ..||              :::||:    .....::.:..:...||   |
Frog    43 --VFGR---ILRANKGKRNF--------------HVQGDI----AHKFSRSAINCKECLWPKDSN 84

  Fly   120 GV--VPYEIRGNFNARDMATIENAIGEYHRRTCIRFVKRSSERDYISIRGDNSGCWSSVGRVGGK 182
            |:  |||.|..:::..:.:.|..|:.|:...||::|:.::.|.|||:|: ...||||.:|..||.
Frog    85 GIVNVPYTISSDYSQNEASLIMAAMQEFATLTCVQFIPQTDEDDYIAIQ-PLDGCWSYIGVNGGA 148

  Fly   183 QEVNLQSPGCLSRPGTAMHELMHALGFLHEQNRMERDGYVAIQYNNVQSSAMNNFEKAARTEAFG 247
            |:|:|...||:.. |...|||.|.|||:||.:|.:||.||.|.|..:....:..|:| ..|:..|
Frog   149 QQVSLGKGGCIYY-GVIQHELNHVLGFVHEHSRSDRDNYVHINYQYISPDNIAFFDK-KDTDNLG 211

  Fly   248 VPYDYGSVMHYSKNAFS-INGQPTILAMQANGADKMGQRNGFSDYDIQKLNRMYDC--------- 302
            :.|||.|||||...::| ..|:.||:.: .|....:|||.|.|..|:.|:||:|.|
Frog   212 LEYDYSSVMHYPGYSYSNTTGKNTIVPI-PNANVPIGQRYGLSTLDVSKINRLYQCDVCSKLFTN 275

  Fly   303 --GTVNAVPVAPGLPAPA 318
              |||.:.......|:.|
Frog   276 ASGTVTSANYPGSYPSNA 293

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6763	NP_001262871.1	Astacin	116..304	CDD:279708	76/204 (37%)
CG6763	NP_001262871.1	ZnMc_astacin_like	119..300	CDD:239807	72/183 (39%)
astl2c	NP_001037864.1	ZnMc_hatching_enzyme	84..266	CDD:239810	73/185 (39%)
		Astacin	89..266	CDD:279708	71/180 (39%)
		CUB	270..380	CDD:238001	5/24 (21%)
		CUB	383..495	CDD:238001
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	160	1.000	Inparanoid score	I4140
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm9530
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.050